| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rudra Rai, Lucy E Wilson, Jacquie Astemborski, Frank Anania, Michael Torbenson, Charles Spoler, David Vlahov, Steffanie A Strathdee, John Boitnott, Kenrad E Nelson, David L Thoma. Severity and correlates of liver disease in hepatitis C virus-infected injection drug users. Hepatology (Baltimore, Md.). vol 35. issue 5. 2002-05-24. PMID:11981775. |
both fibrosis scores of 3 or greater and total scores of 5 or greater were associated with elevated alt, aspartate transaminase (ast), and gamma-glutamyl transpeptidase (ggt) levels (p <.01). |
2002-05-24 |
2023-08-12 |
human |
| Kenneth L Muldrew, Laura P James, Leslie Coop, Sandra S McCullough, Howard P Hendrickson, Jack A Hinson, Philip R Mayeu. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection. Drug metabolism and disposition: the biological fate of chemicals. vol 30. issue 4. 2002-05-17. PMID:11901099. |
analysis of human serum samples for the acetaminophen-cysteine conjugate revealed a positive correlation between acetaminophen-cysteine conjugate concentration and serum aspartate aminotransferase (ast) activity or time. |
2002-05-17 |
2023-08-12 |
mouse |
| Meng-Chuan Huang, A Chao, R Kirwan, C Tschanz, J M Peralta, D A Diersen-Schade, S Cha, J T Brenn. Negligible changes in piglet serum clinical indicators or organ weights due to dietary single-cell long-chain polyunsaturated oils. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 40. issue 4. 2002-05-14. PMID:11893404. |
with litters treated as a blocked variable, no significant differences among groups were found by analysis of variance for the following serum assays: alkaline phosphatase, alanine aminotransferase (alt), aspartate aminotransferase (ast), blood urea nitrogen (bun), creatinine, albumin, glucose, cholesterol, triglycerides, and total protein. |
2002-05-14 |
2023-08-12 |
human |
| Sang K Kim, Young C Ki. Attenuation of bacterial lipopolysaccharide-induced hepatotoxicity by betaine or taurine in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 40. issue 4. 2002-05-14. PMID:11893413. |
supplementation with betaine or taurine protected the animals from induction of lps hepatotoxicity as measured by changes in aspartate aminotransferase (ast), alanine aminotransferase (alt) activities and total bilirubin levels in serum, and hepatic glutathione contents. |
2002-05-14 |
2023-08-12 |
rat |
| T Saetre, T Hovig, M Røger, Y Gundersen, A O Aase. Hepatocellular damage in porcine endotoxemia: beneficial effects of selective versus non-selective nitric oxide synthase inhibition? Scandinavian journal of clinical and laboratory investigation. vol 61. issue 7. 2002-05-09. PMID:11763408. |
lps caused significant increases in aspartate aminotransferase (ast), alkaline phosphatase (alp) and alpha glutathione s-transferase (alpha-gst), l-name caused further increases in ast, alp and alpha-gst, while ae-itu prevented the late increase in alp and alpha-gst observed in the other lps groups. |
2002-05-09 |
2023-08-12 |
Not clear |
| Rheal A Towner, Sharelle A Sturgeon, Nadeem Khan, H Hou, Harold M Swart. In vivo assessment of nodularin-induced hepatotoxicity in the rat using magnetic resonance techniques (MRI, MRS and EPR oximetry). Chemico-biological interactions. vol 139. issue 3. 2002-05-08. PMID:11879814. |
microscopic assessment (histology and electron microscopy) and serum liver enzyme function tests (aminotransferase (alt) and aspartate alt (ast)) confirmed the nodularin-induced tissue injury observed by mri. |
2002-05-08 |
2023-08-12 |
rat |
| S Sezer, B H Ozdemir, Z Arat, M Turan, N F Ozdemir, M Habera. Spectrum of liver damage and correlation with clinical and laboratory parameters in HCV infected hemodialysis patients. Renal failure. vol 23. issue 6. 2002-05-07. PMID:11777320. |
