| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Watanobe, T Tamur. Stimulatory and inhibitory effects of neuropeptide Y on growth hormone secretion in acromegaly in vivo. Neuropeptides. vol 31. issue 1. 1998-06-18. PMID:9574834. |
however, since it has yet to be explored whether npy affects gh secretion in acromegaly in vivo, in this study we attempted to examine the effect of intravenous (i.v.) |
1998-06-18 |
2023-08-12 |
human |
| H Watanobe, T Tamur. Stimulatory and inhibitory effects of neuropeptide Y on growth hormone secretion in acromegaly in vivo. Neuropeptides. vol 31. issue 1. 1998-06-18. PMID:9574834. |
bolus injection of 100 microg of human npy on plasma gh levels in 15 patients with active acromegaly, trying to find a possible correlation among gh responses to npy, thyrotropin-releasing hormone (trh;500 microg, i.v. |
1998-06-18 |
2023-08-12 |
human |
| H Watanobe, T Tamur. Stimulatory and inhibitory effects of neuropeptide Y on growth hormone secretion in acromegaly in vivo. Neuropeptides. vol 31. issue 1. 1998-06-18. PMID:9574834. |
from these results, we hypothesize that the npy-induced increase in gh release may be a feature of somatotroph-like pituitary adenoma causing acromegaly, whereas the npy-induced decrease in gh secretion may be a feature of lactotroph-like adenoma. |
1998-06-18 |
2023-08-12 |
human |
| S R Peacey, A A Toogood, S M Shale. Hypothalamic dysfunction in "cured" acromegaly is treatment modality dependent. The Journal of clinical endocrinology and metabolism. vol 83. issue 5. 1998-06-04. PMID:9589676. |
the current definition of cure after treatment for acromegaly stipulates a reduction in gh levels to less than 2 ng/ml (< 5 mu/l), as such gh concentrations are believed to be associated with normalization of long term survival. |
1998-06-04 |
2023-08-12 |
human |
| S R Peacey, A A Toogood, S M Shale. Hypothalamic dysfunction in "cured" acromegaly is treatment modality dependent. The Journal of clinical endocrinology and metabolism. vol 83. issue 5. 1998-06-04. PMID:9589676. |
we studied 20 patients with cured acromegaly (mean 24-h gh concentration, < 2 ng/ml). |
1998-06-04 |
2023-08-12 |
human |
| X Xu, J Forrer, P J Bechtel, P M Bes. Elevated growth hormone increases the Ca2+ sensitivity of slow- and fast-twitch skeletal muscle of female rats. The American journal of physiology. vol 274. issue 4. 1998-06-02. PMID:9575781. |
to determine the effect of plasma growth hormone (gh) on skeletal muscle function, we measured the free ca2+ concentration-tension relationship of slow-twitch (soleus) and fast-twitch (peroneus longus) muscles isolated from rats undergoing acromegaly in response to implanted, gh-secreting tumors. |
1998-06-02 |
2023-08-12 |
rat |
| b' C Cuerda, T Lucas, R A Silvestre, I Bret\\xc3\\xb3n, P Garc\\xc3\\xada, J Marco, B Barcel\\xc3\\xb. Growth hormone secretory response to intravenous galanin infusion in acromegalic patients. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 106. issue 1. 1998-05-14. PMID:9516063.' |
although the diagnosis of acromegaly involves demonstrating hypersecretion of gh and/or abnormalities in gh secretory dynamics, sometimes it is difficult to establish the activity of the disease. |
1998-05-14 |
2023-08-12 |
human |
| b' C Cuerda, T Lucas, R A Silvestre, I Bret\\xc3\\xb3n, P Garc\\xc3\\xada, J Marco, B Barcel\\xc3\\xb. Growth hormone secretory response to intravenous galanin infusion in acromegalic patients. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 106. issue 1. 1998-05-14. PMID:9516063.' |
our results indicate that the differences in the gh response to galanin in patients with active and cured acromegaly could be of value in the study of the disease. |
1998-05-14 |
2023-08-12 |
human |
| M T Bluet-Pajot, J Epelbaum, D Gourdji, C Hammond, C Kordo. Hypothalamic and hypophyseal regulation of growth hormone secretion. Cellular and molecular neurobiology. vol 18. issue 1. 1998-05-05. PMID:9524732. |
finally, characteristic changes occur in the gh secretory pattern under discrete, pathological conditions, such as abnormal growth and dwarfism, diabetes, and acromegaly, as well as during inflammatory processes. |
1998-05-05 |
2023-08-12 |
Not clear |
| G Minniti, M L Jaffrain-Rea, R Baldelli, E Ferretti, B Caracciolo, A Bultrini, A Gulino, G Tamburran. Acute effects of octreotide, cabergoline and a combination of both drugs on GH secretion in acromegalic patients. La Clinica terapeutica. vol 148. issue 12. 1998-04-27. PMID:9528195. |
the acute gh lowering effects of a single dose of either octreotide (oct) or cabergoline (cab), given alone and in combination, were studied in a series of 21 patients with acromegaly. |
1998-04-27 |
2023-08-12 |
Not clear |
