| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sriparna Majumda. Role of glutamate in the development of visual pathways. Frontiers in ophthalmology. vol 3. 2024-07-10. PMID:38983097. |
all types of photoreceptors, bipolar, ganglion and one type of glycinergic amacrine cells express specific subtypes of vesicular glutamate transporters and are the main source of endogenous glutamate in retina, besides müller glia that are responsible for glutamate homeostasis, release and reuptake. |
2024-07-10 |
2024-07-12 |
Not clear |
| Rui Du, Ping Wang, Ning Tia. CD3ζ-Mediated Signaling Protects Retinal Ganglion Cells in Glutamate Excitotoxicity of the Retina. Cells. vol 13. issue 12. 2024-06-26. PMID:38920637. |
cd3ζ-mediated signaling protects retinal ganglion cells in glutamate excitotoxicity of the retina. |
2024-06-26 |
2024-06-29 |
mouse |
| Amir Attallah, Maryvonne Ardourel, Fabien Lesne, Anthony De Oliveira, Chloé Felgerolle, Sylvain Briault, Isabelle Ranchon-Cole, Olivier Perch. Dietary Supplement Enriched in Antioxidants and Omega-3 Promotes Retinal Glutamine Synthesis. Experimental eye research. 2024-06-08. PMID:38851478. |
only one in-vivo preclinical study demonstrated that dietary supplementation (ds) prevents the retina from light-induced retinal degeneration; and only one in-vitro study on müller cells culture showed that glutamate metabolism cycle was key in oxidative stress response. |
2024-06-08 |
2024-06-11 |
Not clear |
| Amir Attallah, Maryvonne Ardourel, Fabien Lesne, Anthony De Oliveira, Chloé Felgerolle, Sylvain Briault, Isabelle Ranchon-Cole, Olivier Perch. Dietary Supplement Enriched in Antioxidants and Omega-3 Promotes Retinal Glutamine Synthesis. Experimental eye research. 2024-06-08. PMID:38851478. |
therefore, we raised the question about the in-vivo effect of ds on glutamate metabolism in the retina. |
2024-06-08 |
2024-06-11 |
Not clear |
| Stavroula Dionysopoulou, Per Wikstrom, Erik Walum, Spiros Georgakis, Kyriaki Thermo. Investigation of the Effects of a Novel NOX2 Inhibitor, GLX7013170, against Glutamate Excitotoxicity and Diabetes Insults in the Retina. Pharmaceuticals (Basel, Switzerland). vol 17. issue 3. 2024-03-28. PMID:38543179. |
investigation of the effects of a novel nox2 inhibitor, glx7013170, against glutamate excitotoxicity and diabetes insults in the retina. |
2024-03-28 |
2024-03-30 |
Not clear |
| Luis J Knight, Renita M Martis, Paul J Donaldson, Monica L Acosta, Julie C Li. Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice. Molecular vision. vol 29. 2024-01-15. PMID:38222448. |
glutamate is the main neurotransmitter in the retina and plays a key metabolic role as a major anaplerotic substrate in the tricarboxylic acid cycle to generate adenosine triphosphate (atp). |
2024-01-15 |
2024-01-17 |
mouse |
| Luis J Knight, Renita M Martis, Paul J Donaldson, Monica L Acosta, Julie C Li. Changes in glutamate and glutamine distributions in the retinas of cystine/glutamate antiporter knockout mice. Molecular vision. vol 29. 2024-01-15. PMID:38222448. |
in this study, we investigated the role of xct, the light chain subunit responsible for antiporter function, in glutamate pathways in the mouse retina using an xct knockout mouse. |
2024-01-15 |
2024-01-17 |
mouse |
| John A Gaynes, Samuel A Budoff, Michael J Grybko, Alon Poleg-Polsk. Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells. eLife. vol 12. 2023-12-27. PMID:38149980. |
to correlate model predictions to empirical findings, we utilized two-photon glutamate imaging to study the dynamics of bipolar release onto on- and off-starburst dendrites in the murine retina. |
2023-12-27 |
2023-12-29 |
Not clear |
| Isabella Boccuni, Carlos Bas-Orth, Claus Bruehl, Andreas Draguhn, Richard Fairles. Glutamate transporter contribution to retinal ganglion cell vulnerability in a rat model of multiple sclerosis. Neurobiology of disease. 2023-09-21. PMID:37734623. |
collectively, our study highlights the neuroprotective role of glutamate transporters in the eae retina and provides a characterization of tonic glutamate-currents of αrgcs. |
2023-09-21 |
2023-10-07 |
rat |
| Shane P D'Souza, Brian A Upton, Kiara C Eldred, Ian Glass, Kassidy Grover, Abdulla Ahmed, Minh-Thanh Ngyuen, Paul Gamlin, Richard A Lan. Developmental adaptation of rod photoreceptor number via photoreception in melanopsin (OPN4) retinal ganglion cells. bioRxiv : the preprint server for biology. 2023-09-04. PMID:37662196. |
using a combination of genetics, sensory environment manipulations, and computational approaches, we establish a molecular pathway in which light-dependent glutamate release from iprgcs is detected via a transiently expressed kainate receptor (grik3) in immature rods localized to the inner retina. |
