| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Jaber, B Bloch, M G Caron, B Giro. [Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 192. issue 6. 1999-05-03. PMID:10101608. |
mice lacking the the plasma membrane dopamine transporter (dat), following gene inactivation or knock out, show an increase in their spontaneous locomotor activity that is of the same magnitude than in normal mice treated with amphetamine or cocaine, known to increase levels of dopamine in the basal ganglia. |
1999-05-03 |
2023-08-12 |
mouse |
| N R Zahniser, G A Larson, G A Gerhard. In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087014. |
dopamine transporter (dat) inhibitors are expected to decrease dopamine (da) clearance from the extracellular space of the brain. |
1999-04-21 |
2023-08-12 |
rat |
| J K Weatherspoon, L L Werlin. Modulation of amphetamine-stimulated [3H]dopamine release from rat pheochromocytoma (PC12) cells by sigma type 2 receptors. The Journal of pharmacology and experimental therapeutics. vol 289. issue 1. 1999-04-21. PMID:10087015. |
an important regulatory mechanism of synaptic dopamine (da) levels is activation of the dopamine transporter (dat), which is a target for many drugs of abuse, including amphetamine (amph). |
1999-04-21 |
2023-08-12 |
rat |
| G W Miller, J D Erickson, J T Perez, S N Penland, D C Mash, D B Rye, A I Leve. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192785. |
the distribution of vmat2 in striatum and its loss in pd paralleled that of the dopamine transporter (dat), a phenotypic marker of dopamine neurons. |
1999-04-21 |
2023-08-12 |
human |
| G W Miller, J D Erickson, J T Perez, S N Penland, D C Mash, D B Rye, A I Leve. Immunochemical analysis of vesicular monoamine transporter (VMAT2) protein in Parkinson's disease. Experimental neurology. vol 156. issue 1. 1999-04-21. PMID:10192785. |
furthermore, the relative expression of vmat2 compared to that of dat may predict the differential vulnerability of dopamine neurons in pd. |
1999-04-21 |
2023-08-12 |
human |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
the plasma membrane dopamine transporter (dat) is responsible for clearing dopamine from the synapse. |
1999-04-20 |
2023-08-12 |
mouse |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
cocaine blockade of dat leads to increased extracellular dopamine, an effect widely considered to be the primary cause of the reinforcing and addictive properties of cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| B A Rocha, F Fumagalli, R R Gainetdinov, S R Jones, R Ator, B Giros, G W Miller, M G Caro. Cocaine self-administration in dopamine-transporter knockout mice. Nature neuroscience. vol 1. issue 2. 1999-04-20. PMID:10195128. |
in the absence of dat, these mice exhibit high levels of extracellular dopamine, but paradoxically still self-administer cocaine. |
1999-04-20 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
mpp+, which is the oxidation product of mptp, is actively transported into presynaptic dopaminergic nerve terminals through the plasma membrane dopamine transporter (dat). |
1999-04-07 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
thus dopamine cell loss is related to levels of the dat. |
1999-04-07 |
2023-08-12 |
mouse |
| E Bezard, C E Gross, M C Fournier, S Dovero, B Bloch, M Jabe. Absence of MPTP-induced neuronal death in mice lacking the dopamine transporter. Experimental neurology. vol 155. issue 2. 1999-04-07. PMID:10072302. |
these results shed light on the degenerative process of dopamine neurons and suggest that individual differences in developing parkinson's disease in human may be related to differences of uptake through the dat of a yet unidentified neurotoxin. |
1999-04-07 |
2023-08-12 |
mouse |
| M A Hebert, G A Larson, N R Zahniser, G A Gerhard. Age-related reductions in [3H]WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat. The Journal of pharmacology and experimental therapeutics. vol 288. issue 3. 1999-04-01. PMID:10027875. |
