| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shannon Zhuang, Pijush Chakraborty, Markus Zweckstette. Regulation of tau by peptidyl-prolyl isomerases. Current opinion in structural biology. vol 84. 2023-12-07. PMID:38061261. |
therefore, the ability of ppiases to structurally modify and regulate tau should be further investigated due to its potential therapeutic implications for alzheimer's disease and other tauopathies. |
2023-12-07 |
2023-12-17 |
Not clear |
| Kerry T Sun, Tark Patel, Sang-Gyun Kang, Allan Yarahmady, Mahalashmi Srinivasan, Olivier Julien, Jónathan Heras, Sue-Ann Mo. Disease-Associated Mutations in Tau Encode for Changes in Aggregate Structure Conformation. ACS chemical neuroscience. 2023-12-06. PMID:38054595. |
cryo-em studies have shown that the packed fibril core of tau adopts distinct structures in different tauopathies, such as alzheimer's disease, corticobasal degeneration, and progressive supranuclear palsy. |
2023-12-06 |
2023-12-10 |
Not clear |
| Hidetomo Tanaka, Ivan Martinez-Valbuena, Shelley L Forrest, Blas Couto, Nikolai Gil Reyes, Alonso Morales-Rivero, Seojin Lee, Jun Li, Ali M Karakani, David F Tang-Wai, Charles Tator, Mozhgan Khadadadi, Nusrat Sadia, Maria Carmela Tartaglia, Anthony E Lang, Gabor G Kovac. Distinct involvement of the cranial and spinal nerves in progressive supranuclear palsy. Brain : a journal of neurology. 2023-11-16. PMID:37972275. |
to characterize the involvement of the pns in tauopathies, we investigated tau pathology in cranial and spinal nerves (pns-tau) in 54 tauopathy cases (progressive supranuclear palsy: psp, n = 15; alzheimer's disease: ad, n = 18; chronic traumatic encephalopathy: cte, n = 5; and corticobasal degeneration: cbd, n = 6; pick's disease, n = 9; limbic-predominant neuronal inclusion body 4-repeat tauopathy, lnt, n = 1) using immunohistochemistry, gallyas silver staining, biochemistry, and seeding assays. |
2023-11-16 |
2023-11-20 |
Not clear |
| Marc I Diamon. Travels with tau prions. Cytoskeleton (Hoboken, N.J.). 2023-11-11. PMID:37950616. |
tau was originally identified as a microtubule associated protein, and subsequently recognized to constitute the fibrillar assemblies found in alzheimer disease and related neurodegenerative tauopathies. |
2023-11-11 |
2023-11-20 |
mouse |
| Yoon A Kim, Marian Mellen, Caghan Kizil, Ismael Santa-Mari. Mechanisms linking cerebrovascular dysfunction and tauopathy: adding a layer of epiregulatory complexity. British journal of pharmacology. 2023-11-05. PMID:37926507. |
intracellular accumulation of hyperphosphorylated misfolded tau proteins is found in many neurodegenerative tauopathies, including alzheimer's disease (ad). |
2023-11-05 |
2023-11-08 |
Not clear |
| Zhenfeng Song, Kuang-Wei Wang, Hsiao-Tien Chien Hagar, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, Min-Hao Ku. Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine. Molecular neurobiology. 2023-11-03. PMID:37919601. |
abnormal phosphorylation of the microtubule-binding protein tau in the brain is a key pathological marker for alzheimer's disease and additional neurodegenerative tauopathies. |
2023-11-03 |
2023-11-08 |
Not clear |
| Airi Tarutani, Fuyuki Kametani, Marina Tahira, Yuko Saito, Mari Yoshida, Andrew C Robinson, David M A Mann, Shigeo Murayama, Taisuke Tomita, Masato Hasegaw. Distinct tau folds initiate templated seeding and alter the post-translational modification profile. Brain : a journal of neurology. 2023-10-31. PMID:37904205. |
pathological tau accumulates in the brain in tauopathies such as alzheimer's disease, pick's disease, progressive supranuclear palsy and corticobasal degeneration, and forms amyloid-like filaments incorporating various post-translational modifications (ptms). |
2023-10-31 |
2023-11-08 |
Not clear |
| Francesca Parolini, Elham Ataie Kachoie, Giulia Leo, Laura Civiero, Luigi Bubacco, Giorgio Arrigoni, Francesca Munari, Michael Assfalg, Mariapina D'Onofrio, Stefano Capald. Site-Specific Ubiquitination of Tau Amyloids Promoted by the E3 Ligase CHIP. Angewandte Chemie (International ed. in English). 2023-10-25. PMID:37878393. |
post-translational modifications of tau are emerging as key players in determining the onset and progression of different tauopathies such as alzheimer's disease, and are recognized to mediate the structural diversity of the disease-specific tau amyloids. |
2023-10-25 |
2023-11-08 |
Not clear |
| Himanshi Singh, Asmita Das, Mohammad Moshahid Khan, Tayebeh Pourmotabbe. New insights into the therapeutic approaches for the treatment of tauopathies. Neural regeneration research. vol 19. issue 5. 2023-10-20. PMID:37862204. |
tauopathies are a group of neurological disorders, including alzheimer's disease and frontotemporal dementia, which involve progressive neurodegeneration, cognitive deficits, and aberrant tau protein accumulation. |
2023-10-20 |
2023-11-08 |
Not clear |
| Benjamin H Rajewski, Kamlesh M Makwana, Isaac J Angera, Danielle K Geremia, Anna R Zepeda, Grace I Hallinan, Ruben Vidal, Bernardino Ghetti, Arnaldo L Serrano, Juan R Del Vall. β-Bracelets: Macrocyclic Cross-β Epitope Mimics Based on a Tau Conformational Strain. Journal of the American Chemical Society. 2023-10-16. PMID:37844142. |
