| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
therefore, we have evaluated parameters of gh secretion in a larger number of subjects from our cohort of postoperative patients with acromegaly and in healthy subjects in order to determine if gender or age associated differences in these parameters exist. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
ninety-two subjects with acromegaly (49 men, 43 women) and 46 age-matched healthy subjects (26 men, 20 women) were evaluated with baseline gh and igf-i levels and nadir gh levels after a 100 g. ogtt. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
in the subjects with acromegaly, there were no significant gender differences in basal, %gh suppression or nadir gh levels. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
in conclusion, we have not found significant gender or age-related differences in nadir gh levels and thus our data does not support separate ogtt criteria for cure in men and women with acromegaly. |
2002-08-12 |
2023-08-12 |
human |
| Elisa A Hofmann, Kenneth S Polonsky, Roy E Weis. Diagnosis of acromegaly in a patient with type 1 diabetes mellitus. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. vol 8. issue 2. 2002-08-09. PMID:11942776. |
to describe a case of acromegaly in a young patient with poorly controlled diabetes mellitus and suggest guidelines to distinguish acromegaly and high growth hormone (gh) levels previously reported in poorly controlled type 1 diabetes. |
2002-08-09 |
2023-08-12 |
Not clear |
| Annamaria Colao, Letizia Spinelli, Alberto Cuocolo, Stefano Spiezia, Rosario Pivonello, Carolina di Somma, Domenico Bonaduce, Marco Salvatore, Gaetano Lombard. Cardiovascular consequences of early-onset growth hormone excess. The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107207. |
acromegaly has relevant effects on the cardiovascular system, but few data deal with the early effects of gh and igf-i excess. |
2002-08-02 |
2023-08-12 |
human |
| Annamaria Colao, Letizia Spinelli, Alberto Cuocolo, Stefano Spiezia, Rosario Pivonello, Carolina di Somma, Domenico Bonaduce, Marco Salvatore, Gaetano Lombard. Cardiovascular consequences of early-onset growth hormone excess. The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107207. |
to study the early stage of acromegalic cardiomyopathy and give indirect evidence of the mechanisms underlying gh and igf-i action on the human heart, 25 patients with uncomplicated acromegaly [15 young subjects with short-term (< or =5 yr) disease and 10 with long-term (>5 yr) disease] and 25 sex- and age-matched controls were studied. |
2002-08-02 |
2023-08-12 |
human |
| Augusto C F Costa, Adriana Rossi, Carlos E Martinelli, Hélio R Machado, Ayrton C Moreir. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107214. |
these results suggest that the strict physiological normalization of gh levels after ogtt is not often achieved as a therapeutic endpoint in acromegaly. |
2002-08-02 |
2023-08-12 |
human |
| Augusto C F Costa, Adriana Rossi, Carlos E Martinelli, Hélio R Machado, Ayrton C Moreir. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107214. |
in addition to the refinement of gh assays, epidemiological studies have suggested that the mean basal gh levels (<2.5 microg/liter) or ogtt-derived gh levels < 2 microg/liter (ria), or the normalization of igf-i levels, appear to reduce morbidity and mortality in treated acromegaly. |
2002-08-02 |
2023-08-12 |
human |
| Augusto C F Costa, Adriana Rossi, Carlos E Martinelli, Hélio R Machado, Ayrton C Moreir. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107214. |
using this epidemiologically based definition of cure for acromegaly, we reviewed our results obtained with a sensitive gh assay. |
2002-08-02 |
2023-08-12 |
human |
| Augusto C F Costa, Adriana Rossi, Carlos E Martinelli, Hélio R Machado, Ayrton C Moreir. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107214. |
in conclusion, using a sensitive gh assay it can be seen that the strictly normal postglucose gh values less than 0.25 microg/liter required for biochemical control of acromegaly are not often achieved. |
2002-08-02 |
2023-08-12 |
human |
| Augusto C F Costa, Adriana Rossi, Carlos E Martinelli, Hélio R Machado, Ayrton C Moreir. Assessment of disease activity in treated acromegalic patients using a sensitive GH assay: should we achieve strict normal GH levels for a biochemical cure? The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107214. |
