| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Holly F Green, Eimear Treacy, Aoife K Keohane, Aideen M Sullivan, Gerard W O'Keeffe, Yvonne M Nola. A role for interleukin-1β in determining the lineage fate of embryonic rat hippocampal neural precursor cells. Molecular and cellular neurosciences. vol 49. issue 3. 2012-07-13. PMID:22270046. |
prolonged release of interleukin-1β (il-1β) from activated microglia has a deleterious effect on hippocampal neurons and is implicated in the impaired neurogenesis and cognitive dysfunction associated with aging, alzheimer's disease and depression. |
2012-07-13 |
2023-08-12 |
rat |
| Arnold Bakker, Gregory L Krauss, Marilyn S Albert, Caroline L Speck, Lauren R Jones, Craig E Stark, Michael A Yassa, Susan S Bassett, Amy L Shelton, Michela Gallaghe. Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron. vol 74. issue 3. 2012-07-12. PMID:22578498. |
elevated hippocampal activation is observed in conditions that confer risk for alzheimer's disease, including amnestic mild cognitive impairment (amci). |
2012-07-12 |
2023-08-12 |
Not clear |
| J-Y Kim, D H Kim, J H Kim, D Lee, H B Jeon, S-J Kwon, S M Kim, Y J Yoo, E H Lee, S J Choi, S W Seo, J I Lee, D L Na, Y S Yang, W Oh, J W Chan. Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques. Cell death and differentiation. vol 19. issue 4. 2012-07-03. PMID:22015609. |
when hucb-mscs were transplanted into the hippocampus of a 10-month-old transgenic mouse model of alzheimer's disease for 10, 20, or 40 days, nep expression was increased in the mice brains. |
2012-07-03 |
2023-08-12 |
mouse |
| Pierrick Coupé, Simon F Eskildsen, José V Manjón, Vladimir S Fonov, D Louis Collin. Simultaneous segmentation and grading of anatomical structures for patient's classification: application to Alzheimer's disease. NeuroImage. vol 59. issue 4. 2012-07-03. PMID:22094645. |
in this paper, we propose an innovative approach to robustly and accurately detect alzheimer's disease (ad) based on the distinction of specific atrophic patterns of anatomical structures such as hippocampus (hc) and entorhinal cortex (ec). |
2012-07-03 |
2023-08-12 |
human |
| Akihiko Shiino, Toshiyuki Watanabe, Yoshitomo Shirakashi, Emi Kotani, Masahiro Yoshimura, Shigehiro Morikawa, Toshiro Inubushi, Ichiro Akiguch. The profile of hippocampal metabolites differs between Alzheimer's disease and subcortical ischemic vascular dementia, as measured by proton magnetic resonance spectroscopy. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 32. issue 5. 2012-07-03. PMID:22314267. |
the profile of hippocampal metabolites differs between alzheimer's disease and subcortical ischemic vascular dementia, as measured by proton magnetic resonance spectroscopy. |
2012-07-03 |
2023-08-12 |
human |
| Jason L Stein, Sarah E Medland, Alejandro Arias Vasquez, Derrek P Hibar, Rudy E Senstad, Anderson M Winkler, Roberto Toro, Katja Appel, Richard Bartecek, Ørjan Bergmann, Manon Bernard, Andrew A Brown, Dara M Cannon, M Mallar Chakravarty, Andrea Christoforou, Martin Domin, Oliver Grimm, Marisa Hollinshead, Avram J Holmes, Georg Homuth, Jouke-Jan Hottenga, Camilla Langan, Lorna M Lopez, Narelle K Hansell, Kristy S Hwang, Sungeun Kim, Gonzalo Laje, Phil H Lee, Xinmin Liu, Eva Loth, Anbarasu Lourdusamy, Morten Mattingsdal, Sebastian Mohnke, Susana Muñoz Maniega, Kwangsik Nho, Allison C Nugent, Carol O'Brien, Martina Papmeyer, Benno Pütz, Adaikalavan Ramasamy, Jerod Rasmussen, Mark Rijpkema, Shannon L Risacher, J Cooper Roddey, Emma J Rose, Mina Ryten, Li Shen, Emma Sprooten, Eric Strengman, Alexander Teumer, Daniah Trabzuni, Jessica Turner, Kristel van Eijk, Theo G M van Erp, Marie-Jose van Tol, Katharina Wittfeld, Christiane Wolf, Saskia Woudstra, Andre Aleman, Saud Alhusaini, Laura Almasy, Elisabeth B Binder, David G Brohawn, Rita M Cantor, Melanie A Carless, Aiden