All Relations between prefrontal cortex and serotonin

Publication Sentence Publish Date Extraction Date Species
Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. we found that 5-ht expression levels, quantified by immunohistochemistry, and 5-ht release, quantified by in vivo microdialysis in awake mice, are reduced in pfc of adult mpa mice. 2024-03-09 2024-03-12 mouse
Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. 2024-02-16 2024-02-19 mouse
Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. serotonin (5-ht) imbalances in the developing prefrontal cortex (pfc) are linked to long-term behavioral deficits. 2024-02-16 2024-02-19 mouse
Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. we found that chemogenetic suppression and enhancement of 5-ht release in the pfc during the first two postnatal weeks decreased and increased the density and strength of excitatory spine synapses, respectively, on prefrontal layer 2/3 pyramidal neurons in mice. 2024-02-16 2024-02-19 mouse
Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. monoamine content, serotonin (5-ht) release, 5-ht uptake, 5-ht transporter (sert) protein levels, and behaviors were investigated in mice subjected to chronic social defeat stress and in mice with knockdown of slc6a4, in 5-htergic neurons projecting to the prefrontal cortex (pfc). 2024-02-01 2024-02-04 mouse
Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. increased turnover, increased extracellular basal levels, decreased release and decreased uptake of 5-ht, and decreased sert protein levels were observed in the pfc of the stressed mice. 2024-02-01 2024-02-04 mouse
Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. similar to the stressed mice, mice with slc6a4 knockdown in 5-htergic neurons projecting to the pfc also showed decreased release and uptake of 5-ht in the pfc and increased anxiety-like behavior. 2024-02-01 2024-02-04 mouse
Jennie Garcia-Olivares, Brittney Yegla, Frank P Bymaster, Jami Earnest, Jennifer Koch, Chungping Yu, Jonathan Rubi. Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder. Journal of experimental pharmacology. vol 16. 2024-01-22. PMID:38249320. viloxazine increases extracellular concentrations of norepinephrine, dopamine, and serotonin in the rat prefrontal cortex at doses relevant for the treatment of attention-deficit/hyperactivity disorder. 2024-01-22 2024-01-24 rat
Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabac. Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242425. levels of noradrenaline (na), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), glutamate (glu) and gaba were assessed in the prefrontal cortex (pfc). 2024-01-19 2024-01-22 rat
Alberto Fernández-Teruel, Toni Cañete, Daniel Sampedro-Viana, Ignasi Oliveras, Rafael Torrubia, Adolf Tobeñ. Contribution of the Roman rat lines/strains to personality neuroscience: neurobehavioral modeling of internalizing/externalizing psychopathologies. Personality neuroscience. vol 6. 2023-12-19. PMID:38107777. for example, relative to rla rats, rhas exhibit decreased function of the prefrontal cortex (pfc), hippocampus and amygdala, increased functional tone of the mesolimbic dopamine system, a deficit of central metabotropic glutamate-2 (mglu2) receptors, increased density of serotonin 5-ht2a receptors in the pfc, impairment of gabaergic transmission in the pfc, alterations of several synaptic markers and increased density of pyramidal immature dendrític spines in the pfc. 2023-12-19 2023-12-21 rat
Daniël J van Rensburg, Zander Lindeque, Brian H Harvey, Stephan F Stey. Ndufs4 KO mice: A model to study comorbid mood disorders associated with mitochondrial dysfunction. Pharmacology, biochemistry, and behavior. vol 234. 2023-12-13. PMID:38070656. serotonin, kynurenine, and redox status in brain areas relevant to psychiatric pathologies (i.e., prefrontal cortex, hippocampus, and striatum). 2023-12-13 2023-12-17 mouse
Soraia Silva, Carla Fonseca, Joana Bicker, Amílcar Falcão, Ana Fortun. Intranasal administration of sertraline ensures sustained brain delivery and antidepressant effect in a mouse model of depression. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-13. PMID:38092320. noteworthy neurotransmitter alterations were observed, with in sertraline markedly reducing adrenaline in the prefrontal cortex, while serotonin and melatonin increased following both administration routes. 2023-12-13 2023-12-17 mouse
