| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R C Malenka, J A Kauer, D J Perkel, M D Mauk, P T Kelly, R A Nicoll, M N Waxha. An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation. Nature. vol 340. issue 6234. 1989-09-25. PMID:2549423. |
in the ca1 region of the hippocampus, the induction of ltp requires activation of nmda (n-methyl-d-aspartate) receptors by synaptically released glutamate with concomitant postsynaptic membrane depolarization. |
1989-09-25 |
2023-08-11 |
Not clear |
| M P Mattson, S B Kate. Development and selective neurodegeneration in cell cultures from different hippocampal regions. Brain research. vol 490. issue 1. 1989-09-08. PMID:2569350. |
previous studies have shown that pyramidal neurons in hippocampal regions ca1 and ca3 are selectively vulnerable in several neurodegenerative disorders and that a subpopulation of pyramidal neurons in cell cultures of embryonic hippocampus are sensitive to glutamate neurotoxicity. |
1989-09-08 |
2023-08-11 |
rat |
| M P Mattson, S B Kate. Development and selective neurodegeneration in cell cultures from different hippocampal regions. Brain research. vol 490. issue 1. 1989-09-08. PMID:2569350. |
in order to determine whether the patterns of cell loss seen in situ correlate with intrinsic differences in neuronal sensitivities to glutamate-induced degeneration acquired during development, we characterized cultures established from different regions of postnatal rat hippocampus and then examined neuronal sensitivity to glutamate. |
1989-09-08 |
2023-08-11 |
rat |
| E O Nielsen, M Aarslew-Jensen, N H Diemer, P Krogsgaard-Larsen, A Schousbo. Baclofen-induced, calcium-dependent stimulation of in vivo release of D-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis. Neurochemical research. vol 14. issue 4. 1989-09-08. PMID:2761667. |
the release of d-[3h]aspartate (used as a tracer for endogenous glutamate and aspartate) was studied at high k+ (100 mm) and under ischemia in rats implanted with 0.3 mm diameter dialysis tubing through the hippocampus. |
1989-09-08 |
2023-08-11 |
rat |
| N I Kiskin, E M Kliuchko, O A Kryshtal', A Ia Tsyndrenko, N Akaik. [Blocking action of Nephila clavata spider toxin on ionic currents activated by glutamate and its agonists in isolated hippocampal neurons]. Neirofiziologiia = Neurophysiology. vol 21. issue 2. 1989-09-06. PMID:2474133. |
[blocking action of nephila clavata spider toxin on ionic currents activated by glutamate and its agonists in isolated hippocampal neurons]. |
1989-09-06 |
2023-08-11 |
rat |
| A Lehman. Effects of microdialysis-perfusion with anisoosmotic media on extracellular amino acids in the rat hippocampus and skeletal muscle. Journal of neurochemistry. vol 53. issue 2. 1989-08-25. PMID:2501452. |
glutamate, aspartate, gamma-aminobutyrate, and alanine levels in dialysate from the hippocampus increased when the concentration of nacl was decreased by 61 mm, and they were further elevated when nacl was omitted. |
1989-08-25 |
2023-08-11 |
rat |
| T L Babb, J K Pretorius, W R Kupfer, P H Crandal. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 9. issue 7. 1989-08-25. PMID:2501460. |
glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. |
1989-08-25 |
2023-08-11 |
human |
| A J McDonald, A J Beitz, A A Larson, R Kuriyama, C Sellitto, J E Mad. Co-localization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: an immunohistochemical study using monoclonal antibodies. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2568603. |
co-localization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: an immunohistochemical study using monoclonal antibodies. |
1989-08-21 |
2023-08-11 |
rat |
| A J McDonald, A J Beitz, A A Larson, R Kuriyama, C Sellitto, J E Mad. Co-localization of glutamate and tubulin in putative excitatory neurons of the hippocampus and amygdala: an immunohistochemical study using monoclonal antibodies. Neuroscience. vol 30. issue 2. 1989-08-21. PMID:2568603. |
tubulin and glutamate were immunohistochemically localized in the hippocampus and amygdala of rats using monoclonal antibodies to gamma-glu-glu (glu-1) and glutaraldehyde-fixed glutamate (glu-2), respectively. |
1989-08-21 |
2023-08-11 |
rat |
| G Garthwaite, J Garthwait. Quisqualate neurotoxicity: a delayed, CNQX-sensitive process triggered by a CNQX-insensitive mechanism in young rat hippocampal slices. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2568605. |
exposure of slices of young rat hippocampus for 30 min to the glutamate receptor agonist, quisqualate (qa, 30 microm), led, after a 90 min recovery period, to severe 'dark cell degeneration' of pyramidal neurones, most extensively those in ca3. |
