| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anne Rombaut, Danica Jovancevic, Raymond Ching-Bong Wong, Alan Nicol, Rune Brautaset, David I Finkelstein, Christine T O Nguyen, James R Tribble, Pete A William. Intravitreal MPTP drives retinal ganglion cell loss with oral nicotinamide treatment providing robust neuroprotection. Acta neuropathologica communications. vol 12. issue 1. 2024-05-22. PMID:38773545. |
the retina is often affected in common neurodegenerative diseases such as parkinson's and alzheimer's disease. |
2024-05-22 |
2024-05-27 |
mouse |
| Bhakta Prasad Gaire, Yosef Koronyo, Dieu-Trang Fuchs, Haoshen Shi, Altan Rentsendorj, Ron Danziger, Jean-Philippe S Vit, Nazanin Mirzaei, Jonah Doustar, Julia Sheyn, Harald Hampel, Andrea Vergallo, Miyah R Davis, Ousman Jallow, Filippo Baldacci, Steven R Verdooner, Ernesto Barron, Mehdi Mirzaei, Vivek K Gupta, Stuart L Graham, Mourad Tayebi, Roxana O Carare, Alfredo A Sadun, Carol A Miller, Oana M Dumitrascu, Shouri Lahiri, Liang Gao, Keith L Black, Maya Koronyo-Hamaou. Alzheimer's Disease Pathophysiology in the Retina. Progress in retinal and eye research. 2024-05-17. PMID:38759947. |
alzheimer's disease pathophysiology in the retina. |
2024-05-17 |
2024-05-27 |
Not clear |
| Bhakta Prasad Gaire, Yosef Koronyo, Dieu-Trang Fuchs, Haoshen Shi, Altan Rentsendorj, Ron Danziger, Jean-Philippe S Vit, Nazanin Mirzaei, Jonah Doustar, Julia Sheyn, Harald Hampel, Andrea Vergallo, Miyah R Davis, Ousman Jallow, Filippo Baldacci, Steven R Verdooner, Ernesto Barron, Mehdi Mirzaei, Vivek K Gupta, Stuart L Graham, Mourad Tayebi, Roxana O Carare, Alfredo A Sadun, Carol A Miller, Oana M Dumitrascu, Shouri Lahiri, Liang Gao, Keith L Black, Maya Koronyo-Hamaou. Alzheimer's Disease Pathophysiology in the Retina. Progress in retinal and eye research. 2024-05-17. PMID:38759947. |
the retina is an emerging cns target for potential noninvasive diagnosis and tracking of alzheimer's disease (ad). |
2024-05-17 |
2024-05-27 |
Not clear |
| Sarah I Palko, Marc R Benoit, Annie Y Yao, Royce Mohan, Riqiang Ya. ER-stress response in retinal Müller glia occurs significantly earlier than amyloid pathology in the Alzheimer's mouse brain and retina. Glia. 2024-03-18. PMID:38497356. |
er-stress response in retinal müller glia occurs significantly earlier than amyloid pathology in the alzheimer's mouse brain and retina. |
2024-03-18 |
2024-03-20 |
mouse |
| Haoshen Shi, Nazanin Mirzaei, Yosef Koronyo, Miyah R Davis, Edward Robinson, Gila M Braun, Ousman Jallow, Altan Rentsendorj, V Krishnan Ramanujan, Justyna Fert-Bober, Andrei A Kramerov, Alexander V Ljubimov, Lon S Schneider, Warren G Tourtellotte, Debra Hawes, Julie A Schneider, Keith L Black, Rakez Kayed, Maj-Linda B Selenica, Daniel C Lee, Dieu-Trang Fuchs, Maya Koronyo-Hamaou. Identification of retinal tau oligomers, citrullinated tau, and other tau isoforms in early and advanced AD and relations to disease status. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405854. |
this study identifies and quantifies diverse pathological tau isoforms in the retina of both early and advanced-stage alzheimer's disease (ad) and determines their relationship with disease status. |
2024-02-26 |
2024-02-28 |
Not clear |
| Fabio Casciano, Enrico Zauli, Claudio Celeghini, Lorenzo Caruso, Arianna Gonelli, Giorgio Zauli, Angela Pignatell. Retinal Alterations Predict Early Prodromal Signs of Neurodegenerative Disease. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38338966. |
similarly, the visual cortex is modified by the neurofibrillary tangles and neuritic amyloid β plaques typically seen in the alzheimer's disease brain, and this may reflect the accumulation of these biomarkers in the retina during the early stages of the disease, as seen in postmortem retinas of ad patients. |
2024-02-10 |
2024-02-12 |
Not clear |
