| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K Arima, S Hirai, N Sunohara, K Aoto, Y Izumiyama, K Uéda, K Ikeda, M Kawa. Cellular co-localization of phosphorylated tau- and NACP/alpha-synuclein-epitopes in lewy bodies in sporadic Parkinson's disease and in dementia with Lewy bodies. Brain research. vol 843. issue 1-2. 2000-01-24. PMID:10528110. |
the precursor of the non-abeta-component of alzheimer's disease (ad) amyloid (nacp, alpha-synuclein) aggregates into insoluble filaments of lewy bodies (lbs) in parkinson's disease (pd) and dementia with lbs (dlb). |
2000-01-24 |
2023-08-12 |
Not clear |
| G K Wenning, G Ebersbach, M Verny, K R Chaudhuri, K Jellinger, A McKee, W Poewe, I Litva. Progression of falls in postmortem-confirmed parkinsonian disorders. Movement disorders : official journal of the Movement Disorder Society. vol 14. issue 6. 2000-01-20. PMID:10584668. |
although falls are known to occur in several parkinsonian disorders, such as parkinson's disease (pd), multiple system atrophy (msa), dementia with lewy bodies (dlb), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), differences in the evolution of this feature have not been studied systematically in pathologically confirmed cases. |
2000-01-20 |
2023-08-12 |
Not clear |
| J E Duda, U Shah, S E Arnold, V M Lee, J Q Trojanowsk. The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases. Experimental neurology. vol 160. issue 2. 2000-01-14. PMID:10619569. |
although the precise function of these proteins remains unknown, alpha-synuclein has been implicated in synaptic plasticity associated with avian song learning as well as in the pathogenesis of parkinson's disease (pd), dementia with lbs (dlb), some forms of alzheimer's disease (ad), and multiple system atrophy (msa). |
2000-01-14 |
2023-08-12 |
human |
| J Verghese, H A Crystal, D W Dickson, R B Lipto. Validity of clinical criteria for the diagnosis of dementia with Lewy bodies. Neurology. vol 53. issue 9. 2000-01-04. PMID:10599768. |
to assess the clinical validity of clinical diagnostic criteria for dementia with lewy bodies (dlb). |
2000-01-04 |
2023-08-12 |
Not clear |
| T Gómez-Isla, W B Growdon, M McNamara, K Newell, E Gómez-Tortosa, E T Hedley-Whyte, B T Hyma. Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies. Neurology. vol 53. issue 9. 2000-01-04. PMID:10599772. |
to address the relationship between dementia and neuropathologic findings in dementia with lewy bodies (dlb) in comparison with ad. |
2000-01-04 |
2023-08-12 |
Not clear |
| K L Newell, P Boyer, E Gomez-Tortosa, W Hobbs, E T Hedley-Whyte, J P Vonsattel, B T Hyma. Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury. Journal of neuropathology and experimental neurology. vol 58. issue 12. 1999-12-29. PMID:10604751. |
in parkinson disease (pd) and dementia with lewy bodies (dlb), lewy bodies and neurites display prominent alpha-synuclein immunoreactivity. |
1999-12-29 |
2023-08-12 |
Not clear |
| E Gómez-Tortosa, K Newell, M C Irizarry, M Albert, J H Growdon, B T Hyma. Clinical and quantitative pathologic correlates of dementia with Lewy bodies. Neurology. vol 53. issue 6. 1999-12-17. PMID:10522886. |
to examine the distribution of cortical lewy bodies (lb) and their contribution to the clinical syndrome in dementia with lb (dlb) and to address their relationship to the pathologic markers of ad and pd. |
1999-12-17 |
2023-08-12 |
Not clear |
| J E Galvin, K Uryu, V M Lee, J Q Trojanowsk. Axon pathology in Parkinson's disease and Lewy body dementia hippocampus contains alpha-, beta-, and gamma-synuclein. Proceedings of the National Academy of Sciences of the United States of America. vol 96. issue 23. 1999-12-13. PMID:10557341. |
pathogenic alpha-synuclein (alphas) gene mutations occur in rare familial parkinson's disease (pd) kindreds, and wild-type alphas is a major component of lewy bodies (lbs) in sporadic pd, dementia with lbs (dlb), and the lb variant of alzheimer's disease, but beta-synuclein (betas) and gamma-synuclein (gammas) have not yet been implicated in neurological disorders. |
1999-12-13 |
2023-08-12 |
Not clear |
| N Hirono, E Mori, S Tanimukai, H Kazui, M Hashimoto, T Hanihara, T Imamur. Distinctive neurobehavioral features among neurodegenerative dementias. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 4. 1999-12-13. PMID:10570764. |
the distinctive neuropsychiatric features of alzheimer's disease (ad), dementia with lewy bodies (dlb), and frontotemporal dementia (ftd) were investigated by using the neuropsychiatric inventory. |
1999-12-13 |
2023-08-12 |
Not clear |
| N Hirono, E Mori, S Tanimukai, H Kazui, M Hashimoto, T Hanihara, T Imamur. Distinctive neurobehavioral features among neurodegenerative dementias. The Journal of neuropsychiatry and clinical neurosciences. vol 11. issue 4. 1999-12-13. PMID:10570764. |
the findings clearly demonstrate that ad, dlb, and ftd have distinctive neuropsychiatric features, which may correspond to different patterns of cerebral involvement characteristic of these three major degenerative dementias. |
