| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marcello Solinas, Maria Scherma, Liana Fattore, Jessica Stroik, Carrie Wertheim, Gianluigi Tanda, Walter Fratta, Steven R Goldber. Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 21. 2007-06-22. PMID:17522306. |
in rats, systemic administration of the selective alpha7 nicotinic acetylcholine receptor antagonist methyllycaconitine (mla), but not the selective heteromeric non-alpha7 nicotinic acetylcholine receptor antagonist dihydrobetaerythroidine, (1) antagonized the discriminative effects of delta-9-tetrahydrocannabinol (thc), the main active ingredient in cannabis, (2) reduced intravenous self-administration of the synthetic cannabinoid cb1 receptor agonist win55,212-2 [(r)-(+)-[2,3-dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone, mesylate salt], and (3) decreased thc-induced dopamine elevations in the shell of the nucleus accumbens. |
2007-06-22 |
2023-08-12 |
rat |
| Virgina M Pickel, Jane Chan, Christopher S Kearn, Kenneth Macki. Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbens. The Journal of comparative neurology. vol 495. issue 3. 2006-04-28. PMID:16440297. |
these distributions have direct relevance to the rewarding and euphoric as well as motor effects produced by marijuana and by addictive drugs enhancing dopamine levels in the acb. |
2006-04-28 |
2023-08-12 |
rat |
| Xinyu Wang, Diana Dow-Edwards, Virginia Anderson, Howard Minkoff, Yasmin L Hur. In utero marijuana exposure associated with abnormal amygdala dopamine D2 gene expression in the human fetus. Biological psychiatry. vol 56. issue 12. 2005-03-14. PMID:15601599. |
in utero marijuana exposure associated with abnormal amygdala dopamine d2 gene expression in the human fetus. |
2005-03-14 |
2023-08-12 |
human |
| Christopher D Verrico, J David Jentsch, Robert H Rot. Persistent and anatomically selective reduction in prefrontal cortical dopamine metabolism after repeated, intermittent cannabinoid administration to rats. Synapse (New York, N.Y.). vol 49. issue 1. 2003-07-17. PMID:12710016. |
thus, the cognitive dysfunction produced by heavy, long-term cannabis use may be subserved, in part, by drug-induced alterations in frontal cortical dopamine turnover. |
2003-07-17 |
2023-08-12 |
rat |
| Jean-Pol Tassi. [Role of dopamine in drug dependence processes]. Bulletin de l'Academie nationale de medecine. vol 186. issue 2. 2003-04-29. PMID:12145837. |
recent neurobiological data have indicated that almost all drugs of abuse (amphetamine, cocaine, morphine, heroin, cannabis...) increase dopamine release in a sub-cortical structure, the nucleus accumbens. |
2003-04-29 |
2023-08-12 |
Not clear |
| Stuart Brody, Ragnar Preu. Cannabis, tobacco, and caffeine use modify the blood pressure reactivity protection of ascorbic acid. Pharmacology, biochemistry, and behavior. vol 72. issue 4. 2003-01-08. PMID:12062570. |
cannabis, caffeine, and tobacco use are associated with increased mesolimbic dopamine activity. |
2003-01-08 |
2023-08-12 |
Not clear |
| L N Voruganti, P Slomka, P Zabel, A Mattar, A G Awa. Cannabis induced dopamine release: an in-vivo SPECT study. Psychiatry research. vol 107. issue 3. 2001-12-04. PMID:11566433. |
cannabis induced dopamine release: an in-vivo spect study. |
2001-12-04 |
2023-08-12 |
Not clear |
| L N Voruganti, P Slomka, P Zabel, A Mattar, A G Awa. Cannabis induced dopamine release: an in-vivo SPECT study. Psychiatry research. vol 107. issue 3. 2001-12-04. PMID:11566433. |
a comparison of the two sets of images, obtained before and immediately after smoking cannabis, indicated a 20% decrease in the striatal dopamine d2 receptor binding ratio, suggestive of increased synaptic dopaminergic activity. |
2001-12-04 |
2023-08-12 |
Not clear |
| T J De Vries, Y Shaham, J R Homberg, H Crombag, K Schuurman, J Dieben, L J Vanderschuren, A N Schoffelmee. A cannabinoid mechanism in relapse to cocaine seeking. Nature medicine. vol 7. issue 10. 2001-11-01. PMID:11590440. |
the active ingredient of marijuana, delta9-tetrahydrocannabinol, activates the mesolimbic dopamine (da) reward system and has rewarding effects in preclinical models of drug abuse. |
2001-11-01 |
2023-08-12 |
rat |
| M Fritzsch. Are cannabinoid receptor knockout mice animal models for schizophrenia? Medical hypotheses. vol 56. issue 6. 2001-08-23. PMID:11399112. |
in the temporal domain, cannabinoid receptor gene (cb1) knockout mice exhibit behavioural alterations, which parallel symptoms in schizophrenia, cannabis intoxication and dopamine d2 activation. |
2001-08-23 |
2023-08-12 |
mouse |
| D E Comings, K Blu. Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in brain research. vol 126. 2001-01-18. PMID:11105655. |
