| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Celeste Parra Bravo, Sarah A Naguib, Li Ga. Cellular and pathological functions of tau. Nature reviews. Molecular cell biology. 2024-07-16. PMID:39014245. |
tauopathies are neurodegenerative diseases marked by the abnormal accumulation of tau protein aggregates in neurons, as seen, for example, in conditions such as frontotemporal dementia and alzheimer disease. |
2024-07-16 |
2024-07-19 |
human |
| Zidi Yan, Yiwen Zhang, Jialong Jiang, Zhenwu Liu, He Wang, Ying Zhang, Jinsheng He, Tao Hon. [Human tau N-terminal domain-specific monoclonal antibodies: screening and application in blood detection]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 40. issue 5. 2024-05-24. PMID:38783817. |
the antibodies to the microtubule-associated protein tau play a role in basic and clinical studies of alzheimer's disease (ad) and other tauopathies. |
2024-05-24 |
2024-05-27 |
mouse |
| Afrooz Anbaraki, Zahra Dindar, Zahra Mousavi-Jarrahi, Atiyeh Ghasemi, Zahra Moeini, Mina Evini, Ali Akbar Saboury, Arefeh Seyedarab. The novel anti-fibrillary effects of volatile compounds α-asarone and β-caryophyllene on tau protein: Towards promising therapeutic agents for Alzheimer's disease. International journal of biological macromolecules. 2024-05-18. PMID:38761902. |
the abnormal deposition of tau protein is one of the critical causes of tauopathies including alzheimer's disease (ad). |
2024-05-18 |
2024-05-27 |
Not clear |
| Kondalarao Bankapalli, Ruth E Thomas, Evelyn S Vincow, Gillian Milstein, Laura V Fisher, Leo J Pallanc. A bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712083. |
previous work indicates that specific protein components of these aggregates are toxic, including tau in alzheimer's disease and related tauopathies. |
2024-05-07 |
2024-05-27 |
Not clear |
| Chanida Fongsaran, Krit Jirakanwisal, Bi-Hung Peng, Anna Fracassi, Giulio Taglialatela, Kelly T Dineley, Slobodan Paessler, Irma E Cisnero. Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model. Brain, behavior, & immunity - health. vol 38. 2024-05-06. PMID:38706571. |
proteinopathies include synucleinopathies triggered by misfolded amyloid α-synuclein, tauopathies triggered by misfolded tau, and amyloidopathies triggered by misfolded amyloid of which alzheimer's disease (β-amyloid) is most prevalent. |
2024-05-06 |
2024-05-08 |
mouse |
| Jayvik Joshi, Minmin Yao, Aaron Kakazu, Yuxiao Ouyang, Wenzhen Duan, Manisha Aggarwa. Distinguishing microgliosis and tau deposition in the mouse brain using paramagnetic and diamagnetic susceptibility source separation. bioRxiv : the preprint server for biology. 2024-04-25. PMID:38659855. |
tauopathies, including alzheimer's disease (ad), are neurodegenerative disorders characterized by hyperphosphorylated tau protein aggregates in the brain. |
2024-04-25 |
2024-04-28 |
mouse |
| Nathalie Kyalu Ngoie Zola, Clémence Balty, Didier Vertommen, Bernard Jimmy Hanseeu. [Specific modifications of the soluble tau protein distinguish Alzheimer's disease from other tauopathies]. Medecine sciences : M/S. vol 40. issue 4. 2024-04-23. PMID:38651955. |
[specific modifications of the soluble tau protein distinguish alzheimer's disease from other tauopathies]. |
2024-04-23 |
2024-04-26 |
Not clear |
| Jonathan Hulse, Nicole Maphis, Julianne Peabody, Bryce Chackerian, Kiran Bhaska. Virus-like particle (VLP)-based vaccine targeting tau phosphorylated at Ser396/Ser404 (PHF1) site outperforms phosphorylated S199/S202 (AT8) site in reducing tau pathology and restoring cognitive deficits in the rTg4510 mouse model of tauopathy. bioRxiv : the preprint server for biology. 2024-04-22. PMID:38644999. |
