| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Annika B Ozols, Jing Wei, Janet M Campbell, Chengcheng Hu, Shenfeng Qiu, Amelia L Gallitan. Activity of prefrontal cortex serotonin 2A receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug DOI in a sex-dependent manner. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826361. |
activity of prefrontal cortex serotonin 2a receptor expressing neurons is necessary for the head-twitch response of mice to psychedelic drug doi in a sex-dependent manner. |
2024-06-03 |
2024-06-05 |
mouse |
| Matti Bock Guldager, Caroline Biojone, Nicole Rodrigues da Silva, Livea Dornela Godoy, Sâmia Joc. New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect. Progress in neuro-psychopharmacology & biological psychiatry. vol 133. 2024-05-25. PMID:38762160. |
neurochemical and pharmacological evidence indicates that both serotonin and bdnf-trkb signalling in the prefrontal cortex are necessary for the antidepressant effects induced by cbd in animal models. |
2024-05-25 |
2024-05-27 |
Not clear |
| Matti Bock Guldager, Caroline Biojone, Nicole Rodrigues da Silva, Livea Dornela Godoy, Sâmia Joc. New insights into the involvement of serotonin and BDNF-TrkB signalling in cannabidiol's antidepressant effect. Progress in neuro-psychopharmacology & biological psychiatry. vol 133. 2024-05-25. PMID:38762160. |
it is hypothesized that: a) cbd interaction with serotonin receptors on neurons of the dorsal raphe nuclei and the resulting disinhibition of serotonergic neurons would promote rapid serotonin release in the pfc and hence its neuroplastic and antidepressant effects; b) cbd facilitates bdnf-trkb signalling, especially in the pfc, which rapidly triggers neurochemical and neuroplastic effects. |
2024-05-25 |
2024-05-27 |
Not clear |
| Povilas Karvelis, Andreea O Diaconesc. A Computational Model of Hopelessness and Active-Escape Bias in Suicidality. Computational psychiatry (Cambridge, Mass.). vol 6. issue 1. 2024-05-23. PMID:38774778. |
these proposals stem from considering the neurocircuits implicated in stb: how the locus coeruleus - norepinephrine (lc-ne) system together with the amygdala (amy), the dorsal prefrontal cortex (dpfc) and the anterior cingulate cortex (acc) mediate learning in response to acute stress and volatility as well as how the dorsal raphe nucleus - serotonin (drn-5-ht) system together with the ventromedial prefrontal cortex (vmpfc) mediate stress reactivity based on perceived stressor controllability. |
2024-05-23 |
2024-05-27 |
Not clear |
| Maurizio S Riga, Mercedes Pérez-Fernández, Lluis Miquel-Rio, Verónica Paz, Leticia Campa, Magdalena Martínez-Losa, Francisco J Esteban, Luis F Callado, Javier Meana, Francesc Artigas, Analía Bortolozzi, Manuel Álvarez-Dolad. Scn1a haploinsufficiency in the prefrontal cortex engages to cognitive impairment and depressive phenotype. Brain : a journal of neurology. 2024-05-20. PMID:38769595. |
additionally, it reduced extracellular serotonin concentration in the dorsal raphe nucleus and brain-derived neurotrophic factor expression in the hippocampus, two mdd-related brain areas beyond the pfc. |
2024-05-20 |
2024-05-27 |
mouse |
| Alina Díez-Solinska, Olatz Goñi-Balentziaga, Garikoitz Beitia-Oyarzabal, Maider Muñoz-Culla, Oscar Vegas, Garikoitz Azkon. Chronic defeat stress induces monoamine level dysregulation in the prefrontal cortex but not in the hippocampus of OF1 male mice. Behavioural brain research. 2024-04-30. PMID:38688411. |
in addition, stressed mice showed lower levels of tyrosine, dopamine, dopac, mhpg, kynurenine, kynurenic acid, and 5-hiaa levels but higher serotonin levels in the prefrontal cortex, not in the hippocampus. |
2024-04-30 |
2024-05-03 |
mouse |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
the results revealed that, even without pregnancy stress, hn001 reduced postpartum anxiety-related behavior, increased variability in behavioral fragmentation when dams interacted with pups, increased time away from pups, and decreased prefrontal cortex norepinephrine (ne), dopamine (da) and serotonin (5-ht). |
2024-04-03 |
2024-04-06 |
rat |
| Joseph S Lonstein, Taryn A Meinhardt, Pavlina Pavlidi, Nikos Kokras, Christina Dalla, Thierry D Charlier, Jodi L Pawlusk. Maternal probiotic Lactocaseibacillus rhamnosus HN001 treatment alters postpartum anxiety, cortical monoamines, and the gut microbiome. Psychoneuroendocrinology. vol 165. 2024-04-03. PMID:38569396. |
probiotic plus stress consistently reduced the latency to float in the forced swim test, increased da and 5-ht turnovers in the prefrontal cortex, increased hippocampal ne, and reduced hypothalamic da. |
2024-04-03 |
2024-04-06 |
