| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sonal Agrawal, Lei Yu, Sue E Leurgans, Alifiya Kapasi, Lisa L Barnes, David A Bennett, Patricia A Boyle, Julie A Schneide. Grey matter ageing-related tau astrogliopathy: associations with brain pathologies and cognitive decline. Brain : a journal of neurology. 2024-07-24. PMID:39045644. |
in fully adjusted models that controlled for demographics, ad, and common age-related pathologies, an increase in severity of grey matter artag pathology in the superior frontal cortex, but not in the amygdala or the anterior temporal tip, was associated with higher odds of alzheimer's dementia and faster decline in global cognition, episodic memory, and semantic memory. |
2024-07-24 |
2024-07-26 |
human |
| Sonal Agrawal, Lei Yu, Sue E Leurgans, Alifiya Kapasi, Lisa L Barnes, David A Bennett, Patricia A Boyle, Julie A Schneide. Grey matter ageing-related tau astrogliopathy: associations with brain pathologies and cognitive decline. Brain : a journal of neurology. 2024-07-24. PMID:39045644. |
these results provide compelling evidence that grey matter artag, specifically in the superior frontal cortex contributes to alzheimer's dementia and cognitive decline in old age. |
2024-07-24 |
2024-07-26 |
human |
| Hannah M Tayler, Robert Maclachlan, Özge Güzel, Robert A Fisher, Olivia A Skrobot, Mohamed A Abulfadl, Patrick G Kehoe, J Scott Miner. Altered gene expression within the renin-angiotensin system in normal ageing and dementia. The journals of gerontology. Series A, Biological sciences and medical sciences. 2023-10-09. PMID:37813091. |
we characterised ras gene expression in the frontal cortex from (i) a cohort of normal ageing (n = 99, age range = 19-96 y) and (ii) a case-control cohort (n = 209) including ad (n = 66), mixed dementia (vad + ad) (n = 50), pure vascular dementia (vad) (n = 42), and age-matched controls (n = 51). |
2023-10-09 |
2023-10-15 |
Not clear |
| Caglar Cosarderelioglu, Simion Kreimer, Alma I Plaza-Rodriguez, Pablo A Iglesias, C Conover Talbot, Helmy M Siragy, Robert M Carey, Ceereena Ubaida-Mohien, Brian O'Rourke, Luigi Ferrucci, David A Bennett, Jeremy Walston, Peter Abadi. Decoding Angiotensin Receptors: TOMAHAQ-Based Detection and Quantification of Angiotensin Type-1 and Type-2 Receptors. Journal of the American Heart Association. 2023-09-08. PMID:37681524. |
we have used this method to quantify angiotensin type-1 and type-2 receptors in postmortem frontal cortex samples of older adults (n=28) with alzheimer dementia. |
2023-09-08 |
2023-10-07 |
human |
| Yamah Hamsafar, Qian Chen, Alexander D Borowsky, Thomas G Beach, Geidy E Serrano, Lucia I Sue, Charles H Adler, Douglas G Walker, Brittany N Dugge. Biochemical analyses of tau and other neuronal markers in the submandibular gland and frontal cortex across stages of Alzheimer's disease. Neuroscience letters. 2023-06-17. PMID:37330193. |
to further understand the relationships of peripheral tissues to ad, we utilized biochemical methods to evaluate protein levels of total tau and phosphorylated tau (p-tau) as well as other neuronal proteins (i.e., tyrosine hydroxylase (th), neurofilament heavy chain (nf-h), and microtubule-associated protein 2 (map2)) in the submandibular gland and frontal cortex of human cases across different clinicopathological stages of ad (n = 3 criteria not met or low, n = 6 intermediate, and n = 9 high likelihood that dementia is due to ad based on national institute on aging-reagan criteria). |
2023-06-17 |
2023-08-14 |
human |
| Jue Yang, Hui Song, Xiaojiang Ha. Whole-transcriptome sequencing data reveals a disparate cognitive and immune signature in COVID-19 patients with and without dementia. Journal of medical virology. 2022-09-28. PMID:36168207. |
here, we retrieved frontal cortex samples of covid-19 patients from the gene expression omnibus (geo) database and performed a systematic transcriptomic analysis to compare covid-19 patients and controls with or without dementia. |
2022-09-28 |
2023-08-14 |
Not clear |
| Sára Sándor, Dávid Jónás, Kitti Tátrai, Kálmán Czeibert, Eniko Kubiny. Poly(A) RNA sequencing reveals age-related differences in the prefrontal cortex of dogs. GeroScience. 2022-03-15. PMID:35288843. |