tauopathies, including alzheimer's disease (ad) and frontotemporal dementia (ftd), are histopathologically defined by the aggregation of hyperphosphorylated pathological tau (ptau) as neurofibrillary tangles in the brain. |
2024-04-22 |
2024-04-24 |
mouse |
| Savannah Longo, María Laura Messi, Zhong-Min Wang, William Meeker, Osvaldo Delbon. Accelerated sarcopenia precedes learning and memory impairments in the P301S mouse model of tauopathies and Alzheimer's disease. Journal of cachexia, sarcopenia and muscle. 2024-04-22. PMID:38646816. |
accelerated sarcopenia precedes learning and memory impairments in the p301s mouse model of tauopathies and alzheimer's disease. |
2024-04-22 |
2024-04-24 |
mouse |
| Liara Rizzi, Lea T Grinber. Publisher Correction: Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta neuropathologica communications. vol 12. issue 1. 2024-04-12. PMID:38610041. |
publisher correction: exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in alzheimer's disease: implications for biomarker development and therapeutic targeting. |
2024-04-12 |
2024-04-15 |
Not clear |
| Dmytro Morderer, Melissa C Wren, Feilin Liu, Naomi Kouri, Anastasiia Maistrenko, Bilal Khalil, Nora Pobitzer, Michelle Salemi, Brett S Phinney, Dennis W Dickson, Melissa E Murray, Wilfried Rossol. Probe-dependent Proximity Profiling (ProPPr) Uncovers Similarities and Differences in Phospho-Tau-Associated Proteomes Between Tauopathies. bioRxiv : the preprint server for biology. 2024-04-08. PMID:38585836. |
to comprehensively investigate the common and unique protein interactors associated with the variety of tau lesions present across different human tauopathies, alzheimer's disease (ad), corticobasal degeneration (cbd), pick's disease (pid), and progressive supranuclear palsy (psp), were selected to represent the major tauopathy diseases. |
2024-04-08 |
2024-04-10 |
human |
| Jonas E Svensson, Martin Bolin, Daniel Thor, Pete A Williams, Rune Brautaset, Marcus Carlsson, Peder Sörensson, David Marlevi, Rubens Spin-Neto, Monika Probst, Göran Hagman, Anton Forsberg Morén, Miia Kivipelto, Pontus Plavén-Sigra. Evaluating the effect of rapamycin treatment in Alzheimer's disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol. BMC neurology. vol 24. issue 1. 2024-04-04. PMID:38575854. |
results from mouse models of alzheimer's disease have shown beneficial effects of rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers and tauopathies and normalizing synaptic plasticity and cerebral glucose uptake. |
2024-04-04 |
2024-04-07 |
mouse |
| Neha Basheer, Luc Buee, Jean-Pierre Brion, Tomas Smolek, Muhammad Khalid Muhammadi, Jozef Hritz, Tomas Hromadka, Ilse Dewachter, Susanne Wegmann, Isabelle Landrieu, Petr Novak, Amritpal Mudher, Norbert Zilk. Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. Acta neuropathologica communications. vol 12. issue 1. 2024-04-04. PMID:38576010. |
the transcellular propagation of the aberrantly modified protein tau along the functional brain network is a key hallmark of alzheimer's disease and related tauopathies. |
2024-04-04 |
2024-04-07 |
Not clear |
| Nikki McArthur, Bokyung Kang, Felix G Rivera Moctezuma, Akber T Shaikh, Kathryn Loeffler, Nemil N Bhatt, Madison Kidd, Jennifer M Zupancic, Alec A Desai, Naima Djeddar, Anton Bryksin, Peter M Tessier, Rakez Kayed, Levi B Wood, Ravi S Kan. Development of a pan-tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates. Biotechnology progress. 2024-04-03. PMID:38568030. |
alzheimer's disease and other tauopathies are characterized by the misfolding and aggregation of the tau protein into oligomeric and fibrillar structures. |
2024-04-03 |
2024-04-05 |
mouse |
