| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leonardo D Estrada, Didem Ağaç Çobanoğlu, Aaron Wise, Robert W Maples, Murat Can Çobanoğlu, J David Farra. Adrenergic signaling controls early transcriptional programs during CD8+ T cell responses to viral infection. PloS one. vol 17. issue 8. 2022-08-09. PMID:35944008. |
norepinephrine is a key sympathetic neurotransmitter, which acts to suppress cd8 + t cell cytokine secretion and lytic activity by signaling through the β2-adrenergic receptor (adrb2). |
2022-08-09 |
2023-08-14 |
Not clear |
| Youngkyu Kim, Minju Cho, Bjorn Paulson, Sung-Hoon Kim, Jun Ki Ki. Minimizing Motion Artifacts in Intravital Microscopy Using the Sedative Effect of Dexmedetomidine. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 2022-05-23. PMID:35599594. |
as dexmedetomidine blocks the release of the neurotransmitter norepinephrine, pain is suppressed, blood pressure is reduced, and a sedation effect is observed. |
2022-05-23 |
2023-08-13 |
mouse |
| Mengying Wei, Yuanyuan Liu, Zifeng Pi, Kexin Yue, Shizhe Li, Mingxin Hu, Zhiqiang Liu, Fengrui Song, Zhongying Li. Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35. RSC advances. vol 9. issue 32. 2022-05-06. PMID:35515227. |
the neurotransmitter dysfunction was mainly involved in γ-aminobutyric acid (gaba), acetyl choline (ach), glutamic acid (glu), 5-hydroxytryptamine (5-ht), dopamine (da) and norepinephrine (ne). |
2022-05-06 |
2023-08-13 |
rat |
| Zeping Zuo, Ting Kang, Shilong Hu, Wuyue Su, Yu Gan, Zhuang Miao, Hanqing Zhao, Ping Feng, Bowen Ke, Minyong L. A Bioluminescent Probe for Detecting Norepinephrine Analytical chemistry. 2022-04-22. PMID:35452217. |
a bioluminescent probe for detecting norepinephrine as a neurotransmitter, norepinephrine (ne) is critical for psychiatric conditions, neurodegenerative diseases, and pheochromocytoma. |
2022-04-22 |
2023-08-13 |
Not clear |
| Predrag Jovanovic, Yidan Wang, Jean-Philippe Vit, Edward Novinbakht, Nancy Morones, Elliot Hogg, Michele Tagliati, Celine E Rier. Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy. PloS one. vol 17. issue 3. 2022-03-22. PMID:35316276. |
however, non-motor symptoms of parkinson's disease and post-mortem histopathology confirm dysfunction in other brain areas, including the locus coeruleus and its associated neurotransmitter norepinephrine. |
2022-03-22 |
2023-08-13 |
mouse |
| Mikhail Melnikov, Vladimir Rogovskii, Anastasiya Sviridova, Anna Lopatina, Mikhail Pashenkov, Alexey Boyk. The Dual Role of the β International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35054851. |
the dual role of the β norepinephrine is a neurotransmitter that also has an immunomodulatory effect and is involved in multiple sclerosis (ms) pathogenesis. |
2022-01-21 |
2023-08-13 |
Not clear |
| Jia-Hui Zhong, Yan-Zhi Bi, Ya-Zhuo Kong, Zhi-Jie Lu, Li H. [Central neural mechanism of increased pain sensitivity induced by nicotine abstinence]. Sheng li xue bao : [Acta physiologica Sinica]. vol 73. issue 6. 2021-12-28. PMID:34961870. |
then, we summarized the effects of the brain neurotransmitter release (e.g., serotonin, norepinephrine, endogenous opioids, dopamine, and γ-aminobutyric acid) and their corresponding receptor activation changes after nicotine abstinence on pain sensitivity. |
2021-12-28 |
2023-08-13 |
human |
| Jiani Liu, Yue Shang, Juanlan Xiao, Huirong Fan, Min Jiang, Saijun Fan, Gang Ba. Phenotype-Based HPLC-Q-TOF-MS/MS Coupled With Zebrafish Behavior Trajectory Analysis System for the Identification of the Antidepressant Components in Methanol Extract of Anshen Buxin Six Pills. Frontiers in pharmacology. vol 12. 2021-12-11. PMID:34880758. |
cos had been shown to significantly improve the depressive behavior, nerve injury and neurotransmitter levels (5-hydroxytryptamine (5-ht) and norepinephrine (ne)) of zebrafish by inhibiting the high expression of serotonin transporter and norepinephrine transporter induced by reserpine suggesting the antidepressant effect of cos may be related to its effect on 5-ht and ne pathways. |
2021-12-11 |
2023-08-13 |
zebrafish |
