| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. |
hippocampal laminar distribution of tau relates to alzheimer's disease and age of onset. |
2016-01-15 |
2023-08-13 |
Not clear |
| Alon Seifan, Karen S Marder, Jesse Mez, James M Noble, Etty P Cortes, Jean Paul Vonsattel, Lawrence S Honi. Hippocampal laminar distribution of tau relates to Alzheimer's disease and age of onset. Journal of Alzheimer's disease : JAD. vol 43. issue 1. 2016-01-15. PMID:25079799. |
cerebral deposition of phospho-tau in alzheimer's disease (ad) occurs with varying patterns within hippocampus. |
2016-01-15 |
2023-08-13 |
Not clear |
| Xiaoying Tang, Dominic Holland, Anders M Dale, Laurent Younes, Michael I Mille. The diffeomorphometry of regional shape change rates and its relevance to cognitive deterioration in mild cognitive impairment and Alzheimer's disease. Human brain mapping. vol 36. issue 6. 2016-01-15. PMID:25644981. |
we proposed a diffeomorphometry-based statistical pipeline to study the regional shape change rates of the bilateral hippocampus, amygdala, and ventricle in mild cognitive impairment (mci) and alzheimer's disease (ad) compared with healthy controls (hc), using sequential magnetic resonance imaging (mri) scans of 713 subjects (3,123 scans in total). |
2016-01-15 |
2023-08-13 |
human |
| Gerard Ill-Raga, Marta Tajes, Arnau Busquets-García, Eva Ramos-Fernández, Lina M Vargas, Mònica Bosch-Morató, Biuse Guivernau, Victòria Valls-Comamala, Abel Eraso-Pichot, Francesc X Guix, César Fandos, Mark D Rosen, Michael H Rabinowitz, Rafael Maldonado, Alejandra R Alvarez, Andrés Ozaita, Francisco J Muño. Physiological Control of Nitric Oxide in Neuronal BACE1 Translation by Heme-Regulated eIF2α Kinase HRI Induces Synaptogenesis. Antioxidants & redox signaling. vol 22. issue 15. 2016-01-15. PMID:25706765. |
however, hippocampus is dramatically compromised in alzheimer's disease due to the accumulation of amyloid β-peptide, whose production is initiated by β-site app cleaving enzyme 1 (bace1). |
2016-01-15 |
2023-08-13 |
Not clear |
| Evelin L Schaeffer, Wagner F Gatta. Chronic inhibition of brain phospholipase A2 in adult rats impairs the survival of newborn mature neurons in the hippocampus. Journal of neural transmission (Vienna, Austria : 1996). vol 122. issue 5. 2016-01-13. PMID:25160937. |
these findings show that chronic pla2 inhibition in adult rat hippocampus decreases the number of newborn mature neurons in the ventral dg (reflecting in the whole dg), perhaps by impairing neuronal maturation and survival, and suggest that pla2 inhibition reported in the hippocampus of alzheimer disease subjects might partly contribute to the neurogenic abnormalities found in the dg in this disease. |
2016-01-13 |
2023-08-13 |
human |
| Vijay R Varma, Yi-Fang Chuang, Gregory C Harris, Erwin J Tan, Michelle C Carlso. Low-intensity daily walking activity is associated with hippocampal volume in older adults. Hippocampus. vol 25. issue 5. 2016-01-13. PMID:25483019. |
hippocampal atrophy is associated with memory impairment and dementia and serves as a key biomarker in the preclinical stages of alzheimer's disease. |
2016-01-13 |
2023-08-13 |
human |
| Adam D Bachstetter, Linda J Van Eldik, Frederick A Schmitt, Janna H Neltner, Eseosa T Ighodaro, Scott J Webster, Ela Patel, Erin L Abner, Richard J Kryscio, Peter T Nelso. Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging. Acta neuropathologica communications. vol 3. 2016-01-13. PMID:26001591. |
disease-related microglia heterogeneity in the hippocampus of alzheimer's disease, dementia with lewy bodies, and hippocampal sclerosis of aging. |
2016-01-13 |
2023-08-13 |
Not clear |