patients liver enzyme (alanine aminotransferase (alt), aspartate aminotransferase (ast), gamma glutamyl transferase (ggt)) levels were determined monthly and ferritin levels every three months, and the mean value was recorded. |
2002-05-07 |
2023-08-12 |
Not clear |
| Sahar El-Sakka, Ezz El-Din M Salem, Mohamed S Abdel-Rahma. In vitro hepatotoxicity of alachlor and its by-products. Journal of applied toxicology : JAT. vol 22. issue 1. 2002-04-30. PMID:11807927. |
hepatocytes were harvested by a collagenase perfusion technique and were exposed to different concentrations of alachlor and its by-products for up to 2 h. cell viability, the leakage of aspartate transaminase (ast) and alanine transaminase (alt) and glutathione (gsh) depletion were determined throughout the incubation period. |
2002-04-30 |
2023-08-12 |
rat |
| Ron Palmon, Bon Chang A Koo, David A Shoultz, Douglas T Dieteric. Lack of hepatotoxicity associated with nonnucleoside reverse transcriptase inhibitors. Journal of acquired immune deficiency syndromes (1999). vol 29. issue 4. 2002-04-23. PMID:11917237. |
the overall rate of grade 3 to 4 elevations in aspartate aminotransferase (ast) or alanine aminotransferase (alt) was 3 of 272 (1.1%) and did not differ significantly among the three nnrtis. |
2002-04-23 |
2023-08-12 |
Not clear |
| Keon Wook Kang, Sung Hee Choi, Jong Ryul Ha, Choon Won Kim, Sang Geon Ki. Inhibition of dimethylnitrosamine-induced liver fibrosis by [5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione] (oltipraz) in rats: suppression of transforming growth factor-beta1 and tumor necrosis factor-alpha expression. Chemico-biological interactions. vol 139. issue 1. 2002-04-18. PMID:11803029. |
treatment of rats with dmn (10 microl/kg body weight, i.p., three times per week for 4 weeks) resulted in marked increases in plasma alanine aminotransferase (alt), aspartate aminotransferase (ast) and gamma-glutamyl transpeptidase (gamma-gt) activities. |
2002-04-18 |
2023-08-12 |
rat |
| F Burdan, Z Siezieniewska, Z Urbanowic. Combined effects of acetaminophen, isopropylantipyrine and caffeine on pregnant and nonpregnant liver. Human & experimental toxicology. vol 20. issue 11. 2002-04-16. PMID:11926611. |
at day 21 of gestation/experiment blood was taken for determination of activity of alanine (ala) and aspartate (ast) aminotransferase, lactate (ldh) and glutamate (gldh) dehydrogenase, levels of bilirubin (bil), urea (ure), total protein (tp) and thymol turbidity test (ttt). |
2002-04-16 |
2023-08-12 |
rat |
| John S Thompson, Stephen A Brown, Valarie Khurdayan, Amenah Zeynalzadedan, Patrick G Sullivan, Stephen W Schef. Early effects of tribromoethanol, ketamine/xylazine, pentobarbitol, and isoflurane anesthesia on hepatic and lymphoid tissue in ICR mice. Comparative medicine. vol 52. issue 1. 2002-04-04. PMID:11900415. |
three and six hours after intraperitoneal injection of tbe, intramuscular injection of ketamine/xylazine combination (k/x), intraperitoneal injection of pentobarbital (pb), and inhalation of isoflurane (if), or intraperitoneal and intramuscular injection of control saline, mice were exsanguinated and serum was obtained for measurement of hepatic aspartate transaminase (ast), alanine transaminase (alt) and gamma-glutamyltransferase (ggt). |
2002-04-04 |
2023-08-12 |
mouse |
| M G Jeschke, D N Herndon, R Vita, D L Traber, K W Jauch, R E Barro. IGF-I/BP-3 administration preserves hepatic homeostasis after thermal injury which is associated with increases in no and hepatic NF-kappa B. Shock (Augusta, Ga.). vol 16. issue 5. 2002-04-03. PMID:11699076. |
serum aspartate transaminase (ast) and nitric oxide (no), and hepatocyte proliferation and apoptosis, were measured on postburn days 1, 2, 5, and 7. |
2002-04-03 |
2023-08-12 |
rat |
