| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael Madsen, Thomas Krusenstjerna-Hafstrøm, Louise Møller, Britt Christensen, Mikkel Holm Vendelbo, Steen B Pedersen, Jan Frystyk, Niels Jessen, Troels Krarup Hansen, Hans Stødkilde-Jørgensen, Allan Flyvbjerg, Jens Otto L Jørgense. Fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a GH receptor antagonist: a randomized clinical trial. The Journal of clinical endocrinology and metabolism. vol 97. issue 4. 2012-06-11. PMID:22298804. |
fat content in liver and skeletal muscle changes in a reciprocal manner in patients with acromegaly during combination therapy with a somatostatin analog and a gh receptor antagonist: a randomized clinical trial. |
2012-06-11 |
2023-08-12 |
Not clear |
| A M Arafat, L Müller, M Möhlig, B Mayr, N Kremenevskaya, A F H Pfeiffer, M Buchfelder, C Schöf. Comparison of oral glucose tolerance test (OGTT) 100 g with OGTT 75 g for evaluation of acromegalic patients and the impact of gender on test reproducibility. Clinical endocrinology. vol 75. issue 5. 2012-05-10. PMID:21575028. |
growth hormone (gh) measurements during an oral glucose tolerance test (ogtt) are essential for the diagnosis and follow-up management of acromegaly. |
2012-05-10 |
2023-08-12 |
Not clear |
| Zenei Arihara, Kanako Sakurai, Yoshinori Osaki, Hiroshi Fukazawa, Shozo Yamada, Naoko Inoshita, Osamu Murakami, Koji Ohba, Kazuhiro Takahash. ACTH response to desmopressin in a patient with acromegaly; expression of corticotropin-releasing factor, urocortins and vasopressin V1b receptor in GH-producing pituitary adenoma. Endocrine journal. vol 58. issue 12. 2012-04-24. PMID:21908929. |
the diagnosis of acromegaly was confirmed by elevated serum gh and igf-i levels, and the absence of gh suppression by oral glucose tolerance test. |
2012-04-24 |
2023-08-12 |
Not clear |
| C N Jayasena, C Wujanto, M Donaldson, J F Todd, K Meera. Measurement of basal growth hormone (GH) is a useful test of disease activity in treated acromegalic patients. Clinical endocrinology. vol 68. issue 1. 2012-04-24. PMID:18088288. |
nadir gh during oral glucose tolerance test (ogtt) is the gold-standard test of gh secretion in treated acromegaly. |
2012-04-24 |
2023-08-12 |
Not clear |
| Izumi Fukuda, Makiko Kurimoto, Satoshi Tanaka, Yu Yamakado, Toko Muraoka, Kazue Takano, Naomi Hizuk. Effects of GH assay standardization on evaluation of treatment outcomes for acromegaly in Japan. Endocrine journal. vol 58. issue 9. 2012-04-02. PMID:21720049. |
effects of gh assay standardization on evaluation of treatment outcomes for acromegaly in japan. |
2012-04-02 |
2023-08-12 |
human |
| Izumi Fukuda, Makiko Kurimoto, Satoshi Tanaka, Yu Yamakado, Toko Muraoka, Kazue Takano, Naomi Hizuk. Effects of GH assay standardization on evaluation of treatment outcomes for acromegaly in Japan. Endocrine journal. vol 58. issue 9. 2012-04-02. PMID:21720049. |
however, the japanese criteria for evaluating treatment outcomes for acromegaly have remained the same: a nadir gh during a 75 g ogtt <1 µg/l is considered cured, 1≤gh<2.5µg/l is considered inadequately controlled, and ≥2.5 µg/l is considered poorly controlled, instead of these levels were lowered to 60%, i.e. |
2012-04-02 |
2023-08-12 |
human |
| Izumi Fukuda, Makiko Kurimoto, Satoshi Tanaka, Yu Yamakado, Toko Muraoka, Kazue Takano, Naomi Hizuk. Effects of GH assay standardization on evaluation of treatment outcomes for acromegaly in Japan. Endocrine journal. vol 58. issue 9. 2012-04-02. PMID:21720049. |
we investigated the effects of standardization of the gh assay on the evaluation of post-surgical disease activity in 50 patients with acromegaly (m/f 19/31, 21-72 yr.). |
2012-04-02 |
2023-08-12 |
human |
| Chieko Muto, Koji Chiba, Toshio Suw. Population pharmacokinetic and pharmacodynamic modeling of pegvisomant in asian and Western acromegaly patients. Journal of clinical pharmacology. vol 51. issue 12. 2012-03-25. PMID:21209237. |
pegvisomant is a growth hormone (gh) receptor antagonist that normalizes insulin-like growth factor i (igf-i) levels in patients with acromegaly. |
2012-03-25 |
2023-08-12 |
Not clear |
| J G Miquet, J F Giani, C S Martinez, M C Muñoz, L González, A I Sotelo, R K Boparai, M M Masternak, A Bartke, F P Dominici, D Tury. Prolonged exposure to GH impairs insulin signaling in the heart. Journal of molecular endocrinology. vol 47. issue 2. 2012-01-30. PMID:21727153. |
acromegaly is associated with cardiac hypertrophy, which is believed to be a direct consequence of chronically elevated gh and igf1. |
2012-01-30 |
2023-08-12 |
mouse |
| Ana Laura Espinosa-de-los-Monteros, Baldomero González, Guadalupe Vargas, Ernesto Sosa, Moisés Mercad. Clinical and biochemical characteristics of acromegalic patients with different abnormalities in glucose metabolism. Pituitary. vol 14. issue 3. 2012-01-26. PMID:21161601. |
257 patients with acromegaly were evaluated by a 75 g-oral glucose tolerance test with measurements of both gh and glucose (0, 30, 60, 90 120 min) as well as baseline igf-1. |
