| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Romina Coelho, Chiara A De Benedictis, Ann Katrin Sauer, António J Figueira, Hélio Faustino, Andreas M Grabrucker, Cláudio M Gome. Secondary Modification of S100B Influences Anti Amyloid-β Aggregation Activity and Alzheimer's Disease Pathology. International journal of molecular sciences. vol 25. issue 3. 2024-02-10. PMID:38339064. |
secondary modification of s100b influences anti amyloid-β aggregation activity and alzheimer's disease pathology. |
2024-02-10 |
2024-02-12 |
Not clear |
| Mihyun Lim Waugh, Lauren Wolf, James Turner, Lauren Phillips, Shannon Servoss, Melissa Mos. Modulating the RAGE-Induced Inflammatory Response: Peptoids as RAGE Antagonists. Chembiochem : a European journal of chemical biology. 2023-09-07. PMID:37679300. |
while the primary pathology of alzheimer's disease (ad) is defined by brain deposition of amyloid-β (aβ) plaques and tau neurofibrillary tangles, chronic inflammation has emerged as an important factor in ad etiology. upregulated cell surface expression of the receptor for advanced glycation end-products (rage), a key receptor of innate immune response, is reported in ad. in parallel, rage ligands, including aβ aggregates, hmgb1, and s100b, are elevated in ad brain. activation of rage by these ligands triggers release of inflammatory cytokines and upregulates cell surface rage. |
2023-09-07 |
2023-10-07 |
Not clear |
| Fabrizio Michetti, Maria Elisabetta Clementi, Rosa Di Liddo, Federica Valeriani, Francesco Ria, Mario Rende, Gabriele Di Sante, Vincenzo Romano Spic. The S100B Protein: A Multifaceted Pathogenic Factor More Than a Biomarker. International journal of molecular sciences. vol 24. issue 11. 2023-06-11. PMID:37298554. |
in addition, in experimental models of diseases such as alzheimer's and parkinson's diseases, amyotrophic lateral sclerosis, multiple sclerosis, traumatic and vascular acute neural injury, epilepsy, and inflammatory bowel disease, alteration of s100b levels correlates with the occurrence of clinical and/or toxic parameters. |
2023-06-11 |
2023-08-14 |
Not clear |
| Mengyu Pan, James M Roe, Ron Nudel, Andrew J Schork, Olena Iakunchykova, Anders M Fjell, Kristine B Walhovd, Thomas Werge, Chi-Hua Chen, Michael E Benros, Yunpeng Wan. Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study. Translational psychiatry. vol 13. issue 1. 2023-05-24. PMID:37225692. |
we applied two-sample mendelian randomization (mr) on the association statistics from genome-wide association studies (gwas) for circulating s100b levels measured 5-7 days after birth (the ipsych sample) and in an older adult sample (mean age, 72.5 years; the lothian sample), upon those derived from major depression disorder (mdd), schizophrenia (scz), bipolar disorder (bip), autism spectral disorder (asd), alzheimer's disease (ad), and parkinson's disease (pd). |
2023-05-24 |
2023-08-14 |
Not clear |
| António J Figueira, Joana Saavedra, Isabel Cardoso, Cláudio M Gome. S100B chaperone multimers suppress the formation of oligomers during Aβ42 Frontiers in neuroscience. vol 17. 2023-04-07. PMID:37025373. |
s100b chaperone multimers suppress the formation of oligomers during aβ42 extracellular aggregation of the amyloid-β 1-42 (aβ42) peptide is a major hallmark of alzheimer's disease (ad), with recent data suggesting that aβ intermediate oligomers (aβo) are more cytotoxic than mature amyloid fibrils. |
2023-04-07 |
2023-08-14 |
Not clear |
| António J Figueira, Guilherme G Moreira, Joana Saavedra, Isabel Cardoso, Cláudio M Gome. Tetramerization of the S100B chaperone spawns a Ca Journal of molecular biology. 2022-08-15. PMID:35970403. |
tetramerization of the s100b chaperone spawns a ca alzheimer's disease (ad) hallmarks include the aggregation of amyloid-β (aβ), tau and neuroinflammation promoted by several alarmins. |
