| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marco Antonio Ceschi, Jessie Sobieski da Costa, João Paulo Bizarro Lopes, Viktor Saraiva Câmara, Leandra Franciscato Campo, Antonio César de Amorim Borges, Carlos Alberto Saraiva Gonçalves, Daniela Fraga de Souza, Eduardo Luis Konrath, Ana Luiza Martins Karl, Isabella Alvim Guedes, Laurent Emmanuel Dardenn. Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach. European journal of medicinal chemistry. vol 121. 2017-02-13. PMID:27392529. |
furthermore, the compounds 2g and 2e were able to reduce the in vitro basal secretion of s100b, suggesting its therapeutic action in some cases or stages of alzheimer's disease. |
2017-02-13 |
2023-08-13 |
Not clear |
| Carla Cirillo, Elena Capoccia, Teresa Iuvone, Rosario Cuomo, Giovanni Sarnelli, Luca Steardo, Giuseppe Esposit. S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease. BioMed research international. vol 2015. 2016-05-03. PMID:26295040. |
s100b inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of alzheimer's disease. |
2016-05-03 |
2023-08-13 |
mouse |
| Carla Cirillo, Elena Capoccia, Teresa Iuvone, Rosario Cuomo, Giovanni Sarnelli, Luca Steardo, Giuseppe Esposit. S100B Inhibitor Pentamidine Attenuates Reactive Gliosis and Reduces Neuronal Loss in a Mouse Model of Alzheimer's Disease. BioMed research international. vol 2015. 2016-05-03. PMID:26295040. |
among the different signaling molecules released during reactive gliosis occurring in alzheimer's disease (ad), the astrocyte-derived s100b protein plays a key role in neuroinflammation, one of the hallmarks of the disease. |
2016-05-03 |
2023-08-13 |
mouse |
| Orwa Aboud, Robert E Mrak, Frederick A Boop, W Sue T Griffi. Epilepsy: neuroinflammation, neurodegeneration, and APOE genotype. Acta neuropathologica communications. vol 1. 2015-03-31. PMID:24252240. |
to determine if epilepsy-related changes reflect those in another neurological condition, analogous tissue samples harvested from 10 autopsy-verified alzheimer brains, and from 10 neurologically and neuropathologically normal control patients were analyzed using immunofluorescence histochemistry, western immunoblot, and real-time pcr to determine genotype effects on neuronal number and size, neuronal and glial expressions of amyloid β (aβ) precursor protein (βapp), aβ, apolipoprotein e (apoe), s100b, interleukin-1α and β, and α and β secretases; and on markers of neuronal stress, including dna/rna damage and caspase 3 expression. |
2015-03-31 |
2023-08-12 |
Not clear |
| Walter Maetzler, Anja Apel, Markus Langkamp, Christian Deuschle, Sarah Selina Dilger, Johannes Georg Stirnkorb, Claudia Schulte, Erwin Schleicher, Thomas Gasser, Daniela Ber. Comparable autoantibody serum levels against amyloid- and inflammation-associated proteins in Parkinson's disease patients and controls. PloS one. vol 9. issue 2. 2015-01-02. PMID:24586351. |
naturally occurring autoantibodies (nabs) against a number of potentially disease-associated cellular proteins, including amyloid-beta1-42 (abeta1-42), alpha-synuclein (asyn), myelin basic protein (mbp), myelin oligodendrocyte glycoprotein (mog), and s100 calcium binding protein b (s100b) have been suggested to be associated with neurodegenerative disorders, in particular alzheimer's (ad) and parkinson's disease (pd). |
2015-01-02 |
2023-08-12 |
Not clear |
| Donna M Wilcock, W Sue T Griffi. Down's syndrome, neuroinflammation, and Alzheimer neuropathogenesis. Journal of neuroinflammation. vol 10. 2013-11-05. PMID:23866266. |
the discovery of neuroinflammatory changes, including dramatic proliferation of activated glia overexpressing a chromosome 2 gene product--the pluripotent immune cytokine interleukin-1 (il-1)--and a chromosome 21 gene product--s100b--in the brains of fetuses, neonates, and children with ds opened the possibility that early events in alzheimer pathogenesis were driven by cytokines. |
2013-11-05 |
2023-08-12 |
Not clear |
| Lucas N Wafer, Werner W Streicher, Scott A McCallum, George I Makhatadz. Thermodynamic and kinetic analysis of peptides derived from CapZ, NDR, p53, HDM2, and HDM4 binding to human S100B. Biochemistry. vol 51. issue 36. 2012-12-04. PMID:22913742. |
s100b is a member of the s100 subfamily of ef-hand proteins that has been implicated in malignant melanoma and neurodegenerative conditions such as alzheimer's disease and parkinson's disease. |
2012-12-04 |
2023-08-12 |
human |
| S M Hearst, L R Walker, Q Shao, M Lopez, D Raucher, P J S Vi. The design and delivery of a thermally responsive peptide to inhibit S100B-mediated neurodegeneration. Neuroscience. vol 197. 2012-02-27. PMID:21958864. |
s100b, a glial-secreted protein, is believed to play a major role in neurodegeneration in alzheimer's disease, down syndrome, traumatic brain injury, and spinocerebellar ataxia type 1 (sca1). |
2012-02-27 |
2023-08-12 |
mouse |