| M H Ahmida, A A Abdel-Gayoum, M M El-Fakhr. Effect of spironolactone on cisplatin-induced nephrotoxicity in rabbits. Human & experimental toxicology. vol 20. issue 9. 2002-04-02. PMID:11776407. |
non of the drug treatments had any effects on the serum alanine transaminase (alt) and aspartate transaminase (ast) levels (measured as liver function parameters) or liver protein content or hepatic alkaline phosphatase (alp) activity. |
2002-04-02 |
2023-08-12 |
rabbit |
| S J Valberg, T L Ward, B Rush, H Kinde, H Hiraragi, D Nahey, J Fyfe, J R Mickelso. Glycogen branching enzyme deficiency in quarter horse foals. Journal of veterinary internal medicine. vol 15. issue 6. 2002-04-02. PMID:11817063. |
leukopenia (5 of 5 foals) as well as high serum creatine kinase (ck; 5 of 5), aspartate transaminase (ast; 4 of 4), and gamma glutamyl transferase (ggt; 5 of 5) activities were present in most foals, and intermittent hypoglycemia was present in 2 foals. |
2002-04-02 |
2023-08-12 |
Not clear |
| Y Kotake, J Takeda, M Matsumoto, M Tagawa, H Kikuch. Subclinical hepatic dysfunction in laparoscopic cholecystectomy and laparoscopic colectomy. British journal of anaesthesia. vol 87. issue 5. 2002-03-22. PMID:11878531. |
we compared perioperative ad, gst, aspartate aminotransferase (ast, normal range 14-32 iu litre(-1)) and alanine aminotransferase (alt, normal range 8-41 u litre(-1)) concentrations in patients undergoing laparoscopic cholecystectomy or laparoscopic colectomy to study how patient position and surgical manipulation of the liver affect hepatocellular integrity during laparoscopy. |
2002-03-22 |
2023-08-12 |
Not clear |
| F M El-Demerdas. Effects of selenium and mercury on the enzymatic activities and lipid peroxidation in brain, liver, and blood of rats. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. vol 36. issue 4. 2002-03-21. PMID:11495025. |
the following biochemical alterations occurred in response to hg treatment: protein content (brain and liver), acetylcholinesterase (ache) (brain and serum), acid and alkaline (acp and alp) phosphatases (plasma and liver) and glutathione s-transferase (gst) (plasma and liver) activities were significantly (p<0.05) decreased, while lactate dehydrogenase (ldh) (plasma, brain and liver), aspartate and alanine aminotransferase (ast, alt) (serum and liver) activities were significantly increased. |
2002-03-21 |
2023-08-12 |
rat |
| Desley A H Neil, Stefan G Hubsche. Histologic and biochemical changes during the evolution of chronic rejection of liver allografts. Hepatology (Baltimore, Md.). vol 35. issue 3. 2002-03-21. PMID:11870379. |
centrilobular necroinflammation (clni) associated with an elevated aspartate transaminase (ast) level and portal tract features of ar were present at the start. |
2002-03-21 |
2023-08-12 |
Not clear |
| Michael A Schnell, Christine Hardy, Melanie Hawley, Kathleen Joy Propert, James M Wilso. Effect of blood collection technique in mice on clinical pathology parameters. Human gene therapy. vol 13. issue 1. 2002-03-12. PMID:11779419. |
while alanine aminotransferase (alt) values were similar between the ic and vc groups, aspartate aminotransferase (ast) values were associated with less variation for the vc method. |
2002-03-12 |
2023-08-12 |
mouse |
| Aurélie-Anne Chausse, Valérie Nivet-Antoine, Chantal Martin, Jean-Pierre Clot, François-Xavier Gale. Protective effect of nitric oxide on isolated rat hepatocytes submitted to an oxidative stress. Metabolism: clinical and experimental. vol 51. issue 2. 2002-03-07. PMID:11833044. |
a 30-minute incubation of hepatocytes with 100 micromol/l clo(-) maximally decreased cell viability (-40%) and increased bleb formation (+300%) and release of transaminases activities (aspartate transaminase [ast] = +60% and alanine transaminase [alt] = +300%). |
2002-03-07 |
2023-08-12 |
rat |