| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clara Nautrup Pedersen, Fuyu Yang, Samantha Ita, Yibin Xu, Ravikumar Akunuri, Sofia Trampari, Caroline Marie Teresa Neumann, Lasse Messell Desdorf, Birgit Schiøtt, Joseph M Salvino, Ole Valente Mortensen, Poul Nissen, Azadeh Shahsava. Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. Journal of neurochemistry. 2024-07-16. PMID:39010681. |
the regulation of dopamine (da) removal from the synaptic cleft is a crucial process in neurotransmission and is facilitated by the sodium- and chloride-coupled dopamine transporter dat. |
2024-07-16 |
2024-07-18 |
drosophila_melanogaster |
| Miguel Ribeiro, Jonas Campos, Tiffany S Pinho, Belém Sampaio-Marques, Sandra Barata-Antunes, Jorge Ribeiro Cibrão, Ricardo Araújo, Sara Duarte-Silva, Elsa Moreira, Rui A Sousa, Pedro M Costa, António J Salgad. Human platelet lysate supports SH-SY5Y neuroblastoma cell proliferation and differentiation into a dopaminergic-like neuronal phenotype under xenogeneic-free culture conditions. Biotechnology journal. vol 19. issue 7. 2024-07-10. PMID:38987218. |
furthermore, following treatment with retinoic acid (ra) and further stimulation with brain-derived neurotrophic factor (bdnf) and nerve growth factor beta (ngf-β), the percentage of sh-sy5y cells stained positive for dopaminergic neuronal differentiation markers (tyrosine hydroxylase [th] and dopamine transporter [dat]) was higher in hpl or fd-hpl than in fbs, and gene expression of dopaminergic markers th, dat, and dr2 was also detected. |
2024-07-10 |
2024-07-13 |
human |
| Takahide Wada, Keizo Sugaya, Yuri Asano, Yasuhiro Nakata, Rie Naito, Tomoya Kawazoe, Yuji Saitoh, Kota Bokuda, Shinsuke Tobisawa, Toshio Shimizu, Kazushi Takahash. Association of dysphagia severity in multiple system atrophy with the specific binding ratio on dopamine transporter SPECT. Journal of the neurological sciences. vol 463. 2024-07-09. PMID:38981418. |
the present study investigated the relationship between dysphagia severity in msa and the specific binding ratio (sbr) on dopamine transporter (dat) spect using the hyodo score, a qualitative scale for use with fiberoptic endoscopic evaluation of swallowing (fees). |
2024-07-09 |
2024-07-12 |
Not clear |
| Arnav Paul, Diwakar Shukl. Oligomerization of Monoamine Transporters. Sub-cellular biochemistry. vol 104. 2024-07-04. PMID:38963486. |
the mat family functions using the electrochemical gradient of ions across the membrane and comprises three transporters, dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2024-07-04 |
2024-07-10 |
Not clear |
| Ganesh Ambigapathy, Talus J McCowan, Lucia Carvell. Amphetamine exposure during embryogenesis changes expression and function of the dopamine transporter in Caenorhabditis elegans offspring. Journal of neurochemistry. 2024-07-03. PMID:38960397. |
the dopamine transporter (dat) is a transmembrane protein that regulates dopamine (da) neurotransmission by binding to and moving da from the synaptic cleft back into the neurons. |
2024-07-03 |
2024-07-10 |
caenorhabditis_elegans |
| Adrian L Asendorf, Hendrik Theis, Marc Tittgemeyer, Lars Timmermann, Gereon R Fink, Alexander Drzezga, Carsten Eggers, Marina C Ruppert-Junck, David J Pedrosa, Merle C Hoenig, Thilo van Eimere. Dynamic properties in functional connectivity changes and striatal dopamine deficiency in Parkinson's disease. Human brain mapping. vol 45. issue 10. 2024-07-03. PMID:38958131. |
from the parkinson's progression marker initiative (ppmi) cohort, resting-state functional magnetic resonance imaging (rsfmri) and dopamine transporter (dat) single-photon emission computed tomography (spect) were available for 63 pd patients and 16 age- and sex-matched healthy controls. |
2024-07-03 |
2024-07-06 |
human |