therefore, our data lead us to postulate that the biochemical criterion of ogtt gh levels 1 microg/liter or less, determined by immunofluorometric assay, is a useful and accurate marker of safe gh secretion in treated acromegaly. |
2002-08-02 |
2023-08-12 |
human |
| Gregorio Brevetti, Paolo Marzullo, Antonio Silvestro, Rosario Pivonello, Gabriella Oliva, Carolina di Somma, Gaetano Lombardi, Annamaria Cola. Early vascular alterations in acromegaly. The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107220. |
in conclusion, patients with acromegaly have functional and morphological vascular alteration that seems, at least in part, dependent on the gh excess itself. |
2002-08-02 |
2023-08-12 |
human |
| R John Irving, Maggie N Carson, David J Webb, Brian R Walke. Peripheral vascular structure and function in men with contrasting GH levels. The Journal of clinical endocrinology and metabolism. vol 87. issue 7. 2002-08-02. PMID:12107241. |
we studied six age-matched healthy control men, five men with acromegaly, and seven men with adult-onset gh deficiency before and at the end of 16 wk of gh replacement therapy. |
2002-08-02 |
2023-08-12 |
Not clear |
| T Ueland, E N Ebbesen, J S Thomsen, L Mosekilde, K Brixen, A Flyvbjerg, J Bollersle. Decreased trabecular bone biomechanical competence, apparent density, IGF-II and IGFBP-5 content in acromegaly. European journal of clinical investigation. vol 32. issue 2. 2002-07-12. PMID:11895459. |
since insulin-like growth factors (igfs) and their binding proteins (igfbps) in part mediate the effects of gh, the present study aimed to investigate trabecular bone composition of these growth factors in relation to biomechanical properties in acromegaly. |
2002-07-12 |
2023-08-12 |
Not clear |
| F García-Río, J M Pino, J J Díez, A Ruíz, C Villasante, J Villamo. Reduction of lung distensibility in acromegaly after suppression of growth hormone hypersecretion. American journal of respiratory and critical care medicine. vol 164. issue 5. 2002-07-02. PMID:11549545. |
to discriminate these hypotheses, we compared pulmonary distensibility and diffusing capacity among 11 patients with active acromegaly and 11 matched control subjects, evaluating the response of pulmonary distensibility and diffusing capacity to suppression of growth hormone (gh) hypersecretion. |
2002-07-02 |
2023-08-12 |
human |
| F García-Río, J M Pino, J J Díez, A Ruíz, C Villasante, J Villamo. Reduction of lung distensibility in acromegaly after suppression of growth hormone hypersecretion. American journal of respiratory and critical care medicine. vol 164. issue 5. 2002-07-02. PMID:11549545. |
we conclude that the increased lung distensibility with normal diffusion capacity demonstrated in patients with active acromegaly, which was partly reversible after suppression of gh hypersecretion, suggests that lung growth in acromegaly may result from an increase in alveolar size. |
2002-07-02 |
2023-08-12 |
human |
| P B Colligan, H M Brown-Borg, J Duan, B H Ren, J Re. Cardiac contractile function is enhanced in isolated ventricular myocytes from growth hormone transgenic mice. The Journal of endocrinology. vol 173. issue 2. 2002-06-25. PMID:12010633. |
transgenic mice with gh over-expression serve as useful models for acromegaly and exhibit impaired cardiac functions using echocardiography, similar to those of human acromegaly. |
2002-06-25 |
2023-08-12 |
mouse |
| M Bolanowski, D Jedrzejuk, A Milewicz, A Arkowsk. Quantitative ultrasound of the heel and some parameters of bone turnover in patients with acromegaly. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. vol 13. issue 4. 2002-06-20. PMID:12030545. |
acromegaly caused by growth hormone (gh) hypersecretion is characterized by enhanced skeletal growth and soft tissue enlargement. |
2002-06-20 |
2023-08-12 |
Not clear |
| M Bolanowski, D Jedrzejuk, A Milewicz, A Arkowsk. Quantitative ultrasound of the heel and some parameters of bone turnover in patients with acromegaly. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. vol 13. issue 4. 2002-06-20. PMID:12030545. |
however, in some patients with acromegaly, secondary osteoporosis is observed, despite the strong anabolic effect of gh and igf-1 in bones. |
2002-06-20 |
2023-08-12 |
Not clear |