Corvin, Michael Czisch, Joanne E Curran, Gail Davies, Marcio A A de Almeida, Norman Delanty, Chantal Depondt, Ravi Duggirala, Thomas D Dyer, Susanne Erk, Jesen Fagerness, Peter T Fox, Nelson B Freimer, Michael Gill, Harald H H Göring, Donald J Hagler, David Hoehn, Florian Holsboer, Martine Hoogman, Norbert Hosten, Neda Jahanshad, Matthew P Johnson, Dalia Kasperaviciute, Jack W Kent, Peter Kochunov, Jack L Lancaster, Stephen M Lawrie, David C Liewald, René Mandl, Mar Matarin, Manuel Mattheisen, Eva Meisenzahl, Ingrid Melle, Eric K Moses, Thomas W Mühleisen, Matthias Nauck, Markus M Nöthen, Rene L Olvera, Massimo Pandolfo, G Bruce Pike, Ralf Puls, Ivar Reinvang, Miguel E Rentería, Marcella Rietschel, Joshua L Roffman, Natalie A Royle, Dan Rujescu, Jonathan Savitz, Hugo G Schnack, Knut Schnell, Nina Seiferth, Colin Smith, Vidar M Steen, Maria C Valdés Hernández, Martijn Van den Heuvel, Nic J van der Wee, Neeltje E M Van Haren, Joris A Veltman, Henry Völzke, Robert Walker, Lars T Westlye, Christopher D Whelan, Ingrid Agartz, Dorret I Boomsma, Gianpiero L Cavalleri, Anders M Dale, Srdjan Djurovic, Wayne C Drevets, Peter Hagoort, Jeremy Hall, Andreas Heinz, Clifford R Jack, Tatiana M Foroud, Stephanie Le Hellard, Fabio Macciardi, Grant W Montgomery, Jean Baptiste Poline, David J Porteous, Sanjay M Sisodiya, John M Starr, Jessika Sussmann, Arthur W Toga, Dick J Veltman, Henrik Walter, Michael W Weiner, Joshua C Bis, M Arfan Ikram, Albert V Smith, Vilmundur Gudnason, Christophe Tzourio, Meike W Vernooij, Lenore J Launer, Charles DeCarli, Sudha Seshadri, Ole A Andreassen, Liana G Apostolova, Mark E Bastin, John Blangero, Han G Brunner, Randy L Buckner, Sven Cichon, Giovanni Coppola, Greig I de Zubicaray, Ian J Deary, Gary Donohoe, Eco J C de Geus, Thomas Espeseth, Guillén Fernández, David C Glahn, Hans J Grabe, John Hardy, Hilleke E Hulshoff Pol, Mark Jenkinson, René S Kahn, Colm McDonald, Andrew M McIntosh, Francis J McMahon, Katie L McMahon, Andreas Meyer-Lindenberg, Derek W Morris, Bertram Müller-Myhsok, Thomas E Nichols, Roel A Ophoff, Tomas Paus, Zdenka Pausova, Brenda W Penninx, Steven G Potkin, Philipp G Sämann, Andrew J Saykin, Gunter Schumann, Jordan W Smoller, Joanna M Wardlaw, Michael E Weale, Nicholas G Martin, Barbara Franke, Margaret J Wright, Paul M Thompso. Identification of common variants associated with human hippocampal and intracranial volumes. Nature genetics. vol 44. issue 5. 2012-07-02. PMID:22504417. |
the volume of the hippocampus is a biomarker of incipient alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. |
2012-07-02 |
2023-08-12 |
human |
| Joshua C Bis, Charles DeCarli, Albert Vernon Smith, Fedde van der Lijn, Fabrice Crivello, Myriam Fornage, Stephanie Debette, Joshua M Shulman, Helena Schmidt, Velandai Srikanth, Maaike Schuur, Lei Yu, Seung-Hoan Choi, Sigurdur Sigurdsson, Benjamin F J Verhaaren, Anita L DeStefano, Jean-Charles Lambert, Clifford R Jack, Maksim Struchalin, Jim Stankovich, Carla A Ibrahim-Verbaas, Debra Fleischman, Alex Zijdenbos, Tom den Heijer, Bernard Mazoyer, Laura H Coker, Christian Enzinger, Patrick Danoy, Najaf Amin, Konstantinos Arfanakis, Mark A van Buchem, Renée F A G de Bruijn, Alexa Beiser, Carole Dufouil, Juebin Huang, Margherita Cavalieri, Russell Thomson, Wiro J Niessen, Lori B Chibnik, Gauti K Gislason, Albert Hofman, Aleksandra Pikula, Philippe Amouyel, Kevin B Freeman, Thanh G Phan, Ben A Oostra, Jason L Stein, Sarah E Medland, Alejandro Arias Vasquez, Derrek P Hibar, Margaret J Wright, Barbara Franke, Nicholas G Martin, Paul M Thompson, Michael A Nalls, Andre G Uitterlinden, Rhoda Au, Alexis Elbaz, Richard J Beare, John C van Swieten, Oscar L Lopez, Tamara B Harris, Vincent Chouraki, Monique M B Breteler, Philip L De Jager, James T Becker, Meike W Vernooij, David Knopman, Franz Fazekas, Philip A Wolf, Aad van der Lugt, Vilmundur Gudnason, W T Longstreth, Matthew A Brown, David A Bennett, Cornelia M van Duijn, Thomas H Mosley, Reinhold Schmidt, Christophe Tzourio, Lenore J Launer, M Arfan Ikram, Sudha Seshadr. Common variants at 12q14 and 12q24 are associated with hippocampal volume. Nature genetics. vol 44. issue 5. 2012-07-02. PMID:22504421. |
