All Relations between Alzheimer Disease and Tauopathies

Publication Sentence Publish Date Extraction Date Species
Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. 2024-05-06 2024-05-08 mouse
Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. tauopathies, including alzheimer's disease (ad), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. 2024-04-25 2024-04-28 mouse
Nathalie Kyalu Ngoie Zola, Clémence Balty, Didier Vertommen, Bernard Jimmy Hanseeu. [Specific modifications of the soluble tau protein distinguish Alzheimer's disease from other tauopathies]. Medecine sciences : M/S. vol 40. issue 4. 2024-04-23. PMID:38651955. [specific modifications of the soluble tau protein distinguish alzheimer's disease from other tauopathies]. 2024-04-23 2024-04-26 Not clear
Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. 2024-04-22 2024-04-24 mouse
Savannah Longo, María Laura Messi, Zhong-Min Wang, William Meeker, Osvaldo Delbon. Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease. Journal of cachexia, sarcopenia and muscle. 2024-04-22. PMID:38646816. accelerated sarcopenia precedes learning and memory impairments in the p301s mouse model of tauopathies and alzheimer's disease. 2024-04-22 2024-04-24 mouse
Liara Rizzi, Lea T Grinber. Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-04-12. PMID:38610041. publisher correction: exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. 2024-04-12 2024-04-15 Not clear
Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. to comprehensively investigate the common and unique protein interactors associated with the variety of tau lesions present across different human tauopathies, alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp), were selected to represent the major tauopathy diseases. 2024-04-08 2024-04-10 human
Jonas E Svensson, Martin Bolin, Daniel Thor, Pete A Williams, Rune Brautaset, Marcus Carlsson, Peder Sörensson, David Marlevi, Rubens Spin-Neto, Monika Probst, Göran Hagman, Anton Forsberg Morén, Miia Kivipelto, Pontus Plavén-Sigra. Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol. BMC neurology. vol 24. issue 1. 2024-04-04. PMID:38575854. results from mouse models of alzheimer's disease have shown beneficial effects of rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers and tauopathies and normalizing synaptic plasticity and cerebral glucose uptake. 2024-04-04 2024-04-07 mouse
Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. the transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of alzheimer's disease and related tauopathies. 2024-04-04 2024-04-07 Not clear
Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. alzheimer's disease and other tauopathies are characterized by the misfolding and aggregation of the tau protein into oligomeric and fibrillar structures. 2024-04-03 2024-04-05 mouse
Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. genetic forms of tauopathies: inherited causes and implications of alzheimer's disease-like tau pathology in primary and secondary tauopathies. 2024-03-30 2024-04-02 Not clear
b' Dominika Ole\\xc5\\xa1ov\\xc3\\xa1, Dana Dobe\\xc5\\xa1ov\\xc3\\xa1, Petra Majerov\\xc3\\xa1, Radana Brumarov\\xc3\\xa1, Ale\\xc5\\xa1 Kvasni\\xc4\\x8dka, \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1n Kou\\xc5\\x99il, Eva Stevens, Jozef Hanes, \\xc4\\xbdubica Fialov\\xc3\\xa1, Alena Michalicov\\xc3\\xa1, Juraj Pie\\xc5\\xa1\\xc5\\xa5ansk\\xc3\\xbd, Jakub \\xc5\\xa0insk\\xc3\\xbd, Petr Ka\\xc5\\x88ovsk\\xc3\\xbd, David Friedeck\\xc3\\xbd, Andrej Kov\\xc3\\xa1\\xc4\\x8. Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies. Journal of neuroinflammation. vol 21. issue 1. 2024-03-28. PMID:38539208.' accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including alzheimer's disease. 2024-03-28 2024-03-30 Not clear
Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medin. Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions. eLife. vol 12. 2024-03-21. PMID:38512130. by unifying spatial gene expression, structural mri, and cell deconvolution, here we describe how the human brain distribution of canonical cell types extensively predicts tissue damage in 13 neurodegenerative conditions, including early- and late-onset alzheimer's disease, parkinson's disease, dementia with lewy bodies, amyotrophic lateral sclerosis, mutations in presenilin-1, and 3 clinical variants of frontotemporal lobar degeneration (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat and four-repeat tauopathies and tdp43 proteinopathies types a and c. we reconstructed comprehensive whole-brain reference maps of cellular abundance for six major cell types and identified characteristic axes of spatial overlapping with atrophy. 2024-03-21 2024-03-23 human
David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512662. aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. 2024-03-21 2024-03-24 Not clear
Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512671. in neurodegenerative disorders referred to as tauopathies including alzheimer's disease, tau is abnormally hyperphosphorylated and forms fibrillar inclusions in neurons progressing throughout different brain area during the course of the disease. 2024-03-21 2024-03-24 mouse
Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. 2024-03-21 2024-03-24 mouse
Christopher A Ayoub, Khadijah I Moore, Jeff Kure. Quantification of Methylation and Phosphorylation Stoichiometry. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512670. tauopathies including alzheimer's disease (ad) are neurodegenerative disorders accompanied by the conversion of functional forms of the microtubule associated protein tau into non-functional aggregates. 2024-03-21 2024-03-24 Not clear
Geoffrey Canet, Emma Rocaboy, Sofia Diego-Diàz, Robert A Whittington, Carl Julien, Emmanuel Plane. Methods for Biochemical Isolation of Insoluble Tau in Rodent Models of Tauopathies. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512674. the intracellular accumulation of microtubule-associated protein tau is a characteristic feature of tauopathies, a group of neurodegenerative diseases including alzheimer's disease. 2024-03-21 2024-03-24 mouse
Nadine Allroggen, Helen Breuer, Sarah Bachmann, Michael Bell, Hans Zempe. Studying Microtubule Dynamics in Human Neurons: Two-Dimensional Microtubule Tracing and Kymographs in iPSC- and SH-SY5Y-Derived Neurons for Tau Research. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512690. these accumulations of hyperphosphorylated tau in the neurons disrupt the physiological mt-based transport machinery within the cell and can potentially lead to the development of neurodegenerative disorders, such as alzheimer's disease (ad) and related tauopathies. 2024-03-21 2024-03-24 human
Yongna Yuan, Xuqi Mao, Xiaohang Pan, Ruisheng Zhang, Wei S. Kinetic Ensemble of Tau Protein through the Markov State Model and Deep Learning Analysis. Journal of chemical theory and computation. 2024-03-19. PMID:38501645. the ordered assembly of tau protein into filaments characterizes alzheimer's and other neurodegenerative diseases, and thus, stabilization of tau protein is a promising avenue for tauopathies therapy. 2024-03-19 2024-03-21 Not clear