| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kenjiro Ono, Moeko Noguchi-Shinohara, Mitsuhiro Yoshita, Hironobu Naiki, Masahito Yamad. Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro. Experimental neurology. vol 203. issue 2. 2007-03-20. PMID:17011551. |
deposition of alpha-synuclein (alphas) aggregates inside brain cells is a pathological hallmark of several neurodegenerative diseases, including parkinson's disease (pd), and dementia with lewy bodies (dlb). |
2007-03-20 |
2023-08-12 |
Not clear |
| Michael L Kramer, Walter J Schulz-Schaeffe. Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 6. 2007-03-06. PMID:17287515. |
lewy bodies, the pathological hallmark of dementia with lewy bodies (dlb), are large juxtanuclear inclusions of aggregated alpha-synuclein. |
2007-03-06 |
2023-08-12 |
Not clear |
| George Bartzokis, Todd A Tishler, Po H Lu, Pablo Villablanca, Lori L Altshuler, Michele Carter, Danny Huang, Nancy Edwards, Jim Mint. Brain ferritin iron may influence age- and gender-related risks of neurodegeneration. Neurobiology of aging. vol 28. issue 3. 2007-03-01. PMID:16563566. |
brain iron promotes oxidative damage and protein oligomerization that result in highly prevalent age-related proteinopathies such as alzheimer's disease (ad), parkinson's disease (pd), and dementia with lewy bodies (dlb). |
2007-03-01 |
2023-08-12 |
Not clear |
| Hugo Vanderstichele, Karen De Vreese, Kaj Blennow, Niels Andreasen, Christian Sindic, Adrian Ivanoiu, Harald Hampel, Katharina Bürger, Lucilla Parnetti, Alessia Lanari, Allesandro Padovani, Monica DiLuca, Miriam Bläser, Annika Ohrfelt Olsson, Hans Pottel, Frank Hulstaert, Eugeen Vanmechele. Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies. Clinical chemistry and laboratory medicine. vol 44. issue 12. 2007-02-26. PMID:17163825. |
differential diagnosis from dementia with lewy bodies (dlb) in clinical settings is difficult. |
2007-02-26 |
2023-08-12 |
Not clear |
| Moussa B H Youdi. The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168653. |
one of the main reasons for the cognitive deficit in dementia of the alzheimer' type (ad) and in dementia with lewy bodies (dlb) is degeneration of cholinergic cortical neurones and synaptic plasticity. |
2007-02-20 |
2023-08-12 |
human |
| Moussa B H Youdi. The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30. Current Alzheimer research. vol 3. issue 5. 2007-02-20. PMID:17168653. |
employing the pharamcophore of our antiparkinson drug rasagiline (azilect, agilect, n-propagrgyl-1r-aminoindan) we have developed a novel multifunctional neuroprotective drug, ladostigil [tv-3326 (n-propargyl-3r-aminoindan-5yl)-ethyl methylcarbamate)], with both cholinesterase-butyrylesterase (ch-bue) and brain selective monoamine-oxidase (mao) ab inhibitory activities possessing the neuroprotective-neurescue propargyl moiety, as potential treatment of ad and dlb and pd with dementias. |
2007-02-20 |
2023-08-12 |
human |
| Haruo Hanyu, Soichiro Shimizu, Kentaro Hirao, Hirofumi Sakurai, Toshihiko Iwamoto, Taishiro Chikamori, Satoshi Hida, Akira Yamashina, Kiyoshi Koizumi, Kimihiko Ab. The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic. Dementia and geriatric cognitive disorders. vol 22. issue 5-6. 2007-02-15. PMID:16960446. |
reduction in cardiac (123)i-metaiodobenzylguanidine (mibg) uptake is a characteristic feature of parkinson's disease (pd) and dementia with lewy bodies (dlb), and is useful in distinguishing them from other neurodegenerative disorders. |
2007-02-15 |
2023-08-12 |
Not clear |
| Haruo Hanyu, Soichiro Shimizu, Kentaro Hirao, Hirofumi Sakurai, Toshihiko Iwamoto, Taishiro Chikamori, Satoshi Hida, Akira Yamashina, Kiyoshi Koizumi, Kimihiko Ab. The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic. Dementia and geriatric cognitive disorders. vol 22. issue 5-6. 2007-02-15. PMID:16960446. |
thirty out of 32 patients with dlb and all 9 pd with dementia patients had reduced h/m ratios, whereas 37 out of 40 patients with alzheimer's disease had normal h/m ratios. |
2007-02-15 |
2023-08-12 |
Not clear |
| Haruo Hanyu, Soichiro Shimizu, Kentaro Hirao, Hirofumi Sakurai, Toshihiko Iwamoto, Taishiro Chikamori, Satoshi Hida, Akira Yamashina, Kiyoshi Koizumi, Kimihiko Ab. The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic. Dementia and geriatric cognitive disorders. vol 22. issue 5-6. 2007-02-15. PMID:16960446. |
the overall sensitivity to positively identify patients with lewy body disease (including dlb and pd with dementia) was 95%, and the specificity to distinguish them from patients with other types of dementias was 87%. |
2007-02-15 |
2023-08-12 |
Not clear |
| Kurt A Jellinger, Johannes Attem. Does striatal pathology distinguish Parkinson disease with dementia and dementia with Lewy bodies? Acta neuropathologica. vol 112. issue 3. 2007-02-08. PMID:16804711. |
the morphological differentiation of parkinson disease with dementia (pdd) and dementia with lewy bodies (dlb) is a matter of discussion. |
2007-02-08 |
2023-08-12 |
Not clear |
| Isabelle Momjian-Mayor, Gian Paolo Pizzolato, Karim Burkhardt, Theodor Landis, Alessandra Coeytaux, Pierre R Burkhar. Fulminant Lewy body disease. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 10. 2007-02-02. PMID:16830307. |
