| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aldo R Tejeda-Martínez, Ana R Ramos-Molina, Patricia A Brand-Rubalcava, Mario E Flores-Sot. Involvement of serotonergic receptors in depressive processes and their modulation by β-arrestins: A review. Medicine. vol 103. issue 28. 2024-07-12. PMID:38996114. |
disorders such as anxiety, depression, schizophrenia, epilepsy, sexual disorders, and eating disorders, have been closely linked to variations in 5-ht concentrations and modifications in brain structures, including the raphe nuclei (rn), prefrontal cortex, basal ganglia, hippocampus, and hypothalamus, among others. |
2024-07-12 |
2024-07-15 |
Not clear |
| Ji-Su Baek, Dong-Yun Lee, Seung-Won Han, Dong-Hyun Ki. A probiotic NVP1704 alleviates stress-induced sleeplessness/depression-like symptoms in mice by upregulating serotonergic and GABAergic systems and downregulating NF-κB activation. Letters in applied microbiology. 2024-07-08. PMID:38977897. |
nvp1704 increased is-suppressed expression of γ-aminobutyric acid (gaba), gabaa receptor α1 (gabaarα1) and α2 subunits (gabaarα2), serotonin, 5-ht receptors (5-ht1ar and 5-ht1br), melatonin receptors (mt1r, and mt2r) in the prefrontal cortex and thalamus. |
2024-07-08 |
2024-07-12 |
mouse |
| Mariam A Fouad, Mariane G Tadros, Haidy E Miche. Etanercept ameliorates chronic mild stress-induced depressive-like behavior in rats: crosstalk between MAPK and STAT3 pathways and norepinephrine and serotonin transporters. European journal of pharmacology. 2024-06-30. PMID:38945285. |
etanercept also restored serotonin and norepinephrine levels to control values in the prefrontal cortex (pfc). |
2024-06-30 |
2024-07-03 |
rat |
| Pallavi Singh, Priyanka Agrawal, K P Sing. Prenatal exposure to vortioxetine and vilazodone: Impact on depressive- and anxiety-like behavioral manifestations in young rat offspring. Behavioural brain research. 2024-06-30. PMID:38945303. |
additionally, neurotransmitter (serotonin, dopamine, and nor-epinephrine) levels in the prefrontal cortex region of the brain were substantially reduced in exposed offspring. |
2024-06-30 |
2024-07-03 |
rat |
| Nian-Sheng Tzeng, Jing-Yi Chung, Chen-Cheng Lin, Pao-Yun Cheng, Yia-Ping Li. Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related Depression. Pharmaceuticals (Basel, Switzerland). vol 17. issue 6. 2024-06-27. PMID:38931384. |
tissue levels of serotonin (5-ht) and its metabolite 5-hiaa were measured in the hippocampus, the amygdala, and the prefrontal cortex. |
2024-06-27 |
2024-06-29 |
rat |
| Lining Yin, Ying Yu, Fang Han, Qingyun Wan. Unveiling serotonergic dysfunction of obsessive-compulsive disorder on prefrontal network dynamics: a computational perspective. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 6. 2024-06-21. PMID:38904079. |
serotonin (5-ht) regulates working memory within the prefrontal cortex network, which is crucial for understanding obsessive-compulsive disorder. |
2024-06-21 |
2024-06-23 |
Not clear |
| Lining Yin, Ying Yu, Fang Han, Qingyun Wan. Unveiling serotonergic dysfunction of obsessive-compulsive disorder on prefrontal network dynamics: a computational perspective. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 6. 2024-06-21. PMID:38904079. |
here, we incorporate 5-ht receptors (5-ht1a, 5-ht2a) and dopamine receptors into a multistable prefrontal cortex network model, replicating the experimentally observed inverted u-curve phenomenon. |
2024-06-21 |
2024-06-23 |
Not clear |
| Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Francis-Oliveira, Emily Cruvinel, Thainá Soares Franchin, Tania Marcourakis, Henning Ulrich, Roberto De Pasqual. Serotonergic Neuromodulation of Synaptic Plasticity. Neuropharmacology. 2024-06-14. PMID:38876308. |
through a comparative analysis across three main forebrain structures-the hippocampus, amygdala, and prefrontal cortex, this review discusses the actions of 5-ht on synaptic plasticity, offering insights into its role as a neuromodulator involved in emotional and cognitive functions. |
2024-06-14 |
2024-06-17 |
Not clear |
| Abhinav Singh, Maryam Sarwat, Sangeetha Gupt. Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder. Current pharmaceutical design. 2024-06-07. PMID:38847247. |
alterations in the circuits, including the prefrontal cortex, striatum, and limbic system, regulate mood and cause variation in several crucial neurotransmitters, including serotonin, dopamine, gaba, and glutamate. |
2024-06-07 |
2024-06-10 |
Not clear |
| Annika B Ozols, Jing Wei, Janet M Campbell, Chengcheng Hu, Shenfeng Qiu, Amelia L Gallitan. Activity of prefrontal cortex serotonin 2A receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug DOI in a sex-dependent manner. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826361. |
