| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Céline Duval, Alexandre Bejanin, Pascale Piolino, Mickael Laisney, Vincent de La Sayette, Serge Belliard, Francis Eustache, Béatrice Desgrange. Theory of mind impairments in patients with semantic dementia. Brain : a journal of neurology. vol 135. issue Pt 1. 2012-07-19. PMID:22232593. |
results provided objective evidence of an impact of semantic dementia on cognitive and affective theory of mind, consistent with the patients' atrophy in the left temporal lobe and hypometabolism in the temporal lobes and the medial frontal cortex. |
2012-07-19 |
2023-08-12 |
human |
| Gordana Nedić, Fran Borovecki, Natasa Klepac, Zdenko Mubrin, Sanja Hajnsek, Matea Nikolac, Dorotea Muck-Seler, Nela Piva. Association study of a functional catechol-o-methyltransferase polymorphism and cognitive function in patients with dementia. Collegium antropologicum. vol 35 Suppl 1. 2011-08-02. PMID:21648315. |
although met/met genotype with more dopamine available in the frontal cortex should be associated with better neuro-cognitive test results than met/val or val/val genotype, our data on patients with dementia did not confirm this hypothesis. |
2011-08-02 |
2023-08-12 |
human |
| Li Zhou, Eve Diefenbach, Ben Crossett, Sieu L Tran, Thomas Ng, Helen Rizos, Rejane Rua, Bin Wang, Amit Kapur, Kaushal Gandhi, Bruce J Brew, Nitin K Saksen. First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular neurodegeneration. vol 5. 2011-07-14. PMID:20573273. |
first evidence of overlaps between hiv-associated dementia (had) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from hiv+ patients with and without dementia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Ana Navarro, Alberto Boveri. Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease. Frontiers in aging neuroscience. vol 2. 2011-07-14. PMID:20890446. |
mitochondrial dysfunction is more marked in brain areas as rat hippocampus and frontal cortex, in human cortex in parkinson's disease and dementia with lewy bodies, and in substantia nigra in parkinson's disease. |
2011-07-14 |
2023-08-12 |
mouse |
| James Scott Miners, Sean Morris, Seth Love, Patrick Gavin Keho. Accumulation of insoluble amyloid-β in down's syndrome is associated with increased BACE-1 and neprilysin activities. Journal of Alzheimer's disease : JAD. vol 23. issue 1. 2011-05-05. PMID:20930275. |
we have further tested this hypothesis by examination of frontal cortex obtained postmortem from individuals with down's syndrome (ds), in whom ad-like neuropathological changes occur in association with early-onset dementia. |
2011-05-05 |
2023-08-12 |
Not clear |
| C Davis, J Heidler-Gary, R F Gottesman, J Crinion, M Newhart, A Moghekar, D Soloman, D Rigamonti, L Cloutman, A E Hilli. Action versus animal naming fluency in subcortical dementia, frontal dementias, and Alzheimer's disease. Neurocase. vol 16. issue 3. 2010-08-18. PMID:20104387. |
we hypothesized patients with subcortical dementia, e.g., normal pressure hydrocephalus (nph) and patients with dementias predominantly affecting frontal cortex, e.g., behavioral variant frontotemporal dementia (bv-ftd) and progressive nonfluent aphasia (pnfa) have more difficulty on action fluency versus noun fluency (e.g., animal naming). |
2010-08-18 |
2023-08-12 |
human |
| Randall L Woltjer, Kevin Duerson, Joseph M Fullmer, Paramita Mookherjee, Allison M Ryan, Thomas J Montine, Jeffrey A Kaye, Joseph F Quinn, Lisa Silbert, Deniz Erten-Lyons, James B Leverenz, Thomas D Bird, David V Pow, Kohichi Tanaka, G Stennis Watson, David G Coo. Aberrant detergent-insoluble excitatory amino acid transporter 2 accumulates in Alzheimer disease. Journal of neuropathology and experimental neurology. vol 69. issue 7. 2010-07-19. PMID:20535038. |
we investigated whether accumulation of detergent-insoluble eaat2 is related to cognitive impairment and neuropathologic changes in ad by quantifying detergent-insoluble eaat2 levels in hippocampus and frontal cortex of cognitively normal patients, patients with clinical dementia rating of 0.5 (mildly impaired), and ad patients. |
2010-07-19 |