| F Sedaghat, A Notopoulo. S100 protein family and its application in clinical practice. Hippokratia. vol 12. issue 4. 2011-07-14. PMID:19158963. |
we herein provide a wide range of information concerning their clinical application in traumatic brain injuries, alzheimer disease, subarachnoid haemorrhage and other neurologic disorders, malignant melanoma and several other neoplasms (as s100b has been shown to down-regulate p53), as well as inflammatory diseases. |
2011-07-14 |
2023-08-12 |
Not clear |
| Estelle Leclerc, Emmanuel Sturchler, Stefan W Vette. The S100B/RAGE Axis in Alzheimer's Disease. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20672051. |
increasing evidence suggests that the small ef-hand calcium-binding protein s100b plays an important role in alzheimer's disease. |
2011-07-14 |
2023-08-12 |
Not clear |
| Lee A Shapiro, Lynn A Bialowas-McGoey, Patricia M Whitaker-Azmiti. Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease: Studies in an S100B Overexpressing Mouse Model. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20827311. |
effects of s100b on serotonergic plasticity and neuroinflammation in the hippocampus in down syndrome and alzheimer's disease: studies in an s100b overexpressing mouse model. |
2011-07-14 |
2023-08-12 |
mouse |
| Lee A Shapiro, Lynn A Bialowas-McGoey, Patricia M Whitaker-Azmiti. Effects of S100B on Serotonergic Plasticity and Neuroinflammation in the Hippocampus in Down Syndrome and Alzheimer's Disease: Studies in an S100B Overexpressing Mouse Model. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20827311. |
both of these processes are therefore accelerated towards degeneration in disease processes wherein s100b is increased, notably, alzheimer's disease (ad) and down syndrome (ds). |
2011-07-14 |
2023-08-12 |
mouse |
| Takashi Mori, Takao Asano, Terrence Tow. Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20862385. |
targeting s100b in cerebral ischemia and in alzheimer's disease. |
2011-07-14 |
2023-08-12 |
mouse |
| Takashi Mori, Takao Asano, Terrence Tow. Targeting S100B in Cerebral Ischemia and in Alzheimer's Disease. Cardiovascular psychiatry and neurology. vol 2010. 2011-07-14. PMID:20862385. |
based on genetic and pharmacological lines of evidence, we consider such deleterious roles of s100b in two common brain pathologies: ischemic stroke and alzheimer's disease (ad). |
2011-07-14 |
2023-08-12 |
mouse |
| Turker Yardan, Ali Kemal Erenler, Ahmet Baydin, Keramettin Aydin, Cengiz Coklu. Usefulness of S100B protein in neurological disorders. JPMA. The Journal of the Pakistan Medical Association. vol 61. issue 3. 2011-06-21. PMID:21465945. |
s100b is also associated with neurodegenerative diseases like alzheimer's disease or other chronic neurological diseases. |
2011-06-21 |
2023-08-12 |
human |
| Peter J B Anderson, Helena R Watts, Sheila Jen, Stephen M Gentleman, Juliet A Moncaster, D T Walsh, Ling-Sun Je. Differential effects of interleukin-1beta and S100B on amyloid precursor protein in rat retinal neurons. Clinical ophthalmology (Auckland, N.Z.). vol 3. 2011-05-26. PMID:19668572. |
interleukin-1beta (il-1beta) and s100b calcium binding protein b (s100b) have been implicated in the pathogenesis of alzheimer's disease. |
2011-05-26 |
2023-08-12 |
rat |
| Emily Roltsch, Leigh Holcomb, Keith A Young, Alexander Marks, Danna B Zimme. PSAPP mice exhibit regionally selective reductions in gliosis and plaque deposition in response to S100B ablation. Journal of neuroinflammation. vol 7. 2011-04-12. PMID:21080947. |
numerous studies have reported that increased expression of s100b, an intracellular ca2+ receptor protein and secreted neuropeptide, exacerbates alzheimer's disease (ad) pathology. |
2011-04-12 |
2023-08-12 |
mouse |
| Vincenzo Bramanti, Daniele Tomassoni, Marcello Avitabile, Francesco Amenta, Roberto Avol. Biomarkers of glial cell proliferation and differentiation in culture. Frontiers in bioscience (Scholar edition). vol 2. 2010-09-30. PMID:20036968. |
the role of s100b in astrocytes, neurons, and microglia is particularly studied in alzheimer's disease. |
2010-09-30 |
2023-08-12 |
Not clear |
| Márcia L Chaves, Ana L Camozzato, Eduardo D Ferreira, Isabel Piazenski, Renata Kochhann, Oscar Dall'Igna, Guilherme S Mazzini, Diogo O Souza, Luis V Portel. Serum levels of S100B and NSE proteins in Alzheimer's disease patients. Journal of neuroinflammation. vol 7. 2010-04-27. PMID:20105309. |
serum levels of s100b and nse proteins in alzheimer's disease patients. |
2010-04-27 |
2023-08-12 |
Not clear |
| Takashi Mori, Naoki Koyama, Gary W Arendash, Yuko Horikoshi-Sakuraba, Jun Tan, Terrence Tow. Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease. Glia. vol 58. issue 3. 2010-03-08. PMID:19705461. |
overexpression of human s100b exacerbates cerebral amyloidosis and gliosis in the tg2576 mouse model of alzheimer's disease. |
2010-03-08 |
2023-08-12 |
mouse |