Handan Deng, Yongjun Yu, Qi Sha, Weiyi Sun, Lundan Liang, Feier Ren, Hua Ji, Xiangdi Shen, Xingli Fa. Construction of antibiotic-induced depression mice model and the function of intestinal microbiota. Frontiers in microbiology. vol 14. 2023-12-13. PMID:38088959. by using these antibiotics, the concentrations of norepinephrine (ne), 5-hydroxytryptamine (5-ht), and brain-derived neurotrophic factor (bdnf) in mice hippocampus and prefrontal cortex tissues were significantly decreased. 2023-12-13 2023-12-17 mouse
Pooja Gusain, Makiko Taketoshi, Yoko Tominaga, Takashi Tominag. Functional dissection of ipsilateral and contralateral neural activity propagation using voltage-sensitive dye imaging in mouse prefrontal cortex. eNeuro. 2023-11-17. PMID:37977827. these findings highlight the importance of understanding the pfc functional anatomy in evaluating neuromodulators like serotonin and dopamine, as well as other factors related to neuropsychiatric diseases. 2023-11-17 2023-11-20 mouse
Tyler G Ekins, Isla Brooks, Sameer Kailasa, Chloe Rybicki-Kler, Izabela Jedrasiak-Cape, Ethan Donoho, George A Mashour, Jason Rech, Omar J Ahme. Cellular rules underlying psychedelic control of prefrontal pyramidal neurons. bioRxiv : the preprint server for biology. 2023-11-14. PMID:37961554. classical psychedelic drugs are thought to increase excitability of pyramidal cells in prefrontal cortex via activation of serotonin 2 2023-11-14 2023-11-20 Not clear
Benneth Ben-Azu, Olusegun G Adebayo, Emuesiri G Moke, Adrian I Omogbiya, Benjamin Oritsemuelebi, Emmanuel O Chidebe, Emuesiri Umukoro, Eze K Nwangwa, Emmanuel Etijoro, Emmanuel Umukoro, Elizabeth J Mamudu, Chineye Chukwum. Geraniol attenuates behavioral and neurochemical impairments by inhibitions of HPA-axis and oxido-inflammatory perturbations in mice exposed to post-traumatic stress disorder. Journal of psychiatric research. vol 168. 2023-11-01. PMID:37913743. geraniol also increased glutathione, superoxide-dismutase, and catalase levels as well as dopamine, serotonin concentrations and gabaergic glutamic acid decarboxylase enzyme activity in the striatum, prefrontal cortex and hippocampus in the ptsd-mice relative to sps control. 2023-11-01 2023-11-08 mouse
Kaito Kurogi, Fuka Taniguchi, Ryohei Matsuo, Marina Shinozuka, Raiki Suzaki, Shinobu Yasu. Increased depression-like behaviors with altered brain dopamine metabolisms in male mice housed in large cages are alleviated by bupropion. European journal of pharmacology. 2023-10-20. PMID:37858834. in mice housed in large cages, sex-specific dysregulation of brain monoamine systems was observed; dopamine turnover to homovanillic acid or norepinephrine in the prefrontal cortex was elevated in males, while serotonin turnover to 5-hydroxyindoleacetic acid in the amygdala was increased in females. 2023-10-20 2023-11-08 mouse
Mauritz Frederick Herselman, Larisa Bobrovskay. The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice. International journal of molecular sciences. vol 24. issue 19. 2023-10-14. PMID:37834073. cums induced anxiety-like behaviour, dysregulated the tryptophan and serotonin metabolic pathways in the hippocampus, prefrontal cortex, and colon, and altered the composition of the gut microbiota. 2023-10-14 2023-10-15 mouse
Huijuan Guo, Xinxu Liu, Ti Chen, Xiaoping Wang, Xiaojie Zhan. Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice. Molecular neurobiology. 2023-09-05. PMID:37668965. more importantly, akk implantation significantly increased the level of 5-ht in the gut and pfc of both the alcohol exposure mice and the cums mice. 2023-09-05 2023-09-07 mouse
Francesco Tortora, Abed L Hadipour, Simone Battaglia, Alessandra Falzone, Alessio Avenanti, Carmelo M Vicari. The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies. Brain sciences. vol 13. issue 8. 2023-08-26. PMID:37626553. accumulating evidence from both animal and human studies suggests that brain regions involved in fc, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-ht receptors, implicating the crucial involvement of serotonin in aversive learning. 2023-08-26 2023-09-07 human