2023-08-12 |
human |
| Linda L Chao, Shannon T Buckley, John Kornak, Norbert Schuff, Catherine Madison, Kristine Yaffe, Bruce L Miller, Joel H Kramer, Michael W Weine. ASL perfusion MRI predicts cognitive decline and conversion from MCI to dementia. Alzheimer disease and associated disorders. vol 24. issue 1. 2010-06-17. PMID:20220321. |
results from linear mixed effects modeling suggest that baseline perfusion from the right precuneus predicted subsequent declines in clinical dementia rating sum of boxes (p=0.002), functional activates questionnaire (p=0.01), and selective attention (ie, stroop switching, p=0.009) whereas baseline perfusion from the right middle frontal cortex predicted subsequent episodic memory decline (ie, total recognition discriminability score from the california verbal learning test, p=0.03). |
2010-06-17 |
2023-08-12 |
human |
| Xiao Ming Zhang, Shu Han, Liang Zho. [The investigation of Syn and NPY expression in brain tissues of diabetic model rat induced by streptozotocin]. Shi yan sheng wu xue bao. vol 37. issue 6. 2010-06-08. PMID:15789763. |
it is suggested that the decrease in neuron number and syn, npy expression in frontal cortex and hippocampus may be one of the factors leading to diabetic dementia. |
2010-06-08 |
2023-08-12 |
rat |
| Floyd Sarsoza, Tommy Saing, Rakez Kayed, Robert Dahlin, Malcolm Dick, Camille Broadwater-Hollifield, Scott Mobley, Ira Lott, Eric Doran, Daniel Gillen, Clifford Anderson-Bergman, David H Cribbs, Charles Glabe, Elizabeth Hea. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta neuropathologica. vol 118. issue 4. 2009-10-08. PMID:19360426. |
further, there was a significant correlation between the extent of frontal cortex fibrillar deposit accumulation and dementia severity (mmse r = -0.72). |
2009-10-08 |
2023-08-12 |
mouse |
| Ana Navarro, Alberto Boveris, Manuel J Bández, María Jesús Sánchez-Pino, Carmen Gómez, Gerard Muntané, Isidro Ferre. Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies. Free radical biology & medicine. vol 46. issue 12. 2009-09-17. PMID:19298851. |
frontal cortex samples from frozen human brains were used to assess tissue respiration; content of mitochondria; mitochondrial oxygen uptake; activity of respiratory complexes and of mitochondrial nitric oxide synthase (mtnos); content of cytochromes a, b, and c; oxidative damage (protein carbonyls and tbars); and expression of mn-sod in patients with parkinson disease (pd) and with dementia with lewy bodies (dlb) in comparison with those of normal healthy controls. |
2009-09-17 |
2023-08-12 |
human |
| Marta Barrachina, Isidre Ferre. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. Journal of neuropathology and experimental neurology. vol 68. issue 8. 2009-09-01. PMID:19606065. |
dna methylation was analyzed in selected regions of mapt, app, and psen1 in the frontal cortex and hippocampus of controls (n=26) and those with alzheimer disease at stages i to ii (n=17); alzheimer disease at stages iii to iv (n=15); alzheimer disease at stages v to vi (n=12); argyrophilic grain disease (n=10); frontotemporal lobar degeneration linked to tau mutations (n=6); frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions (n=4); frontotemporal lobar degeneration with motor neuron disease (n=3); pick disease (n=3); parkinson disease (n=8); dementia with lewy bodies, pure form (n=5); and dementia with lewy bodies, common form (n=15). |
2009-09-01 |
2023-08-12 |
human |
| Anna Gómez, Isidre Ferre. Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases. Journal of neuroscience research. vol 87. issue 4. 2009-04-08. PMID:18855937. |
the three enzymes were oxidized in the frontal cortex in the majority of cases of incidental parkinson's disease (ipd), pd, and dementia with lewy bodies (dlb). |
2009-04-08 |
2023-08-12 |
human |
| Marisa Saldaña, Laura Pujols, Jordi Roca-Ferrer, Adriana Cardozo, Esther Aguilar, Mercè Bonastre, Concepció Mari. Relevance of COX-2 gene expression in dementia with lewy bodies associated with Alzheimer pathology. Movement disorders : official journal of the Movement Disorder Society. vol 23. issue 6. 2008-08-06. PMID:18307244. |