in the present study, we used the potent cocaine analog [3h]win 35, 428 to map and quantify binding to the dopamine transporter (dat) within the dorsal striatum, nucleus accumbens, substantia nigra, and ventral tegmental area in young (6-month-old), middle-aged (12-month-old), and aged (18- and 24-month-old) fischer 344 rats. |
1999-04-01 |
2023-08-12 |
rat |
| N H Chen, J H Ding, Y L Wan. Characterization of [125I]RTI-121 binding to dopamine transporter in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica. vol 18. issue 2. 1999-03-25. PMID:10072960. |
to characterize the binding of [125i]3 beta-(4-iodophenyl) tropane-2 beta-carboxylic acid isopropyl ester (rti-121) to the dopamine transporter (dat) under physiologically relevant conditions. |
1999-03-25 |
2023-08-12 |
Not clear |
| H K Wayment, H Deutsch, M M Schweri, J O Schen. Effects of methylphenidate analogues on phenethylamine substrates for the striatal dopamine transporter: potential as amphetamine antagonists? Journal of neurochemistry. vol 72. issue 3. 1999-03-18. PMID:10037500. |
methylphenidate (mpd) was found to inhibit competitively the striatal dopamine transporter (dat) and bind at sites on the dat in common with both cocaine (a non-substrate site ligand) and amphetamine (a substrate site ligand). |
1999-03-18 |
2023-08-12 |
Not clear |
| M Batchelor, J O Schen. Protein kinase A activity may kinetically upregulate the striatal transporter for dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 24. 1999-02-25. PMID:9852568. |
the neuronal dopamine transporter (dat) plays a key role in terminating dopaminergic chemical neurotransmission; thus, the study of the regulation of dat activity is important in defining parameters relevant to the control of dopaminergic neurotransmission. |
1999-02-25 |
2023-08-12 |
Not clear |
| N D Volkow, G J Wang, J S Fowler, S J Gatley, J Logan, Y S Ding, S L Dewey, R Hitzemann, A N Gifford, N R Pappa. Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of "high". The Journal of pharmacology and experimental therapeutics. vol 288. issue 1. 1999-02-05. PMID:9862747. |
the reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (dat). |
1999-02-05 |
2023-08-12 |
human |
| R R Gainetdinov, W C Wetsel, S R Jones, E D Levin, M Jaber, M G Caro. Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity. Science (New York, N.Y.). vol 283. issue 5400. 1999-01-28. PMID:9888856. |
mice lacking the gene encoding the plasma membrane dopamine transporter (dat) have elevated dopaminergic tone and are hyperactive. |
1999-01-28 |
2023-08-12 |
mouse |
| S D Dickinson, J Sabeti, G A Larson, K Giardina, M Rubinstein, M A Kelly, D K Grandy, M J Low, G A Gerhardt, N R Zahnise. Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum. Journal of neurochemistry. vol 72. issue 1. 1999-01-21. PMID:9886065. |
presynaptic d2 dopamine (da) autoreceptors, which are well known to modulate da release, have recently been shown to regulate da transporter (dat) activity. |
1999-01-21 |
2023-08-12 |
mouse |
| C Mitsuhata, S Kitayama, K Morita, D Vandenbergh, G R Uhl, T Doh. Tyrosine-533 of rat dopamine transporter: involvement in interactions with 1-methyl-4-phenylpyridinium and cocaine. Brain research. Molecular brain research. vol 56. issue 1-2. 1999-01-14. PMID:9602072. |
to improve our understanding of structure-function relationships for neurotransmitter transporters, we performed site-directed mutagenesis of the rat dopamine transporter (dat) and assessed the functions of the mutants in transiently-expressing cos cells. |
1999-01-14 |
2023-08-12 |
human |
| M P Martres, B Demeneix, N Hanoun, M Hamon, B Giro. Up- and down-expression of the dopamine transporter by plasmid DNA transfer in the rat brain. The European journal of neuroscience. vol 10. issue 12. 1999-01-14. PMID:9875340. |
the functional role of the dopamine transporter (dat) in central dopaminergic neurotransmission was assessed further by investigating the consequences on dopamine (da) turn-over of up- and down-regulation of this protein induced by a non-viral gene transfer approach. |
1999-01-14 |
2023-08-12 |
rat |