| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Lorcy, S Perdu, B Sevray, R Cohe. [Acromegaly due to ectopic GH RH secretion by a bronchial carcinoid tumor: a case report]. Annales d'endocrinologie. vol 63. issue 6 Pt 1. 2003-03-25. PMID:12527856. |
[acromegaly due to ectopic gh rh secretion by a bronchial carcinoid tumor: a case report]. |
2003-03-25 |
2023-08-12 |
Not clear |
| Y Lorcy, S Perdu, B Sevray, R Cohe. [Acromegaly due to ectopic GH RH secretion by a bronchial carcinoid tumor: a case report]. Annales d'endocrinologie. vol 63. issue 6 Pt 1. 2003-03-25. PMID:12527856. |
ectopic gh rh is a very uncommon cause of acromegaly (<1% of acromegaly). |
2003-03-25 |
2023-08-12 |
Not clear |
| Y Lorcy, S Perdu, B Sevray, R Cohe. [Acromegaly due to ectopic GH RH secretion by a bronchial carcinoid tumor: a case report]. Annales d'endocrinologie. vol 63. issue 6 Pt 1. 2003-03-25. PMID:12527856. |
acromegaly due to ectopic gh rh secretion was confirmed by very high plasma immunoreactive gh rh level. |
2003-03-25 |
2023-08-12 |
Not clear |
| Izumi Fukuda, Naomi Hizuka, Emina Itoh, Kumiko Yasumoto, Yukiko Ishikawa, Yuko Murakami, Akira Sata, Kazue Takan. Acid-labile subunit in growth hormone excess and deficiency in adults: evaluation of its diagnostic value in comparison with insulin-like growth factor (IGF)-I and IGF-binding protein-3. Endocrine journal. vol 49. issue 3. 2003-03-18. PMID:12201224. |
furthermore, our results indicate that serum igfbp-3 is the most suitable marker of gh secretion for adult ghd, especially co, while igf-i may be the most useful in acromegaly. |
2003-03-18 |
2023-08-12 |
Not clear |
| H Vierhapper, G Heinze, A Gessl, M Exner, C Bieglmay. Use of the oral glucose tolerance test to define remission in acromegaly. Metabolism: clinical and experimental. vol 52. issue 2. 2003-03-14. PMID:12601629. |
an oral glucose tolerance test (ogtt) was used to assess growth hormone (gh) secretion in patients with acromegaly prior to (n = 26) and after (n = 71) transsphenoidal adenomectomy as well as in 196 controls. |
2003-03-14 |
2023-08-12 |
Not clear |
| H Vierhapper, G Heinze, A Gessl, M Exner, C Bieglmay. Use of the oral glucose tolerance test to define remission in acromegaly. Metabolism: clinical and experimental. vol 52. issue 2. 2003-03-14. PMID:12601629. |
having calculated the reference intervals for suppressed gh concentrations to be expected for any given age and bmi, we compared these individually predicted ranges to gh concentrations actually observed in patients with acromegaly during ogtt. |
2003-03-14 |
2023-08-12 |
Not clear |
| Helene Nørrelund, Anne Lene Riis, Niels Mølle. Effects of GH on protein metabolism during dietary restriction in man. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 12. issue 4. 2003-02-27. PMID:12175652. |
gh has potent protein anabolic actions, as evidenced by a significant decrease in lean body mass and muscle mass in chronic gh deficiency, and vice versa in patients with acromegaly. |
2003-02-27 |
2023-08-12 |
human |
| D Bétéa, H Valdes Socin, I Hansen, A Stevenaert, A Becker. [Acromegaly and pregnancy]. Annales d'endocrinologie. vol 63. issue 5. 2003-02-12. PMID:12442089. |
acromegaly usually results from gh hypersecretion by a somatotroph adenoma. |
2003-02-12 |
2023-08-12 |
Not clear |
| Annamaria Colao, Carolina Di Somma, Stefano Spiezia, Mariagiovanna Filippella, Rosario Pivonello, Gaetano Lombard. Effect of growth hormone (GH) and/or testosterone replacement on the prostate in GH-deficient adult patients. The Journal of clinical endocrinology and metabolism. vol 88. issue 1. 2003-02-11. PMID:12519835. |
the prostate is a target organ of the gh and igf-i axis because prostate hypertrophy is found in acromegaly, reduced prostate size is found in gh deficiency (ghd) patients, and additionally, igf-i is reported to be a positive predictor factor of prostate cancer. |
2003-02-11 |
2023-08-12 |
Not clear |
| Vincent Goffin, Philippe Tourain. Pegvisomant. Pharmacia. Current opinion in investigational drugs (London, England : 2000). vol 3. issue 5. 2003-01-27. PMID:12090548. |
pegvisomant, a polyethylene glycol (peg) derivative of human growth hormone (gh) that acts as a highly selective gh receptor antagonist, is under development by pharmacia (formerly sensus) as a potential treatment for acromegaly. |
2003-01-27 |
2023-08-12 |
human |
| A Saveanu, E Lavaque, G Gunz, A Barlier, S Kim, J E Taylor, M D Culler, A Enjalbert, P Jaque. Demonstration of enhanced potency of a chimeric somatostatin-dopamine molecule, BIM-23A387, in suppressing growth hormone and prolactin secretion from human pituitary somatotroph adenoma cells. The Journal of clinical endocrinology and metabolism. vol 87. issue 12. 2003-01-17. PMID:12466351. |
