| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |
| Christopher A Ayoub, Khadijah I Moore, Jeff Kure. Quantification of Methylation and Phosphorylation Stoichiometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512670. |
tauopathies including alzheimer's disease (ad) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein tau into non-functional aggregates. |
2024-03-21 |
2024-03-24 |
Not clear |
| Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. |
the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Nadine Allroggen, Helen Breuer, Sarah Bachmann, Michael Bell, Hans Zempe. Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512690. |
these accumulations of hyperphosphorylated tau in the neurons disrupt the physiological mt-based transport machinery within the cell and can potentially lead to the development of neurodegenerative disorders, such as alzheimer's disease (ad) and related tauopathies. |
2024-03-21 |
2024-03-24 |
human |
| Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. |
the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. |
2024-03-19 |
2024-03-21 |
Not clear |
| Sharif Arar, Md Anzarul Haque, Nemil Bhatt, Yingxin Zhao, Rakez Kaye. Effect of Natural Osmolytes on Recombinant Tau Monomer: Propensity of Oligomerization and Aggregation. ACS chemical neuroscience. 2024-03-19. PMID:38503425. |
the pathological misfolding and aggregation of the microtubule associated protein tau (mapt), a full length tau2n4r with 441aa, is considered the principal disease relevant constituent in tauopathies including alzheimer's disease (ad) with an imbalanced ratio in 3r/4r isoforms. |
2024-03-19 |
2024-03-23 |
Not clear |
| Lun Zhang, Yongkang Gai, Yushuang Liu, Dongli Meng, Yi Zeng, Yong Luo, Huiliang Zhang, Zhuoqun Wang, Mengzhe Yang, Yunfan Li, Yi Liu, Yiwen Lai, Jiayu Yang, Gang Wu, Yu Chen, Jingtan Zhu, Shaojun Liu, Tingting Yu, Ji Zeng, Jianzhi Wang, Dan Zhu, Xiaochuan Wang, Xiaoli Lan, Rong Li. Tau induces inflammasome activation and microgliosis through acetylating NLRP3. Clinical and translational medicine. vol 14. issue 3. 2024-03-15. PMID:38488468. |
alzheimer's disease (ad) and related tauopathies are characterised by the pathologically hyperphosphorylated and aggregated microtubule-associated protein tau, which is accompanied by neuroinflammation mediated by activated microglia. |
2024-03-15 |
2024-03-17 |
Not clear |
| Yu Zou, Lulu Guan, Jingwang Tan, Bote Qi, Yunxiang Sun, Fengjuan Huang, Qingwen Zhan. Molecular Insights into the Differential Effects of Acetylation on the Aggregation of Tau Microtubule-Binding Repeats. Journal of chemical information and modeling. 2024-03-15. PMID:38489841. |
aggregation of tau protein into intracellular fibrillary inclusions is characterized as the hallmark of tauopathies, including alzheimer's disease and chronic traumatic encephalopathy. |
2024-03-15 |
2024-03-18 |
Not clear |
| Hong Xu, Qi Qiu, Peng Hu, Kevt'her Hoxha, Elliot Jang, Mia O'Reilly, Christopher Kim, Zhuohao He, Nicholas Marotta, Lakshmi Changolkar, Bin Zhang, Hao Wu, Gerard D Schellenberg, Brian Kraemer, Kelvin C Luk, Edward B Lee, John Q Trojanowski, Kurt R Brunden, Virginia M-Y Le. MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. Acta neuropathologica. vol 147. issue 1. 2024-03-13. PMID:38472475. |
inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include alzheimer's disease (ad). |
2024-03-13 |
2024-03-15 |
mouse |
| Cassis Varlow, Chester A Mathis, Neil Vasde. In vitro evaluation of [ Nuclear medicine and biology. vol 130-131. 2024-03-08. PMID:38458074. |
in vitro evaluation of [ alzheimer's disease (ad) and non-ad tauopathies such as chronic traumatic encephalopathy (cte), progressive supranuclear palsy (psp), and corticobasal degeneration (cbd) are characterized by the abnormal aggregation of three-repeat (3r) and/or four-repeat (4r) tau isoforms. |
2024-03-08 |
2024-03-11 |
human |
| YouJin Lee, Eric M Morro. Quantitative Measurement of Tau Aggregation in Genetically Modified Rats with Neurodegeneration. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427245. |
also, certain rat models can represent deposition of tau, which is one of the key pathological features of alzheimer's diseases and tauopathies. |
2024-03-01 |
2024-03-03 |
mouse |
| Abhay Kumar Singh, Karthikeyan Selvarasu, Siva Sundara Kumar Durairaja. Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427247. |