the goal of the current study was to explore the transcriptomic differences between young and old dogs' frontal cortex, which is a brain region often affected by various forms of age-related dementia in humans. |
2022-03-15 |
2023-08-13 |
human |
| Gabriel Casagrande Zabot, Eduarda Behenck Medeiros, Ariandne Oliveira Marques, Bárbara Machado Naspolini Macarini, Adrielly Vargas, Ana Carolina Nunes Colombo, João Behenck, Gustavo De Bem Silveira, Gabriela Serafim Keller, Lisienny Campoli Tono Rempel, Daniel Proença Feijó, Ewa Kucharska, Paulo Cesar Lock Silveira, Gislaine Zilli Réus, Josiane Budn. The involvement of inflammation in the effect of the administration of donepezil, galantamine, memantine and/or fluoxetine in an animal model of depression and dementia. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35109296. |
therefore, the present study evaluated the levels of cytokines such as tumor necrosis factor alpha (tnf-α), interleukin (il) -1β, il-6 and il-10 in the frontal cortex and hippocampus of wistar rats subjected to chronic mild stress protocol (cms) for induction of an animal model of depression and administration of intra-hippocampal β-amyloid (βa) oligomers for induction of the dementia model. |
2022-02-03 |
2023-08-13 |
rat |
| Keping Chai, Jiawei Liang, Xiaolin Zhang, Panlong Cao, Shufang Chen, Huaqian Gu, Weiping Ye, Rong Liu, Wenjun Hu, Caixia Peng, Gang Logan Liu, Daojiang She. Application of Machine Learning and Weighted Gene Co-expression Network Algorithm to Explore the Hub Genes in the Aging Brain. Frontiers in aging neuroscience. vol 13. 2021-11-05. PMID:34733151. |
here, we use machine learning and weighted gene co-expression network (wgcna) to explore the relationship between aging and gene expression in the human frontal cortex and reveal potential biomarkers and therapeutic targets of neurodegeneration and dementia related to aging. |
2021-11-05 |
2023-08-13 |
human |
| Maria Garofalo, Stella Gagliardi, Susanna Zucca, Cecilia Pandini, Francesca Dragoni, Daisy Sproviero, Orietta Pansarasa, Tino Emanuele Poloni, Valentina Medici, Annalisa Davin, Silvia Damiana Visonà, Matteo Moretti, Antonio Guaita, Mauro Ceroni, Livio Tronconi, Cristina Cered. COVID-19 patients and Dementia: Frontal cortex transcriptomic data. Data in brief. vol 38. 2021-10-05. PMID:34604485. |
since the association of sars-cov-2 infection with nervous system (ns) manifestations, we performed rna-sequencing analysis in frontal cortex of covid-19 positive or negative individuals and affected or not by dementia individuals. |
2021-10-05 |
2023-08-13 |
Not clear |
| Maria Garofalo, Stella Gagliardi, Susanna Zucca, Cecilia Pandini, Francesca Dragoni, Daisy Sproviero, Orietta Pansarasa, Tino Emanuele Poloni, Valentina Medici, Annalisa Davin, Silvia Damiana Visonà, Matteo Moretti, Antonio Guaita, Mauro Ceroni, Livio Tronconi, Cristina Cered. COVID-19 patients and Dementia: Frontal cortex transcriptomic data. Data in brief. vol 38. 2021-10-05. PMID:34604485. |
covid-19 patients and dementia: frontal cortex transcriptomic data. |
2021-10-05 |
2023-08-13 |
Not clear |
| Lindsey G Soll, Julia N Eisen, Karina J Vargas, Audrey T Medeiros, Katherine M Hammar, Jennifer R Morga. α-Synuclein-112 Impairs Synaptic Vesicle Recycling Consistent With Its Enhanced Membrane Binding Properties. Frontiers in cell and developmental biology. vol 8. 2021-02-24. PMID:32548120. |
α-syn-112 is upregulated in the substantia nigra, frontal cortex, and cerebellum of parkinsonian brains and higher expression levels are correlated with susceptibility to parkinson's disease (pd), dementia with lewy bodies (dlb), and multiple systems atrophy (msa). |
2021-02-24 |
2023-08-13 |
Not clear |
| Judith A Potashkin, Virginie Bottero, Jose A Santiago, James P Quin. Bioinformatic Analysis Reveals Phosphodiesterase 4D-Interacting Protein as a Key Frontal Cortex Dementia Switch Gene. International journal of molecular sciences. vol 21. issue 11. 2021-02-12. PMID:32471155. |
