| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| E F Adams, M Buchfelder, A Hüttner, S Moreth, R Fahlbusc. Recent advances in the molecular biology of growth-hormone secreting human pituitary tumours. Experimental and clinical endocrinology. vol 101. issue 1. 1993-05-24. PMID:8477819. |
in our own studies, we demonstrate that it is unlikely that a defect within the promoter region of the gh gene will prove to be a cause of excessive gh secretion in acromegaly. |
1993-05-24 |
2023-08-12 |
human |
| H Kotzmann, P Bernecker, P Hübsch, P Pietschmann, W Woloszczuk, T Svoboda, G Geyer, A Luge. Bone mineral density and parameters of bone metabolism in patients with acromegaly. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 8. issue 4. 1993-05-20. PMID:8475795. |
to assess the effect of chronically elevated plasma growth hormone (gh) levels on bone metabolism and bone mineral density (bmd), 16 patients (10 females and 6 males) with a mean age of 49.1 +/- 13.2 years (range 33-68) with active acromegaly were studied and compared to a control group of 16 sex- and age-matched subjects. |
1993-05-20 |
2023-08-12 |
human |
| G Turner, R C Brown, I Weeks, G E Butler, F N Creagh, J S Woodhea. Urinary growth hormone excretion as measured by a sensitive immunochemiluminometric assay. Annals of clinical biochemistry. vol 30 ( Pt 2). 1993-05-05. PMID:8466150. |
there was a good correlation between serum growth hormone (gh) and ugh concentrations in 20 patients with acromegaly and six volunteers following an intravenous injection of recombinant gh. |
1993-05-05 |
2023-08-12 |
human |
| N Sicolo, F Bui, M Sicolo, L Varotto, C Martini, C Macor, G Federspi. Acromegalic cardiopathy: a left ventricular scintigraphic study. Journal of endocrinological investigation. vol 16. issue 2. 1993-05-04. PMID:8463547. |
these findings indicate that chronic growth hormone (gh) hypersecretion, as observed in acromegaly, deteriorate the cardiac ventricular relaxation (diastolic phase) while it has no influence on contractility (systolic phase). |
1993-05-04 |
2023-08-12 |
human |
| A L Ogilvy-Stuart, S M Shale. Tumour occurrence and recurrence. Hormone research. vol 38 Suppl 1. 1993-04-19. PMID:1295813. |
in acromegaly, in which there is a pathologically sustained high gh level, there is a significantly increased incidence of cancer in general and specifically of colonic neoplasia. |
1993-04-19 |
2023-08-11 |
rat |
| A Giustina, M Doga, A R Bussi, M Licini, M Schettin. Effect of long-term treatment with bromocriptine on the growth hormone response to galanin in patients with acromegaly. Acta endocrinologica. vol 128. issue 2. 1993-04-12. PMID:7680832. |
galanin elicits growth hormone (gh) secretion in normal man but may cause a paradoxical fall of gh in acromegaly. |
1993-04-12 |
2023-08-12 |
human |
| A Giustina, M Doga, A R Bussi, M Licini, M Schettin. Effect of long-term treatment with bromocriptine on the growth hormone response to galanin in patients with acromegaly. Acta endocrinologica. vol 128. issue 2. 1993-04-12. PMID:7680832. |
our results confirm that the dose of galanin capable of increasing plasma gh levels in normal subjects can decrease gh values in patients with acromegaly. |
1993-04-12 |
2023-08-12 |
human |
| A Giustina, M Doga, A R Bussi, M Licini, M Schettin. Effect of long-term treatment with bromocriptine on the growth hormone response to galanin in patients with acromegaly. Acta endocrinologica. vol 128. issue 2. 1993-04-12. PMID:7680832. |
therefore, the paradoxical decreasing effect of galanin on plasma gh levels in acromegaly seems not to be mediated via dopaminergic pathways. |
1993-04-12 |
2023-08-12 |
human |
| A Giustina, A R Bussi, M Licini, G Pizzocolo, M Schettino, W B Wehrenber. Acute effects of hydrocortisone on circulating growth hormone levels in patients with acromegaly. Hormone research. vol 37. issue 6. 1993-04-08. PMID:1363409. |
aim of our study was to investigate the acute effects of intravenous infusion of hydrocortisone on circulating growth hormone (gh) levels in acromegaly. |
1993-04-08 |
2023-08-11 |
human |
| A Giustina, A R Bussi, M Licini, G Pizzocolo, M Schettino, W B Wehrenber. Acute effects of hydrocortisone on circulating growth hormone levels in patients with acromegaly. Hormone research. vol 37. issue 6. 1993-04-08. PMID:1363409. |
our data show that acute and sustained hypercortisolism, decreases circulating gh levels in acromegaly. |
1993-04-08 |
2023-08-11 |
human |
| A Quade, M Rahn, H U Schweikert, F Bidlingmaier, D Klingmülle. Urinary excretion of GH in healthy individuals and patients with acromegaly, hypopituitarism and dwarfism. Acta endocrinologica. vol 128. issue 1. 1993-04-06. PMID:8447191. |