| Angela Heck, Matthias Fastenrath, David Coynel, Bianca Auschra, Horst Bickel, Virginie Freytag, Leo Gschwind, Francina Hartmann, Frank Jessen, Hanna Kaduszkiewicz, Wolfgang Maier, Annette Milnik, Michael Pentzek, Steffi G Riedel-Heller, Klara Spalek, Christian Vogler, Michael Wagner, Siegfried Weyerer, Steffen Wolfsgruber, Dominique J-F de Quervain, Andreas Papassotiropoulo. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA psychiatry. vol 72. issue 10. 2016-01-12. PMID:26332608. |
genetic analysis of association between calcium signaling and hippocampal activation, memory performance in the young and old, and risk for sporadic alzheimer disease. |
2016-01-12 |
2023-08-13 |
human |
| Angela Heck, Matthias Fastenrath, David Coynel, Bianca Auschra, Horst Bickel, Virginie Freytag, Leo Gschwind, Francina Hartmann, Frank Jessen, Hanna Kaduszkiewicz, Wolfgang Maier, Annette Milnik, Michael Pentzek, Steffi G Riedel-Heller, Klara Spalek, Christian Vogler, Michael Wagner, Siegfried Weyerer, Steffen Wolfsgruber, Dominique J-F de Quervain, Andreas Papassotiropoulo. Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease. JAMA psychiatry. vol 72. issue 10. 2016-01-12. PMID:26332608. |
human episodic memory performance is linked to the function of specific brain regions, including the hippocampus; declines as a result of increasing age; and is markedly disturbed in alzheimer disease (ad), an age-associated neurodegenerative disorder that primarily affects the hippocampus. |
2016-01-12 |
2023-08-13 |
human |
| Charles Duyckaerts, Heiko Braak, Jean-Pierre Brion, Luc Buée, Kelly Del Tredici, Michel Goedert, Glenda Halliday, Manuela Neumann, Maria Grazia Spillantini, Markus Tolnay, Toshiki Uchihar. PART is part of Alzheimer disease. Acta neuropathologica. vol 129. issue 5. 2016-01-11. PMID:25628035. |
it has been proposed that tau aggregation confined to entorhinal cortex and hippocampus, with no or only minimal aβ deposition, should be considered as a 'primary age-related tauopathy' (part) that is not integral to the continuum of sporadic alzheimer disease (ad). |
2016-01-11 |
2023-08-13 |
Not clear |
| Mansi B Parekh, Brian K Rutt, Ryan Purcell, Yuanxin Chen, Michael M Zeine. Ultra-high resolution in-vivo 7.0T structural imaging of the human hippocampus reveals the endfolial pathway. NeuroImage. vol 112. 2016-01-11. PMID:25701699. |
the hippocampus is a very important structure in memory formation and retrieval, as well as in various neurological disorders such as alzheimer's disease, epilepsy and depression. |
2016-01-11 |
2023-08-13 |
human |
| Holly C Hunsberger, Daniel S Weitzner, Carolyn C Rudy, James E Hickman, Eric M Libell, Rebecca R Speer, Greg A Gerhardt, Miranda N Ree. Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression. Journal of neurochemistry. vol 135. issue 2. 2016-01-11. PMID:26146790. |
hyperexcitability of the hippocampus is a commonly observed phenomenon in the years preceding a diagnosis of alzheimer's disease (ad). |
2016-01-11 |
2023-08-13 |
mouse |
| Tian Ge, Thomas E Nichols, Debashis Ghosh, Elizabeth C Mormino, Jordan W Smoller, Mert R Sabunc. A kernel machine method for detecting effects of interaction between multidimensional variable sets: an imaging genetics application. NeuroImage. vol 109. 2016-01-07. PMID:25600633. |
as a demonstration of application, we applied the method to the data from the alzheimer's disease neuroimaging initiative (adni) to detect the effects of the interactions between candidate alzheimer's disease (ad) risk genes and a collection of cardiovascular disease (cvd) risk factors, on hippocampal volume measurements derived from structural brain magnetic resonance imaging (mri) scans. |
