| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F Thibaut, J M Vaugeois, M Peti. [The dopamine transporter: characterization and physiopathologic implications]. L'Encephale. vol 21. issue 6. 1996-08-09. PMID:8674469. |
the dat terminates the action of dopamine (da) in the synapse via reuptake and thus regulates da neurotransmission. |
1996-08-09 |
2023-08-12 |
Not clear |
| R T Malison, S E Best, E A Wallace, E McCance, M Laruelle, S S Zoghbi, R M Baldwin, J S Seibyl, P B Hoffer, L H Pric. Euphorigenic doses of cocaine reduce [123I]beta-CIT SPECT measures of dopamine transporter availability in human cocaine addicts. Psychopharmacology. vol 122. issue 4. 1996-07-30. PMID:8657833. |
the in vivo potency of euphorigenic doses of intravenous cocaine for displacing [123i]beta-cit ([123i]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane) binding to striatal dopamine transporters (dat) was assessed in human cocaine addicts using single photon emission computed tomography (spect). |
1996-07-30 |
2023-08-12 |
human |
| J M Wilson, S J Kis. The vesicular monoamine transporter, in contrast to the dopamine transporter, is not altered by chronic cocaine self-administration in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 10. 1996-06-21. PMID:8627383. |
although much evidence suggests that the brain dopamine transporter (dat) is susceptible to dopaminergic regulation, only limited information is available for the vesicular monoamine transporter (vmat2). |
1996-06-21 |
2023-08-12 |
rat |
| M Fujita, K Takatoku, Y Matoba, M Nishiura, K Kobayashi, O Inoue, T Nishimur. Differential kinetics of [123I]beta-CIT binding to dopamine and serotonin transporters. European journal of nuclear medicine. vol 23. issue 4. 1996-06-06. PMID:8612664. |
iodine-123-labelled 3beta-(4-iodophenyl)tropane-2beta-carboxylic acid ([123i]beta-cit) labels both the dopamine transporter (dat) and the serotonin transporter (5-htt) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. |
1996-06-06 |
2023-08-12 |
rat |
| N M Richtand, J R Kelsoe, D S Segal, R Kuczensk. Regional quantification of dopamine transporter mRNA in rat brain using a ribonuclease protection assay. Neuroscience letters. vol 200. issue 2. 1996-06-06. PMID:8614566. |
we describe the regional distribution of dopamine transporter (dat) mrna in selected regions of rat brain using a highly sensitive and specific nuclease protection assay. |
1996-06-06 |
2023-08-12 |
rat |
| S N Haber, H Ryoo, C Cox, W L. Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. The Journal of comparative neurology. vol 362. issue 3. 1996-03-12. PMID:8576447. |
this study examined the distribution of the mrnas for the dopamine transporter molecule (dat) and the d2 receptor in the midbrain of monkeys by using in situ hybridization. |
1996-03-12 |
2023-08-12 |
monkey |
| S N Haber, H Ryoo, C Cox, W L. Subsets of midbrain dopaminergic neurons in monkeys are distinguished by different levels of mRNA for the dopamine transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. The Journal of comparative neurology. vol 362. issue 3. 1996-03-12. PMID:8576447. |
these results show that in monkeys, the ventral tegmental area and the dorsal pars compacta form a dorsal continuum of dopamine neurons which express lower levels of mrna for dat and d2 receptor than the ventral tier. |
1996-03-12 |
2023-08-12 |
monkey |
| J L Neumeyer, G Tamagnan, S Wang, Y Gao, R A Milius, N S Kula, R J Baldessarin. N-substituted analogs of 2 beta-carbomethoxy-3 beta- (4'-iodophenyl)tropane (beta-CIT) with selective affinity to dopamine or serotonin transporters in rat forebrain. Journal of medicinal chemistry. vol 39. issue 2. 1996-02-28. PMID:8558525. |
this report concerns the synthesis and chemical characterization of novel series of n-substituted 2 beta-carbomethoxy-3 beta-(4'-iodophenyl)tropane (beta-cit, 2) analogs and their neuropharmacological evaluation for affinity at dopamine (dat), serotonin (5-htt), and norepinephrine membrane transporters in rat brain tissue. |
1996-02-28 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
these functions are initiated through the release of dopamine from axon terminals in the striatum or from dendrites in the substantia nigra (sn) and are terminated by the reuptake of dopamine by the sodium- and chloride-dependent dopamine transporter (dat). |
1996-02-22 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
dat also can transport dopamine neurotoxins and has been implicated in the selective vulnerability of nigrostriatal dopaminergic neurons in major models of parkinson's disease. |