rat |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
on the other hand, environmental enrichment (ee) is associated with a reduction in anxiety-like and depression-like behavior, as well as an increase in serotonin (5-ht) levels in the prefrontal cortex and hippocampus in rodents. |
2024-03-25 |
2024-03-27 |
human |
| Roxana Patrícia Bezerra da Silva, Isabeli Lins Pinheiro, Regina Katiuska Bezerra da Silva, Eduarda Correia Moretti, Olavo Barbosa de Oliveira Neto, Kelli Ferraz-Pereira, Lígia Cristina Monteiro Galind. Social isolation and post-weaning environmental enrichment effects on rat emotional behavior and serotonergic system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2024-03-25. PMID:38526313. |
furthermore, ee increased 5-ht levels in the hippocampus and prefrontal cortex of rodents. |
2024-03-25 |
2024-03-27 |
human |
| Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. |
neurons that release serotonin (5-ht) project to the pfc, and compounds modulating 5-ht activity influence emotion and cognition. |
2024-03-09 |
2024-03-12 |
mouse |
| Karen K Y Lee, Bidisha Chattopadhyaya, Antônia Samia Fernandes do Nascimento, Luc Moquin, Pedro Rosa-Neto, Bénédicte Amilhon, Graziella Di Crist. Neonatal hypoxia impairs serotonin release and cognitive functions in adult mice. Neurobiology of disease. 2024-03-09. PMID:38460800. |
we found that 5-ht expression levels, quantified by immunohistochemistry, and 5-ht release, quantified by in vivo microdialysis in awake mice, are reduced in pfc of adult mpa mice. |
2024-03-09 |
2024-03-12 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. |
2024-02-16 |
2024-02-19 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
serotonin (5-ht) imbalances in the developing prefrontal cortex (pfc) are linked to long-term behavioral deficits. |
2024-02-16 |
2024-02-19 |
mouse |
| Roberto Ogelman, Luis E Gomez Wulschner, Victoria M Hoelscher, In-Wook Hwang, Victoria N Chang, Won Chan O. Serotonin modulates excitatory synapse maturation in the developing prefrontal cortex. Nature communications. vol 15. issue 1. 2024-02-16. PMID:38365905. |
we found that chemogenetic suppression and enhancement of 5-ht release in the pfc during the first two postnatal weeks decreased and increased the density and strength of excitatory spine synapses, respectively, on prefrontal layer 2/3 pyramidal neurons in mice. |
2024-02-16 |
2024-02-19 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
monoamine content, serotonin (5-ht) release, 5-ht uptake, 5-ht transporter (sert) protein levels, and behaviors were investigated in mice subjected to chronic social defeat stress and in mice with knockdown of slc6a4, in 5-htergic neurons projecting to the prefrontal cortex (pfc). |
2024-02-01 |
2024-02-04 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
increased turnover, increased extracellular basal levels, decreased release and decreased uptake of 5-ht, and decreased sert protein levels were observed in the pfc of the stressed mice. |
2024-02-01 |
2024-02-04 |
mouse |
| Ryota Araki, Ayami Kita, Yukio Ago, Takeshi Yab. Chronic social defeat stress induces anxiety-like behaviors via downregulation of serotonin transporter in the prefrontal serotonergic system in mice. Neurochemistry international. 2024-02-01. PMID:38301899. |
similar to the stressed mice, mice with slc6a4 knockdown in 5-htergic neurons projecting to the pfc also showed decreased release and uptake of 5-ht in the pfc and increased anxiety-like behavior. |
2024-02-01 |
2024-02-04 |
mouse |
| Jennie Garcia-Olivares, Brittney Yegla, Frank P Bymaster, Jami Earnest, Jennifer Koch, Chungping Yu, Jonathan Rubi. Viloxazine Increases Extracellular Concentrations of Norepinephrine, Dopamine, and Serotonin in the Rat Prefrontal Cortex at Doses Relevant for the Treatment of Attention-Deficit/Hyperactivity Disorder. Journal of experimental pharmacology. vol 16. 2024-01-22. PMID:38249320. |
viloxazine increases extracellular concentrations of norepinephrine, dopamine, and serotonin in the rat prefrontal cortex at doses relevant for the treatment of attention-deficit/hyperactivity disorder. |
2024-01-22 |
2024-01-24 |
rat |
| Maria Bove, Maria Grazia Morgese, Stefania Dimonte, Vladyslav Sikora, Lisa Pia Agosti, Maria Adelaide Palmieri, Paolo Tucci, Stefania Schiavone, Luigia Trabac. Increased stress vulnerability in the offspring of socially isolated rats: Behavioural, neurochemical and redox dysfunctions. Progress in neuro-psychopharmacology & biological psychiatry. 2024-01-19. PMID:38242425. |
levels of noradrenaline (na), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), glutamate (glu) and gaba were assessed in the prefrontal cortex (pfc). |
2024-01-19 |
2024-01-22 |
rat |