| Felix Langerscheidt, Tamara Wied, Mohamed Aghyad Al Kabbani, Thilo van Eimeren, Gilbert Wunderlich, Hans Zempe. Genetic forms of tauopathies: inherited causes and implications of Alzheimer's disease-like TAU pathology in primary and secondary tauopathies. Journal of neurology. 2024-03-30. PMID:38554150. |
genetic forms of tauopathies: inherited causes and implications of alzheimer's disease-like tau pathology in primary and secondary tauopathies. |
2024-03-30 |
2024-04-02 |
Not clear |
| b' Dominika Ole\\xc5\\xa1ov\\xc3\\xa1, Dana Dobe\\xc5\\xa1ov\\xc3\\xa1, Petra Majerov\\xc3\\xa1, Radana Brumarov\\xc3\\xa1, Ale\\xc5\\xa1 Kvasni\\xc4\\x8dka, \\xc5\\xa0t\\xc4\\x9bp\\xc3\\xa1n Kou\\xc5\\x99il, Eva Stevens, Jozef Hanes, \\xc4\\xbdubica Fialov\\xc3\\xa1, Alena Michalicov\\xc3\\xa1, Juraj Pie\\xc5\\xa1\\xc5\\xa5ansk\\xc3\\xbd, Jakub \\xc5\\xa0insk\\xc3\\xbd, Petr Ka\\xc5\\x88ovsk\\xc3\\xbd, David Friedeck\\xc3\\xbd, Andrej Kov\\xc3\\xa1\\xc4\\x8. Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies. Journal of neuroinflammation. vol 21. issue 1. 2024-03-28. PMID:38539208.' |
accumulation of tau leads to neuroinflammation and neuronal cell death in tauopathies, including alzheimer's disease. |
2024-03-28 |
2024-03-30 |
Not clear |
| Veronika Pak, Quadri Adewale, Danilo Bzdok, Mahsa Dadar, Yashar Zeighami, Yasser Iturria-Medin. Distinctive whole-brain cell types predict tissue damage patterns in thirteen neurodegenerative conditions. eLife. vol 12. 2024-03-21. PMID:38512130. |
by unifying spatial gene expression, structural mri, and cell deconvolution, here we describe how the human brain distribution of canonical cell types extensively predicts tissue damage in 13 neurodegenerative conditions, including early- and late-onset alzheimer's disease, parkinson's disease, dementia with lewy bodies, amyotrophic lateral sclerosis, mutations in presenilin-1, and 3 clinical variants of frontotemporal lobar degeneration (behavioral variant, semantic and non-fluent primary progressive aphasia) along with associated three-repeat and four-repeat tauopathies and tdp43 proteinopathies types a and c. we reconstructed comprehensive whole-brain reference maps of cellular abundance for six major cell types and identified characteristic axes of spatial overlapping with atrophy. |
2024-03-21 |
2024-03-23 |
human |
| David Horsley, Janet E Rickard, Thomas Vorley, Matilda F Leeper, Claude M Wischik, Charles R Harringto. Assays for the Screening and Characterization of Tau Aggregation Inhibitors. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512662. |
aggregation of tau protein is a pathological hallmark of alzheimer's disease and other neurodegenerative tauopathies. |
2024-03-21 |
2024-03-24 |
Not clear |
| Léa El Hajjar, Clarisse Bridot, Marine Nguyen, François-Xavier Cantrelle, Isabelle Landrieu, Caroline Smet-Nocc. The O-GlcNAc Modification of Recombinant Tau Protein and Characterization of the O-GlcNAc Pattern for Functional Study. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512671. |
in neurodegenerative disorders referred to as tauopathies including alzheimer's disease, tau is abnormally hyperphosphorylated and forms fibrillar inclusions in neurons progressing throughout different brain area during the course of the disease. |
2024-03-21 |
2024-03-24 |
mouse |
| Parissa Fereydouni-Forouzandeh, Geoffrey Canet, Sofia Diego-Diàz, Emma Rocaboy, Serena Petry, Robert A Whittington, Emmanuel Plane. Western Blot of Tau Protein from Mouse Brains Extracts: How to Avoid Signal Artifacts. Methods in molecular biology (Clifton, N.J.). vol 2754. 2024-03-21. PMID:38512673. |
in alzheimer's disease and other neurodegenerative diseases known as tauopathies, tau undergoes several abnormal post-translational modifications including hyperphosphorylation, conformational changes, oligomerization, and aggregation. |
2024-03-21 |
2024-03-24 |
mouse |