| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yukihiko Shirayama, Chun Yang, Ji-chun Zhang, Qian Ren, Wei Yao, Kenji Hashimot. Alterations in brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in the brain regions of a learned helplessness rat model and the antidepressant effects of a TrkB agonist and antagonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 12. 2016-10-05. PMID:26419294. |
role of brain-derived neurotrophic factor (bdnf)-trkb signaling in a learned helplessness (lh) model of depression was investigated. |
2016-10-05 |
2023-08-13 |
rat |
| Yeshwant Kurhe, Radhakrishnan Mahes. Mechanisms linking depression co-morbid with obesity: An approach for serotonergic type 3 receptor antagonist as novel therapeutic intervention. Asian journal of psychiatry. vol 17. 2016-09-28. PMID:26243683. |
depression and obesity share some common pathological pathways such as hyperactivity of hypothalamic-pituitary-adrenal (hpa) axis, dysregulation of oxidant/antioxidant system balance, higher level of inflammatory cytokines, leptin resistance, altered plasma glucose, insulin resistance, reduced neuronal brain derived neurotrophic factor (bdnf) and decreased serotonergic neurotransmission in various regions of brain. |
2016-09-28 |
2023-08-13 |
Not clear |
| R Ghosh, R Gupta, M S Bhatia, A K Tripathi, L K Gupt. Comparison of efficacy, safety and brain derived neurotrophic factor (BDNF) levels in patients of major depressive disorder, treated with fluoxetine and desvenlafaxine. Asian journal of psychiatry. vol 18. 2016-09-26. PMID:26514447. |
this randomized, open label, prospective, observational study compared clinical efficacy, safety alongwith plasma bdnf levels in outpatients of depression treated with fluoxetine and desvenlafaxine. |
2016-09-26 |
2023-08-13 |
Not clear |
| Murilo Khede Lamego, Antonio Marcos de Souza Moura, Flávia Paes, Nuno Barbosa Ferreira Rocha, Alberto Souza de Sá Filho, Eduardo Lattari, Ridson Rimes, João Manochio, Henning Budde, Mirko Wegner, Gioia Mura, Oscar Arias-Carrión, Ti-Fei Yuan, Antonio Egidio Nardi, Sergio Machad. Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients. CNS & neurological disorders drug targets. vol 14. issue 9. 2016-09-19. PMID:26556073. |
thus, the aim of this study is to present a review investigating the acute and chronic effects of aerobic exercise on bdnf and cortisol levels in individuals with depression. |
2016-09-19 |
2023-08-13 |
Not clear |
| Jun Shen, Junjian Zhang, Min Deng, Yue Liu, Yuan Hu, Lei Zhan. The Antidepressant Effect of Angelica sinensis Extracts on Chronic Unpredictable Mild Stress-Induced Depression Is Mediated via the Upregulation of the BDNF Signaling Pathway in Rats. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-09-19. PMID:27642354. |
the antidepressant effect of angelica sinensis extracts on chronic unpredictable mild stress-induced depression is mediated via the upregulation of the bdnf signaling pathway in rats. |
2016-09-19 |
2023-08-13 |
rat |
| Jiao Chen, Zhen-zhen Wang, Wei Zuo, Shuai Zhang, Shi-feng Chu, Nai-hong Che. Effects of chronic mild stress on behavioral and neurobiological parameters - Role of glucocorticoid. Hormones and behavior. vol 78. 2016-09-15. PMID:26592454. |
in addition, astrocytic disability and dysfunction of neurotrophin brain-derived neurotrophin factor (bdnf) greatly influence the development of depression and anxiety disorders. |
2016-09-15 |
2023-08-13 |
rat |
| Yuefeng Li, Siyue Li, Jinchuan Yan, Dongqing Wang, Ruigen Yin, Liang Zhao, Yan Zhu, Xiaolan Zh. miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like effects in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 65. 2016-09-14. PMID:26368940. |
emerging evidence shows that brain-derived neurotrophic factor (bdnf) and micrornas (mirnas) play critical roles in the etiology of depression. |
2016-09-14 |
2023-08-13 |
rat |
| Y-C Li, L-L Wang, Y-Y Pei, J-D Shen, H-B Li, B-Y Wang, M Ba. Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone. Neuroscience. vol 311. 2016-09-13. PMID:26480816. |
the present results confirmed the antidepressant-like effects of baicalin in a mice model of depression induced by corticosterone and suggested that its mechanism was possibly involved in reducing serum corticosterone and thereby increasing bdnf in the hippocampus. |
2016-09-13 |
2023-08-13 |
mouse |
| Caitlin Webb, Jane M Gunn, Maria Potiriadis, Ian P Everall, Chad A Bousma. The Brain-Derived Neurotrophic Factor Val66Met Polymorphism Moderates the Effects of Childhood Abuse on Severity of Depressive Symptoms in a Time-Dependent Manner. Frontiers in psychiatry. vol 7. 2016-09-13. PMID:27621711. |
cross-sectional studies have demonstrated that the brain-derived neurotrophic factor (bdnf) val66met single-nucleotide polymorphism moderates the association between exposure to negative life events and depression outcomes. |
2016-09-13 |
2023-08-13 |
Not clear |