aging is associated with reductions in hippocampal volume that are accelerated by alzheimer's disease and vascular risk factors. |
2012-07-02 |
2023-08-12 |
Not clear |
| Marielle S Kahn, Dinko Kranjac, Chris A Alonzo, Jennifer H Haase, Rudy O Cedillos, Kristina A McLinden, Gary W Boehm, Michael J Chumle. Prolonged elevation in hippocampal Aβ and cognitive deficits following repeated endotoxin exposure in the mouse. Behavioural brain research. vol 229. issue 1. 2012-06-26. PMID:22249135. |
alzheimer's disease (ad) is characterized by neuronal cell death and atrophy in regions of the adult brain, including the hippocampus and cortex, due to formation of amyloid beta (aβ) plaques and neurofibrillary tangles. |
2012-06-26 |
2023-08-12 |
mouse |
| Hidekazu Tomimot. Subcortical vascular dementia. Neuroscience research. vol 71. issue 3. 2012-06-25. PMID:21821070. |
subcortical vascular dementia may exhibit slowly progressive vascular parkinsonism and dementia but can be differentiated from alzheimer's disease because it is associated with more extensive white matter lesions, less severe hippocampal atrophy and the absence of cerebral amyloid angiopathy (caa), which may be indicated radiologically by lobar microbleeds, cortical subarachnoid hemorrhage (sah) and cortical microinfarctions. |
2012-06-25 |
2023-08-12 |
Not clear |
| Raquel Sanchez-Varo, Laura Trujillo-Estrada, Elisabeth Sanchez-Mejias, Manuel Torres, David Baglietto-Vargas, Ines Moreno-Gonzalez, Vanessa De Castro, Sebastian Jimenez, Diego Ruano, Marisa Vizuete, Jose Carlos Davila, Jose Manuel Garcia-Verdugo, Antonio Jesus Jimenez, Javier Vitorica, Antonia Gutierre. Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus. Acta neuropathologica. vol 123. issue 1. 2012-06-25. PMID:22020633. |
abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young alzheimer's mice hippocampus. |
2012-06-25 |
2023-08-12 |
mouse |
| Geon Ha Kim, Seun Jeon, Sang Won Seo, Min-Jeong Kim, Jong Hun Kim, Jee Hoon Roh, Ji Soo Shin, Chi Hun Kim, Kiho Im, Jong-Min Lee, Anqi Qiu, Sung Tae Kim, Duk L N. Topography of cortical thinning areas associated with hippocampal atrophy (HA) in patients with Alzheimer's disease (AD). Archives of gerontology and geriatrics. vol 54. issue 2. 2012-06-22. PMID:22088936. |
topography of cortical thinning areas associated with hippocampal atrophy (ha) in patients with alzheimer's disease (ad). |
2012-06-22 |
2023-08-12 |
human |
| Liana G Apostolova, Amity E Green, Sona Babakchanian, Kristy S Hwang, Yi-Yu Chou, Arthur W Toga, Paul M Thompso. Hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (MCI), and Alzheimer Disease. Alzheimer disease and associated disorders. vol 26. issue 1. 2012-06-20. PMID:22343374. |
hippocampal atrophy and ventricular enlargement in normal aging, mild cognitive impairment (mci), and alzheimer disease. |
2012-06-20 |
2023-08-12 |
Not clear |
| Riitta Miettinen, Tibor Hajszan, Anett Riedel, Klara Szigeti-Buck, Csaba Lerant. Estimation of the total number of hippocampal CA1 pyramidal neurons: new methodology applied to helpless rats. Journal of neuroscience methods. vol 205. issue 1. 2012-06-15. PMID:22230770. |
our method provides an improved tool for studies aiming to evaluate hippocampal atrophy and cell loss, the most characteristic features in many neurodegenerative diseases, such as alzheimer's disease, temporal lobe epilepsy and ischemia, as well as in several psychiatric disorders. |
2012-06-15 |
2023-08-12 |
rat |
