| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Schürk. [What is migraine?]. Der Nervenarzt. vol 80. issue 10. 2010-01-06. PMID:19322554. |
the former is supported by the cortical spreading depression being the aura correlate and by brainstem and hypothalamic activation during the pain phase; the latter is suggested by the association between migraine and cardiovascular disease and findings of pathological vasoreactivity and endothelial dysfunction. |
2010-01-06 |
2023-08-12 |
Not clear |
| Till Sprenger, Peter J Goadsb. Migraine pathogenesis and state of pharmacological treatment options. BMC medicine. vol 7. 2009-12-17. PMID:19917094. |
this review discusses the current pathophysiological concepts of migraine and migraine aura, such as a possible brainstem dysfunction and cortical spreading depression. |
2009-12-17 |
2023-08-12 |
Not clear |
| Fm Cutre. New information in our evolving understanding of migraine aura and cortical spreading depression. Cephalalgia : an international journal of headache. vol 29. issue 10. 2009-11-23. PMID:19735539. |
new information in our evolving understanding of migraine aura and cortical spreading depression. |
2009-11-23 |
2023-08-12 |
Not clear |
| P L Durham, F G Garret. Neurological mechanisms of migraine: potential of the gap-junction modulator tonabersat in prevention of migraine. Cephalalgia : an international journal of headache. vol 29 Suppl 2. 2009-11-17. PMID:19723120. |
the exact pathophysiological mechanism underlying migraine is not fully understood; however, cortical spreading depression (csd) is thought to provide the basis for migraine aura and may serve as a trigger of migraine pain. |
2009-11-17 |
2023-08-12 |
Not clear |
| S D Silberstei. Tonabersat, a novel gap-junction modulator for the prevention of migraine. Cephalalgia : an international journal of headache. vol 29 Suppl 2. 2009-11-17. PMID:19723123. |
recent research has pointed to the role of cortical spreading depression in the genesis of migraine aura and pain, with neuronal-glial gap junctions playing a prominent part in cortical spreading depression. |
2009-11-17 |
2023-08-12 |
Not clear |
| Katharina Eikermann-Haerter, Michael J Baum, Michel D Ferrari, Arn M J M van den Maagdenberg, Michael A Moskowitz, Cenk Ayat. Androgenic suppression of spreading depression in familial hemiplegic migraine type 1 mutant mice. Annals of neurology. vol 66. issue 4. 2009-11-17. PMID:19847904. |
mutant mice carrying the fhm1 r192q mutation exhibit increased propensity for cortical spreading depression (csd), a propagating wave of neuroglial depolarization implicated in migraine aura. |
2009-11-17 |
2023-08-12 |
mouse |
| Lyudmila V Vinogradova, Galina D Kuznetsova, Antonius M L Coene. Unilateral cortical spreading depression induced by sound in rats. Brain research. vol 1286. 2009-10-20. PMID:19559681. |
cortical spreading depression (sd) is thought to underlie the migraine aura but the mechanisms of triggering sd in the human cortex remain unknown. |
2009-10-20 |
2023-08-12 |
human |
| Todd J Schwedt, David W Dodic. Advanced neuroimaging of migraine. The Lancet. Neurology. vol 8. issue 6. 2009-06-23. PMID:19446275. |
functional imaging has confirmed the importance of cortical spreading depression (csd) as the pathophysiological mechanism of migraine aura in human beings, whereas novel animal studies are unravelling the mechanistic underpinnings of csd. |
2009-06-23 |
2023-08-12 |
human |
| Markus A Dahlem, Nouchine Hadjikhan. Migraine aura: retracting particle-like waves in weakly susceptible cortex. PloS one. vol 4. issue 4. 2009-06-12. PMID:19337363. |
cortical spreading depression (sd) has been suggested to underlie migraine aura. |
2009-06-12 |
2023-08-12 |
human |
| Gogi Kumar, Leonid Topper, Joseph Mayta. Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report. Headache. vol 49. issue 1. 2009-04-30. PMID:18624711. |
we report a case of familial hemiplegic migraine with prolonged aura where multimodality imaging showed hemispheric cytotoxic edema along with evidence of hypometabolism in the affected hemisphere while there was no evidence of hypoperfusion of the affected hemisphere demonstrating that neuronal depression is a more plausible explanation in its pathogenesis. |
2009-04-30 |
2023-08-12 |
Not clear |
