| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W P Fairfield, G Sesmilo, L Katznelson, K Pulaski, P U Freda, S Stavrou, D Kleinberg, A Klibansk. Effects of a growth hormone receptor antagonist on bone markers in acromegaly. Clinical endocrinology. vol 57. issue 3. 2002-10-16. PMID:12201832. |
in patients with acromegaly who are treated with a gh receptor antagonist, selective blockade of the gh receptor results in a decrease in circulating igf-i levels in the majority of cases. |
2002-10-16 |
2023-08-12 |
Not clear |
| W P Fairfield, G Sesmilo, L Katznelson, K Pulaski, P U Freda, S Stavrou, D Kleinberg, A Klibansk. Effects of a growth hormone receptor antagonist on bone markers in acromegaly. Clinical endocrinology. vol 57. issue 3. 2002-10-16. PMID:12201832. |
we hypothesized that, in acromegaly, antagonism of gh receptors would result in a decrease in serum markers of bone turnover, including serum procollagen i carboxy-terminal propeptide (picp), osteocalcin and n-telopeptide (ntx). |
2002-10-16 |
2023-08-12 |
Not clear |
| Kin-Chuen Leung, Chris Howe, Lily Y-Y Gui, Graham Trout, Johannes D Veldhuis, Ken K Y H. Physiological and pharmacological regulation of 20-kDa growth hormone. American journal of physiology. Endocrinology and metabolism. vol 283. issue 4. 2002-10-10. PMID:12217902. |
mean 24-h levels of 20- and 22-kda gh were higher in acromegaly and lower in gh deficiency than in normal subjects, with the 20-to-22-kda ratio not different between the three groups. |
2002-10-10 |
2023-08-12 |
human |
| A Colao, M De Rosa, R Pivonello, A Balestrieri, P Cappabianca, A Di Sarno, V Rochira, C Carani, G Lombard. Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly. The Journal of clinical endocrinology and metabolism. vol 87. issue 9. 2002-10-03. PMID:12213870. |
short-term suppression of gh and igf-i levels improves gonadal function and sperm parameters in men with acromegaly. |
2002-10-03 |
2023-08-12 |
Not clear |
| A Colao, M De Rosa, R Pivonello, A Balestrieri, P Cappabianca, A Di Sarno, V Rochira, C Carani, G Lombard. Short-term suppression of GH and IGF-I levels improves gonadal function and sperm parameters in men with acromegaly. The Journal of clinical endocrinology and metabolism. vol 87. issue 9. 2002-10-03. PMID:12213870. |
to understand the effects of short-term gh and igf-i suppression on the gonadal axis and seminal fluid characteristics in men with acromegaly, we evaluated 35 patients (age 27-59 yr) with active disease and 35 age-matched healthy controls. |
2002-10-03 |
2023-08-12 |
Not clear |
| Thomas O'Connell, David R Clemmon. IGF-I/IGF-binding protein-3 combination improves insulin resistance by GH-dependent and independent mechanisms. The Journal of clinical endocrinology and metabolism. vol 87. issue 9. 2002-10-03. PMID:12213898. |
this study was conducted to determine whether administration of a gh receptor antagonist to patients with acromegaly and insulin resistance would result in improvement in insulin sensitivity and whether igf-i had any additional insulin-sensitizing effects over and above those induced by its ability to suppress gh secretion. |
2002-10-03 |
2023-08-12 |
human |
| Thomas O'Connell, David R Clemmon. IGF-I/IGF-binding protein-3 combination improves insulin resistance by GH-dependent and independent mechanisms. The Journal of clinical endocrinology and metabolism. vol 87. issue 9. 2002-10-03. PMID:12213898. |
five patients with active acromegaly were treated for 2 wk with a gh receptor antagonist. |
2002-10-03 |
2023-08-12 |
human |
| M Gasperi, E Martino, L Manetti, M Arosio, S Porretti, G Faglia, S Mariotti, A M Colao, G Lombardi, R Baldelli, F Camanni, A Liuzz. Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study. Journal of endocrinological investigation. vol 25. issue 3. 2002-09-20. PMID:11936466. |
an italian multicenter study was performed on 258 patients with active acromegaly (high levels of igf-i and lack of suppression of serum gh levels below 2 microg/l after an ogtt). |
2002-09-20 |
2023-08-12 |
human |
| M Gasperi, E Martino, L Manetti, M Arosio, S Porretti, G Faglia, S Mariotti, A M Colao, G Lombardi, R Baldelli, F Camanni, A Liuzz. Prevalence of thyroid diseases in patients with acromegaly: results of an Italian multi-center study. Journal of endocrinological investigation. vol 25. issue 3. 2002-09-20. PMID:11936466. |