2016-01-07 |
2023-08-13 |
Not clear |
| Xiang-Hua Liu, Zhao Geng, Jing Yan, Ting Li, Qun Chen, Qun-Ye Zhang, Zhe-Yu Che. Blocking GSK3β-mediated dynamin1 phosphorylation enhances BDNF-dependent TrkB endocytosis and the protective effects of BDNF in neuronal and mouse models of Alzheimer's disease. Neurobiology of disease. vol 74. 2016-01-06. PMID:25484286. |
moreover, we found that beta-amyloid (aβ) oligomer exposure could impair bdnf-dependent trkb endocytosis and akt activation through enhancing gsk3β activity in cultured hippocampal neurons, which suggested that bdnf-induced trkb endocytosis and the subsequent signaling were impaired in neuronal model of alzheimer's disease (ad). |
2016-01-06 |
2023-08-13 |
mouse |
| Janine Bayer, Gabriele Rune, Heidrun Schultz, Michael J Tobia, Imke Mebes, Olaf Katzler, Tobias Somme. The effect of estrogen synthesis inhibition on hippocampal memory. Psychoneuroendocrinology. vol 56. 2016-01-05. PMID:25863445. |
we thus infer that the inhibition of e2 synthesis specifically impairs hippocampal functioning in humans, whereas the increased prefrontal activity presumably reflects a compensatory mechanism, which is already known from studies on cognitive aging and alzheimer's disease. |
2016-01-05 |
2023-08-13 |
Not clear |
| Avik Roy, Khushbu K Modi, Saurabh Khasnavis, Supurna Ghosh, Richard Watson, Kalipada Paha. Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase. PloS one. vol 9. issue 7. 2016-01-01. PMID:25007337. |
finally, in the 5xfad transgenic model of alzheimer's disease (ad), rns60 treatment upregulated expression of plasticity-related proteins psd95 and nr2a and increased ampa- and nmda-dependent hippocampal calcium influx. |
2016-01-01 |
2023-08-13 |
mouse |
| Xuejiao Cheng, Qian Wang, Na Li, Haifeng Zha. [Effects of resveratrol on hippocampal astrocytes and expression of TNF-α in Alzheimer's disease model rate]. Wei sheng yan jiu = Journal of hygiene research. vol 44. issue 4. 2015-12-29. PMID:26454959. |
[effects of resveratrol on hippocampal astrocytes and expression of tnf-α in alzheimer's disease model rate]. |
2015-12-29 |
2023-08-13 |
rat |
| Xuejiao Cheng, Qian Wang, Na Li, Haifeng Zha. [Effects of resveratrol on hippocampal astrocytes and expression of TNF-α in Alzheimer's disease model rate]. Wei sheng yan jiu = Journal of hygiene research. vol 44. issue 4. 2015-12-29. PMID:26454959. |
to explore the effects of resveratrol on astrocyte and tnf-α in hippocampus of alzheimer's disease (ad) model rats. |
2015-12-29 |
2023-08-13 |
rat |
| Kirsten L Viola, James Sbarboro, Ruchi Sureka, Mrinmoy De, Maíra A Bicca, Jane Wang, Shaleen Vasavada, Sreyesh Satpathy, Summer Wu, Hrushikesh Joshi, Pauline T Velasco, Keith MacRenaris, E Alex Waters, Chang Lu, Joseph Phan, Pascale Lacor, Pottumarthi Prasad, Vinayak P Dravid, William L Klei. Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nature nanotechnology. vol 10. issue 1. 2015-12-28. PMID:25531084. |
when intranasally administered to an alzheimer's disease mouse model, the probe readily reached hippocampal aβ oligomers. |
2015-12-28 |
2023-08-13 |
mouse |
| Lei Luo, Guo-jie Sun, Yan-jun D. [Effect of "Kidney-reinforcing and Govenor Vessel-regulating" of Acupuncture plus Moxibustion on Mitochondrial Dynamics-related Proteins in Hippocampal Neurons of Rats with Alzheimer's Disease]. Zhen ci yan jiu = Acupuncture research. vol 40. issue 4. 2015-12-22. PMID:26502539. |
[effect of "kidney-reinforcing and govenor vessel-regulating" of acupuncture plus moxibustion on mitochondrial dynamics-related proteins in hippocampal neurons of rats with alzheimer's disease]. |
2015-12-22 |
2023-08-13 |
rat |