1999-12-13 |
2023-08-12 |
Not clear |
| K Ohara, S Takauchi, M Kokai, Y Morimura, T Nakajima, Y Morit. Familial dementia with Lewy bodies (DLB). Clinical neuropathology. vol 18. issue 5. 1999-11-19. PMID:10505432. |
familial dementia with lewy bodies (dlb). |
1999-11-19 |
2023-08-12 |
Not clear |
| K Ohara, S Takauchi, M Kokai, Y Morimura, T Nakajima, Y Morit. Familial dementia with Lewy bodies (DLB). Clinical neuropathology. vol 18. issue 5. 1999-11-19. PMID:10505432. |
we report a rare familial case of dementia with lewy bodies (dlb). |
1999-11-19 |
2023-08-12 |
Not clear |
| K Ohara, S Takauchi, M Kokai, Y Morimura, T Nakajima, Y Morit. Familial dementia with Lewy bodies (DLB). Clinical neuropathology. vol 18. issue 5. 1999-11-19. PMID:10505432. |
although these patients with familial dlb displayed clinical variability, all three siblings showed progressive dementia of early onset and progressive language disorder with paraphasia and difficulty in finding words. |
1999-11-19 |
2023-08-12 |
Not clear |
| G K Wenning, C Scherfler, R Granata, S Bösch, M Verny, K R Chaudhuri, K Jellinger, W Poewe, I Litva. Time course of symptomatic orthostatic hypotension and urinary incontinence in patients with postmortem confirmed parkinsonian syndromes: a clinicopathological study. Journal of neurology, neurosurgery, and psychiatry. vol 67. issue 5. 1999-11-19. PMID:10519868. |
although both orthostatic hypotension and urinary incontinence have been reported in a number of parkinsonian syndromes, such as parkinson's disease (pd), multiple system atrophy (msa), dementia with lewy bodies (dlb), corticobasal degeneration (cbd), and progressive supranuclear palsy (psp), differences in the evolution of these features have not been studied systematically in pathologically confirmed cases. |
1999-11-19 |
2023-08-12 |
Not clear |
| K L Newell, B T Hyman, J H Growdon, E T Hedley-Whyt. Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease. Journal of neuropathology and experimental neurology. vol 58. issue 11. 1999-11-17. PMID:10560657. |
we applied this method to 84 brains from subjects with clinical and neuropathological diagnoses of ad (n = 33), non-ad dementing illnesses (n = 34), including dementia with lewy bodies (dlb) and progressive supranuclear palsy (psp), and no neurological disease (n = 17). |
1999-11-17 |
2023-08-12 |
human |
| I G McKeith, E K Perry, R H Perr. Report of the second dementia with Lewy body international workshop: diagnosis and treatment. Consortium on Dementia with Lewy Bodies. Neurology. vol 53. issue 5. 1999-11-15. PMID:10496243. |
the second international workshop of the consortium on dementia with lewy bodies (dlb) met to review developments since publication of consensus guidelines for the clinical and pathologic diagnosis of dlb in 1996. |
1999-11-15 |
2023-08-12 |
Not clear |
| T Imamura, K Ishii, N Hirono, M Hashimoto, S Tanimukai, H Kazuai, T Hanihara, M Sasaki, E Mor. Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB). Neuroreport. vol 10. issue 9. 1999-11-10. PMID:10501530. |
visual hallucinations and regional cerebral metabolism in dementia with lewy bodies (dlb). |
1999-11-10 |
2023-08-12 |
Not clear |
| T Imamura, K Ishii, N Hirono, M Hashimoto, S Tanimukai, H Kazuai, T Hanihara, M Sasaki, E Mor. Visual hallucinations and regional cerebral metabolism in dementia with Lewy bodies (DLB). Neuroreport. vol 10. issue 9. 1999-11-10. PMID:10501530. |
to investigate the neurobiological bases of visual hallucinations in dementia with lewy bodies (dlb), regional cerebral glucose metabolism was compared among three patient groups; dlb with visual hallucinations, dlb without visual hallucinations and alzheimer's disease (ad) without visual hallucinations. |
1999-11-10 |
2023-08-12 |
Not clear |
| J G Culvenor, C A McLean, S Cutt, B C Campbell, F Maher, P Jäkälä, T Hartmann, K Beyreuther, C L Masters, Q X L. Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid. The American journal of pathology. vol 155. issue 4. 1999-11-04. PMID:10514400. |
alpha-synuclein (alphasn), also termed the precursor of the non-abeta component of alzheimer's disease (ad) amyloid (nacp), is a major component of lewy bodies and lewy neurites pathognomonic of parkinson's disease (pd) and dementia with lewy bodies (dlb). |
1999-11-04 |
2023-08-12 |
human |
| D S Horoupian, P H Wasserstei. Alzheimer's disease pathology in motor cortex in dementia with Lewy bodies clinically mimicking corticobasal degeneration. Acta neuropathologica. vol 98. issue 3. 1999-10-20. PMID:10483792. |
we report here a 70-year-old woman whose initial clinical presentation suggested corticobasal degeneration, but autopsy revealed dementia with lewy bodies (dlb) with severe alzheimer's disease (ad)-type pathology accentuated in the motor cortex, in conjunction with a high burden of both cortical and brain stem lb. |
1999-10-20 |
2023-08-12 |
Not clear |