| Frederike C Oertel, Daniel Casillas, Yann Cobigo, Shivany Condor Montes, Hilary W Heuer, Makenna Chapman, Alexandra Beaudry-Richard, Henriette Reinsberg, Ahmed Abdelhak, Christian Cordano, Bradley F Boeve, Bradford C Dickerson, Murray Grossman, Edward Huey, David J Irwin, Irene Litvan, Alexander Pantelyat, M Carmela Tartaglia, Lawren Vandevrede, Adam Boxer, Ari J Gree. Scientific commentary on: "Phosphorylated tau in the retina correlates with tau pathology in the brain in Alzheimer's disease and primary tauopathies". Acta neuropathologica. vol 147. issue 1. 2024-02-03. PMID:38308717. |
scientific commentary on: "phosphorylated tau in the retina correlates with tau pathology in the brain in alzheimer's disease and primary tauopathies". |
2024-02-03 |
2024-02-06 |
Not clear |
| Laura Carrero, Desireé Antequera, Cristina Municio, Eva Carr. Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease? Neural regeneration research. vol 19. issue 9. 2024-01-16. PMID:38227523. |
however, the mechanistic link between circadian dysfunction and the pathological changes affecting the retina in alzheimer's disease is not fully understood, although some studies point to the possibility that retinal dysfunction could be considered an early pathological process that directly modulates the circadian rhythm. |
2024-01-16 |
2024-01-18 |
Not clear |
| Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, K Peter R Nilsson, Malin Wennströ. The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer's disease patients and App Alzheimer's research & therapy. vol 16. issue 1. 2024-01-03. PMID:38167557. |
the fluorescent ligand btvbt2 reveals increased p-tau uptake by retinal microglia in alzheimer's disease patients and app amyloid beta (aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of alzheimer's disease (ad) patients and transgenic ad mice. |
2024-01-03 |
2024-01-06 |
mouse |
| Varisha Zuhair, Hussain Sohail Rangwala, Zaib Un Nisa Mughal, Hareer Fatima, Areeba Tufail Shaikh, Abdullah Mussara. Viewing the Brain Through Retina: A New Avenue for Early Diagnosis of Alzheimer's Disease. Annals of neurosciences. vol 30. issue 4. 2023-12-01. PMID:38020399. |
viewing the brain through retina: a new avenue for early diagnosis of alzheimer's disease. |
2023-12-01 |
2023-12-07 |
Not clear |
| Varisha Zuhair, Hussain Sohail Rangwala, Zaib Un Nisa Mughal, Hareer Fatima, Areeba Tufail Shaikh, Abdullah Mussara. Viewing the Brain Through Retina: A New Avenue for Early Diagnosis of Alzheimer's Disease. Annals of neurosciences. vol 30. issue 4. 2023-12-01. PMID:38020399. |
viewing the brain through retina: a new avenue for early diagnosis of alzheimer's disease. |
2023-11-29 |
2023-12-07 |
Not clear |
| Louise Kelly, Christopher Brown, Daniel Michalik, Cheryl A Hawkes, Roxana Aldea, Nivedita Agarwal, Rami Salib, Aiman Alzetani, Douglas W Ethell, Scott E Counts, Mony de Leon, Silvia Fossati, Maya Koronyo-Hamaoui, Fabrizio Piazza, Steven A Rich, Frank J Wolters, Heather Snyder, Ozama Ismail, Fanny Elahi, Steven T Proulx, Ajay Verma, Hilary Wunderlich, Mareike Haack, Jean Cosme Dodart, Norman Mazer, Roxana O Carar. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-07. PMID:37897797. |
cerebrovascular disease and the failure of elimination of amyloid-β from the brain and retina with age and alzheimer's disease: opportunities for therapy. |
2023-11-07 |
2023-11-08 |
Not clear |
| Louise Kelly, Christopher Brown, Daniel Michalik, Cheryl A Hawkes, Roxana Aldea, Nivedita Agarwal, Rami Salib, Aiman Alzetani, Douglas W Ethell, Scott E Counts, Mony de Leon, Silvia Fossati, Maya Koronyo-Hamaoui, Fabrizio Piazza, Steven A Rich, Frank J Wolters, Heather Snyder, Ozama Ismail, Fanny Elahi, Steven T Proulx, Ajay Verma, Hilary Wunderlich, Mareike Haack, Jean Cosme Dodart, Norman Mazer, Roxana O Carar. Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-07. PMID:37897797. |
