| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Long Tao, Xiao-Xiao Li, Xin-Ru Tu, Rui Liu, Jia-Wen Xu, Yi-Li Lv, Yu-You Ya. Hippocampal Crhr1 conditional gene knockout ameliorated the depression-like behavior and pathological damage in male offspring mice caused by chronic stress during pregnancy. Behavioural brain research. 2024-07-05. PMID:38969017. |
it has also been observed that high levels of corticotropin-releasing hormone (crh) can damage hippocampal neurons, and intraperitoneal injection of a corticotropin releasing hormone receptor 1 (crhr1) antagonist decreases depression-like behavior and hippocampal neuronal damage in a mouse depression model. |
2024-07-05 |
2024-07-08 |
mouse |
| Long Tao, Xiao-Xiao Li, Xin-Ru Tu, Rui Liu, Jia-Wen Xu, Yi-Li Lv, Yu-You Ya. Hippocampal Crhr1 conditional gene knockout ameliorated the depression-like behavior and pathological damage in male offspring mice caused by chronic stress during pregnancy. Behavioural brain research. 2024-07-05. PMID:38969017. |
however, whether csdp causes hippocampal damage and depression in offspring through the interaction of crh and hippocampal crhr1 remains unknown and warrants further investigation. |
2024-07-05 |
2024-07-08 |
mouse |
| Weikang Gong, Yan Fu, Bang-Sheng Wu, Jingnan Du, Liu Yang, Ya-Ru Zhang, Shi-Dong Chen, JuJiao Kang, Ying Mao, Qiang Dong, Lan Tan, Jianfeng Feng, Wei Cheng, Jin-Tai Y. Whole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals. Nature communications. vol 15. issue 1. 2024-07-02. PMID:38956042. |
mendelian randomization analysis reveals six causal relationships from regional brain iron to brain disorders, such as from the hippocampus to depression and from the substantia nigra to parkinson's. |
2024-07-02 |
2024-07-06 |
human |
| Qing Du, Minglan Yu, Xuemei Liang, Tingting Wang, Rongfang He, Wei Lei, Jing Chen, Chaohua Huang, Kezhi Liu, Bo Xian. [Identification of novel genetic loci associated with major depressive disorder and the hippocampus in a European population using the condFDR method]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 41. issue 7. 2024-07-01. PMID:38946356. |
to identify additional loci associated with depression and the hippocampus (hip) through genome-wide association study. |
2024-07-01 |
2024-07-03 |
Not clear |
| Toshinori Yoshioka, Akiyoshi Saito. [Underlying mechanisms for psychotropic effects of delta opioid receptor agonists]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 159. issue 4. 2024-06-30. PMID:38945905. |
then, we employed a valid animal model of depression, chronic vicarious social defeat stress (cvsds) mice, and investigated that the influence of dop activation on pathopsychological factors in depression such as the adult hippocampal neurogenesis, hypothalamic-pituitary-adrenal (hpa) axis, and neuroinflammation. |
2024-06-30 |
2024-07-03 |
mouse |
| Nuo Chen, Xinyi Xu, Yaxin Guo, Ming Zhao, Yubin Li, Tian Zhou, Xinyue Zhang, Jie Gao, Faliang Zhu, Chun Guo, Yongyu Shi, Qun Wang, Wenxian Wu, Lining Zhang, Yan L. Brain Short-Chain Fatty Acids Induce ACSS2 to Ameliorate Depressive-Like Behavior via PPARγ-TPH2 Axis. Research (Washington, D.C.). vol 7. 2024-06-28. PMID:38939042. |
in chronic-restraint-stress-induced depression mice, neuronal acss2 knockdown by stereotaxic injection of adeno-associated virus in the hippocampus abolished scfa-mediated improvements in depressive-like behaviors of mice, supporting that acss2 is required for scfa-mediated antidepressant responses. |
2024-06-28 |
2024-06-30 |
mouse |
