| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Radmila Manev, Hari Mane. Could treatment with arundic acid (ONO-2506) increase vulnerability for depression? Medical hypotheses. vol 67. issue 5. 2009-05-20. PMID:16797859. |
here we hypothesize that available data that link s100b with depression, along with the proposed inhibitory action of ono-2506 on s100b synthesis, indicate that this compound could increase vulnerability for depression in patients at risk for this disorder, and we propose that evaluation of patients with stroke and alzheimer's disease for the presence of depression should be routine in clinical trials employing ono-2506. |
2009-05-20 |
2023-08-12 |
Not clear |
| Daniela F de Souza, Marina C Leite, André Quincozes-Santos, Patrícia Nardin, Lucas S Tortorelli, Maurício M Rigo, Carmem Gottfried, Rodrigo B Leal, Carlos-Alberto Gonçalve. S100B secretion is stimulated by IL-1beta in glial cultures and hippocampal slices of rats: Likely involvement of MAPK pathway. Journal of neuroimmunology. vol 206. issue 1-2. 2009-04-02. PMID:19042033. |
s100b is an astrocyte-derived cytokine implicated in the il-1beta-triggered cytokine cycle in alzheimer's disease. |
2009-04-02 |
2023-08-12 |
rat |
| Lynn A Bialowas-McGoey, Agnieszka Lesicka, Patricia M Whitaker-Azmiti. Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging. Glia. vol 56. issue 16. 2009-03-16. PMID:18649404. |
s100b and its receptor rage (receptor for advanced glycation end products) have been found to be increased in alzheimer's disease, down syndrome, with tissue trauma and ischemia. |
2009-03-16 |
2023-08-12 |
mouse |
| Giuseppe Esposito, Caterina Scuderi, Jie Lu, Claudia Savani, Daniele De Filippis, Teresa Iuvone, Luca Steardo, Volney Sheen, Luca Steard. S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells. Journal of cellular and molecular medicine. vol 12. issue 3. 2008-09-17. PMID:18494933. |
previous studies suggest that levels of the astrocyte-derived s100b protein, such as those occurring in brain extra-cellular spaces consequent to persistent astroglial activation, may have a pathogenetic role in alzheimer's disease (ad). |
2008-09-17 |
2023-08-12 |
human |
| M M Edwards, S R Robinso. TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16736247. |
tnf alpha affects the expression of gfap and s100b: implications for alzheimer's disease. |
2007-09-05 |
2023-08-12 |
Not clear |
| M M Edwards, S R Robinso. TNF alpha affects the expression of GFAP and S100B: implications for Alzheimer's disease. Journal of neural transmission (Vienna, Austria : 1996). vol 113. issue 11. 2007-09-05. PMID:16736247. |
neurodegenerative disorders such as alzheimer's disease are characterized by increased intracellular and extracellular concentrations of the astrocytic proteins glial fibrillary acidic protein (gfap) and s100b. |
2007-09-05 |
2023-08-12 |
Not clear |
| Marina A Gruden, Tatyana B Davidova, Mantas Malisauskas, Robert D E Sewell, Nina I Voskresenskaya, Kristina Wilhelm, Elena I Elistratova, Vladimir V Sherstnev, Ludmilla A Morozova-Roch. Differential neuroimmune markers to the onset of Alzheimer's disease neurodegeneration and dementia: autoantibodies to Abeta((25-35)) oligomers, S100b and neurotransmitters. Journal of neuroimmunology. vol 186. issue 1-2. 2007-08-15. PMID:17477976. |
differential neuroimmune markers to the onset of alzheimer's disease neurodegeneration and dementia: autoantibodies to abeta((25-35)) oligomers, s100b and neurotransmitters. |
2007-08-15 |
2023-08-12 |
Not clear |
| Jon Sen, Antonio Bell. S100B in neuropathologic states: the CRP of the brain? Journal of neuroscience research. vol 85. issue 7. 2007-07-02. PMID:17348038. |
this review summarises the historic development and current knowledge of s100b, including recent interesting findings relating s100b to a diversity of cns pathologies such as traumatic brain injury, alzheimer's disease, down's syndrome, schizophrenia, and tourette's syndrome. |
2007-07-02 |
2023-08-12 |
Not clear |
| Narito Tateishi, Taiji Shimoda, Nobumichi Yada, Rika Shinagawa, Yoshifumi Kagamiish. [S100B: astrocyte specific protein]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 1. 2006-06-15. PMID:16637591. |
on the other hand, elevations of s100b levels in blood or cerebrospinal fluid have been observed in patients with alzheimer's disease, down's syndrome, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, depression, cerebral stroke and traumatic brain injury, and the levels have reached micromol/l-order at focal regions. |
2006-06-15 |
2023-08-12 |
Not clear |