| Francis Fezeu, Omar F Jbara, Ahda Jbarah, Anis Choucha, Lucio De Maria, Elena Ciaglia, Matteo De Simone, Samuel Samnic. PET imaging for a very early detection of rapid eye movement sleep behaviour disorder and Parkinson's disease - A model-based cost-effectiveness analysis. Clinical neurology and neurosurgery. vol 243. 2024-06-29. PMID:38944021. |
on the other hand, pd triggers neurological variations that affect differences in the dopamine transporter (dat) and in glucose metabolism. |
2024-06-29 |
2024-07-02 |
Not clear |
| Heisuke Mizukami, Makoto Shiraishi, Sakae Hino, Mayumi Kaburagi, Hirofumi Matsumoto, Yuta Hagiwara, Yoshihisa Yaman. Utility of Combining Transcranial Sonography and MIBG Myocardial Scintigraphy to Evaluate Substantia Nigra in Patients with Parkinson's Disease. Brain sciences. vol 14. issue 6. 2024-06-27. PMID:38928525. |
we investigated iodine-123 metaiodobenzylguanidine (mibg) and tcs during the examination and diagnosis of high-signal-intensity substantia nigra lesion (hsi-snl) incidence in pd patients previously diagnosed with dopamine transporter scintigraphy (dat). |
2024-06-27 |
2024-06-29 |
human |
| Shuntaro Itagaki, Takashi Ohnishi, Wataru Toda, Aya Sato, Junya Matsumoto, Hiroshi Ito, Shiro Ishii, Ryo Yamakuni, Itaru Miura, Hirooki Yab. Reduced dopamine transporter availability in drug-naive adult attention-deficit/hyperactivity disorder. PCN reports : psychiatry and clinical neurosciences. vol 3. issue 1. 2024-06-13. PMID:38868484. |
this study aimed to clarify the abnormalities in dopamine transporter (dat) availability in drug-naive adult patients with attention-deficit/hyperactivity disorder (adhd) and the relationship between adhd symptoms and abnormalities in dat availability. |
2024-06-13 |
2024-06-15 |
Not clear |
| David Eidelberg, Chris Tang, Yoshikazu Nakano, An Vo, Nha Nguyen, Katharina Schindlbeck, Kathleen Poston, Jean-François Gagnon, Ronald Postuma, Martin Niethammer, Yilong Ma, Shichun Peng, Vijay Dhawa. Longitudinal Network Changes and Phenoconversion Risk in Isolated REM Sleep Behavior Disorder. Research square. 2024-06-10. PMID:38853923. |
expression levels for the pd-related motor and cognitive networks (pdrp and pdcp) were measured at baseline, 2 and 4 years, along with dopamine transporter (dat) binding. |
2024-06-10 |
2024-06-14 |
Not clear |
| Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Baha. Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments. Current research in physiology. vol 7. 2024-06-05. PMID:38836245. |
we present here a comparative study of the structural dynamics and ligand-binding properties of two mats, dopamine transporter (dat) and serotonin transporter (sert), with focus on the allosteric modulation of their transport function by drugs or substrates that consistently bind a secondary site s2, proposed to serve as an allosteric site. |
2024-06-05 |
2024-06-07 |
human |
| Haotang Zhao, Honghao Qian, Jianwei Cui, Zhili Ge, Jingjing Shi, Yingchao Huo, Yuezhu Zhang, Lin Y. Endocrine toxicity of atrazine and its underlying mechanisms. Toxicology. vol 505. 2024-05-31. PMID:38815618. |
the toxic effects of atr on the endocrine system and its underlying molecular mechanisms are summarized as follows: influencing the expression of kisspeptin in the hpg axis, consequently affecting steroid synthesis; disrupting dna synthesis and meiosis, as well as modifying dna methylation levels, leading to reproductive and developmental toxicity; impacting dopamine by altering nurr1, vmat2, and dat expression, consequently affecting dopamine synthesis and transporter expression, and influencing other neurotransmitters, resulting in neurotoxicity; and changing adipose tissue synthesis and metabolism by reducing basal metabolism, impairing cellular oxidative phosphorylation, and inducing insulin resistance. |
2024-05-31 |
2024-06-02 |
human |
| Simone Larsen Bærentzen, Jakob Borup Thomsen, Majken Borup Thomsen, Steen Jakobsen, Mette Theilgaard Simonsen, Gregers Wegener, David J Brooks, Anne M Landa. Subanesthetic S-ketamine does not acutely alter striatal dopamine transporter binding in healthy Sprague Dawley female rats. Synapse (New York, N.Y.). vol 78. issue 4. 2024-05-30. PMID:38813759. |