tau protein in alzheimer's disease (ad) and tauopathies becomes insoluble due to hyperphosphorylation, conformational alterations, and aggregation. |
2024-03-01 |
2024-03-03 |
mouse |
| Abhay Kumar Singh, Karthikeyan Selvarasu, Siva Sundara Kumar Durairaja. Isolation and Detection of Pathological Tau Species in a Tauopathy Mouse Model. Methods in molecular biology (Clifton, N.J.). vol 2761. 2024-03-01. PMID:38427247. |
additionally, the study employs immunohistochemistry to visualize and quantify the pathological tau species in the brain tissue of transgenic mice, aiming to identify and analyze pathological tau species such as hyperphosphorylated tau to further our understanding of tauopathies such as alzheimer's disease. |
2024-03-01 |
2024-03-03 |
mouse |
| Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. |
tau immunotherapies for alzheimer's disease and related tauopathies: status of trials and insights from preclinical studies. |
2024-03-01 |
2024-03-04 |
Not clear |
| Einar M Sigurdsso. Tau Immunotherapies for Alzheimer's Disease and Related Tauopathies: Status of Trials and Insights from Preclinical Studies. Journal of Alzheimer's disease : JAD. 2024-03-01. PMID:38427486. |
the tau protein undergoes pathological changes in alzheimer's disease and other tauopathies that eventually lead to functional impairments. |
2024-03-01 |
2024-03-04 |
Not clear |
| Sergio Pérez-Oliveira, Juan Castilla-Silgado, Cèlia Painous, Iban Aldecoa, Manuel Menéndez-González, Marta Blázquez-Estrada, Daniela Corte, Cristina Tomás-Zapico, Yaroslau Compta, Esteban Muñoz, Albert Lladó, Mircea Balasa, Gemma Aragonès, Pablo García-González, Maitée Rosende-Roca, Mercè Boada, Agustín Ruíz, Pau Pastor, Beatriz De la Casa-Fages, Alberto Rabano, Raquel Sánchez-Valle, Laura Molina-Porcel, Victoria Álvare. Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights. Brain pathology (Zurich, Switzerland). 2024-02-28. PMID:38418081. |
we genotyped the htt gene cag repeat number and apoe-ℰ isoforms in a cohort of patients with neuropathological diagnoses of tauopathies (n=588), including 34 corticobasal degeneration (cbd), 98 progressive supranuclear palsy (psp) and 456 alzheimer's disease (ad). |
2024-02-28 |
2024-03-02 |
human |
| Liara Rizzi, Lea T Grinber. Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-02-28. PMID:38419122. |
exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-02-28 |
2024-03-02 |
Not clear |
| Nuo Jia, Dhasarathan Ganesan, Hongyuan Guan, Yu Young Jeong, Sinsuk Han, Marialaina Nissenbaum, Alexander W Kusnecov, Qian Ca. Mitochondrial bioenergetics stimulates autophagy for pathological tau clearance in tauopathy neurons. bioRxiv : the preprint server for biology. 2024-02-26. PMID:38405759. |
hyperphosphorylation and aggregation of microtubule-associated tau is a pathogenic hallmark of tauopathies and a defining feature of alzheimer's disease (ad). |
2024-02-26 |
2024-02-28 |
mouse |
| Bang Wang, Xiaoshu Pan, I-Ting Teng, Xiaowei Li, Firas Kobeissy, Zo-Yu Wu, Jiepei Zhu, Guangzheng Cai, He Yan, Xin Yan, Mingwei Liang, Fahong Yu, Jianrong Lu, Zunyi Yang, Elisa Biondi, William Haskins, Y Charles Cao, Steven A Benner, Weihong Tan, Kevin Wan. Functional Selection of Tau Oligomerization-Inhibiting Aptamers. Angewandte Chemie (International ed. in English). 2024-02-26. PMID:38407551. |
pathological hyperphosphorylation and aggregation of microtubule-associated tau protein contribute to alzheimer's disease (ad) and other related tauopathies. |
2024-02-26 |
2024-02-28 |
Not clear |
| Abigail Alexander, Victor E Alvarez, Bertrand R Huber, Michael L Alosco, Jesse Mez, Yorghos Tripodis, Raymond Nicks, Douglas I Katz, Brigid Dwyer, Daniel H Daneshvar, Brett Martin, Joseph Palmisano, Lee E Goldstein, John F Crary, Christopher Nowinski, Robert C Cantu, Neil W Kowall, Robert A Stern, Ivana Delalle, Ann C McKee, Thor D Stei. Cortical-sparing chronic traumatic encephalopathy (CSCTE): a distinct subtype of CTE. Acta neuropathologica. vol 147. issue 1. 2024-02-26. PMID:38407651. |
other comorbid tauopathies likely contributed in part to these differences: when cases with concurrent alzheimer dementia or frontal temporal lobar degeneration with tau pathology were excluded, differences were largely retained, but only remained significant for faq (p = 0.042), meta-cognition index t score (p = 0.014) and age of parkinsonian motor symptom onset (p = 0.046). |
2024-02-26 |
2024-02-28 |
human |