| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Asmaa M ShamsEldeen, Bahjat Al-Ani, Hasnaa A Ebrahim, Laila Rashed, Amul M Badr, Abeer Attia, Ayman M Farag, Samaa S Kamar, Mohamed A Haidara, Suliman Al Humayed, Mohammed Ali Eshr. Resveratrol suppresses cholestasis-induced liver injury and fibrosis in rats associated with the inhibition of TGFβ1-Smad3-miR21 axis and profibrogenic and hepatic injury biomarkers. Clinical and experimental pharmacology & physiology. vol 48. issue 10. 2021-09-30. PMID:34157155. |
in addition, rsv significantly (p ≤ 0.0027) inhibited bdl-induced hepatic tgfβ1, smad3, mir21, the profibrogenic biomarker tissue inhibitor of metalloproteinases-1 (timp-1), malondialdehyde (mda), interleukin-17a (il-17a), and blood levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), and bilirubin. |
2021-09-30 |
2023-08-13 |
rat |
| Chang Liu, Jing-Xin Ding, Ying Zhou, Zhi-Gang Yin, Hong-Tao Luo, Wei-Tao Kon. [Protective effects of Lonicerae Japonicae Flos against acute alcoholic liver injury in rats based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 17. 2021-09-29. PMID:34581059. |
the levels of aspartate transaminase(ast), alanine transaminase(alt), interleukin-6(il6) and tumor necrosis factor-α(tnf-α) in serum and malondialdehyde(mda), glutathione(gsh), superoxide dismutase(sod) and glutathione peroxidase(gsh-px) in liver tissue of rats in each group were detected. |
2021-09-29 |
2023-08-13 |
rat |
| Yang Guo, Chunhui Hu, Bintong Xia, Xianwen Zhou, Sihan Luo, Ruijia Gan, Peng Duan, Yan Ta. Iodine excess induces hepatic, renal and pancreatic injury in female mice as determined by attenuated total reflection Fourier-transform infrared spectrometry. Journal of applied toxicology : JAT. 2021-09-29. PMID:34585417. |
our research showed that serum alanine aminotransferase (alt), aspartate aminotransferase (ast), blood urea nitrogen (bun), serum creatinine (scr), insulin, blood glucose levels and homeostasis model assessment for insulin resistance (homa-ir) index in the 1200 and 2400 μg/l iodine-treated groups were significantly increased compared with those in the control group. |
2021-09-29 |
2023-08-13 |
mouse |
| Karim Naraki, Ramin Rezaee, Gholamreza Karim. A review on the protective effects of naringenin against natural and chemical toxic agents. Phytotherapy research : PTR. vol 35. issue 8. 2021-09-28. PMID:33724584. |
nrg has shown strong anti-inflammatory and antioxidant activities in body organs via mechanisms such as enhancement of glutathione s-transferase (gst), superoxide dismutase (sod), glutathione peroxidase (gsh-px), and catalase (cat) activity, but reduction of serum levels of alanine aminotransferase (alt), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and malondialdehyde (mda). |
2021-09-28 |
2023-08-13 |
cat |
| Gang Tang, Linyu Zhang, Jie Tao, Zhengqiang We. Effect of Nigella sativa in the treatment of nonalcoholic fatty liver disease: A systematic review and meta-analysis of randomized controlled trials. Phytotherapy research : PTR. vol 35. issue 8. 2021-09-28. PMID:33728708. |
although ns has no beneficial effect on the levels of total cholesterol (tc) and low-density lipoprotein cholesterol (ldl), triglyceride (tg), insulin, and tumor necrosis factor α (tnf-α), its supplementation did improve the levels of alanine transaminase (alt), aspartate transaminase (ast), fasting blood sugar (fbs), high-density lipoprotein cholesterol (hdl), high-sensitivity c reactive protein (hs-crp), and grade of fatty liver compared with placebo. |
2021-09-28 |
2023-08-13 |
human |
| Yuting Huang, Robert L Kruse, Hui Ding, Mohamad I Itani, Jonathan Morrison, Zack Z Wang, Florin M Selaru, Vivek Kumbhar. Parameters of biliary hydrodynamic injection during endoscopic retrograde cholangio-pancreatography in pigs for applications in gene delivery. PloS one. vol 16. issue 4. 2021-09-28. PMID:33909609. |
pigs tolerated repeated biliary hydrodynamic injections with only occasional, mild, isolated elevation in aspartate aminotransferase (ast), which returned to normal levels within one day post-injection. |
2021-09-28 |
2023-08-13 |