| Elizabeth Hitchner, Doug Morrison, Phoebe Liao, Allyson Rosen, Wei Zho. Genetic Polymorphisms Influence Cognition in Patients Undergoing Carotid Interventions. The International journal of angiology : official publication of the International College of Angiology, Inc. vol 25. issue 3. 2016-08-30. PMID:27574384. |
after correcting for age and genetic polymorphisms in bdnf and serotonin transporter (5-htt), apoe 4 allele was associated with depression (p= 0.044) and showed a trend with baseline cognitive impairment (p= 0.10). |
2016-08-30 |
2023-08-13 |
Not clear |
| Saïd M'Dahoma, Sandrine Barthélemy, Claire Tromilin, Tiffany Jeanson, Florent Viguier, Benoit Michot, Sophie Pezet, Michel Hamon, Sylvie Bourgoi. Respective pharmacological features of neuropathic-like pain evoked by intrathecal BDNF versus sciatic nerve ligation in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26343858. |
numerous reported data support the idea that brain derived neurotrophic factor (bdnf) is critically involved in both depression and comorbid pain. |
2016-08-26 |
2023-08-13 |
rat |
| Li-Tao Yi, Liu Luo, Yong-Jing Wu, Bin-Bin Liu, Xiao-Long Liu, Di Geng, Qing Li. Circadian variations in behaviors, BDNF and cell proliferation in depressive mice. Metabolic brain disease. vol 30. issue 6. 2016-08-23. PMID:26183613. |
brain-derived neurotrophic factor (bdnf), one of the most widely distributed and the most highly studied neurotrophic factors, has been demonstrated to play an important role in the pathophysiology of depression and the mechanism of antidepressants. |
2016-08-23 |
2023-08-13 |
mouse |
| Tuğçe Demirtaş Şahin, Ayşe Karson, Fuat Balcı, Yusufhan Yazır, Dilek Bayramgürler, Tijen Utka. TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression. Behavioural brain research. vol 292. 2016-08-17. PMID:26112756. |
tnf-alpha inhibition prevents cognitive decline and maintains hippocampal bdnf levels in the unpredictable chronic mild stress rat model of depression. |
2016-08-17 |
2023-08-13 |
rat |
| Ling-yun Hui, Ya-wen Wang, Fu-ling Zhou, Xian-cang Ma, Run-zhi Yan, Lin Zhang, Quan-li Wang, Xuewen Y. Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women. Journal of women's health (2002). vol 25. issue 1. 2016-08-08. PMID:26176177. |
association between mkp-1, bdnf, and gonadal hormones with depression on perimenopausal women. |
2016-08-08 |
2023-08-13 |
mouse |
| Ling-yun Hui, Ya-wen Wang, Fu-ling Zhou, Xian-cang Ma, Run-zhi Yan, Lin Zhang, Quan-li Wang, Xuewen Y. Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women. Journal of women's health (2002). vol 25. issue 1. 2016-08-08. PMID:26176177. |
here we focus on the change of serum mkp-1, bdnf, testosterone (t), and estradiol (e2) levels, in order to test the hypothesis that dysregulation of mkp-1, bdnf, t, and e2 are associated with depression in perimenopausal women. |
2016-08-08 |
2023-08-13 |
mouse |
| János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Kőrösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, Xenia Gonda, Zoltán Rihmer, Judit Hodrea, Zsófia Nemcsik-Bencze, Andrea Feket. Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level. Annals of general psychiatry. vol 15. 2016-08-01. PMID:27478486. |
here, we measured serum bdnf (sebdnf) level in hypertensive patients (ht) and healthy controls (cont) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters. |
2016-08-01 |
2023-08-13 |
Not clear |
| Q Ren, M Ma, C Yang, J-C Zhang, W Yao, K Hashimot. BDNF-TrkB signaling in the nucleus accumbens shell of mice has key role in methamphetamine withdrawal symptoms. Translational psychiatry. vol 5. 2016-07-19. PMID:26506052. |
brain-derived neurotrophic factor (bdnf) and its specific receptor, tropomyosin-related kinase (trkb), have a role the in pathophysiology of depression. |
2016-07-19 |
2023-08-13 |
mouse |
| H N Buttenschøn, D Demontis, M Kaas, B Elfving, S Mølgaard, C Gustafsen, L Kaerlev, C M Petersen, A D Børglum, O Mors, S Gleru. Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF. Translational psychiatry. vol 5. 2016-07-19. PMID:26556286. |
increased serum levels of sortilin are associated with depression and correlated with bdnf and vegf. |
2016-07-19 |
2023-08-13 |
Not clear |
| N Jennifer Klinedinst, Barbara Resnick, Laura M Yerges-Armstrong, Susan G Dorse. The Interplay of Genetics, Behavior, and Pain with Depressive Symptoms in the Elderly. The Gerontologist. vol 55 Suppl 1. 2016-07-11. PMID:26055783. |
commonly studied candidate genes associated with depression include those that influence serotonin (slc6a4), dopamine (comt), or neuroplasticity (bdnf, ntrk3). |
2016-07-11 |
2023-08-13 |
Not clear |
| Meilei Su, Jun Hong, Yongzhi Zhao, Shuai Liu, Xiang Xu. MeCP2 controls hippocampal brain-derived neurotrophic factor expression via homeostatic interactions with microRNA‑132 in rats with depression. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26239616. |
the aim of the present study was to investigate the regulatory association between bdnf, mecp2 and mir-132 in an animal model of chronic stress‑induced depression. |
2016-06-27 |
2023-08-13 |
human |