| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Virginie Vives, Gérard Alonso, Anne Cohen Solal, Dominique Joubert, Catherine Legraveren. Visualization of S100B-positive neurons and glia in the central nervous system of EGFP transgenic mice. The Journal of comparative neurology. vol 457. issue 4. 2003-06-20. PMID:12561079. |
s100b, the ef-hand ca(++)-binding protein with gliotrophic and neurotrophic properties implicated in the pathogenesis of alzheimer's disease, is coined as a glial marker, despite its documented presence in rodent brain neurons. |
2003-06-20 |
2023-08-12 |
mouse |
| A Petzold, R Jenkins, H C Watt, A J E Green, E J Thompson, G Keir, N C Fox, M N Rosso. Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease. Neuroscience letters. vol 336. issue 3. 2003-04-03. PMID:12505619. |
cerebrospinal fluid s100b correlates with brain atrophy in alzheimer's disease. |
2003-04-03 |
2023-08-12 |
human |
| A Petzold, R Jenkins, H C Watt, A J E Green, E J Thompson, G Keir, N C Fox, M N Rosso. Cerebrospinal fluid S100B correlates with brain atrophy in Alzheimer's disease. Neuroscience letters. vol 336. issue 3. 2003-04-03. PMID:12505619. |
concentrations of s100b were measured in the cerebrospinal fluid (csf) of 31 patients with alzheimer's disease (ad), 36 patients with frontotemporal lobe dementia (ftld) and 49 patients with other non-inflammatory neurological diseases. |
2003-04-03 |
2023-08-12 |
human |
| R E Mrak, W S Griffinb. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754999. |
the role of activated astrocytes and of the neurotrophic cytokine s100b in the pathogenesis of alzheimer's disease. |
2002-02-28 |
2023-08-12 |
Not clear |
| R E Mrak, W S Griffinb. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754999. |
astrocytic overexpression of s100b in the neuritic plaques of alzheimer's disease correlates with the degree of neuritic pathology in abeta plaques in this disease, suggesting a pathogenic role for s100b's neurotrophic properties in the evolution of these lesions. |
2002-02-28 |
2023-08-12 |
Not clear |
| R E Mrak, W S Griffinb. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754999. |
astrocytic overexpression of s100b, in turn, is promoted by high levels of interleukin-1 (il-1), originating from activated microglia that are also constant components of abeta plaques in alzheimer's disease. |
2002-02-28 |
2023-08-12 |
Not clear |
| R E Mrak, W S Griffinb. The role of activated astrocytes and of the neurotrophic cytokine S100B in the pathogenesis of Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754999. |
similar patterns of astrocyte activation, s100b overexpression, microglial activation, and il-1 overexpression are seen in conditions that confer risk for alzheimer's disease (aging, head trauma, down's syndrome), in conditions that predispose to accelerated appearance of alzheimer-like neuropathologic changes (chronic epilepsy, hiv infection), and in animal models of alzheimer's disease. |
2002-02-28 |
2023-08-12 |
Not clear |
| R E Mrak, W S Griffi. Interleukin-1, neuroinflammation, and Alzheimer's disease. Neurobiology of aging. vol 22. issue 6. 2002-02-28. PMID:11754997. |
il-1 has a number of actions relevant to alzheimer's disease, including excessive expression of neuronal abeta precursor protein and other plaque-associated proteins, and induction of astrocyte activation and astrocytic overexpression of s100b. |
2002-02-28 |
2023-08-12 |
Not clear |
| E R Peskind, W S Griffin, K T Akama, M A Raskind, L J Van Eldi. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578776. |
cerebrospinal fluid s100b is elevated in the earlier stages of alzheimer's disease. |
2001-12-28 |
2023-08-12 |
human |
| E R Peskind, W S Griffin, K T Akama, M A Raskind, L J Van Eldi. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578776. |
postmortem demonstration of increased expression of biologically active s100b in alzheimer's disease (ad) and its relation to progression of neuropathological changes across the cortical regions suggests involvement of this astrocytic cytokine in the pathophysiology of ad. |
2001-12-28 |
2023-08-12 |
human |
| E R Peskind, W S Griffin, K T Akama, M A Raskind, L J Van Eldi. Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease. Neurochemistry international. vol 39. issue 5-6. 2001-12-28. PMID:11578776. |
the hypothesis that the overexpression of s100b in alzheimer brain is related to the progression of clinical symptoms was addressed in living persons by measuring s100b concentrations in cerebrospinal fluid (csf) from ad patients with a broad range of clinical dementia severity and from healthy older persons. |
2001-12-28 |
2023-08-12 |
human |
| H Matsumura, T Shiba, T Inoue, S Harada, Y Ka. A novel mode of target recognition suggested by the 2.0 A structure of holo S100B from bovine brain. Structure (London, England : 1993). vol 6. issue 2. 1998-05-07. PMID:9519413. |
s100b is found abundantly in nervous tissue and has been implicated in alzheimer's disease and down's syndrome. |
1998-05-07 |
2023-08-12 |
cattle |
| P M Kilby, L J Van Eldik, G C Robert. The solution structure of the bovine S100B protein dimer in the calcium-free state. Structure (London, England : 1993). vol 4. issue 9. 1996-11-07. PMID:8805590. |
s100b is a neurite-extension factor and levels of s100b are elevated in the brains of patients with alzheimer's disease or down's syndrome: the pattern of s100b overexpression in alzheimer's disease correlates with the pattern of neuritic-plaque formation. |
1996-11-07 |
2023-08-12 |
cattle |