| A Teubner, M Breidert, T Baehring, J Hensen, S R Bornstei. [Clinical picture, diagnosis and therapy of acromegaly patients in Eastern and Western Germany]. Zeitschrift fur arztliche Fortbildung und Qualitatssicherung. vol 91. issue 8. 1998-04-08. PMID:9487627. |
acromegaly, a chronic disease characterized by an excessive secretion of growth hormone (gh), is not commonly diagnosed timely enough. |
1998-04-08 |
2023-08-12 |
Not clear |
| N C Thalassinos, S Tsagarakis, G Ioannides, I Tzavara, C Papavasilio. Megavoltage pituitary irradiation lowers but seldom leads to safe GH levels in acromegaly: a long-term follow-up study. European journal of endocrinology. vol 138. issue 2. 1998-03-24. PMID:9506859. |
megavoltage pituitary irradiation lowers but seldom leads to safe gh levels in acromegaly: a long-term follow-up study. |
1998-03-24 |
2023-08-12 |
Not clear |
| N C Thalassinos, S Tsagarakis, G Ioannides, I Tzavara, C Papavasilio. Megavoltage pituitary irradiation lowers but seldom leads to safe GH levels in acromegaly: a long-term follow-up study. European journal of endocrinology. vol 138. issue 2. 1998-03-24. PMID:9506859. |
in conclusion, megavoltage rt is an effective treatment for the control of gh hypersecretion in acromegaly, with a continuing lowering effect for several years following rt but seldom leads to safe gh levels. |
1998-03-24 |
2023-08-12 |
Not clear |
| G van den Berg, S M Pincus, M Frölich, J D Veldhuis, F Roelfsem. Reduced disorderliness of growth hormone release in biochemically inactive acromegaly after pituitary surgery. European journal of endocrinology. vol 138. issue 2. 1998-03-24. PMID:9506860. |
the episodicity of 24 h gh release was studied in 18 patients with active acromegaly, 12 patients 7-10 days after pituitary surgery, 14 patients long after operation (3-17 years), and 21 healthy gender- and age-matched control subjects, using a recently introduced scale- and model-independent regularity statistic, approximate entropy (apen). |
1998-03-24 |
2023-08-12 |
human |
| Y Murakami, T Mori, K Koshimura, M Kurosaki, T Hori, N Yanaihara, Y Kat. Stimulation by urocortin of growth hormone (GH) secretion in GH-producing human pituitary adenoma cells. Endocrine journal. vol 44. issue 4. 1998-03-13. PMID:9447301. |
both ucn (10 nm) and crh (10 nm) elicited an increase in gh release from the pituitary adenoma cells in one patient with acromegaly. |
1998-03-13 |
2023-08-12 |
human |
| Y Murakami, T Mori, K Koshimura, M Kurosaki, T Hori, N Yanaihara, Y Kat. Stimulation by urocortin of growth hormone (GH) secretion in GH-producing human pituitary adenoma cells. Endocrine journal. vol 44. issue 4. 1998-03-13. PMID:9447301. |
in contrast, gh release from the pituitary adenoma cells was stimulated by ucn but not by crh in the other patient with acromegaly. |
1998-03-13 |
2023-08-12 |
human |
| Y Murakami, T Mori, K Koshimura, M Kurosaki, T Hori, N Yanaihara, Y Kat. Stimulation by urocortin of growth hormone (GH) secretion in GH-producing human pituitary adenoma cells. Endocrine journal. vol 44. issue 4. 1998-03-13. PMID:9447301. |
these preliminary findings suggest that type-2 crh receptors are expressed in some population of gh-producing human pituitary adenoma cells and that ucn might be involved in gh secretion from tumorous tissues in patients with acromegaly. |
1998-03-13 |
2023-08-12 |
human |
| G Lombardi, A Colao, A Cuocolo, S Longobardi, C Di Somma, F Orio, B Merola, E Nicolai, M Salvator. Cardiological aspects of growth hormone and insulin-like growth factor-I. Journal of pediatric endocrinology & metabolism : JPEM. vol 10. issue 6. 1998-03-12. PMID:9467124. |
these abnormalities of the cardiovascular system are partially reversed after normalization of gh and igf-i levels, by octreotide in acromegaly or after gh replacement therapy in ghd patients. |
1998-03-12 |
2023-08-12 |
Not clear |
| R Abs, J Verhelst, D Maiter, K Van Acker, F Nobels, J L Coolens, C Mahler, A Becker. Cabergoline in the treatment of acromegaly: a study in 64 patients. The Journal of clinical endocrinology and metabolism. vol 83. issue 2. 1998-02-27. PMID:9467544. |
the results of this study suggest that cabergoline is an effective, well tolerated therapy that should be considered in the management of acromegaly, especially if the pituitary adenoma cosecretes gh and prl or if pretreatment plasma igf-i levels are below 750 micrograms/l. |
1998-02-27 |
2023-08-12 |
Not clear |
| W Saeger, D K Lüdecke, M Los. [Combined neuronal and endocrine tumors of the sellar region]. Der Pathologe. vol 18. issue 6. 1998-02-26. PMID:9451729. |
as only the adenomas can secrete gh, the adenomas and not the gangliocytomas are directly responsible for acromegaly so that such an adenoma has to be present in cases of acromegaly. |
1998-02-26 |
2023-08-12 |
Not clear |