2023-09-04 |
2023-09-07 |
human |
| John A Gaynes, Samuel A Budoff, Michael J Grybko, Alon Poleg-Polsk. Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells. bioRxiv : the preprint server for biology. 2023-08-14. PMID:37577661. |
to correlate model predictions to empirical findings, we utilized two-photon glutamate imaging to study the dynamics of bipolar release onto on- and off-starburst dendrites in the murine retina. |
2023-08-14 |
2023-08-16 |
Not clear |
| Pinghui Wei, Guoge Han, Yan Wan. Effects of dopamine D2 receptor antagonists on retinal pigment epithelial/choroid complex metabolism in form-deprived myopic guinea pigs. Proteomics. 2023-07-26. PMID:37491763. |
the rpe/choroid may provide glutamate to the retina by activating proline metabolism via metabolic coupling with the retina. |
2023-07-26 |
2023-08-14 |
Not clear |
| Wallace B Thoreson, Bhavana Chhunchh. EAAT5 glutamate transporter rapidly binds glutamate with micromolar affinity in mouse rods. The Journal of general physiology. vol 155. issue 9. 2023-07-21. PMID:37477643. |
light responses of rod photoreceptor cells in the retina are encoded by changes in synaptic glutamate release that is in turn shaped by reuptake involving eaat5 plasma membrane glutamate transporters. |
2023-07-21 |
2023-08-14 |
mouse |
| Xiaonan Zhang, Mengxue Xia, Yingjie Wu, Fang Zhan. Branched-Chain Amino Acids Metabolism and Their Roles in Retinopathy: From Relevance to Mechanism. Nutrients. vol 15. issue 9. 2023-07-11. PMID:37432261. |
recently, it has been shown that bcaas are highly related to neuroprotection, oxidative stress, inflammatory and glutamate toxicity in the retina of retinopathy. |
2023-07-11 |
2023-08-14 |
Not clear |
| Jin Kim, Bokyeong Ryu, Junpil Bang, C-Yoon Kim, Jae-Hak Par. Postnatal exposure to trimethyltin chloride induces retinal developmental neurotoxicity in mice via glutamate and its transporter related changes. Reproductive toxicology (Elmsford, N.Y.). 2023-05-10. PMID:37164060. |
we exposed 0.75 and 1.5mg/kg of tmt to neonatal icr mice (1:1 ratio of male and female) up to postnatal day 14 and performed analysis of the retina: histopathology, apoptosis, electrophysiological function, glutamate concentration, gene expression, and fluorescence immunostaining. |
2023-05-10 |
2023-08-14 |
mouse |
| Siyan Zhu, Rong Xu, Abbi Engel, Yekai Wang, Rachel McNeel, James B Hurley, Jennifer R Chao, Jianhai D. Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina. bioRxiv : the preprint server for biology. 2023-05-03. PMID:37131780. |
co-culture of human rpe with the retina showed that the retina can take up the amino acids, especially glutamate, aspartate and glutamine, generated from proline nitrogen in the rpe. |
2023-05-03 |
2023-08-14 |
mouse |
| A T Duarte-Silva, L G R Ximenes, M Guimarães-Souza, I Domith, R Paes-de-Carvalh. Chemical signaling in the developing avian retina: Focus on cyclic AMP and AKT-dependent pathways. Frontiers in cell and developmental biology. vol 10. 2022-12-26. PMID:36568967. |
by the other hand, glutamate modulates nitric oxide production and akt activation in cultured retinal cells and this pathway controls neuronal survival in retina. |
2022-12-26 |
2023-08-14 |
chicken |
| Victor J DePiero, Bart G Borghui. Phase advancing is a common property of multiple neuron classes in the mouse retina. eNeuro. 2022-08-22. PMID:35995559. |
to address this, we studied the timing of object motion-evoked responses at multiple signaling stages within the mouse retina using two-photon fluorescence calcium and glutamate imaging, targeted whole-cell electrophysiology, and computational modeling. |
2022-08-22 |
2023-08-14 |
mouse |
| Darya V Telegina, Anna K Antonenko, Anzhela Zh Fursova, Nataliya G Kolosov. The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. Biogerontology. 2022-08-15. PMID:35969289. |
glutamate and -aminobutyric acid (gaba) are the most abundant amino acids in the retina. |
2022-08-15 |
2023-08-14 |
rat |
| Darya V Telegina, Anna K Antonenko, Anzhela Zh Fursova, Nataliya G Kolosov. The glutamate/GABA system in the retina of male rats: effects of aging, neurodegeneration, and supplementation with melatonin and antioxidant SkQ1. Biogerontology. 2022-08-15. PMID:35969289. |
at a late stage of amd-like retinopathy in oxys rats (18 months), there was significant upregulation of glutaminase and downregulation of glutamine synthetase, possibly indicating an increasing level of glutamate in the retina. |
2022-08-15 |
2023-08-14 |
rat |