the clinical distinction between parkinson's disease (pd) with dementia (pdd) and dementia with lewy bodies (dlb) is challenged by most neuropathological studies showing nearly identical changes in both conditions. |
2007-02-02 |
2023-08-12 |
Not clear |
| Isabelle Momjian-Mayor, Gian Paolo Pizzolato, Karim Burkhardt, Theodor Landis, Alessandra Coeytaux, Pierre R Burkhar. Fulminant Lewy body disease. Movement disorders : official journal of the Movement Disorder Society. vol 21. issue 10. 2007-02-02. PMID:16830307. |
we report an unusual case of pd evolving into a rapidly progressive dementia leading to death within 3 months that showed nearly all clinical features of dlb. |
2007-02-02 |
2023-08-12 |
Not clear |
| Elizabeth Head, Arnold Starr, Ronald C Kim, Anna Parachikova, Genaro E Lopez, Malcolm Dick, David H Cribb. Relapsing polychondritis with features of dementia with Lewy bodies. Acta neuropathologica. vol 112. issue 2. 2007-02-01. PMID:16832629. |
we describe a 72-year old man with clinical features suggestive of dementia with lewy bodies (dlb) who proved neuropathologically to have degeneration induced by relapsing polychondritis (rp), an autoimmune inflammatory disorder of cartilaginous tissues. |
2007-02-01 |
2023-08-12 |
Not clear |
| Marco Guidi, Lucia Paciaroni, Susy Paolini, Silvia De Padova, Osvaldo Scarpin. Differences and similarities in the neuropsychological profile of dementia with Lewy bodies and Alzheimer's disease in the early stage. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16784757. |
the literature concerning the neuropsychological profile of dementia with lewy bodies (dlb) reports contrasting data even though a main impairment in attentional and visuospatial processes is mostly pointed out. |
2007-01-23 |
2023-08-12 |
Not clear |
| K A Jellinge. The morphological basis of mental dysfunction in Parkinson's disease. Journal of the neurological sciences. vol 248. issue 1-2. 2007-01-23. PMID:16797594. |
whereas cortical lewy body stages 5 and 6 without additional pathologies only rarely were associated with dementia, around 20% of demented pd cases were classified as dementia with lewy bodies (dlb) with variable degrees of alzheimer (ad) pathology, and around one third showed severe neuritic ad lesions which occurred in pd patients with later disease onset and significantly shorter survival. |
2007-01-23 |
2023-08-12 |
Not clear |
| Kenichi Yasui, Yuichi Inoue, Takashi Kanbayashi, Takashi Nomura, Masayoshi Kusumi, Kenji Nakashim. CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration. Journal of the neurological sciences. vol 250. issue 1-2. 2007-01-23. PMID:17005202. |
in this study, orexin was measured in csf collected by lumbar puncture in 62 patients with pd, 13 patients with dementia with lewy bodies (dlb), 16 patients with progressive supranuclear palsy (psp), and 7 patients with corticobasal degeneration (cbd). |
2007-01-23 |
2023-08-12 |
Not clear |
| Haruo Hanyu, Soichiro Shimizu, Kentaro Hirao, Hidekazu Kanetaka, Hirofumi Sakurai, Toshihiko Iwamoto, Kiyoshi Koizumi, Kimihiko Ab. Differentiation of dementia with Lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT. Journal of the neurological sciences. vol 250. issue 1-2. 2007-01-23. PMID:17005204. |
to determine whether combined studies of mini-mental state examination (mmse) and brain single photon emission ct (spect) would provide more useful means of differentiating between dementia with lewy bodies (dlb) and alzheimer's disease (ad), we studied 36 patients with probable dlb and 96 patients with probable ad. |
2007-01-23 |
2023-08-12 |
Not clear |
| Anne-Lenora Henriksen, Clarke St Dennis, Stephen M Setter, John T Tra. Dementia with lewy bodies: therapeutic opportunities and pitfalls. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists. vol 21. issue 7. 2007-01-16. PMID:16934009. |
to review diagnoses and challenges of treating patients with dementia with lewy bodies (dlb), commonly considered the second most common form of dementia. |
2007-01-16 |
2023-08-12 |
Not clear |
| Zheng-Tong Ding, Yin Wang, Yu-Ping Jiang, Yoshio Hashizume, Mari Yoshida, Maya Mimuro, Toshiaki Inagaki, Tamaki Iwas. Characteristics of alpha-synucleinopathy in centenarians. Acta neuropathologica. vol 111. issue 5. 2007-01-09. PMID:16520971. |
coronal slices were prepared from a section of the cerebral hemisphere, following the guidelines of the consortium to establish a registry for alzheimer's disease (ad) (cerad) and the consensus guidelines for the clinical and pathologic diagnosis of dementia with lewy bodies (dlb). |
2007-01-09 |
2023-08-12 |
Not clear |
| Tiago Fleming Outeiro, Jochen Klucken, Katherine E Strathearn, Fang Liu, Paul Nguyen, Jean-Christophe Rochet, Bradley T Hyman, Pamela J McLea. Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochemical and biophysical research communications. vol 351. issue 3. 2007-01-09. PMID:17081499. |
alpha-synuclein (asyn) is the main protein component of inclusions called lewy bodies (lb) which are pathognomic of pd, dementia with lewy bodies (dlb), and other diseases collectively known as lb diseases. |
2007-01-09 |
2023-08-12 |
Not clear |