| Narito Tateishi, Taiji Shimoda, Nobumichi Yada, Rika Shinagawa, Yoshifumi Kagamiish. [S100B: astrocyte specific protein]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 26. issue 1. 2006-06-15. PMID:16637591. |
on studies using some animal models of the cerebral stroke or alzheimer's disease, it is suggested that the excessive s100b produced by activated astrocytes precedes neurodegenerations. |
2006-06-15 |
2023-08-12 |
Not clear |
| R Businaro, S Leone, C Fabrizi, G Sorci, R Donato, G M Lauro, L Fumagall. S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses. Journal of neuroscience research. vol 83. issue 5. 2006-06-01. PMID:16477616. |
s100b is detected within senile plaques in alzheimer's disease, where its role is unknown. |
2006-06-01 |
2023-08-12 |
Not clear |
| Yasuhiko Ikeda, Kazuo Umemur. [Analysis of reference values of serum S100B concentrations of Japanese adults]. Rinsho byori. The Japanese journal of clinical pathology. vol 53. issue 5. 2005-08-16. PMID:15966402. |
it is reported that the serum s100b level increase with various cns diseases, such as stroke, head injury, schizophrenia, major depression and alzheimer's disease. |
2005-08-16 |
2023-08-12 |
Not clear |
| Ling Liu, Yuekui Li, Linda J Van Eldik, W Sue T Griffin, Steven W Barge. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. Journal of neurochemistry. vol 92. issue 3. 2005-06-24. PMID:15659225. |
both the astrocytic cytokine s100b and the pro-inflammatory interleukin-1 (il-1) are elevated in alzheimer's disease, and each has been implicated in alzheimer-related neuropathology. |
2005-06-24 |
2023-08-12 |
Not clear |
| Ling Liu, Yuekui Li, Linda J Van Eldik, W Sue T Griffin, Steven W Barge. S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors. Journal of neurochemistry. vol 92. issue 3. 2005-06-24. PMID:15659225. |
our results suggest that the elevation of s100b and il-1 in alzheimer brain and consequent neurodegenerative events are mediated through cell-type specific gene-regulatory events, providing mechanistic insight into connections between glial activation and neuronal dysfunction. |
2005-06-24 |
2023-08-12 |
Not clear |
| Maria Rosario Fernandez-Fernandez, Dmitry B Veprintsev, Alan R Fersh. Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 13. 2005-06-09. PMID:15781852. |
s100b protein is elevated in the brains of patients with early stages of alzheimer's disease and down's syndrome. |
2005-06-09 |
2023-08-12 |
Not clear |
| Lee A Shapiro, Patricia M Whitaker-Azmiti. Expression levels of cytoskeletal proteins indicate pathological aging of S100B transgenic mice: an immunohistochemical study of MAP-2, drebrin and GAP-43. Brain research. vol 1019. issue 1-2. 2004-11-04. PMID:15306236. |
the gene for s100b is located on chromosome 21 and levels of the protein are elevated in down syndrome (ds) and alzheimer's disease (ad). |
2004-11-04 |
2023-08-12 |
mouse |
| Lee A Shapiro, Alexander Marks, Patricia M Whitaker-Azmiti. Increased clusterin expression in old but not young adult S100B transgenic mice: evidence of neuropathological aging in a model of Down Syndrome. Brain research. vol 1010. issue 1-2. 2004-09-01. PMID:15126113. |
in humans, the gene for s100b is found on chromosome 21, within what is considered the obligate region for down syndrome (ds) and levels of s100b are increased in brain of both ds and alzheimer's disease (ad). |
2004-09-01 |
2023-08-12 |
mouse |
| Robert E Mrak, W Sue T Griffi. Trisomy 21 and the brain. Journal of neuropathology and experimental neurology. vol 63. issue 7. 2004-08-26. PMID:15290893. |
s100b overexpression correlates with alzheimer pathology in post-adolescent down syndrome patients and has been implicated in abeta plaque pathogenesis. |
2004-08-26 |
2023-08-12 |
mouse |
| Robert E Mrak, W Sue T Griffi. Trisomy 21 and the brain. Journal of neuropathology and experimental neurology. vol 63. issue 7. 2004-08-26. PMID:15290893. |
il-1 upregulates betaapp and s100b expression and drives numerous neurodegenerative and self-amplifying cascades that support a neuroinflammatory component in the pathogenesis of sporadic and down syndrome-related alzheimer disease. |
2004-08-26 |
2023-08-12 |
mouse |
| Mustafa Akhisaroglu, Radmila Manev, Ezgi Akhisaroglu, Tolga Uz, Hari Mane. Both aging and chronic fluoxetine increase S100B content in the mouse hippocampus. Neuroreport. vol 14. issue 11. 2003-11-20. PMID:12960766. |
s100b is a cytokine with neurotrophic and neurite-extending activity that has been implicated in the mechanism of action of anti-depressants and in the pathobiology of aging associated disorders such as alzheimer's disease. |
2003-11-20 |
2023-08-12 |
mouse |