| Min Song, Jia-xiang Xiong, Yan-yan Wang, Jun Tang, Bo Zhang, Yun Ba. VIP enhances phagocytosis of fibrillar beta-amyloid by microglia and attenuates amyloid deposition in the brain of APP/PS1 mice. PloS one. vol 7. issue 2. 2012-06-11. PMID:22328918. |
the aβ load was significantly reduced in the hippocampus of this animal model of alzheimer's disease, possibly due to the accumulation and activation of cd11b-immunoactive microglial cells. |
2012-06-11 |
2023-08-12 |
mouse |
| Gloria C Chiang, Philip S Insel, Duygu Tosun, Norbert Schuff, Diana Truran-Sacrey, Sky T Raptentsetsang, Paul M Thompson, Eric M Reiman, Clifford R Jack, Nick C Fox, William J Jagust, Danielle J Harvey, Laurel A Beckett, Anthony Gamst, Paul S Aisen, Ron C Petersen, Michael W Weine. Impact of apolipoprotein E4-cerebrospinal fluid β-amyloid interaction on hippocampal volume loss over 1 year in mild cognitive impairment. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 7. issue 5. 2012-06-06. PMID:21889115. |
apolipoprotein ɛ4 (apoe ɛ4), a genetic risk factor for alzheimer's disease, is also known to be associated with hippocampal volume loss. |
2012-06-06 |
2023-08-12 |
Not clear |
| Eric M Blalock, Heather M Buechel, Jelena Popovic, James W Geddes, Philip W Landfiel. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. Journal of chemical neuroanatomy. vol 42. issue 2. 2012-06-01. PMID:21756998. |
microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient alzheimer's disease. |
2012-06-01 |
2023-08-12 |
human |
| Eric M Blalock, Heather M Buechel, Jelena Popovic, James W Geddes, Philip W Landfiel. Microarray analyses of laser-captured hippocampus reveal distinct gray and white matter signatures associated with incipient Alzheimer's disease. Journal of chemical neuroanatomy. vol 42. issue 2. 2012-06-01. PMID:21756998. |
in a prior microarray study we correlated gene expression in hippocampus with degree of alzheimer's disease and found close associations between upregulation of apparent glial transcription factor/epigenetic/tumor suppressor genes and incipient ad. |
2012-06-01 |
2023-08-12 |
human |
| Alejandra Romero-Curiel, Diana López-Carpinteyro, Citlalli Gamboa, Fidel De la Cruz, Sergio Zamudio, Gonzalo Flore. Apamin induces plastic changes in hippocampal neurons in senile Sprague-Dawley rats. Synapse (New York, N.Y.). vol 65. issue 10. 2012-05-30. PMID:21465567. |
several behavioral and electrophysiological studies indicate that sk-blockade by apamin may enhance neuron excitability, synaptic plasticity, and long-term potentiation in the ca1 hippocampal region, and, for that reason, apamin has been proposed as a therapeutic agent in alzheimer's disease treatment. |
2012-05-30 |
2023-08-12 |
rat |
| Elisa Mura, Stefania Zappettini, Stefania Preda, Fabrizio Biundo, Cristina Lanni, Massimo Grilli, Anna Cavallero, Guendalina Olivero, Alessia Salamone, Stefano Govoni, Mario March. Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus. PloS one. vol 7. issue 1. 2012-05-29. PMID:22253754. |
in this paper we focused on the hippocampus, a brain area which is sensitive to alzheimer's disease pathology, evaluating the effect of aβ (at different concentrations) on the neurotransmitter release stimulated by the activation of pre-synaptic cholinergic nicotinic receptors (nachrs, α4β2 and α7 subtypes). |
2012-05-29 |
2023-08-12 |
rat |
| Anouk G W van Norden, Karlijn F de Laat, Ilma Fick, Inge W M van Uden, Lucas J B van Oudheusden, Rob A R Gons, David G Norris, Marcel P Zwiers, Roy P C Kessels, Frank-Erik de Leeu. Diffusion tensor imaging of the hippocampus and verbal memory performance: the RUN DMC study. Human brain mapping. vol 33. issue 3. 2012-05-23. PMID:21391278. |
cerebral small vessel disease (svd) and hippocampal atrophy are related to verbal memory failures and may ultimately result in alzheimer's disease. |
2012-05-23 |
2023-08-12 |
Not clear |