urinary excretion of gh in healthy individuals and patients with acromegaly, hypopituitarism and dwarfism. |
1993-04-06 |
2023-08-12 |
human |
| A Quade, M Rahn, H U Schweikert, F Bidlingmaier, D Klingmülle. Urinary excretion of GH in healthy individuals and patients with acromegaly, hypopituitarism and dwarfism. Acta endocrinologica. vol 128. issue 1. 1993-04-06. PMID:8447191. |
gh excretion of patients with acromegaly differs significantly from healthy subjects (72 ng/24 h +/- 49 vs 3.9 ng/24 h +/- 2.3). |
1993-04-06 |
2023-08-12 |
human |
| M Pholséna, Y Le Bouc, E Rousseau, R Christol, P Birman, L Périn, F Girar. Evaluation of acromegaly by measurement of 24-hourly urinary growth hormone excretion. Acta endocrinologica. vol 128. issue 1. 1993-04-06. PMID:8447199. |
log-transformed values for subjects with acromegaly showed significant correlations between 24-h ugh and levels of igf-i (r = 0.63, p < 0.01), fasting plasma gh (r = 0.92, p < 0.001) and plasma gh after glucose loading (r = 0.85, p < 0.001). |
1993-04-06 |
2023-08-12 |
human |
| K K Ho, E Valiontis, M J Waters, I A Rajkovi. Regulation of growth hormone binding protein in man: comparison of gel chromatography and immunoprecipitation methods. The Journal of clinical endocrinology and metabolism. vol 76. issue 2. 1993-03-17. PMID:8432772. |
neither gh administration to gh-deficient and normal subjects, nor octreotide treatment of patients with acromegaly, significantly altered ghbp activity. |
1993-03-17 |
2023-08-12 |
human |
| S Yamada, T Sano, L Stefaneanu, K Kovacs, T Aiba, S Sawano, Y Shishib. Endocrine and morphological study of a clinically silent somatotroph adenoma of the human pituitary. The Journal of clinical endocrinology and metabolism. vol 76. issue 2. 1993-03-17. PMID:8432778. |
we report here the case of a 46-yr-old woman with a large pituitary macroadenoma, slightly elevated serum gh levels, high serum insulin-like growth factor-i levels, and abnormal gh dynamics, but no acromegaly. |
1993-03-17 |
2023-08-12 |
human |
| S Yamada, T Sano, L Stefaneanu, K Kovacs, T Aiba, S Sawano, Y Shishib. Endocrine and morphological study of a clinically silent somatotroph adenoma of the human pituitary. The Journal of clinical endocrinology and metabolism. vol 76. issue 2. 1993-03-17. PMID:8432778. |
thus, it is conceivable that this tumor secreted only small quantities of gh and for only short periods, providing an explanation for the lack of acromegaly. |
1993-03-17 |
2023-08-12 |
human |
| G Faglia, M Arosi. [Therapeutic use of somatostatin analogues in endocrinology]. Recenti progressi in medicina. vol 83. issue 11. 1993-03-12. PMID:1363150. |
evidence is accumulating that octreotide treatment is effective in improving the cure rate of pituitary surgery in acromegaly by shrinking the tumour size, and in lowering gh and igf-i levels in the vaste majority of patients. |
1993-03-12 |
2023-08-11 |
human |
| W M Nazaimoon, M L Ng, N Satgunasingam, B A Khali. Evaluation of suppression of growth hormone levels following a 75g oral glucose tolerance test. The Medical journal of Malaysia. vol 47. issue 2. 1993-03-08. PMID:1494329. |
growth hormone (gh) levels were measured after a 75g oral glucose load (ogtt) in normal adults, patients with impaired glucose tolerance (igt), insulin-dependent diabetes mellitus (iddm) and acromegaly. |
1993-03-08 |
2023-08-11 |
human |
| L Fiszlejder, O Penacini, S Ratz, A Oneto, M Storani, L Rizzo, A Guitelma. Cholinergic modulation of GH secretion in acromegalic patients before and after pituitary surgery. Acta endocrinologica. vol 127. issue 6. 1993-03-02. PMID:1362848. |
the finding that muscarinic receptor activity recovered after the reduction of serum gh basal levels by pituitary surgery lends support to the proposed pathophysiological role of gh excess as a possible determinant factor in cholinergic-somatostatinergic dysfunction in acromegaly. |
1993-03-02 |
2023-08-11 |
human |
| G T Tindall, N M Oyesiku, N B Watts, R V Clark, J H Christy, D A Adam. Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: outcome analysis and determinants of failure. Journal of neurosurgery. vol 78. issue 2. 1993-02-17. PMID:8421204. |
the results of transsphenoidal adenomectomy for growth hormone (gh)-secreting pituitary adenomas in acromegaly performed over a 17-year period were analyzed retrospectively to determine which preoperative factors significantly influenced the long-term surgical outcome. |
1993-02-17 |
2023-08-12 |
Not clear |