| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mattias Haglund, Raj Kalaria, Janet Y Slade, Elisabet Englun. Differential deposition of amyloid beta peptides in cerebral amyloid angiopathy associated with Alzheimer's disease and vascular dementia. Acta neuropathologica. vol 111. issue 5. 2007-01-09. PMID:16555084. |
to better understand caa mechanisms in dementia, we assessed the frontal cortex of 62 consecutive cases of alzheimer's disease (ad), vascular dementia (vad), and mixed dementia (md) using immunohistochemistry with antibodies to abeta, smooth muscle actin and the carboxyl-terminal peptides to detect abeta(40) and abeta(42). |
2007-01-09 |
2023-08-12 |
mouse |
| V Haroutunian, P Davies, C Vianna, J D Buxbaum, D P Purohi. Tau protein abnormalities associated with the progression of alzheimer disease type dementia. Neurobiology of aging. vol 28. issue 1. 2006-12-28. PMID:16343696. |
concentrations of conformationally altered tau increased with increasing dementia severity and the levels of mc1 immunoreactivity increased in the frontal cortex of mildly demented subjects before the appearance of nft bearing neurons, suggesting that conformational alterations in tau occur early in the course of ad and its cognitive symptoms and may precede histologically identified nfts. |
2006-12-28 |
2023-08-12 |
human |
| Jonathan T Stewar. The frontal/subcortical dementias: common dementing illnesses associated with prominent and disturbing behavioral changes. Geriatrics. vol 61. issue 8. 2006-10-12. PMID:16901194. |
although the most common cause of dementia is alzheimer's disease, many other common dementing illnesses in the elderly affect the frontal cortex and associated subcortical structures and present with very different symptoms. |
2006-10-12 |
2023-08-12 |
Not clear |
| Marta Barrachina, Esther Castaño, Isidro Ferre. TaqMan PCR assay in the control of RNA normalization in human post-mortem brain tissue. Neurochemistry international. vol 49. issue 3. 2006-09-15. PMID:16522342. |
this has been carried out in samples of the frontal cortex in a series of control and diseased cases covering parkinson's disease, dementia with lewy bodies pure form and common form, and alzheimer's disease. |
2006-09-15 |
2023-08-12 |
human |
| Ken Umemura, Nobuyuki Yamashita, Xiaonian Yu, Kunimasa Arima, Takashi Asada, Takao Makifuchi, Shigeo Murayama, Yuko Saito, Kazutomi Kanamaru, Yuichi Goto, Shinichi Kohsaka, Ichiro Kanazawa, Hideo Kimur. Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients. Neuroscience letters. vol 400. issue 1-2. 2006-08-04. PMID:16529861. |
autotaxin expression is enhanced in frontal cortex of alzheimer-type dementia patients. |
2006-08-04 |
2023-08-12 |
Not clear |
| S Theodore, W A Cass, W F Marago. Methamphetamine and human immunodeficiency virus protein Tat synergize to destroy dopaminergic terminals in the rat striatum. Neuroscience. vol 137. issue 3. 2006-04-12. PMID:16338084. |
previous studies have shown that human immunodeficiency virus-1-associated dementia patients with a history of drug abuse have rapid neurological progression, prominent psychomotor slowing, more severe encephalitis and more severe dendritic and neuronal damage in the frontal cortex compared with human immunodeficiency virus-1-associated dementia patients without a history of drug abuse. |
2006-04-12 |
2023-08-12 |
human |
| Marong Fang, Jicheng Li, S C Tiu, Lihong Zhang, Mingwei Wang, David T Ye. N-methyl-D-aspartate receptor and apoptosis in Alzheimer's disease and multiinfarct dementia. Journal of neuroscience research. vol 81. issue 2. 2005-11-03. PMID:15931666. |
