Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
D W Self, L Stei. Receptor subtypes in opioid and stimulant reward. Pharmacology & toxicology. vol 70. issue 2. 1992-09-18. PMID:1324497. |
the reward-relevant opioid and dopamine receptors, as well as the cannabinoid (marijuana) receptor, share the ability to couple gi proteins that mediate inhibition of adenylate cyclase and stimulation of k+ conductance. |
1992-09-18 |
2023-08-11 |
Not clear |
J P Chen, W Paredes, J Li, D Smith, J Lowinson, E L Gardne. Delta 9-tetrahydrocannabinol produces naloxone-blockable enhancement of presynaptic basal dopamine efflux in nucleus accumbens of conscious, freely-moving rats as measured by intracerebral microdialysis. Psychopharmacology. vol 102. issue 2. 1991-02-26. PMID:2177204. |
this study examined the effects of acute administration of delta-9-tetrahydrocannabinol (delta 9-thc), the psychoactive ingredient in marijuana, on extracellular efflux of dopamine (da) and its metabolites as measured by in vivo microdialysis in nucleus accumbens of conscious, freely-moving rats. |
1991-02-26 |
2023-08-11 |
rat |
L L Murphy, R W Steger, M S Smith, A Bartk. Effects of delta-9-tetrahydrocannabinol, cannabinol and cannabidiol, alone and in combinations, on luteinizing hormone and prolactin release and on hypothalamic neurotransmitters in the male rat. Neuroendocrinology. vol 52. issue 4. 1991-02-07. PMID:1979838. |
the acute effects of low oral doses of delta 9-tetrahydrocannabinol (thc), cannabinol (cbn) and cannabidiol (cbd) administered alone or in combinations on lh and prolactin (prl) secretion and on hypothalamic norepinephrine (ne), dopamine (da) and serotonin (5-ht) dynamics were examined in adult male rats. |
1991-02-07 |
2023-08-11 |
rat |
J M Ng Cheong Ton, G A Gerhardt, M Friedemann, A M Etgen, G M Rose, N S Sharpless, E L Gardne. The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study. Brain research. vol 451. issue 1-2. 1989-07-31. PMID:2855215. |
the effect of systemically administered delta 9-tetrahydrocannabinol (thc), the psychoactive ingredient in marijuana, on the potassium-evoked release of dopamine (da) was examined in the neostriatum of the chloral hydrate anesthetized rat. |
1989-07-31 |
2023-08-11 |
rat |
J M Ng Cheong Ton, G A Gerhardt, M Friedemann, A M Etgen, G M Rose, N S Sharpless, E L Gardne. The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study. Brain research. vol 451. issue 1-2. 1989-07-31. PMID:2855215. |
given the previous extensive evidence for an involvement of portions of the mesotelencephalic da system in mediating the reinforcing and euphorigenic properties of many classes of abused drugs, and in mediating direct electrical brain stimulation reward, we suggest that the presently demonstrated effects of thc on forebrain dopamine function may be related to marijuana's euphorigenic properties and, thus, to its abuse potential. |
1989-07-31 |
2023-08-11 |
rat |
M Markianos, A Vaki. Effects of acute cannabis use on urinary neurotransmitter metabolites and cyclic nucleotides in man. Drug and alcohol dependence. vol 14. issue 2. 1985-01-31. PMID:6210186. |
the results indicate that cannabis use interferes with catecholaminergic mechanisms in man, decreasing the noradrenaline and increasing dopamine turnover, probably through action on presynaptic receptors. |
1985-01-31 |
2023-08-12 |
human |
S T Westerman, A Golz, F S Komorowski, L M Gilber. Qualitative measurement of drugs. The Laryngoscope. vol 94. issue 2 Pt 1. 1984-03-16. PMID:6694484. |
drug specific waveforms, termed drug evoked potentials (dep), have been identified by using the eng for alcohol, marijuana, cocaine, tranquilizers, amphetamines, barbiturates, opiates, hallucinogens, caffeine, aminophylline, dopamine, several gases and approximately 75 combinations of drugs (n = 821). |
1984-03-16 |
2023-08-12 |
human |
M K Poddar, W L Dewe. Effects of cannabinoids on catecholamine uptake and release in hypothalamic and striatal synaptosomes. The Journal of pharmacology and experimental therapeutics. vol 214. issue 1. 1980-09-26. PMID:7391971. |
in vitro effects of delta 9-tetrahydrocannabinol (delta 9-thc), delta 8-tetrahydrocannabinol (delta 8-thc), cannabinol (cbn) and cannabidiol (cbd) have been studied on the uptake and release of 3h-labeled dopamine (da) and norepinephrine (ne) in the synaptosomal preparation of rat brain corpus striatum and hypothalamus. |
1980-09-26 |
2023-08-12 |
rat |
K I MacLean, J M Littleto. Environmental stress as a factor in the response of rat brain catecholamine metabolism to delta8-tetrahydrocannabinol. European journal of pharmacology. vol 41. issue 2. 1977-03-21. PMID:832673. |
it is suggested that some of the behavioural effects of cannabis administered under stressful conditions may be related to alterations in striatal dopamine metabolism. |
1977-03-21 |
2023-08-11 |
rat |