the aim of the present study was to investigate whether cyclooxygenase-2 (cox-2) expression is involved in the pathogenesis of neurodegeneration in dementia with lewy bodies (dlb) by measuring cox-2 mrna and protein expression in frontal cortex and substantia nigra pars compacta of dlb and control human brains. |
2008-08-06 |
2023-08-12 |
human |
| Kimmo J Hatanpaa, Eileen H Bigio, Nigel J Cairns, Kyle B Womack, Sandra Weintraub, John C Morris, Chan Foong, Guanghua Xiao, Christa Hladik, Tina Y Mantanona, Charles L Whit. TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. Journal of neuropathology and experimental neurology. vol 67. issue 4. 2008-06-12. PMID:18379440. |
we studied tdp-43 pathology in the hippocampus and frontal cortex of autopsy brains from patients with ftld-u (n = 68), dementia lacking distinctive histopathology (n = 4), other neurodegenerative diseases (n = 23), and controls (n = 12) using a sensitive immunohistochemistry protocol. |
2008-06-12 |
2023-08-12 |
Not clear |
| Ezra Mulugeta, Francisco Molina-Holgado, Mark S Elliott, Tibor Hortobagyi, Robert Perry, Rajesh N Kalaria, Clive G Ballard, Paul T Franci. Inflammatory mediators in the frontal lobe of patients with mixed and vascular dementia. Dementia and geriatric cognitive disorders. vol 25. issue 3. 2008-05-20. PMID:18303264. |
we have examined inflammatory mediators (interleukin (il)-1beta, il-1alpha, il-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (mcp)-1 and granulocyte macrophage colony-stimulating factor) in brain homogenates from grey and white matter of the frontal cortex (brodmann area 9) from patients with vad (n = 11), those with concurrent vad and ad (mixed dementia; n = 8) and from age-matched controls (n = 13) using elisa assays. |
2008-05-20 |
2023-08-12 |
Not clear |
| Mihaela Oana Romanitan, Bogdan O Popescu, Bengt Winblad, Ovidiu Alexandru Bajenaru, Nenad Bogdanovi. Occludin is overexpressed in Alzheimer's disease and vascular dementia. Journal of cellular and molecular medicine. vol 11. issue 3. 2007-11-07. PMID:17635647. |
therefore in this study, applying an immunohistochemical approach, we decided to explore the occludin expression in frontal cortex (fc) and basal ganglia in ageing control, alzheimer's disease (ad), and vascular dementia (vd) brains, as far as all these pathologies associate microangiopathy and disruption of bbb. |
2007-11-07 |
2023-08-12 |
Not clear |
| Shino Magaki, Ravi Raghavan, Claudius Mueller, Kerby C Oberg, Harry V Vinters, Wolff M Kirsc. Iron, copper, and iron regulatory protein 2 in Alzheimer's disease and related dementias. Neuroscience letters. vol 418. issue 1. 2007-07-12. PMID:17408857. |
in this pilot study we extracted and measured the levels of loosely bound, non-heme and total iron and copper in the frontal cortex and hippocampus of patients with mild-moderate ad (n=3), severe ad (n=8) and dementia with lewy bodies (dlb, n=6), using graphite furnace atomic absorption spectrometry (gfaas). |
2007-07-12 |
2023-08-12 |
Not clear |
| Naoya Oishi, Kazuo Hashikawa, Hidefumi Yoshida, Koichi Ishizu, Masashi Ueda, Hidekazu Kawashima, Hideo Saji, Hidenao Fukuyam. Quantification of nicotinic acetylcholine receptors in Parkinson's disease with (123)I-5IA SPECT. Journal of the neurological sciences. vol 256. issue 1-2. 2007-07-06. PMID:17367812. |
these findings suggest that patients with pd without dementia can show reductions especially in the brainstem and frontal cortex. |
2007-07-06 |
2023-08-12 |
human |
| I Ferrer, E Perez, E Dalfó, M Barrachin. Abnormal levels of prohibitin and ATP synthase in the substantia nigra and frontal cortex in Parkinson's disease. Neuroscience letters. vol 415. issue 3. 2007-06-01. PMID:17284347. |
prohibitin and atp synthase protein levels were examined in the substantia nigra and frontal cortex (area 8) in five cases of parkinson's disease (pd), five cases of dementia with lewy bodies pure form (pdlb), five cases of early alzheimer's disease (ad stage iia, b), nine cases with advanced ad (stages v/vic), and nine controls. |
2007-06-01 |
2023-08-12 |
Not clear |