activity of prefrontal cortex serotonin 2a receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug doi in a sex-dependent manner. |
2024-06-03 |
2024-06-05 |
mouse |
| Matti Bock Guldager, Caroline Biojone, Nicole Rodrigues da Silva, Livea Dornela Godoy, Sâmia Joc. New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect. Progress in neuro-psychopharmacology & biological psychiatry. vol 133. 2024-05-25. PMID:38762160. |
neurochemical and pharmacological evidence indicates that both serotonin and bdnf-trkb signalling in the prefrontal cortex are necessary for the antidepressant effects induced by cbd in animal models. |
2024-05-25 |
2024-05-27 |
Not clear |
| Matti Bock Guldager, Caroline Biojone, Nicole Rodrigues da Silva, Livea Dornela Godoy, Sâmia Joc. New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect. Progress in neuro-psychopharmacology & biological psychiatry. vol 133. 2024-05-25. PMID:38762160. |
it is hypothesized that: a) cbd interaction with serotonin receptors on neurons of the dorsal raphe nuclei and the resulting disinhibition of serotonergic neurons would promote rapid serotonin release in the pfc and hence its neuroplastic and antidepressant effects; b) cbd facilitates bdnf-trkb signalling, especially in the pfc, which rapidly triggers neurochemical and neuroplastic effects. |
2024-05-25 |
2024-05-27 |
Not clear |
| Povilas Karvelis, Andreea O Diaconesc. A Computational Model of Hopelessness and Active-Escape Bias in Suicidality. Computational psychiatry (Cambridge, Mass.). vol 6. issue 1. 2024-05-23. PMID:38774778. |
these proposals stem from considering the neurocircuits implicated in stb: how the locus coeruleus - norepinephrine (lc-ne) system together with the amygdala (amy), the dorsal prefrontal cortex (dpfc) and the anterior cingulate cortex (acc) mediate learning in response to acute stress and volatility as well as how the dorsal raphe nucleus - serotonin (drn-5-ht) system together with the ventromedial prefrontal cortex (vmpfc) mediate stress reactivity based on perceived stressor controllability. |
2024-05-23 |
2024-05-27 |
Not clear |
| Maurizio S Riga, Mercedes Pérez-Fernández, Lluis Miquel-Rio, Verónica Paz, Leticia Campa, Magdalena Martínez-Losa, Francisco J Esteban, Luis F Callado, Javier Meana, Francesc Artigas, Analía Bortolozzi, Manuel Álvarez-Dolad. Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype. Brain : a journal of neurology. 2024-05-20. PMID:38769595. |
additionally, it reduced extracellular serotonin concentration in the dorsal raphe nucleus and brain-derived neurotrophic factor expression in the hippocampus, two mdd-related brain areas beyond the pfc. |
2024-05-20 |
2024-05-27 |
mouse |
| Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkon. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behavioural brain research. 2024-04-30. PMID:38688411. |
in addition, stressed mice showed lower levels of tyrosine, dopamine, dopac, mhpg, kynurenine, kynurenic acid, and 5-hiaa levels but higher serotonin levels in the prefrontal cortex, not in the hippocampus. |
2024-04-30 |
2024-05-03 |
mouse |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
the results revealed that, even without pregnancy stress, hn001 reduced postpartum anxiety-related behavior, increased variability in behavioral fragmentation when dams interacted with pups, increased time away from pups, and decreased prefrontal cortex norepinephrine (ne), dopamine (da) and serotonin (5-ht). |
2024-04-03 |
2024-04-06 |
rat |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
probiotic plus stress consistently reduced the latency to float in the forced swim test, increased da and 5-ht turnovers in the prefrontal cortex, increased hippocampal ne, and reduced hypothalamic da. |
2024-04-03 |
2024-04-06 |
rat |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
on the other hand, environmental enrichment (ee) is associated with a reduction in anxiety-like and depression-like behavior, as well as an increase in serotonin (5-ht) levels in the prefrontal cortex and hippocampus in rodents. |
2024-03-25 |
2024-03-27 |
human |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
furthermore, ee increased 5-ht levels in the hippocampus and prefrontal cortex of rodents. |
2024-03-25 |
2024-03-27 |
human |
| Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. |
neurons that release serotonin (5-ht) project to the pfc, and compounds modulating 5-ht activity influence emotion and cognition. |
2024-03-09 |
2024-03-12 |
mouse |