thyroid volume was correlated with the estimated duration of acromegaly (r=0.7, p<000.1), but not with age or with serum gh, igf-i and tsh concentrations. |
2002-09-20 |
2023-08-12 |
human |
| C Parkinson, A G Renehan, W D J Ryder, S T O'Dwyer, S M Shalet, P J Traine. Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly. Clinical endocrinology. vol 57. issue 1. 2002-09-10. PMID:12100070. |
gender and age influence the relationship between serum gh and igf-i in patients with acromegaly. |
2002-09-10 |
2023-08-12 |
Not clear |
| C Parkinson, A G Renehan, W D J Ryder, S T O'Dwyer, S M Shalet, P J Traine. Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly. Clinical endocrinology. vol 57. issue 1. 2002-09-10. PMID:12100070. |
in a selected cohort of patients with active acromegaly, studied off medical therapy using a single fasting serum gh and igf-i measurement, we have reported previously that, for a given gh level, women have significantly lower circulating igf-i. |
2002-09-10 |
2023-08-12 |
Not clear |
| Ana Laura Espinosa-de-los-Monteros, Moisés Mercado, Ernesto Sosa, Oscar Lizama, Gerardo Guinto, Blas Lopez-Felix, Oscar Garcia, Irma Hernández, Alfonso Ovalle, Victoria Mendoz. Changing patterns of insulin-like growth factor-I and glucose-suppressed growth hormone levels after pituitary surgery in patients with acromegaly. Journal of neurosurgery. vol 97. issue 2. 2002-09-04. PMID:12186455. |
according to a recent consensus statement on the treatment of acromegaly, its biochemical cure is defined as the normalization of age- and sex-adjusted insulin-like growth factor (igf)-i levels and the suppression of growth hormone (gh) by glucose to lower than 1 ng/ml. |
2002-09-04 |
2023-08-12 |
Not clear |
| Eleni V Dimaraki, Craig A Jaffe, Roberta DeMott-Friberg, William F Chandler, Ariel L Barka. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161471. |
acromegaly with apparently normal gh secretion: implications for diagnosis and follow-up. |
2002-08-30 |
2023-08-12 |
human |
| Eleni V Dimaraki, Craig A Jaffe, Roberta DeMott-Friberg, William F Chandler, Ariel L Barka. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161471. |
the biochemical diagnosis of acromegaly is conventionally based on elevated plasma gh levels that fail to suppress after an oral glucose load. |
2002-08-30 |
2023-08-12 |
human |
| Eleni V Dimaraki, Craig A Jaffe, Roberta DeMott-Friberg, William F Chandler, Ariel L Barka. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161471. |
we studied 16 newly diagnosed patients with acromegaly with normal mean plasma gh but elevated age and gender-adjusted plasma igf-i concentrations (476 +/- 29 microg/liter, mean +/- se). |
2002-08-30 |
2023-08-12 |
human |
| Eleni V Dimaraki, Craig A Jaffe, Roberta DeMott-Friberg, William F Chandler, Ariel L Barka. Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up. The Journal of clinical endocrinology and metabolism. vol 87. issue 8. 2002-08-30. PMID:12161471. |
revised gh criteria in combination with plasma igf-i should be used for the diagnosis and follow-up of acromegaly. |
2002-08-30 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
the principal biochemical criteria for cure in acromegaly are normalization of both glucose-suppressed gh levels and igf-i levels. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
as we have reported previously, measurement of gh by highly sensitive assay in conjunction with igf-i levels has led to a re-appraisal of "normal" gh suppression criteria during an ogtt in subjects with acromegaly. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
in some patients with active acromegaly, glucose-suppressed gh levels as measured by highly sensitive assay are much lower than could previously be appreciated with less sensitive gh assays and some other patients in apparent remission have subtle abnormalities of gh suppression. |
2002-08-12 |
2023-08-12 |
human |
| P U Freda, R E Landman, R E Sundeen, K D Pos. Gender and age in the biochemical assessment of cure of acromegaly. Pituitary. vol 4. issue 3. 2002-08-12. PMID:12138989. |
a question to arise is whether gender differences in glucose-suppressed gh levels as found by others in young healthy subjects should be considered in our interpretation of ogtt criteria for cure in acromegaly. |
2002-08-12 |
2023-08-12 |
human |