the overarching objectives of the clic group are to: (1) understand the age-related physiology changes that underlie impaired clearance of interstitial fluid (isf) and cerebrospinal fluid (csf) (clic); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (ipad) in the brain; (3) establish novel diagnostic tests for alzheimer's disease (ad), cerebral amyloid angiopathy (caa), retinal amyloid vasculopathy, amyloid-related imaging abnormalities (aria) of spontaneous and iatrogenic caa-related inflammation (caa-ri), and vasomotion; and (4) establish novel therapies that facilitate ipad to eliminate amyloid β (aβ) from the aging brain and retina, to prevent or reduce ad and caa pathology and aria side events associated with ad immunotherapy. |
2023-11-07 |
2023-11-08 |
Not clear |
| Jessica Alber, Femke Bouwman, Jurre den Haan, Robert A Rissman, Lies De Groef, Maya Koronyo-Hamaoui, Imre Lengyel, Dietmar Rudolf Tha. Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-02. PMID:37917365. |
retina pathology as a target for biomarkers for alzheimer's disease: current status, ophthalmopathological background, challenges, and future directions. |
2023-11-02 |
2023-11-08 |
Not clear |
| Jessica Alber, Femke Bouwman, Jurre den Haan, Robert A Rissman, Lies De Groef, Maya Koronyo-Hamaoui, Imre Lengyel, Dietmar Rudolf Tha. Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-11-02. PMID:37917365. |
there is emerging evidence that amyloid beta protein (aβ) and tau-related lesions in the retina are associated with alzheimer's disease (ad). |
2023-11-02 |
2023-11-08 |
Not clear |
| Mattia Di Paolo, Francesca Corsi, Chiara Cerri, Silvia Bisti, Ilaria Piano, Claudia Gargin. A Window to the Brain: The Retina to Monitor the Progression and Efficacy of Saffron Repron Pharmaceuticals (Basel, Switzerland). vol 16. issue 9. 2023-09-28. PMID:37765115. |
a window to the brain: the retina to monitor the progression and efficacy of saffron repron a mechanism shared by most neurodegenerative diseases, like alzheimer's disease (ad) and parkinson's disease (pd), is neuroinflammation. |
2023-09-28 |
2023-10-07 |
mouse |
| Shuntai Chen, Dian Zhang, Honggang Zheng, Tianyu Cao, Kun Xia, Mingwan Su, Qinggang Men. The association between retina thinning and hippocampal atrophy in Alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review. Frontiers in aging neuroscience. vol 15. 2023-09-08. PMID:37680540. |
the association between retina thinning and hippocampal atrophy in alzheimer's disease and mild cognitive impairment: a meta-analysis and systematic review. |
2023-09-08 |
2023-10-07 |
human |
| Grzegorz Walkiewicz, Alicja Ronisz, Rita Van Ginderdeuren, Sophie Lemmens, Femke H Bouwman, Jeroen J M Hoozemans, Tjado H J Morrema, Annemieke J Rozemuller, Frederique J Hart de Ruyter, Lies De Groef, Ingeborg Stalmans, Dietmar Rudolf Tha. Primary retinal tauopathy: A tauopathy with a distinct molecular pattern. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-08-24. PMID:37615275. |
phosphorylated tau (p-tau) accumulation, a hallmark of alzheimer's disease (ad), can also be found in the retina. |
2023-08-24 |
2023-09-07 |
Not clear |
| Valentina Latina, Anna Atlante, Francesca Malerba, Federico La Regina, Bijorn Omar Balzamino, Alessandra Micera, Annabella Pignataro, Egidio Stigliano, Sebastiano Cavallaro, Pietro Calissano, Giuseppina Amador. The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer's Disease Mouse Model. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298634. |
beyond deficits in hippocampal-dependent episodic memory, alzheimer's disease (ad) features sensory impairment in visual cognition consistent with extensive neuropathology in the retina. |
2023-06-11 |
2023-08-14 |
mouse |
| Seyed Mostafa Hosseinpour Mashkani, David P Bishop, Newsha Raoufi-Rad, Paul A Adlard, Olga Shimoni, S Mojtaba Golza. Distribution of Copper, Iron, and Zinc in the Retina, Hippocampus, and Cortex of the Transgenic APP/PS1 Mouse Model of Alzheimer's Disease. Cells. vol 12. issue 8. 2023-05-16. PMID:37190053. |
distribution of copper, iron, and zinc in the retina, hippocampus, and cortex of the transgenic app/ps1 mouse model of alzheimer's disease. |
2023-05-16 |
2023-08-14 |
mouse |