the aggregation of misfolded tau into neurotoxic fibrils is linked to the progression of alzheimer's disease (ad) and related tauopathies. |
2023-10-16 |
2023-11-08 |
Not clear |
| Kuang-Wei Wang, Gary Zhang, Min-Hao Ku. Frontotemporal Dementia P301L Mutation Potentiates but Is Not Sufficient to Cause the Formation of Cytotoxic Fibrils of Tau. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834443. |
understanding the conditions and mechanisms whereby selective mutations aggravate the pathogenic activities of tau can provide pivotal clues on novel strategies for drug development for frontotemporal dementia and other related neurodegenerative tauopathies, including alzheimer's disease. |
2023-10-14 |
2023-10-15 |
Not clear |
| Jiaxin Hu, Wenchi Sha, Shuangshuang Yuan, Jiarui Wu, Yunpeng Huan. Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834471. |
tau protein aggregates can be found in a number of devastating neurodegenerative diseases known as "tauopathies", such as alzheimer's disease (ad), frontotemporal dementia (ftd), corticobasal degeneration (cbd), etc. |
2023-10-14 |
2023-10-15 |
Not clear |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
aging, tau pathology, and chronic inflammation in the brain play crucial roles in synaptic loss, neurodegeneration, and cognitive decline in tauopathies, including alzheimer's disease. |
2023-10-10 |
2023-10-15 |
Not clear |
| Sagar Gaikwad, Sudipta Senapati, Md Anzarul Haque, Rakez Kaye. Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer's disease: Evidence from clinical and preclinical studies. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023-10-10. PMID:37814508. |
highlights: senescence, oligomeric tau (tauo), and brain inflammation accelerate the aging process and promote the progression of tauopathies, including alzheimer's disease. |
2023-10-10 |
2023-10-15 |
Not clear |
| Joshua T Emmerson, Janice C Malcolm, Sonia Do Carmo, Phuoc Nguyen, Lionel Breuillaud, Julio C Martinez-Trujillo, A Claudio Cuell. Neuronal loss and inflammation preceding fibrillary tau pathology in a rat model with early human-like tauopathy. Neurobiology of disease. 2023-10-06. PMID:37802153. |
in tauopathies such as alzheimer's disease (ad) and frontotemporal dementia (ftd), the microtubule associated protein tau undergoes conformational and posttranslational modifications in a gradual, staged pathological process. |
2023-10-06 |
2023-10-15 |
human |
| Salvatore P Mangiafico, Qing-Zhang Tuo, Xiao-Lan Li, Yu Liu, Christian Haralambous, Xu-Long Ding, Scott Ayton, Qing Wang, D Ross Laybutt, Jeng Yie Chan, Xiang Zhang, Cameron Kos, Helen E Thomas, Thomas Loudovaris, Chieh-Hsin Yang, Christos N Joannides, Benjamin J Lamont, Lunzhi Dai, Hai-Huai He, Biao Dong, Sofianos Andrikopoulos, Ashley I Bush, Peng Le. Tau suppresses microtubule-regulated pancreatic insulin secretion. Molecular psychiatry. 2023-09-22. PMID:37735502. |
tau protein is implicated in the pathogenesis of alzheimer's disease (ad) and other tauopathies, but its physiological function is in debate. |
2023-09-22 |
2023-10-07 |
mouse |
| Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M Vorberg, Loren B Andreas, Markus Zweckstette. Acetylation discriminates disease-specific tau deposition. Nature communications. vol 14. issue 1. 2023-09-22. PMID:37739953. |
pathogenic aggregation of the protein tau is a hallmark of alzheimer's disease and several other tauopathies. |
2023-09-22 |
2023-10-07 |
Not clear |
| Cristina Di Primio, Paola Quaranta, Marianna Mignanelli, Giacomo Siano, Matteo Bimbati, Arianna Scarlatti, Carmen Rita Piazza, Piero Giorgio Spezia, Paola Perrera, Fulvio Basolo, Anello Marcello Poma, Mario Costa, Mauro Pistello, Antonino Cattane. Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons. PNAS nexus. vol 2. issue 9. 2023-09-21. PMID:37731949. |
upon infection, tau is phosphorylated at several pathological epitopes associated with alzheimer's disease and other tauopathies. |
2023-09-21 |
2023-10-07 |
mouse |
| Nina Rostgaard, Pia Holm Jul, Mats Garmer, Christiane Volbrach. Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice. Journal of integrative neuroscience. vol 22. issue 5. 2023-09-21. PMID:37735138. |
tauopathies such as alzheimer's disease (ad) are characterized by abnormal hyperphosphorylation of the microtubule-associated protein tau (mapt) aggregating into neurofibrillary tangles (nfts). |
2023-09-21 |
2023-10-07 |
mouse |
| Lenka Hromadkova, Chae Kim, Tracy Haldiman, Lihua Peng, Xiongwei Zhu, Mark Cohen, Rohan de Silva, Jiri G Safa. Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau. Cell & bioscience. vol 13. issue 1. 2023-09-18. PMID:37723591. |
although accumulation of misfolded tau species has been shown to predict cognitive decline in patients with alzheimer's disease (ad) and other tauopathies but with the remarkable diversity of clinical manifestations, neuropathology profiles, and time courses of disease progression remaining unexplained by current genetic data. |
2023-09-18 |
2023-10-07 |
Not clear |