depressed human subjects have lower striatal dopamine transporter (dat) availability compared to healthy controls. |
2024-05-30 |
2024-06-08 |
human |
| Shu Yuan, Si-Cong Jiang, Zhong-Wei Zhang, Zi-Lin Li, Jing H. Substance Addiction Rehabilitation Drugs. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794185. |
both the dopamine transporter (dat) hypothesis and d3 dopamine receptor (d3r) hypothesis are proposed. |
2024-05-25 |
2024-05-27 |
Not clear |
| Shu Yuan, Si-Cong Jiang, Zhong-Wei Zhang, Zi-Lin Li, Jing H. Substance Addiction Rehabilitation Drugs. Pharmaceuticals (Basel, Switzerland). vol 17. issue 5. 2024-05-25. PMID:38794185. |
dat activators reduce the extracellular dopamine level, and d3r antagonists reduce the neuron's sensitivity to dopamine, both of which may exacerbate the withdrawal symptoms subsequently. |
2024-05-25 |
2024-05-27 |
Not clear |
| Adithya Gopinath, Adolfo Ramirez-Zamora, Stephen Franks, Tabish Riaz, Aidan Smith, Glen Dizon, Lauryn Hornstein, Jordan Follett, Camille Swartz, Jonathan Bravo, E Lee Kugelmann, Matthew Farrer, Michael S Okun, Habibeh Khoshboue. Immunophenotyping Tracks Motor Progression in Parkinson's Disease Associated with a TH Mutation. Journal of Parkinson's disease. 2024-05-24. PMID:38788089. |
our previous research indicated that pd patients with increased dopamine transporter (dat) and tyrosine hydroxylase (th) in peripheral blood mononuclear cells (pbmcs) might show disease progression and respond to levodopa treatment. |
2024-05-24 |
2024-05-27 |
Not clear |
| Fares J P Sayegh, Lionel Mouledous, Catherine Macri, Juliana Pi Macedo, Camille Lejards, Claire Rampon, Laure Verret, Lionel Daha. Ventral tegmental area dopamine projections to the hippocampus trigger long-term potentiation and contextual learning. Nature communications. vol 15. issue 1. 2024-05-21. PMID:38773091. |
here, we used optogenetic manipulation of midbrain dopamine neurons in male dat::cre mice, and discovered that stimulating the schaffer collaterals - the glutamatergic axons connecting ca3 and ca1 regions - of the dorsal hippocampus concomitantly with midbrain dopamine terminals within a 200 millisecond time-window triggers ltp at glutamatergic synapses. |
2024-05-21 |
2024-05-27 |
mouse |
| Francesco Di Carlo, Mauro Pettorruso, Mario Santorelli, Fabrizio Cocciolillo, Giacomo d'Andrea, Marco Di Nicola, Stefano S Sensi, Giovanni Martinotti, Jon E Grant, Giovanni Camardese, Daniela Di Giud. Linking Striatal Dopaminergic Asymmetry with Personality Traits: Insights from Gambling Disorder. Journal of gambling studies. 2024-05-16. PMID:38755422. |
the aim of this study was to investigate potential correlations between striatal dopamine transporter (dat) lateralization and asymmetry index, as assessed by |
2024-05-16 |
2024-05-27 |
Not clear |
| Haylee R Hammond, Shainnel O Eans, Thomas J Cirino, Subramaniam Ananthan, Ana Catya Jimenez-Torres, Jun Zhu, Jay P McLaughli. SRI-30827, a novel allosteric modulator of the dopamine transporter, alleviates HIV-1 Tat-induced potentiation of cocaine conditioned place preference in mice. NeuroImmune pharmacology and therapeutics. vol 3. issue 1. 2024-05-08. PMID:38711842. |
allosteric modulators of the dopamine transporter (dat) have been shown to reverse tat-induced dat dysfunction. |
2024-05-08 |
2024-05-27 |
mouse |
| Mélodie Ferrat, Mohammad M Moein, Carmen Cananau, Tetyana Tegnebratt, Paul Saliba, Fredrik Norman, Carsten Steiger, Klas Bratteby, Erik Samén, Kenneth Dahl, Thuy A Tra. GMP production of [ EJNMMI radiopharmacy and chemistry. vol 9. issue 1. 2024-05-02. PMID:38696063. |
dopamine transporter (dat) positron emission tomography (pet) imaging has emerged as a powerful and non-invasive method to quantify dopaminergic function in the living brain. |
2024-05-02 |
2024-05-04 |
Not clear |