mouse |
| Elena Aloisio, Giulia Colombo, Claudia Arrigo, Alberto Dolci, Mauro Panteghin. Sources and clinical significance of aspartate aminotransferase increases in COVID-19. Clinica chimica acta; international journal of clinical chemistry. vol 522. 2021-09-28. PMID:34411557. |
aspartate aminotransferase (ast) is often increased in covid-19 and, in some studies, ast abnormalities were associated with mortality risk. |
2021-09-28 |
2023-08-13 |
Not clear |
| Dan Zhou, Feng Yang, Ling Lin, Li Tang, Longjiang Li, Yongqiang Yang, Dingrong Liu, Chong Zhang, Tong Wu, Huijie Wei, Xiaoming Zhang, Li Zhan. The sirtuin 1 activator SRT1720 alleviated endotoxin-induced fulminant hepatitis in mice. Experimental animals. vol 70. issue 3. 2021-09-27. PMID:33678756. |
the results indicated that treatment with srt1720 inhibited lps/d-gal-induced elevation of alanine aminotransferase (alt) and aspartate aminotransferase (ast), alleviated the histological abnormalities, suppressed the induction of tumor necrosis factor alpha (tnf-α) and il-6, mitigated the phosphorylation of c-jun n-terminal kinase (jnk), downregulated the activities of caspase 8, caspase 9 and caspase 3, decreased the level of cleaved caspase 3, reduced the tunel-positive cells, and improved the survival rate of the lps/d-gal-exposed mice. |
2021-09-27 |
2023-08-13 |
mouse |
| Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang, Jianghua Zhon. The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction. Bioengineered. vol 12. issue 1. 2021-09-27. PMID:34506248. |
also, its treatment proved effective as it reduced the levels of several myocardial injury indicators, including creatine kinase-mb (ck-mb), aspartate aminotransferase (ast), lactate dehydrogenase (ldh), and both the cardiac and plasma levels of tnf-α and il-6, highlighting its effect on the stz-induced myocardial injury. |
2021-09-27 |
2023-08-13 |
mouse |
| Pradeep K Ram, Shanker K Singh, Vikrant Suda. The phenotypic and haemato-biochemical appraisal of tropical theileriosis in newborn calves. Tropical animal health and production. vol 53. issue 5. 2021-09-27. PMID:34557986. |
significantly (p ≤ 0.001) elevated activities of serum aspartate aminotransferase (ast), alanine aminotransferase (alt) and lactate dehydrogenase (ldh) enzymes were observed in diseased calves. |
2021-09-27 |
2023-08-13 |
Not clear |
| Doaa El Amrousy, Dina Abdelhai, Dina Shawk. Vitamin D and nonalcoholic fatty liver disease in children: a randomized controlled clinical trial. European journal of pediatrics. 2021-09-25. PMID:34459959. |
anthropometric measurements, vitamin d levels, aspartate aminotransferase (ast), alanine aminotransferase (alt), total cholesterol (tc), serum triglyceride (tg), low-density lipoprotein (ldl), high-density lipoprotein (hdl), fasting blood glucose (fbg), fasting blood insulin level (fbi), homeostasis model assessment of insulin resistance (homa-ir), and serum calcium level were measured at the beginning and the end of the study. |
2021-09-25 |
2023-08-13 |
Not clear |
| Peng Wang, Xiaoxia Gao, Meili Liang, Yuan Fang, Jinping Jia, Junsheng Tian, Zhenyu Li, Xuemei Qi. Dose-Effect/Toxicity of Bupleuri Radix on Chronic Unpredictable Mild Stress and Normal Rats Based on Liver Metabolomics. Frontiers in pharmacology. vol 12. 2021-09-25. PMID:34557088. |
in cums rats, pbr improved the depression-like behaviors including reduced body growth rate, anhedonia, and locomotor activities, and markedly reduced the contents of alanine aminotransferase (alt) and aspartate aminotransferase (ast). |
2021-09-25 |
2023-08-13 |
rat |
| Haijun Niu, Rongyan Jiang, Songwu Dong, Linhu Xia, Hongyi Fan. Research on Association between Levels of Serum Adiponectin, Hs-CRP, and sICAM-1 and Hypertensive Cerebrovascular Complications. BioMed research international. vol 2021. 2021-09-25. PMID:34557545. |
the content of aspartate aminotransferase (ast), alanine aminotransferase (alt), blood urea nitrogen (bun), and serum creatinine (scr) in the experimental group was significantly higher than that in control group ( |
2021-09-25 |
2023-08-13 |
Not clear |