| Angelita Tottene, Rossella Conti, Alessandra Fabbro, Dania Vecchia, Maryna Shapovalova, Mirko Santello, Arn M J M van den Maagdenberg, Michel D Ferrari, Daniela Pietrobo. Enhanced excitatory transmission at cortical synapses as the basis for facilitated spreading depression in Ca(v)2.1 knockin migraine mice. Neuron. vol 61. issue 5. 2009-04-01. PMID:19285472. |
knockin mice carrying a fhm1 mutation show increased neuronal p/q-type current and facilitation of induction and propagation of cortical spreading depression (csd), the phenomenon that underlies migraine aura and may activate migraine headache mechanisms. |
2009-04-01 |
2023-08-12 |
mouse |
| Takahiro Takano, Maiken Nedergaar. Deciphering migraine. The Journal of clinical investigation. vol 119. issue 1. 2009-03-10. PMID:19104145. |
migrainous aura is caused by cortical spreading depression (csd) - a slowly advancing wave of tissue depolarization in the cortex. |
2009-03-10 |
2023-08-12 |
mouse |
| Katharina Eikermann-Haerter, Ergin Dileköz, Chiho Kudo, Sean I Savitz, Christian Waeber, Michael J Baum, Michel D Ferrari, Arn M J M van den Maagdenberg, Michael A Moskowitz, Cenk Ayat. Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1. The Journal of clinical investigation. vol 119. issue 1. 2009-03-10. PMID:19104150. |
spreading depression (sd), a slowly propagating neuronal and glial cell depolarization that leads to depression of neuronal activity, is the most likely cause of migraine aura. |
2009-03-10 |
2023-08-12 |
mouse |
| Simon Akerman, Philip R Holland, Peter J Goadsb. Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade. Brain research. vol 1229. 2009-02-03. PMID:18656463. |
the regional cerebral blood flow (rcbf) changes that occur during cortical spreading depression (csd) are considered to be an experimental correlate of aura. |
2009-02-03 |
2023-08-12 |
human |
| F Richter, A Lehmenkühle. [Cortical spreading depression (CSD): a neurophysiological correlate of migraine aura]. Schmerz (Berlin, Germany). vol 22. issue 5. 2008-12-04. PMID:18483750. |
[cortical spreading depression (csd): a neurophysiological correlate of migraine aura]. |
2008-12-04 |
2023-08-12 |
Not clear |
| M Schürks, H-C Diene. [Pathophysiology of migraine and clinical implications]. Schmerz (Berlin, Germany). vol 22. issue 5. 2008-12-04. PMID:18600349. |
cortical spreading depression is the electrophysiological correlate of the aura and can activate the trigemino-vascular system. |
2008-12-04 |
2023-08-12 |
Not clear |
| Chiho Kudo, Ala Nozari, Michael A Moskowitz, Cenk Ayat. The impact of anesthetics and hyperoxia on cortical spreading depression. Experimental neurology. vol 212. issue 1. 2008-07-17. PMID:18501348. |
cortical spreading depression (csd), a transient neuronal and glial depolarization that propagates slowly across the cerebral cortex, is the putative electrophysiological event underlying migraine aura. |
2008-07-17 |
2023-08-12 |
human |
| Yilong Cui, Yosky Kataoka, Takashi Inui, Takatoshi Mochizuki, Hirotaka Onoe, Kiyoshi Matsumura, Yoshihiro Urade, Hisao Yamada, Yasuyoshi Watanab. Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats. Journal of neuroscience research. vol 86. issue 4. 2008-07-08. PMID:17929312. |
cortical spreading depression is an excitatory wave of depolarization spreading throughout cerebral cortex at a rate of 2-5 mm/min and has been implicated in various neurological disorders, such as epilepsy, migraine aura, and trauma. |
2008-07-08 |
2023-08-12 |
rat |
| Shahab Dehbandi, Erwin-Josef Speckmann, Hans Christian Pape, Ali Gorj. Cortical spreading depression modulates synaptic transmission of the rat lateral amygdala. The European journal of neuroscience. vol 27. issue 8. 2008-07-01. PMID:18412626. |
cortical spreading depression (csd) plays a causative role in the generation of aura symptoms. |
2008-07-01 |
2023-08-12 |
rat |
| Frank Richter, Reinhard Bauer, Alfred Lehmenkühler, Hans-Georg Schaibl. Spreading depression in the brainstem of the adult rat: electrophysiological parameters and influences on regional brainstem blood flow. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 28. issue 5. 2008-06-26. PMID:18059430. |
cortical spreading depression is a pathophysiological excitation wave that occurs during pathophysiological brain conditions such as ischemic brain infarction, migraine aura, and others. |
2008-06-26 |
2023-08-12 |
rat |