| Yun Ji, Wenjiao Shi, Jie Yang, Bingjie Ma, Tian Jin, Bingbing Cao, Xianguo Liu, Ke M. Effect of sympathetic sprouting on the excitability of dorsal root ganglion neurons and afferents in a rat model of neuropathic pain. Biochemical and biophysical research communications. vol 587. 2021-12-09. PMID:34864395. |
however, the mechanism of the neurotransmitter norepinephrine (ne) released by sympathetic nerve fiber endings on the excitability of drg neurons is still controversial, and the adrenergic receptor subtypes involved in this biological process are also controversial. |
2021-12-09 |
2023-08-13 |
rat |
| Xiao Xiao, Ling Yong, Bingqing Jiao, Hui Yang, Chunlai Liang, Xudong Jia, Zhaoping Liu, Yaxin Sang, Yan Son. Postweaning exposure to lanthanum alters neurological behavior during early adulthood in rats. Neurotoxicology. vol 83. 2021-11-26. PMID:33359004. |
further results showed that lanthanum treatment significantly decreased plasma neurotransmitter levels of acetylcholine and norepinephrine as well as the number of neurons in the ca1 area of the hippocampus. |
2021-11-26 |
2023-08-13 |
rat |
| Andrew M Smith, Linda P Dwoskin, James R Paul. Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences. Journal of pediatric biochemistry. vol 1. issue 2. 2021-10-21. PMID:24904708. |
the purpose of the current review is to provide an overview of the role that nicotinic achrs play in the developing cns and to describe the effects of nicotine exposure during early development on neuronal cell biology, nicotinic achr expression and neurotransmitter system (e.g., dopamine, norepinephrine, serotonin) function. |
2021-10-21 |
2023-08-13 |
Not clear |
| Soon Young Kwon, Kyung Ju Chun, Hong Kwon Kil, Narae Jung, Hyun-Ah Shin, Jeon Yeob Jang, Hyo Geun Choi, Kyoung-Ho Oh, Min-Su Ki. β2-adrenergic receptor expression and the effects of norepinephrine and propranolol on various head and neck cancer subtypes. Oncology letters. vol 22. issue 5. 2021-10-12. PMID:34630711. |
the present study aimed to investigate expression of β2-adrenergic receptor (ar), the effect of the stress-related neurotransmitter norepinephrine (ne) on cell viability, proliferation and the therapeutic effect of propranolol, which is a typical β-blocker in various type of head and neck cancers for the first time. |
2021-10-12 |
2023-08-13 |
Not clear |
| Yushu Qiu, Kan Yu, Xiaogang Yu, Xiaoping Yi, Kang Cai, Huajun Li, Shanshan Xu, Weiye Wang, Lisu Huan. Long-term low-dose oxytetracycline potentially leads to neurobehavioural changes. Ecotoxicology and environmental safety. vol 223. 2021-08-23. PMID:34330038. |
additionally, monoamine neurotransmitter (5-hydroxytryptamine, dopamine, norepinephrine) levels were decreased and gene expression of monoamine oxidase (mao) involved in neurotransmitter metabolism was upregulated at the transcription level after otc exposure. |
2021-08-23 |
2023-08-13 |
zebrafish |
| He Yu, Zhong-Mei He, Kun Shi, Yan Zhao, Ying Zong, Jian-Ming Li, Wei-Jia Chen, Rui D. [Study on antidepressant effect of total alkaloids of Fibraurea recisa]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 14. 2021-08-18. PMID:34402292. |
this study aimed to investigate the antidepressant effects of total alkaloids of fibraurea recisa in ht22 cells damaged by corticosterone (cort) in vitro and in a mouse model of chronic unpredictable mild stress (cums) as well as the underlying mechanisms.in cellular experiments,the viability of cort-damaged ht22 cells was detected using cell counting kit-8 (cck-8),and the cell apoptosis was detected by hoechst 33258 staining.in animal experiments,c57bl/6n mice were randomly divided into the control group,model group,low (100 mg·kg~(-1)),medium (200 mg·kg~(-1)) and high (400 mg·kg~(-1))-dose of total alkaloids of f.recisa groups,and positive control group.after 21 days of cums exposure,their depressive behaviors were observed in behavioral and morris water maze tests.the serum levels of 5-hydroxytryptamine (5-ht),dopamine (da),and norepinephrine (ne) were assessed by elisa.the expression levels of apoptosis-related proteins bcl-2,bax and cleaved caspase-3 in ht22 cells and mouse hippocampus were