however, the same release of dopamine and production of sensations of pleasure can be produced by 'unnatural rewards' such as alcohol, cocaine, methamphetamine, heroin, nicotine, marijuana, and other drugs, and by compulsive activities such as gambling, eating, and sex, and by risk taking behaviors. |
2001-01-18 |
2023-08-12 |
human |
| F Nava, G Carta, A M Battasi, G L Gess. D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration. British journal of pharmacology. vol 130. issue 6. 2000-09-13. PMID:10903956. |
our findings suggest that impairment of working memory and inhibition of hippocampal extracellular acetylcholine concentration are mediated by the concomitant activation of d(2) dopamine and cb(1) cannabinoid receptors, and that d(2) dopamine receptor antagonists may be useful in the treatment of the cognitive deficits induced by marijuana. |
2000-09-13 |
2023-08-12 |
rat |
| X Wu, E D Frenc. Effects of chronic delta9-tetrahydrocannabinol on rat midbrain dopamine neurons: an electrophysiological assessment. Neuropharmacology. vol 39. issue 3. 2000-05-16. PMID:10698005. |
since ventral tegmental dopamine neurons play a pivotal role in drug reinforcement and reward, and possibly in the euphorigenic quality of marijuana, the present study sought to determine whether tolerance develops to the neurophysiological response elicited in these neurons by delta9-thc. |
2000-05-16 |
2023-08-12 |
rat |
| J D Jentsch, C D Verrico, D Le, R H Rot. Repeated exposure to delta 9-tetrahydrocannabinol reduces prefrontal cortical dopamine metabolism in the rat. Neuroscience letters. vol 246. issue 3. 1999-06-07. PMID:9792619. |
thus, cognitive deficits in heavy abusers of cannabis may be subserved by drug-induced alterations in frontal cortical dopamine transmission. |
1999-06-07 |
2023-08-12 |
rat |
| E Schlicker, M Göther. Interactions between the presynaptic alpha2-autoreceptor and presynaptic inhibitory heteroreceptors on noradrenergic neurones. Brain research bulletin. vol 47. issue 2. 1999-01-22. PMID:9820729. |
such interactions (which have also been obtained in human tissue) may, if not considered, prevent the identification of a putative heteroreceptor or the quantitative estimation of the effect mediated by this receptor, and they may explain drug interactions in humans in vivo; many ligands at the alpha2-autoreceptor and at the heteroreceptors may be simultaneously used for therapeutic reasons (e.g., carbachol, clonidine, dopamine, sumatriptan, mianserin, and misoprostol) or abused (e.g., heroin, lsd, and delta9-tetrahydrocannabinol in hashish or marijuana). |
1999-01-22 |
2023-08-12 |
human |
| G L Gessa, M Melis, A L Muntoni, M Dian. Cannabinoids activate mesolimbic dopamine neurons by an action on cannabinoid CB1 receptors. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489854. |
these findings support the contention that cannabinoids regulate mesolimbic dopamine transmission and may help to explain the addictive properties of marijuana. |
1998-04-29 |
2023-08-12 |
rat |
| K R Müller-Vahl, H Kolbe, R Dengle. [Gilles de la Tourette syndrome. Effect of nicotine, alcohol and marihuana on clinical symptoms]. Der Nervenarzt. vol 68. issue 12. 1998-04-01. PMID:9465342. |
we suggest that marijuana influences an assumed interaction between cannabinoid and dopamine receptors and, by this, influences the dopaminergic processes in basal ganglia and motor activity. |
1998-04-01 |
2023-08-12 |
Not clear |
| G Tanda, F E Pontieri, G Di Chiar. Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science (New York, N.Y.). vol 276. issue 5321. 1997-07-16. PMID:9197269. |
the effects of the active ingredient of cannabis, delta9-tetrahydrocannabinol (delta9-thc), and of the highly addictive drug heroin on in vivo dopamine transmission in the nucleus accumbens were compared in sprague-dawley rats by brain microdialysis. |
1997-07-16 |
2023-08-12 |
rat |
| E D French, K Dillon, X W. Cannabinoids excite dopamine neurons in the ventral tegmentum and substantia nigra. Neuroreport. vol 8. issue 3. 1997-07-03. PMID:9106740. |
these results may provide a mechanism by which psychoactive cannabinoids increase extracellular dopamine levels in mesolimbic and striatal tissues, and thereby contribute to the reinforcing effects of marijuana. |
1997-07-03 |
2023-08-12 |
Not clear |
| J Chen, R Marmur, A Pulles, W Paredes, E L Gardne. Ventral tegmental microinjection of delta 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient. Brain research. vol 621. issue 1. 1993-12-09. PMID:8221074. |
ventral tegmental microinjection of delta 9-tetrahydrocannabinol enhances ventral tegmental somatodendritic dopamine levels but not forebrain dopamine levels: evidence for local neural action by marijuana's psychoactive ingredient. |
1993-12-09 |
2023-08-12 |
rat |