this study investigates the role of excitotoxicity in alzheimer's disease and in multiinfarct dementia by examining, via immunohistochemical methods, the number of cells that are positive for n-methyl-d-aspartate (nmda) receptor and the degree of colocalization between nmda receptor and apoptosis markers such as tunel or activated caspase-3 in the frontal cortex of individuals with these two conditions, comparing the results with those from subjects who died of normal aging. |
2005-11-03 |
2023-08-12 |
human |
| Esther Dalfó, Manuel Portero-Otín, Victoria Ayala, Anna Martínez, Reinald Pamplona, Isidre Ferre. Evidence of oxidative stress in the neocortex in incidental Lewy body disease. Journal of neuropathology and experimental neurology. vol 64. issue 9. 2005-10-12. PMID:16141792. |
these changes were not associated to alpha-synuclein aggregation in cortex, contrasting with aggregates found in sds-soluble fractions of frontal cortex in dementia with lewy bodies (dlb) cases. |
2005-10-12 |
2023-08-12 |
Not clear |
| N Ogawa, K Mizukawa, M Asanuma, I Kanazaw. Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease. Archives of gerontology and geriatrics. vol 17. issue 2. 2005-03-10. PMID:15374321. |
receptor binding assays and in vitro macroautoradiography were used to analyze muscarinic cholinergic receptors (mcr) in the cerebral frontal cortex of alzheimer's disease (ad), senile dementia of alzheimer type (sdat), and age-matched control brains at autopsy. |
2005-03-10 |
2023-08-12 |
Not clear |
| N Ogawa, K Mizukawa, M Asanuma, I Kanazaw. Abnormalities in muscarinic cholinergic receptors and their G-protein coupling systems in the cerebral frontal cortex in Alzheimer's disease. Archives of gerontology and geriatrics. vol 17. issue 2. 2005-03-10. PMID:15374321. |
our findings that there are alterations in the structural distribution of mcr as well as reductions and abnormalities in second messenger systems in ad cerebral frontal cortex, suggest that drug therapy with acetylcholine precursors, choline esterase inhibitors and muscarinic agonists cannot eliminate symptoms in dementia patients. |
2005-03-10 |
2023-08-12 |
Not clear |
| Osamu Yokota, Seishi Terada, Hideki Ishizu, Takeshi Ishihara, Hanae Nakashima, Aki Kugo, Kuniaki Tsuchiya, Kenji Ikeda, Toshiyuki Hayabara, Yuko Saito, Shigeo Murayama, Kenji Uéda, Frédéric Checler, Shigetoshi Kurod. Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia. Acta neuropathologica. vol 107. issue 5. 2004-06-28. PMID:14991384. |
in this study, to assess the relationship between the neuronal cox-2 expression in the cerebrum, the formation of tau- and alpha-synuclein-negative but ubiquitin-positive neuronal inclusions (upis), and dementia in motor neuron disease (mnd), we examined neuronal cox-2 immunoreactivity in the frontal cortex and hippocampus of patients with non-demented als without upis ( n=11), alsd with upis ( n=6), and normal controls ( n=24) using a quantitative immunohistochemical technique. |
2004-06-28 |
2023-08-12 |
Not clear |
| Pilar Andrés, Martial Van der Linde. Are central executive functions working in patients with focal frontal lesions? Neuropsychologia. vol 40. issue 7. 2002-06-11. PMID:11900734. |
these findings suggest that not all-executive processes are exclusively sustained by the frontal cortex [quart j exp psychol 9 (1996) 5; curr opin neurobiol 10 (2000) 195; neuropsychology (1994) 544; the cognitive neuropsychology of alzheimer-type dementia. |
2002-06-11 |
2023-08-12 |
human |
| E Adamec, H T Chang, E G Stopa, J C Hedreen, J P Vonsatte. Tau protein expression in frontotemporal dementias. Neuroscience letters. vol 315. issue 1-2. 2001-12-26. PMID:11711205. |
the expression of the microtubule-associated protein tau was studied in postmortem samples of frontal cortex of 19 cases (12 pick's disease a, b, c; 4 dementia lacking distinct histology; 3 motor neuron disease type) by western blotting with a phosphorylation-independent anti-tau antibody. |