| Jia-Rui Zhang, Shi-Yu Shen, Zu-Qi Shen, Shu-Yuan Yin, Ke Ye, Wei Li, Hao-Yuan Li, Ling-Feng Liang, Yan-Qing Wang, Xiao-Yun Guo, Jin Y. Role of mitochondria-associated membranes in the hippocampus in the pathogenesis of depression. Journal of affective disorders. 2024-06-24. PMID:38914161. |
role of mitochondria-associated membranes in the hippocampus in the pathogenesis of depression. |
2024-06-24 |
2024-06-27 |
Not clear |
| Jia-Rui Zhang, Shi-Yu Shen, Zu-Qi Shen, Shu-Yuan Yin, Ke Ye, Wei Li, Hao-Yuan Li, Ling-Feng Liang, Yan-Qing Wang, Xiao-Yun Guo, Jin Y. Role of mitochondria-associated membranes in the hippocampus in the pathogenesis of depression. Journal of affective disorders. 2024-06-24. PMID:38914161. |
pathological changes, such as microglia activation in the hippocampus frequently occur in individuals with animal models of depression; however, they may share a common cellular mechanism, such as endoplasmic reticulum (er) stress and mitochondrial dysfunction. |
2024-06-24 |
2024-06-27 |
Not clear |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
one mechanism for the promotion of depression by chronic stress in adulthood is the loss of hippocampal microglia. |
2024-06-21 |
2024-06-24 |
mouse |
| Haojie Zhu, Hainan Pan, Yunli Fang, Hanxiao Wang, Zhuo Chen, Wenfeng Hu, Lijuan Tong, Jie Ren, Xu Lu, Chao Huan. Apoptosis-induced decline in hippocampal microglia mediates the development of depression-like behaviors in adult mice triggered by unpredictable stress during adolescence. European journal of pharmacology. 2024-06-21. PMID:38906239. |
these findings reveal a novel mechanism for the development of depression-like behaviors in animals triggered by deleterious stress in adolescence and suggest that reversing microglial decline in the hippocampus may be a hopeful strategy for the treatment of depression triggered by deleterious stress in adolescence. |
2024-06-21 |
2024-06-24 |
mouse |
| Wu-Jing Zhang, Ze-Xuan Guo, Yi-di Wang, Shao-Yi Fang, Chun-Miao Wan, Xiao-Long Yu, Xiao-Fang Guo, Yue-Yue Chen, Xuan Zhou, Jun-Qing Huang, Xiao-Juan Li, Jia-Xu Chen, Li-Li Fa. From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan. Chinese journal of integrative medicine. 2024-06-20. PMID:38900227. |
in this review, we have summarized the association between depression and aberrant hippocampal neuroplasticity. |
2024-06-20 |
2024-06-22 |
Not clear |
| Wu-Jing Zhang, Ze-Xuan Guo, Yi-di Wang, Shao-Yi Fang, Chun-Miao Wan, Xiao-Long Yu, Xiao-Fang Guo, Yue-Yue Chen, Xuan Zhou, Jun-Qing Huang, Xiao-Juan Li, Jia-Xu Chen, Li-Li Fa. From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan. Chinese journal of integrative medicine. 2024-06-20. PMID:38900227. |
the hippocampus is one of the most commonly studied brain regions in the context of depression. |
2024-06-20 |
2024-06-22 |
Not clear |
| Wu-Jing Zhang, Ze-Xuan Guo, Yi-di Wang, Shao-Yi Fang, Chun-Miao Wan, Xiao-Long Yu, Xiao-Fang Guo, Yue-Yue Chen, Xuan Zhou, Jun-Qing Huang, Xiao-Juan Li, Jia-Xu Chen, Li-Li Fa. From Perspective of Hippocampal Plasticity: Function of Antidepressant Chinese Medicine Xiaoyaosan. Chinese journal of integrative medicine. 2024-06-20. PMID:38900227. |
furthermore, we have discussed the researches published in the last 30 years on the effects of xys on hippocampal neuroplasticity in order to elucidate the possible mechanisms underlying its therapeutic action against depression. |
2024-06-20 |
2024-06-22 |
Not clear |
| YuSheng Liang, Yan Yang, Zhi Jie, Xu Kang, Heng Xu, HaiWang Zhang, Xian W. Hippocampal GPR35 Participates in the Pathogenesis of Cognitive Deficits and Emotional Alterations Induced by Aβ Molecular neurobiology. 2024-06-15. PMID:38878116. |