2022-08-15 |
2023-08-14 |
Not clear |
| Monika Zaręba-Kozioł, Michał Burdukiewicz, Aleksandra Wysłouch-Cieszyńsk. Intracellular Protein S-Nitrosylation-A Cells Response to Extracellular S100B and RAGE Receptor. Biomolecules. vol 12. issue 5. 2022-05-28. PMID:35625541. |
overexpression of s100b occurs in down syndrome, alzheimer's disease, creutzfeldt-jakob disease, schizophrenia, multiple sclerosis, brain tumors, epilepsy, melanoma, myocardial infarction, muscle disorders, and sarcopenia. |
2022-05-28 |
2023-08-13 |
human |
| Leticia Rodrigues, Krista Minéia Wartchow, Michael Buchfelder, Diogo O Souza, Carlos Alberto Gonçalves, Andrea Kleindiens. Amyloid-like deposits in the brain of transgenic mice overexpressing S100B protein. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 3. 2022-02-03. PMID:35108885. |
mice overexpressing s100b (s100btg) was firstly developed to better understand the down syndrome and alzheimer's disease, once both s100b and amyloid precursor protein (app) genes are located in chromosome 21. |
2022-02-03 |
2023-08-13 |
mouse |
| Urvashi Langeh, Shamsher Sing. Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders. Current neuropharmacology. vol 19. issue 2. 2021-11-25. PMID:32727332. |
s100b protein plays a crucial role in alzheimer's disease, parkinson's disease, multiple sclerosis, schizophrenia and epilepsy because the high expression of this protein directly targets astrocytes and promotes neuroinflammation. |
2021-11-25 |
2023-08-13 |
Not clear |
| Jaydip R Chaudhuri, Kandadai R Mridula, Chikkirala Rathnakishore, Alluri Anamika, Naveen R Samala, Banda Balaraju, Vcs Srinivasarao Bandar. Association Serum S100B Protein in Alzheimer's Disease: A Case Control Study from South India. Current Alzheimer research. vol 17. issue 12. 2021-11-04. PMID:33463467. |
association serum s100b protein in alzheimer's disease: a case control study from south india. |
2021-11-04 |
2023-08-13 |
Not clear |
| Jaydip R Chaudhuri, Kandadai R Mridula, Chikkirala Rathnakishore, Alluri Anamika, Naveen R Samala, Banda Balaraju, Vcs Srinivasarao Bandar. Association Serum S100B Protein in Alzheimer's Disease: A Case Control Study from South India. Current Alzheimer research. vol 17. issue 12. 2021-11-04. PMID:33463467. |
recent evidence points to a possible link between the inflammatory modulatory protein s100b protein and the pathogenesis of alzheimer's disease (ad). |
2021-11-04 |
2023-08-13 |
Not clear |
| Fabrizio Michetti, Gabriele Di Sante, Maria Elisabetta Clementi, Beatrice Sampaolese, Patrizia Casalbore, Cinzia Volonté, Vincenzo Romano Spica, Pier Paolo Parnigotto, Rosa Di Liddo, Susanna Amadio, Francesco Ri. Growing role of S100B protein as a putative therapeutic target for neurological- and nonneurological-disorders. Neuroscience and biobehavioral reviews. vol 127. 2021-08-03. PMID:33971224. |
indeed, modulation of s100b levels correlates with the occurrence of clinical and/or toxic parameters in experimental models of diseases such as alzheimer's and parkinson's diseases, amyotrophic lateral sclerosis, muscular dystrophy, multiple sclerosis, acute neural injury, inflammatory bowel disease, uveal and retinal disorders, obesity, diabetes and cancer, thus directly linking the levels of s100b to pathogenic mechanisms. |
2021-08-03 |
2023-08-13 |
Not clear |
| Joana S Cristóvão, Guilherme G Moreira, Filipe E P Rodrigues, Ana P Carapeto, Mário S Rodrigues, Isabel Cardoso, António E N Ferreira, Miguel Machuqueiro, Guenter Fritz, Cláudio M Gome. Cu Chemical communications (Cambridge, England). vol 57. issue 3. 2021-06-15. PMID:33326534. |
cu s100b is an extracellular protein implicated in alzheimer's disease and a suppressor of amyloid-β aggregation. |
2021-06-15 |
2023-08-13 |