2001-12-26 |
2023-08-12 |
Not clear |
| N Bogdanovic, P Davidsson, I Volkmann, B Winblad, K Blenno. Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study. Journal of neural transmission (Vienna, Austria : 1996). vol 107. issue 4. 2001-05-10. PMID:11215757. |
in the frontal cortex, there was a significant negative correlation between gap-43 and duration of dementia (r = -0.58; p < 0.02) and a positive correlation between gap-43 and the synaptic vesicle-specific protein rab3a (r = 0.62; p < 0.05), while no such correlation were found in the hippocampus. |
2001-05-10 |
2023-08-12 |
human |
| L A Kalashnikova, T S Gulevskaya, E M Kashin. Disorders of higher mental function due to single infarctions in the thalamus and in the area of the thalamofrontal tracts. Neuroscience and behavioral physiology. vol 29. issue 4. 2000-01-11. PMID:10582221. |
it is suggested that disconnection of these pathways leads to cognitive lesions or dementia because of functional inactivation of the frontal cortex. |
2000-01-11 |
2023-08-12 |
Not clear |
| A M Lidström, N Bogdanovic, C Hesse, I Volkman, P Davidsson, K Blenno. Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease. Experimental neurology. vol 154. issue 2. 1999-02-04. PMID:9878186. |
within the ad group, there was a significant negative correlation between clusterin levels in hippocampus and severity of dementia (r = -0.40), while no such correlation was found in frontal cortex (r = 0.12). |
1999-02-04 |
2023-08-12 |
human |
| P Davidsson, K Blenno. Neurochemical dissection of synaptic pathology in Alzheimer's disease. International psychogeriatrics. vol 10. issue 1. 1998-09-10. PMID:9629521. |
the material included postmortem brain tissue (frontal cortex, hippocampus, and cerebellum) from 8 patients with early-onset ad (ead), 11 patients with late-onset ad (lad), 6 patients with vascular dementia (vad), and 9 control subjects. |
1998-09-10 |
2023-08-12 |
human |
| Y Koshi, S Kitamura, T Komiyama, O Sakayori, Y Komaba, M Ohyama, T Tsuganesawa, M Mishina, A Ishiwata, H Soya, M Nakazawa, A Terash. [A quantitative study of regional cerebral blood flow in patients with dementia of Alzheimer type using single photon emission computed tomography--clinical application of the IMP autoradiographic method (IMP ARG method)]. Kaku igaku. The Japanese journal of nuclear medicine. vol 33. issue 9. 1996-12-17. PMID:8921667. |
moreover, the correlations between the score by the hasegawa dementia scale (hds-r) and each rcbf were significant in the temporal, parietal, and frontal cortex. |
1996-12-17 |
2023-08-12 |
human |
| K Blennow, N Bogdanovic, I Alafuzoff, R Ekman, P Davidsso. Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele. Journal of neural transmission (Vienna, Austria : 1996). vol 103. issue 5. 1996-12-10. PMID:8811505. |
in contrast, no significant correlations were found between sp counts and duration or severity of dementia, while higher nft counts in the frontal cortex were found with increasing severity of dementia (r = 0.54, p < 0.05). |
1996-12-10 |
2023-08-12 |
human |
| D Mantle, G Falkous, S Ishiura, R H Perry, E K Perr. Comparison of cathepsin protease activities in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease. Journal of the neurological sciences. vol 131. issue 1. 1995-11-20. PMID:7561949. |
for comparative purposes, activity levels of the above enzymes were also determined in frontal cortex tissue from cases with lewy body dementia and parkinson's disease, and in caudate tissue from control and huntington's disease cases. |
1995-11-20 |
2023-08-12 |
Not clear |