2012-01-26 |
2023-08-12 |
human |
| Sameera Daud, Amir H Hamrahian, Robert J Weil, Marwan Hamaty, Richard A Prayson, Leann Olansk. Acromegaly with negative pituitary MRI and no evidence of ectopic source: the role of transphenoidal pituitary exploration? Pituitary. vol 14. issue 4. 2012-01-26. PMID:19904612. |
we report a patient with acromegaly and an unremarkable pituitary mr imaging who had negative work up for ectopic growth hormone-releasing hormone (ghrh) or gh secreting tumors. |
2012-01-26 |
2023-08-12 |
Not clear |
| Sameera Daud, Amir H Hamrahian, Robert J Weil, Marwan Hamaty, Richard A Prayson, Leann Olansk. Acromegaly with negative pituitary MRI and no evidence of ectopic source: the role of transphenoidal pituitary exploration? Pituitary. vol 14. issue 4. 2012-01-26. PMID:19904612. |
the acromegaly was treated with resection of the pituitary adenoma and normalization of serum insulin-like growth factor 1 (igf-1) and gh levels. |
2012-01-26 |
2023-08-12 |
Not clear |
| Sameera Daud, Amir H Hamrahian, Robert J Weil, Marwan Hamaty, Richard A Prayson, Leann Olansk. Acromegaly with negative pituitary MRI and no evidence of ectopic source: the role of transphenoidal pituitary exploration? Pituitary. vol 14. issue 4. 2012-01-26. PMID:19904612. |
in a patient with acromegaly and unremarkable pituitary mr imaging, with no evidence of ectopic gh and ghrh production, transsphenoidal pituitary exploration is a reasonable approach and may result in clinical improvement and biochemical cure in the hand of experienced surgeon. |
2012-01-26 |
2023-08-12 |
Not clear |
| Vinni Makin, Betul Hatipoglu, Amir H Hamrahian, Andrea V Arrossi, P Daniel Knott, Joung H Lee, Burak Sad. Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. American journal of otolaryngology. vol 32. issue 5. 2012-01-19. PMID:20888068. |
patients with acromegaly usually present with characteristic clinical features or comorbidities associated with excess insulinlike growth factor 1 (igf-1)/growth hormone (gh) or may come to medical attention secondary to mass effects causing visual field distortions. |
2012-01-19 |
2023-08-12 |
Not clear |
| Vinni Makin, Betul Hatipoglu, Amir H Hamrahian, Andrea V Arrossi, P Daniel Knott, Joung H Lee, Burak Sad. Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. American journal of otolaryngology. vol 32. issue 5. 2012-01-19. PMID:20888068. |
nadir gh during oral glucose tolerance test was 5.5 ng/ml and confirmed the diagnosis of acromegaly. |
2012-01-19 |
2023-08-12 |
Not clear |
| P Caro. Acromegaly and pregnancy. Annales d'endocrinologie. vol 72. issue 4. 2012-01-03. PMID:21820101. |
in women with acromegaly due to growth hormone (gh)-secreting pituitary adenomas, the occurrence of pregnancy warrants consideration of: (1) the consequences of pregnancy on the pituitary adenoma including the tumor syndrome and gh/igf-1 secretion, (2) the consequence of gh/igf-1 hypersecretion on the pregnant woman and the fetus, (3) the consequences of pituitary surgery and medical treatment (dopamine agonists, somatostatin analogs, gh receptor antagonist) on the pregnant woman and the developing fetus. |
2012-01-03 |
2023-08-12 |
Not clear |
| Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Akira Takeshita, Hisanori Suzuki, Megumi Miyakawa, Yasuhiro Takeuch. GH deficiency in patients after cure of acromegaly by surgery alone. European journal of endocrinology. vol 165. issue 6. 2012-01-03. PMID:21964960. |
gh deficiency in patients after cure of acromegaly by surgery alone. |
2012-01-03 |
2023-08-12 |
Not clear |
| Shozo Yamada, Noriaki Fukuhara, Hiroshi Nishioka, Akira Takeshita, Hisanori Suzuki, Megumi Miyakawa, Yasuhiro Takeuch. GH deficiency in patients after cure of acromegaly by surgery alone. European journal of endocrinology. vol 165. issue 6. 2012-01-03. PMID:21964960. |
the aim of this study was to determine the frequency and characteristics of severe gh deficiency (sghd) in patients after treatment of acromegaly by surgery alone. |
2012-01-03 |
2023-08-12 |
Not clear |
| C N Jayasena, A N Comninos, H Clarke, M Donaldson, K Meeran, W S Dhill. The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly. Clinical endocrinology. vol 75. issue 2. 2011-12-27. PMID:21521288. |
acromegaly is characterized by the hypersecretion of growth hormone (gh) and insulin-like growth factor-1 (igf-1). |
2011-12-27 |
2023-08-12 |
Not clear |
| C N Jayasena, A N Comninos, H Clarke, M Donaldson, K Meeran, W S Dhill. The effects of long-term growth hormone and insulin-like growth factor-1 exposure on the development of cardiovascular, cerebrovascular and metabolic co-morbidities in treated patients with acromegaly. Clinical endocrinology. vol 75. issue 2. 2011-12-27. PMID:21521288. |
the relationship between the cumulative exposure to gh and igf-1 with co-morbidities in acromegaly has not previously been reported. |
2011-12-27 |
2023-08-12 |
Not clear |