| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuoli Sun, Lina Jia, Dandan Shi, Yi He, Yanping Ren, Jian Yang, Xin M. Deep brain stimulation improved depressive-like behaviors and hippocampal synapse deficits by activating the BDNF/mTOR signaling pathway. Behavioural brain research. 2021-12-10. PMID:34890598. |
recent work has shown that deficits in brain-derived neurotrophic factor (bdnf) and its downstream proteins, including mammalian target of rapamycin (mtor), might be involved in the pathogenesis of depression. |
2021-12-10 |
2023-08-13 |
rat |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
hippocampal mir-206-3p participates in the pathogenesis of depression via regulating the expression of bdnf. |
2021-12-07 |
2023-08-13 |
mouse |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
recently, mir-206 has been demonstrated to regulate the biosynthesis of brain-derived neurotrophic factor (bdnf), a very popular target involved in depression and antidepressant responses. |
2021-12-07 |
2023-08-13 |
mouse |
| Wei Guan, Da-Wei Xu, Chun-Hui Ji, Cheng-Niu Wang, Yue Liu, Wen-Qian Tang, Jiang-Hong Gu, Yan-Mei Chen, Jie Huang, Jian-Feng Liu, Bo Jian. Hippocampal miR-206-3p participates in the pathogenesis of depression via regulating the expression of BDNF. Pharmacological research. vol 174. 2021-12-07. PMID:34628001. |
taken together, hippocampal mir-206-3p participates in the pathogenesis of depression by regulating bdnf biosynthesis and is a feasible antidepressant target. |
2021-12-07 |
2023-08-13 |
mouse |
| Natalie Prowse, Shawn Hayle. Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype. Neuroscience and biobehavioral reviews. vol 131. 2021-12-03. PMID:34537262. |
we will then assess sex-based differences in microglial function and bdnf expression, and how microglia are involved in the stress response and related disorders such as depression. |
2021-12-03 |
2023-08-13 |
Not clear |
| YuanYuan Hou, YunLei Wang, ShaoFei Song, Yao Zuo, HaoJie Zhang, Chen Bai, HaiTao Zhao, Tong Zhan. Long-term variable photoperiod exposure impairs the mPFC and induces anxiety and depression-like behavior in male wistar rats. Experimental neurology. vol 347. 2021-12-03. PMID:34710402. |
we compared the numbers of neurons, astrocytes, and dendritic spines; dendrite morphology; long-term potentiation (ltp), long-term depression (ltd) and paired-pulse ratio (ppr); expression of glutamate receptor [n-methyl-d-aspartate receptor (nmdar) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (ampar)] subunits and brain-derived neurotrophic factor (bdnf) in the medial prefrontal cortex (mpfc); and the anxiety and depression behaviors between rats in the circadian misalignment (cm) and circadian alignment (ca, with normal circadian rhythm) groups. |
2021-12-03 |
2023-08-13 |
rat |
| Steven Paul Woods, Michelle Babicz, Lokesh Shahani, Gabriela Delevati Colpo, Erin E Morgan, Antonio L Teixeir. Brain-derived neurotrophic factor (BDNF) is associated with depressive symptoms in older adults with HIV disease. Journal of neurovirology. vol 27. issue 1. 2021-11-30. PMID:33145707. |
this study examined the possible role of brain-derived neurotrophic factor (bdnf) in symptoms of depression and other aspects of mood in 109 pwh and 43 seronegative participants aged 50 and older. |
2021-11-30 |
2023-08-13 |
human |
| Dore Loef, Kristof Vansteelandt, Mardien L Oudega, Philip van Eijndhoven, Angela Carlier, Eric van Exel, Didi Rhebergen, Pascal Sienaert, Mathieu Vandenbulcke, Filip Bouckaert, Annemiek Dol. The ratio and interaction between neurotrophin and immune signaling during electroconvulsive therapy in late-life depression. Brain, behavior, & immunity - health. vol 18. 2021-11-30. PMID:34841285. |
we examine the relation, interaction, and ratio between the neurotrophic brain-derived neurotrophic factor (bdnf) and the proinflammatory cytokines interleukin-6 (il-6) and tumor necrosis factor α (tnf-α), and depression severity during ect. |
2021-11-30 |
2023-08-13 |
Not clear |
| Chih-Ming Cheng, Chen-Jee Hong, Hui-Ching Lin, Po-Jui Chu, Mu-Hong Chen, Pei-Chi Tu, Ya-Mei Bai, Wen-Han Chang, Chi-Hung Juan, Wei-Chen Lin, Shih-Jen Tsai, Tung-Ping Su, Cheng-Ta L. Predictive roles of brain-derived neurotrophic factor Val66Met polymorphism on antidepressant efficacy of different forms of prefrontal brain stimulation monotherapy: A randomized, double-blind, sham-controlled study. Journal of affective disorders. vol 297. 2021-11-29. PMID:34715162. |
hence, we investigated the bdnf polymorphism contribution to the antidepressant effect of different forms left-sided prefrontal stimulations in a randomized, sham-controlled study methods: seventy-five patients with medication-resistant depression were randomly assigned into three monotherapy groups: pitbs, high-frequency(hf) rtms, or sham. |
2021-11-29 |
2023-08-13 |
Not clear |
| Acieh Alizadeh Makvandi, Mohsen Khalili, Mehrdad Roghani, Sara Amiri Moghadda. Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. Journal of chemical neuroanatomy. vol 117. 2021-11-26. PMID:34246766. |
hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal bdnf and oxidative stress in a rat model of depression. |
2021-11-26 |
2023-08-13 |
rat |
| Yu Zhang, Ya-Xin Bi, Jie Chen, Shuang Li, Xia-Xin Wu, Lu Zhang, Zhi-Jie Lin, Sen Han, Shi-Zhen Din. Association of Peroxiredoxin 1 and brain-derived neurotrophic factor serum levels with depression and anxiety symptoms in patients with irritable bowel syndrome. General hospital psychiatry. vol 68. 2021-11-25. PMID:33338736. |
this study determined the possible association of serum peroxiredoxin 1 (prdx1; a key antioxidant enzyme) and brain-derived neurotrophic factor (bdnf) with anxiety and depression symptoms in ibs patients. |
2021-11-25 |
2023-08-13 |
Not clear |
| Katarzyna Mlynie. Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression. Current neuropharmacology. vol 19. issue 11. 2021-11-25. PMID:33632103. |
interaction between zinc, gpr39, bdnf and neuropeptides in depression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Yuhua Xing, Ting Sun, Guangxue Li, Guoan Xu, Jia Cheng, Shugui Ga. The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value. Journal of clinical laboratory analysis. vol 35. issue 11. 2021-11-25. PMID:34528295. |
the role of bdnf exon i region methylation in the treatment of depression with sertraline and its clinical diagnostic value. |
2021-11-25 |
2023-08-13 |
Not clear |
| Yuhua Xing, Ting Sun, Guangxue Li, Guoan Xu, Jia Cheng, Shugui Ga. The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value. Journal of clinical laboratory analysis. vol 35. issue 11. 2021-11-25. PMID:34528295. |
brain-derived neurotrophic factor (bdnf) is considered to be one of the best candidate genes for depression. |
2021-11-25 |
2023-08-13 |
Not clear |
| Chun-Hui Ji, Jiang-Hong Gu, Yue Liu, Wen-Qian Tang, Wei Guan, Jie Huang, Yan-Mei Chen, Da-Wei Xu, Bo Jian. Hippocampal MSK1 regulates the behavioral and biological responses of mice to chronic social defeat stress: Involving of the BDNF-CREB signaling and neurogenesis. Biochemical pharmacology. 2021-11-24. PMID:34774532. |
currently, besides to the monoaminergic system, the brain-derived neurotrophic factor (bdnf)-camp response element-binding protein (creb) signaling is one of the most attractive signaling pathways for treating depression. |
2021-11-24 |
2023-08-13 |
mouse |
| Mu-Hong Chen, Hui-Ju Wu, Cheng-Ta Li, Wei-Chen Lin, Shih-Jen Tsai, Chen-Jee Hong, Pei-Chi Tu, Ya-Mei Bai, Wei-Chung Mao, Tung-Ping S. Low-dose ketamine infusion for treating subjective cognitive, somatic, and affective depression symptoms of treatment-resistant depression. Asian journal of psychiatry. vol 66. 2021-11-19. PMID:34592639. |
whether the antidepressant effects of low-dose ketamine infusion and the therapeutic impact of val66met brain-derived neurotrophic factor (bdnf) polymorphism vary across different depression symptom domains, namely affective, cognitive, and somatic, remains unclear. |
2021-11-19 |
2023-08-13 |
Not clear |
| J Bakusic, E Vrieze, M Ghosh, D A Pizzagalli, B Bekaert, S Claes, L Godderi. Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression. Clinical epigenetics. vol 13. issue 1. 2021-11-18. PMID:34325733. |
interplay of val66met and bdnf methylation: effect on reward learning and cognitive performance in major depression. |
2021-11-18 |
2023-08-13 |
Not clear |
| Yufeng Jia, Xiao Zhuang, Yi Zhang, Ming Zhao, Nuo Chen, Wen Li, Faliang Zhu, Chun Guo, Yan Li, Qun Wang, Yuan Li, Lining Zhan. The brain targeted delivery of programmed cell death 4 specific siRNA protects mice from CRS-induced depressive behavior. Cell death & disease. vol 12. issue 11. 2021-11-18. PMID:34772918. |
therefore, promoting bdnf expression provides a strategy for the treatment of depression. |
2021-11-18 |
2023-08-13 |
mouse |
| Bangkun Yang, Lesheng Wang, Ying Nie, Wei Wei, Wenping Xion. proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model. Translational psychiatry. vol 11. issue 1. 2021-11-17. PMID:34759285. |
brain-derived neurotrophic factor (bdnf) plays an important role in the pathophysiology of post-stroke depression (psd). |
2021-11-17 |
2023-08-13 |
Not clear |
| F Leblhuber, S Geisler, D Ehrlich, K Steiner, G Reibnegger, Dietmar Fuchs, K Kur. Repetitive transcranial magnetic stimulation in the treatment of resistant depression: changes of specific neurotransmitter precursor amino acids. Journal of neural transmission (Vienna, Austria : 1996). vol 128. issue 8. 2021-11-16. PMID:34244826. |
in this interventional study safety, symptom development and changes of serum concentrations of neurotransmitter precursor amino acids, of immune activation and inflammation markers, of brain-derived neurotrophic factor (bdnf), nitrite as well as of salivary amylase were measured before and after a frontal polar cortex stimulation using rtms as add-on treatment in 38 patients with treatment-resistant depression. |
2021-11-16 |
2023-08-13 |
Not clear |