in acromegaly, the combination of somatostatin (ss) and dopamine (da) agonists has been shown to enhance suppression of gh secretion. |
2003-01-17 |
2023-08-12 |
human |
| Kazunori Kageyama, Takeshi Nigawara, Yoshimasa Kamata, Ken Terui, Jiichi Anzai, Satoru Sakihara, Toshihiro Sud. A multihormonal pituitary adenoma with growth hormone and adrenocorticotropic hormone production, causing acromegaly and Cushing disease. The American journal of the medical sciences. vol 324. issue 6. 2003-01-17. PMID:12495300. |
pituitary adenoma with growth hormone (gh) and corticotropin (acth) production causing apparent acromegaly and cushing disease is extremely rare. |
2003-01-17 |
2023-08-12 |
Not clear |
| M Bondanelli, M R Ambrosio, E C degli Ubert. Pathogenesis and prevalence of hypertension in acromegaly. Pituitary. vol 4. issue 4. 2003-01-15. PMID:12501974. |
the lowering of blood pressure observed concomitantly with the reduction in gh levels after successful therapy for acromegaly suggests a relationship between gh and/or igf-i excess and hypertension. |
2003-01-15 |
2023-08-12 |
Not clear |
| M Bondanelli, M R Ambrosio, E C degli Ubert. Pathogenesis and prevalence of hypertension in acromegaly. Pituitary. vol 4. issue 4. 2003-01-15. PMID:12501974. |
the exact mechanisms underlying the development of hypertension in acromegaly are still not clear but may include several factors depending on the chronic exposure to gh and/or igf-i excess. |
2003-01-15 |
2023-08-12 |
Not clear |
| A Colao, G Amato, A M Pedroncelli, R Baldelli, S Grottoli, V Gasco, M Petretta, C Carella, G Pagani, G Tambura, G Lombard. Gender- and age-related differences in the endocrine parameters of acromegaly. Journal of endocrinological investigation. vol 25. issue 6. 2002-12-30. PMID:12109625. |
at diagnosis, elderly patients with acromegaly have lower gh and igf-i levels, lower gh nadir after glucose load and smaller adenomas than young patients. |
2002-12-30 |
2023-08-12 |
Not clear |
| Sunday O Akintoye, Caroline Chebli, Susan Booher, Penelope Feuillan, Harvey Kushner, Derek Leroith, Natasha Cherman, Paolo Bianco, Shlomo Wientroub, Pamela Gehron Robey, Michael T Collin. Characterization of gsp-mediated growth hormone excess in the context of McCune-Albright syndrome. The Journal of clinical endocrinology and metabolism. vol 87. issue 11. 2002-12-09. PMID:12414879. |
fifty-eight patients with mas were screened, and 22 with stigmata of acromegaly and/or elevated gh or igf-i underwent oral glucose tolerance testing. |
2002-12-09 |
2023-08-12 |
Not clear |
| M Bolanowski, J Schopohl, M Marciniak, M Rzeszutko, K Zatonska, J Daroszewski, A Milewicz, J Malczewska, R Badowsk. Acromegaly due to GHRH-secreting large bronchial carcinoid. Complete recovery following tumor surgery. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. vol 110. issue 4. 2002-12-04. PMID:12058343. |
this case of acromegaly due to ectopic ghrh secretion by bronchial carcinoid differs from others described in the literature by an atypical large tumor size, the suppression of elevated gh secretion by oral bromocriptine and a concomitant meningioma. |
2002-12-04 |
2023-08-12 |
Not clear |
| Alb Becker. [Gigantism: a mystery explained]. Bulletin et memoires de l'Academie royale de medecine de Belgique. vol 157. issue 1-2. 2002-11-07. PMID:12371275. |
some years later, it became clear that acromegaly and gigantism share the same etiology: gh hypersecretion due to a pituitary adenoma, induces gigantism if already present during puberty, or an acromegalic if it appears only during the adulthood. |
2002-11-07 |
2023-08-12 |
Not clear |
| Yuzuru Kato, Yoshio Murakami, Motoi Sohmiya, Masateru Nishik. Regulation of human growth hormone secretion and its disorders. Internal medicine (Tokyo, Japan). vol 41. issue 1. 2002-10-21. PMID:11838603. |
gh hypersecretion mostly results from a pituitary tumor and causes acromegaly or gigantism. |
2002-10-21 |
2023-08-12 |
human |
| W P Fairfield, G Sesmilo, L Katznelson, K Pulaski, P U Freda, S Stavrou, D Kleinberg, A Klibansk. Effects of a growth hormone receptor antagonist on bone markers in acromegaly. Clinical endocrinology. vol 57. issue 3. 2002-10-16. PMID:12201832. |
excess gh secretion, as occurs in acromegaly, is associated with abnormalities in bone turnover markers and bone mineral density (bmd). |
2002-10-16 |
2023-08-12 |
Not clear |