Not clear |
| Huan Yu, Hui Li, Xiaoqian Liu, Xiaoli Du, Binbin Den. Levels of serum S100B are associated with cognitive dysfunction in patients with type 2 diabetes. Aging. vol 12. issue 5. 2021-02-18. PMID:32112645. |
the predictive role of s100b in a variety of neurodegenerative diseases such as alzheimer's disease, has been shown to be closely related to cognitive function. |
2021-02-18 |
2023-08-13 |
Not clear |
| Julia Christl, Sandra Verhülsdonk, Francesca Pessanha, Til Menge, Rüdiger J Seitz, Milenko Kujovic, Barbara Höft, Tillmann Supprian, Christian Lange-Asschenfeld. Association of Cerebrospinal Fluid S100B Protein with Core Biomarkers and Cognitive Deficits in Prodromal and Mild Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683478. |
association of cerebrospinal fluid s100b protein with core biomarkers and cognitive deficits in prodromal and mild alzheimer's disease. |
2020-12-04 |
2023-08-13 |
Not clear |
| Julia Christl, Sandra Verhülsdonk, Francesca Pessanha, Til Menge, Rüdiger J Seitz, Milenko Kujovic, Barbara Höft, Tillmann Supprian, Christian Lange-Asschenfeld. Association of Cerebrospinal Fluid S100B Protein with Core Biomarkers and Cognitive Deficits in Prodromal and Mild Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 72. issue 4. 2020-12-04. PMID:31683478. |
increased expression of the astroglial ca2+-binding protein s100b has been observed in various neurodegenerative diseases and also seems to play a role in the unfolding of pathophysiological events at early stages of alzheimer's disease (ad). |
2020-12-04 |
2023-08-13 |
Not clear |
| Karen Roksund Hov, Nils Bolstad, Ane-Victoria Idland, Henrik Zetterberg, Kaj Blennow, Farrukh A Chaudhry, Frede Frihagen, Johan Ræder, Torgeir Bruun Wyller, Leiv Otto Watn. Cerebrospinal Fluid S100B and Alzheimer's Disease Biomarkers in Hip Fracture Patients with Delirium. Dementia and geriatric cognitive disorders extra. vol 7. issue 3. 2020-10-01. PMID:29282410. |
cerebrospinal fluid s100b and alzheimer's disease biomarkers in hip fracture patients with delirium. |
2020-10-01 |
2023-08-13 |
Not clear |
| Simone Hagmeyer, Joana S Cristóvão, John J E Mulvihill, Tobias M Boeckers, Cláudio M Gomes, Andreas M Grabrucke. Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain. Frontiers in molecular neuroscience. vol 10. 2020-09-30. PMID:29386995. |
one such protein is neuronal s100b, a calcium and zinc binding damage-associated molecular pattern (damp), whose chronic upregulation is associated with aging, alzheimer's disease (ad), motor neuron disease and traumatic brain injury (tbi). |
2020-09-30 |
2023-08-13 |
Not clear |
| Kelly N Z Fuller, Edwin R Miranda, John P Thyfault, Jill K Morris, Jacob M Hau. Metabolic Derangements Contribute to Reduced sRAGE Isoforms in Subjects with Alzheimer's Disease. Mediators of inflammation. vol 2018. 2018-09-17. PMID:29681765. |
although there is evidence for metabolic dysfunction and chronic inflammation in alzheimer's disease (ad), circulating levels of soluble receptor for advanced glycation end products (srage) and the receptor for advanced glycation end products (rage) ligand s100b have not been characterized. |
2018-09-17 |
2023-08-13 |
human |
| Maria E Clementi, Beatrice Sampaolese, Bruno Giardin. S100b Induces Expression of Myoglobin in APβ Treated Neuronal Cells In Vitro: A Possible Neuroprotective Mechanism. Current aging science. vol 9. issue 4. 2017-12-18. PMID:26899964. |
in this study, human neuroblastoma cells (imr32) treated with amyloid beta peptide (apβ), were used as model to evaluate the molecular basis of protective role of s100b, a neurotrophic factor and neuronal survival protein, highly expressed by reactive astrocytes close to amyloid deposition in the cortex of alzheimer's patients. |
2017-12-18 |
2023-08-13 |
human |