bioinformatic analysis reveals phosphodiesterase 4d-interacting protein as a key frontal cortex dementia switch gene. |
2021-02-12 |
2023-08-13 |
Not clear |
| Paula Garcia-Esparcia, Irene López-González, Oriol Grau-Rivera, María Francisca García-Garrido, Anusha Konetti, Franc Llorens, Saima Zafar, Margarita Carmona, José Antonio Del Rio, Inga Zerr, Ellen Gelpi, Isidro Ferre. Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Frontiers in neurology. vol 8. 2020-10-01. PMID:28348546. |
the goal of this study was to assess mitochondrial function, energy, and purine metabolism, protein synthesis machinery from the nucleolus to the ribosome, inflammation, and expression of newly identified ectopic olfactory receptors (ors) and taste receptors (tasrs) in the frontal cortex of typical cases of dementia with lewy bodies (dlb) and cases with rapid clinical course (rpdlb: 2 years or less) compared with middle-aged non-affected individuals, in order to learn about the biochemical abnormalities underlying lewy body pathology. |
2020-10-01 |
2023-08-13 |
Not clear |
| Paula Garcia-Esparcia, Irene López-González, Oriol Grau-Rivera, María Francisca García-Garrido, Anusha Konetti, Franc Llorens, Saima Zafar, Margarita Carmona, José Antonio Del Rio, Inga Zerr, Ellen Gelpi, Isidro Ferre. Dementia with Lewy Bodies: Molecular Pathology in the Frontal Cortex in Typical and Rapidly Progressive Forms. Frontiers in neurology. vol 8. 2020-10-01. PMID:28348546. |
dementia with lewy bodies: molecular pathology in the frontal cortex in typical and rapidly progressive forms. |
2020-10-01 |
2023-08-13 |
Not clear |
| Paula Garcia-Esparcia, Daniela Diaz-Lucena, Marina Ainciburu, Benjamin Torrejón-Escribano, Margarita Carmona, Franc Llorens, Isidro Ferre. Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:29755340. |
glutamate transporter solute carrier family 1, member 2 (glt1/eaat2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of alzheimer disease (ad) and terminal stages of dementia with lewy bodies (dlb) in order to gain understanding of astrogliopathy in diseases manifested by dementia. |
2020-10-01 |
2023-08-13 |
human |
| Troy T Rohn, Jacob M Mac. Apolipoprotein E Fragmentation within Lewy Bodies of the Human Parkinson's Disease Brain. International journal of neurodegenerative disorders. vol 1. issue 1. 2020-10-01. PMID:30272057. |
conversely, little staining was observed in the substantia nigra from pick's disease or in the frontal cortex of dementia with lewy bodies (dlb) cases, suggesting a specificity for napoecfp17 immunoreactivity in pd. |
2020-10-01 |
2023-08-13 |
human |
| Ravi Rajmohan, Ronald C Anderson, Dan Fang, Austin G Meyer, Pavis Laengvejkal, Parunyou Julayanont, Greg Hannabas, Kitten Linton, John Culberson, Hafiz Khan, John De Toledo, P Hemachandra Reddy, Michael W O'Boyl. Lower Activation in Frontal Cortex and Posterior Cingulate Cortex Observed during Sex Determination Test in Early-Stage Dementia of the Alzheimer Type. Frontiers in aging neuroscience. vol 9. 2020-09-29. PMID:28588478. |
lower activation in frontal cortex and posterior cingulate cortex observed during sex determination test in early-stage dementia of the alzheimer type. |
2020-09-29 |
2023-08-13 |
human |
| Sylvia E Perez, Jennifer C Miguel, Bin He, Michael Malek-Ahmadi, Eric E Abrahamson, Milos D Ikonomovic, Ira Lott, Eric Doran, Melissa J Alldred, Stephen D Ginsberg, Elliott J Mufso. Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia. Acta neuropathologica. vol 137. issue 3. 2020-04-20. PMID:30734106. |
frontal cortex and striatal cellular and molecular pathobiology in individuals with down syndrome with and without dementia. |
2020-04-20 |
2023-08-13 |
Not clear |
| Jing Ji Wang, Sheng Bing Wu, Hong Liang Cheng, Chao Yang, Yun Chen, Jun Yan. [Effect of moxibustion on expression of RAGE and LRP-1 and neuronal ultrastructure of frontal cortex and hippocampus in vascular dementia rats]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 1. 2020-03-12. PMID:32144906. |
[effect of moxibustion on expression of rage and lrp-1 and neuronal ultrastructure of frontal cortex and hippocampus in vascular dementia rats]. |
2020-03-12 |
2023-08-13 |
rat |