hippocampal gpr35 participates in the pathogenesis of cognitive deficits and emotional alterations induced by aβ the amyloid-beta (aβ) aggregation in alzheimer's disease (ad) triggers neuroinflammation, and neurodegeneration, which lead to cognitive deficits along with other neuropsychiatric symptoms, including depression and anxiety. |
2024-06-15 |
2024-06-18 |
Not clear |
| Bente M Hofstra, Martien J H Kas, Dineke S Verbee. Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease. Translational psychiatry. vol 14. issue 1. 2024-06-11. PMID:38862462. |
several pathways were identified as shared between alzheimer's disease and depression by conducting clustering pathway analysis on hippocampal co-expressed genes; synaptic signaling and organization, myelination, development, and the immune system. |
2024-06-11 |
2024-06-14 |
Not clear |
| Bente M Hofstra, Martien J H Kas, Dineke S Verbee. Comprehensive analysis of genetic risk loci uncovers novel candidate genes and pathways in the comorbidity between depression and Alzheimer's disease. Translational psychiatry. vol 14. issue 1. 2024-06-11. PMID:38862462. |
this study highlights trans-synaptic signaling and synaptoimmunology in the hippocampus as main shared pathomechanisms of alzheimer's disease and depression. |
2024-06-11 |
2024-06-14 |
Not clear |
| Abudurousuli Adili, Aerken Dilihumaer, Huhu Zhu, Huifang Tan. Research progress on phosphodiesterase 4 inhibitors in central nervous system diseases. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2024-06-11. PMID:38860393. |
pde4 inhibitors play a role in depression; autism spectrum and huntington's disease by inhibiting the advanced glycation end product receptor (rage), tlr4 and nlrp3 pathways in the hippocampus, reducing the activation of microglia and the production of interleukin-1β, down-regulating hmgb1/rage signaling pathway and inhibiting inflammatory factors and increase the nociception threshold. |
2024-06-11 |
2024-06-14 |
Not clear |
| Xueyi Chen, Xiaolong Mo, Yangdong Zhang, Dian He, Rui Xiao, Qisheng Cheng, Haiyang Wang, Lanxiang Liu, Wen-Wen Li, Peng Xi. A comprehensive analysis of the differential expression in the hippocampus of depression induced by gut microbiota compared to traditional stress. Gene. 2024-06-05. PMID:38838871. |
a comprehensive analysis of the differential expression in the hippocampus of depression induced by gut microbiota compared to traditional stress. |
2024-06-05 |
2024-06-08 |
mouse |
| Bente M Hofstra, Emmy E Hoeksema, Martien Jh Kas, Dineke S Verbee. Cross-species analysis uncovers the mitochondrial stress response in the hippocampus as a shared mechanism in mouse early life stress and human depression. Neurobiology of stress. vol 31. 2024-05-27. PMID:38800537. |
cross-species analysis uncovers the mitochondrial stress response in the hippocampus as a shared mechanism in mouse early life stress and human depression. |
2024-05-27 |
2024-05-31 |
mouse |
| Bente M Hofstra, Emmy E Hoeksema, Martien Jh Kas, Dineke S Verbee. Cross-species analysis uncovers the mitochondrial stress response in the hippocampus as a shared mechanism in mouse early life stress and human depression. Neurobiology of stress. vol 31. 2024-05-27. PMID:38800537. |
a combination of genetic and environmental factors such as early life stress (els) increase the risk for development of depression in humans, and a clear role for the hippocampus in the pathophysiology of depression has been shown. |
2024-05-27 |
2024-05-31 |
mouse |