| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Hutton, J Lewis, D Dickson, S H Yen, E McGowa. Analysis of tauopathies with transgenic mice. Trends in molecular medicine. vol 7. issue 10. 2002-01-09. PMID:11597522. |
intraneuronal filamentous inclusions composed of the microtubule-associated protein tau are a feature of several neurodegenerative diseases (including alzheimer's disease) known as tauopathies. |
2002-01-09 |
2023-08-12 |
mouse |
| A Alonso, T Zaidi, M Novak, I Grundke-Iqbal, K Iqba. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 12. 2001-06-28. PMID:11381127. |
the microtubule-associated protein tau is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in the form of paired helical filaments (phf) in the brains of patients with alzheimer's disease (ad) and patients with several other tauopathies. |
2001-06-28 |
2023-08-12 |
Not clear |
| L A Reed, Z K Wszolek, M Hutto. Phenotypic correlations in FTDP-17. Neurobiology of aging. vol 22. issue 1. 2001-05-31. PMID:11164280. |
missense mutations affecting constitutively expressed exons affect all six major tau isoforms and result in neurofibrillary tangles similar to those present in secondary tauopathies, such as alzheimer's disease. |
2001-05-31 |
2023-08-12 |
Not clear |
| S F Fabre, C Forsell, M Viitanen, M Sjögren, A Wallin, K Blennow, M Blomberg, C Andersen, L O Wahlund, L Lannfel. Clinic-based cases with frontotemporal dementia show increased cerebrospinal fluid tau and high apolipoprotein E epsilon4 frequency, but no tau gene mutations. Experimental neurology. vol 168. issue 2. 2001-05-10. PMID:11259129. |
some tauopathies, like alzheimer's disease (ad), consistently show increased levels of tau protein in cerebrospinal fluid (csf). |
2001-05-10 |
2023-08-12 |
Not clear |
| A C Ludolph, A Sperfeld, B M Collatz, A Storc. [Tauopathies--a new class of neurodegenerative diseases]. Der Nervenarzt. vol 72. issue 2. 2001-05-03. PMID:11256158. |
the discovery of mutations in the tau gene causing a distinct neurodegenerative disease in humans has firmly established the importance of the tau gene for neurodegenerative processes, not only in tauopathies but also in other degenerative disorders with tau pathology, such as corticobasal degeneration, supranuclear progressive paralysis, amyotropic lateral sclerosis, parkinsonism-dementia complex of guam, and alzheimer's disease. |
2001-05-03 |
2023-08-12 |
Not clear |
| T Ishihara, B Zhang, M Higuchi, Y Yoshiyama, J Q Trojanowski, V M Le. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159192. |
intraneuronal filamentous tau inclusions such as neurofibrillary tangles (nfts) are neuropathological hallmarks of alzheimer's disease (ad) and related sporadic and familial tauopathies. |
2001-04-05 |
2023-08-12 |
mouse |
| G F Hall, V M Lee, G Lee, J Ya. Staging of neurofibrillary degeneration caused by human tau overexpression in a unique cellular model of human tauopathy. The American journal of pathology. vol 158. issue 1. 2001-02-22. PMID:11141497. |
the hyperphosphorylation of human tau and its aggregation into neurofibrillary tangles are central pathogenic events in familial tauopathies and alzheimer's disease. |
2001-02-22 |
2023-08-12 |
human |
| K Spittaels, C Van den Haute, J Van Dorpe, H Geerts, M Mercken, K Bruynseels, R Lasrado, K Vandezande, I Laenen, T Boon, J Van Lint, J Vandenheede, D Moechars, R Loos, F Van Leuve. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. The Journal of biological chemistry. vol 275. issue 52. 2001-01-26. PMID:11007782. |
protein tau filaments in brain of patients suffering from alzheimer's disease, frontotemporal dementia, and other tauopathies consist of protein tau that is hyperphosphorylated. |
2001-01-26 |
2023-08-12 |
mouse |
| J P Brio. [Neurofibrillary tangles and early modification of the neuronal cytoskeleton in Alzheimer's disease and in experimental models]. Bulletin et memoires de l'Academie royale de medecine de Belgique. vol 154. issue 6 Pt 2. 2000-10-05. PMID:10992876. |
neurofibrillary tangles, a hallmark neuropathological lesion of alzheimer's disease and of the other tauopathies, are composed of hyperphosphorylated tau proteins (a microtubule-associated protein) assembled in the form of abnormal filaments. |
2000-10-05 |
2023-08-12 |
Not clear |
| G F Hall, B Chu, G Lee, J Ya. Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease. Journal of cell science. vol 113 ( Pt 8). 2000-07-31. PMID:10725221. |
the intracellular accumulation of tau protein and its aggregation into filamentous deposits is the intracellular hallmark of neurofibrillary degenerative diseases such as alzheimer's disease and familial tauopathies in which tau is now thought to play a critical pathogenic role. |
2000-07-31 |
2023-08-12 |
human |
| T Ishihara, M Hong, B Zhang, Y Nakagawa, M K Lee, J Q Trojanowski, V M Le. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron. vol 24. issue 3. 2000-01-04. PMID:10595524. |
these tg mice recapitulate key features of tauopathies and provide models for elucidating mechanisms underlying diverse tauopathies, including alzheimer's disease (ad). |
2000-01-04 |
2023-08-12 |
mouse |
| K Spittaels, C Van den Haute, J Van Dorpe, K Bruynseels, K Vandezande, I Laenen, H Geerts, M Mercken, R Sciot, A Van Lommel, R Loos, F Van Leuve. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. The American journal of pathology. vol 155. issue 6. 1999-12-28. PMID:10595944. |
this transgenic model, overexpressing the longest isoform of human tau protein, recapitulates features of known neurodegenerative diseases, including alzheimer's disease and other tauopathies. |
1999-12-28 |
2023-08-12 |
mouse |