1996-02-22 |
2023-08-12 |
rat |
| M J Nirenberg, R A Vaughan, G R Uhl, M J Kuhar, V M Picke. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 16. issue 2. 1996-02-22. PMID:8551328. |
these findings support the proposed topological model for dat and suggest that this transporter is strategically located to facilitate uptake of dopamine and neurotoxins into distal dendritic and axonal processes of nigrostriatal dopaminergic neurons. |
1996-02-22 |
2023-08-12 |
rat |
| C Freed, R Revay, R A Vaughan, E Kriek, S Grant, G R Uhl, M J Kuha. Dopamine transporter immunoreactivity in rat brain. The Journal of comparative neurology. vol 359. issue 2. 1996-01-18. PMID:7499533. |
the dopamine transporter (dat) is a primary site for the action of cocaine in inducing euphoria. |
1996-01-18 |
2023-08-12 |
rat |
| J T Kuikka, K Akerman, K A Bergström, J Karhu, J Hiltunen, J Haukka, J Heikkinen, J Tiihonen, S Wang, J L Neumeye. Iodine-123 labelled N-(2-fluoroethyl)-2 beta-carbomethoxy-3 beta-(4-iodophenyl)nortropane for dopamine transporter imaging in the living human brain. European journal of nuclear medicine. vol 22. issue 7. 1996-01-17. PMID:7498231. |
there are several cocaine analogs which have potential for imaging the dopamine transporters (dat). |
1996-01-17 |
2023-08-12 |
human |
| J Daniels, J Williams, P Asherson, P McGuffin, M Owe. No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT). American journal of medical genetics. vol 60. issue 1. 1995-12-15. PMID:7485241. |
no association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (cyp2d6) and the dopamine transporter (dat). |
1995-12-15 |
2023-08-12 |
Not clear |
| J Daniels, J Williams, P Asherson, P McGuffin, M Owe. No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT). American journal of medical genetics. vol 60. issue 1. 1995-12-15. PMID:7485241. |
the present study used the association approach to test the hypothesis that mutations in the genes for debrisoquine 4-hydroxylase (cyp2d6) and the dopamine transporter (dat) confer susceptibility to schizophrenia. |
1995-12-15 |
2023-08-12 |
Not clear |
| S J Gatley, N D Volkow, J S Fowler, S L Dewey, J Loga. Sensitivity of striatal [11C]cocaine binding to decreases in synaptic dopamine. Synapse (New York, N.Y.). vol 20. issue 2. 1995-10-26. PMID:7570343. |
we have previously shown that tracer concentrations of [11c]cocaine binding to the dopamine transporter (dat) in human and baboon striatum can be visualized using positron emission tomography (pet). |
1995-10-26 |
2023-08-12 |
human |
| K Y Little, F I Carroll, B J Cassi. Characterization and localization of [125I]RTI-121 binding sites in human striatum and medial temporal lobe. The Journal of pharmacology and experimental therapeutics. vol 274. issue 3. 1995-10-25. PMID:7562524. |
dopamine transporter (dat) binding sites in medial temporal lobe structures are much less dense than in striatum and have been difficult to image and quantitate. |
1995-10-25 |
2023-08-12 |
human |
| G J Wang, N D Volkow, J S Fowler, Y S Ding, J Logan, S J Gatley, R R MacGregor, A P Wol. Comparison of two pet radioligands for imaging extrastriatal dopamine transporters in human brain. Life sciences. vol 57. issue 14. 1995-10-23. PMID:7564877. |
we compared the sensitivity of two dopamine transporter (dat) ligands ([c-11]cocaine and [c-11]d-threo-methylphenidate) for measurement of extrastriatal dat availability using positron emission tomography (pet) on separated groups of 10 age matched male volunteers (age range, 21-49 years). |
1995-10-23 |
2023-08-12 |
human |
| D M Donovan, D J Vandenbergh, M P Perry, G S Bird, R Ingersoll, E Nanthakumar, G R Uh. Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. Brain research. Molecular brain research. vol 30. issue 2. 1995-09-13. PMID:7637582. |
synaptic reaccumulation of the neurotransmitter dopamine is mediated by the dopamine transporter (dat), a member of the family of twelve transmembrane domain, sodium- and chloride-dependent neurotransmitter transporters. |
1995-09-13 |
2023-08-12 |
mouse |
| T Himi, M Cao, N Mor. Reduced expression of the molecular markers of dopaminergic neuronal atrophy in the aging rat brain. The journals of gerontology. Series A, Biological sciences and medical sciences. vol 50. issue 4. 1995-08-18. PMID:7614230. |
expression of mrnas encoding the dopamine transporter (dat) and tyrosine hydroxylase (th) in dopaminergic neurons of the substantia nigra (sn) was examined in young and aged fischer 344 rats by in situ hybridization. |
1995-08-18 |
2023-08-12 |
rat |