| H A Abdel Maksoud, Omayma A R Abou Zaid, Mohamed G Elharrif, M A Omnia, E A Ala. Selenium cleome droserifolia nanoparticles (Se-CNPs) and it's ameliorative effects in experimentally induced diabetes mellitus. Clinical nutrition ESPEN. vol 40. 2021-09-24. PMID:33183567. |
glucose and insulin levels, alanine aminotransferase (alt) and aspartate aminotransferase (ast), total cholesterol (tc), triacylglycerols (tg), high density lipoprotein (hdl-c), very low density lipoprotein cholesterol (vldl-c), low density lipoprotein cholesterol (ldl-c) and (nefas), urea and creatinine were evaluated. |
2021-09-24 |
2023-08-13 |
rat |
| Shengjie Fan, Haiyan Zhang, Yahui Wang, Yuanyuan Zhao, Lingling Luo, Hongrun Wang, Gen Chen, Lianjun Xing, Peiyong Zheng, Cheng Huan. LXRα/β Antagonism Protects against Lipid Accumulation in the Liver but Increases Plasma Cholesterol in Chemical research in toxicology. vol 34. issue 3. 2021-09-24. PMID:33647205. |
the compounds did not alter plasma glucose, apolipoprotein a (apoa), apob, apoe, lipoprotein (a) (lpa), nonesterified fatty acid (nefa), aspartate transaminases (ast), creatinine (crea), urea nitrogen (un), and creatine kinase (ck) levels. |
2021-09-24 |
2023-08-13 |
monkey |
| Shalom Z Frager, James Szymanski, Jonathan M Schwartz, Hatef S Massoumi, Milan Kinkhabwala, Allan W Wolkof. Hepatic Predictors of Mortality in Severe Acute Respiratory Syndrome Coronavirus 2: Role of Initial Aspartate Aminotransferase/Alanine Aminotransferase and Preexisting Cirrhosis. Hepatology communications. vol 5. issue 3. 2021-09-24. PMID:33681677. |
the aim of this study was to evaluate the effect of initial aspartate aminotransferase (ast) and alanine aminotransferase (alt) levels and preexisting liver disease, including cirrhosis, in a cohort of patients admitted with covid-19 infection at a tertiary care hospital network in the bronx, new york. |
2021-09-24 |
2023-08-13 |
Not clear |
| Mohammed Al-Haddab, Alanoud Alhuqayl, Heba Alsharif, Dana Alolyet, Rawan Altale. Results of Laboratory Monitoring in Patients Taking Isotretinoin for Acne. Cutis. vol 108. issue 1. 2021-09-24. PMID:34397358. |
each patient's medical records were evaluated to determine baseline alanine aminotransferase (alt), aspartate aminotransferase (ast), total cholesterol, and triglycerides (tgs) compared to levels recorded at 2 later readings following initiation of treatment with oral isotretinoin. |
2021-09-24 |
2023-08-13 |
Not clear |
| Paulina Vidal-Cevallos, Fatima Higuera-De-La-Tijera, Norberto C Chávez-Tapia, Francisco Sanchez-Giron, Eira Cerda-Reyes, Victor Hugo Rosales-Salyano, Alfredo Servin-Caamaño, Martín Uriel Vázquez-Medina, Nahum Méndez-Sánche. Lactate-dehydrogenase associated with mortality in hospitalized patients with COVID-19 in Mexico: a multi-centre retrospective cohort study. Annals of hepatology. vol 24. 2021-09-22. PMID:33647501. |
different degrees of alanine aminotransferase (alt) and/or aspartate aminotransferase (ast) abnormalities have been reported in these patients, its association with a mortality risk remains controversial. |
2021-09-22 |
2023-08-13 |
Not clear |
| Xuehua Piao, Xiaodan Sui, Baohai Liu, Tingfang Cui, Zinan Q. Picroside II Improves Severe Acute Pancreatitis-Induced Hepatocellular Injury in Rats by Affecting JAK2/STAT3 Phosphorylation Signaling. BioMed research international. vol 2021. 2021-09-22. PMID:34368363. |
we measured hepatocellular enzymes (amylase (amy), alanine aminotransferase (alt), and aspartate aminotransferase (ast)), oxidative stress factors (superoxidase dismutase (sod) and malondialdehyde (mda)), and inflammatory factors (tumor necrosis factor |
2021-09-22 |
2023-08-13 |
rat |
| Bingquan Ma, Peng Li, Hengyuan An, Zhiming Son. Electroacupuncture Attenuates Liver Inflammation in Nonalcoholic Fatty Liver Disease Rats. Inflammation. vol 43. issue 6. 2021-09-21. PMID:32737656. |
ea could significantly reduce serum alanine aminotransferase (alt), aspartate aminotransferase (ast), serum triglyceride (tg), serum cholesterol (tc), and serum cytokines, and improve liver histopathological changes in rats. |
2021-09-21 |
2023-08-13 |
rat |