detected by western blot.the results suggested that total alkaloids of f.recisa alleviated the damage of ht22 cells induced by cort in a dose-dependent manner.the hoechst 33258 staining uncovered that total alkaloids of f.recisa better reduced the blue spots and inhibited cell apoptosis.the results of animal experiments showed that total alkaloids of f.recisa significantly improved the depression-like behaviors of mice and increased the serum levels of 5-ht,da and ne as compared with those in the model group.the western blot assays revealed a significant up-regulation of bcl-2 protein expression,but an obvious reduction in bax and cleaved caspase-3protein expression in the total alkaloids of f.recisa group.in conclusion,total alkaloids of f.recisa inhibited depression possibly by regulating the apoptosis-related protein expression or elevating the monoamine neurotransmitter levels in the brain. |
2021-08-18 |
2023-08-13 |
mouse |
| David S Goldstein, Risa Isonaka, Courtney Holmes, Yu-Shin Ding, Yehonatan Sharab. Cardiac sympathetic innervation and vesicular storage in pure autonomic failure. Annals of clinical and translational neurology. vol 7. issue 10. 2021-08-17. PMID:32945121. |
pure autonomic failure (paf) is a rare disease characterized by neurogenic orthostatic hypotension (noh), absence of signs of central neurodegeneration, and profound deficiency of the sympathetic neurotransmitter norepinephrine. |
2021-08-17 |
2023-08-13 |
Not clear |
| Yanni Wang, Tingwei Wang, Yukai Du, Dan Hu, Yu Zhang, Honghui Li, Wenyan Pe. Polygenic risk of genes involved in the catecholamine and serotonin pathways for ADHD in children. Neuroscience letters. vol 760. 2021-08-17. PMID:34174344. |
a pathway-based study was conducted in this study to test the association of gene-gene interaction and the cumulative effect of genetic polymorphisms within the dopamine, norepinephrine, and serotonin neurotransmitter pathways with adhd susceptibility. |
2021-08-17 |
2023-08-13 |
Not clear |
| Zhentao Li, Qiaoyan Li, Yuanyuan Fu, Changjun Hu, Yikun Liu, Wen Li, Zilin Che. A lipase-based chiral stationary phase for direct chiral separation in capillary electrochromatography. Talanta. vol 233. 2021-07-07. PMID:34215110. |
outstanding enantioseparation performance for three types of monoamine neurotransmitter enantiomers including epinephrine, norepinephrine and phenylephrine was obtained by the calb immobilized column. |
2021-07-07 |
2023-08-13 |
Not clear |
| K P Briski, Prabhat R Napit, Ali Md Haider, A A Alshamrani, A R Alhamyani, Khaggeswar Bheemanapally, Mostafa M H Ibrahi. Hindbrain catecholamine regulation of ventromedial hypothalamic nucleus glycogen metabolism during acute versus recurring insulin-induced hypoglycemia in male versus female rat. Endocrine and metabolic science. vol 3. 2021-07-01. PMID:33997825. |
the hindbrain metabolic-sensitive catecholamine (ca) neurotransmitter norepinephrine controls vmn glycogen phosphorylase (gp)-muscle (gpmm) and -brain (gpbb) type expression in male rats. |
2021-07-01 |
2023-08-13 |
rat |
| Paul J Fitzgerald, Pho J Hale, Anjesh Ghimire, Brendon O Watso. The cholinesterase inhibitor donepezil has antidepressant-like properties in the mouse forced swim test. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32712627. |
furthermore, the classically engaged monoaminergic neurotransmitter systems in depression treatment-serotonin, norepinephrine, and dopamine-interact directly at times with cholinergic signaling. |
2021-06-18 |
2023-08-13 |
mouse |
| Ayed A Alshamrani, Khaggeswar Bheemanapally, Mostafa M H Ibrahim, Karen P Brisk. Impact of caudal hindbrain glycogen metabolism on A2 noradrenergic neuron AMPK activation and ventromedial hypothalamic nucleus norepinephrine activity and glucoregulatory neurotransmitter marker protein expression. Neuropeptides. vol 82. 2021-06-01. PMID:32451071. |
impact of caudal hindbrain glycogen metabolism on a2 noradrenergic neuron ampk activation and ventromedial hypothalamic nucleus norepinephrine activity and glucoregulatory neurotransmitter marker protein expression. |
2021-06-01 |
2023-08-13 |
rat |