1989-08-18 |
2023-08-11 |
rat |
| A Represa, E Tremblay, Y Ben-Ar. Transient increase of NMDA-binding sites in human hippocampus during development. Neuroscience letters. vol 99. issue 1-2. 1989-08-18. PMID:2568608. |
in the human hippocampus, the density of glutamate and n-methyl-d-aspartate (nmda) binding sites follows during development a bell-shaped curve with a peak at 23-27 fetal weeks. |
1989-08-18 |
2023-08-11 |
human |
| T Kaneko, T Nakazawa, M Ueno, Y Furuya, M Ikeda, M Mihara, K Abe, K Tanaka, T Uzuo, T Fukud. Anti-ischemic effect of the novel anti-ischemic agent 2-(4-(p-fluorobenzoyl)-piperidin-1-yl)-2'-acetonaphthone hydrochloride and possible mechanism of its action. Arzneimittel-Forschung. vol 39. issue 4. 1989-08-18. PMID:2751730. |
e-2001 suppressed the high potassium-evoked release of glutamate from rat hippocampal slices. |
1989-08-18 |
2023-08-11 |
mouse |
| G L Wenk, C M Grey, D K Ingram, E L Spangler, D S Olto. Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat. Behavioral neuroscience. vol 103. issue 3. 1989-08-10. PMID:2544208. |
in the present study, a significant correlation was found between the number of nmda-displaceable, na+-independent l-[3h]glutamate binding sites in the hippocampus and neocortex of young rats and the mean number of errors during retention, but not acquisition, in a 14-unit t-maze. |
1989-08-10 |
2023-08-11 |
rat |
| J H Garcia, M L Anderso. Physiopathology of cerebral ischemia. Critical reviews in neurobiology. vol 4. issue 4. 1989-07-10. PMID:2655939. |
several potential culprits have been tried: (1) "energy failure", or depletion of high-energy phosphates, occurs very quickly after ischemia, but energy metabolites recover even in tissues where functional return does not occur; (2) "tissue lactacidosis" enhances ischemic cell necrosis, but this factor is not the indispensable cause of neuronal necrosis because acidosis is minimal or nonexistent under conditions of hypoglycemia and seizures; (3) "impairment of the microcirculation" may be a contributing factor, but such microcirculatory impairment cannot be the initiating event as it is known that irreversible neuronal injury precedes the development of microcirculatory abnormalities; (4) the effects of "excitatory neurotransmitters", especially glutamate, may explain the "delayed neuronal death" or the protracted necrosis of neurons in the ca1 sector of the hippocampus; (5) ionic pump alterations: studies of experimental myocardial ischemia tend to support a contributory role of ca2+ in the aggravation of cell necrosis; however, lack of an experimental model in which steady-state conditions can be maintained has left unresolved the potential participation of calcium ions in ischemic cell necrosis; (6) the same statement, concerning the lack of an experimental model, can be made about the role of free-radical species; oxygen free radicals and superoxides are abundant in the reperfusion stage of ischemic injury, but it is unclear how significant their contribution might be as initiators of ischemic necrosis; and (7) the "ischemic penumbra" is a zone or portion of brain tissue that is sufficiently hypoperfused as to be functionless, but where the cells are likely to recover once normal perfusion is reestablished. |
1989-07-10 |
2023-08-11 |
Not clear |
| M Frotsche. Mossy fiber synapses on glutamate decarboxylase-immunoreactive neurons: evidence for feed-forward inhibition in the CA3 region of the hippocampus. Experimental brain research. vol 75. issue 2. 1989-07-07. PMID:2721621. |
mossy fiber synapses on glutamate decarboxylase-immunoreactive neurons: evidence for feed-forward inhibition in the ca3 region of the hippocampus. |
1989-07-07 |
2023-08-11 |
Not clear |
| E Salinska, R Pluta, J W Lazarewic. Participation of NMDA-receptors in ischemic changes of calcium homeostasis in rabbit brain. Biomedica biochimica acta. vol 48. issue 2-3. 1989-07-06. PMID:2567159. |
these results indicate that calcium channels coupled to nmda-sensitive glutamate receptors, rather than voltage-dependent calcium channels play a key role in ischemic calcium influx to hippocampal neurons. |
1989-07-06 |
2023-08-11 |
rabbit |
| J D Michenfelder, W L Lanier, B W Scheithauer, W J Perkins, G T Shearman, J H Mild. Evaluation of the glutamate antagonist dizocilipine maleate (MK-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology. Brain research. vol 481. issue 2. 1989-06-30. PMID:2655824. |
evaluation of the glutamate antagonist dizocilipine maleate (mk-801) on neurologic outcome in a canine model of complete cerebral ischemia: correlation with hippocampal histopathology. |
1989-06-30 |
2023-08-11 |
Not clear |
| C J Liu, P Grandes, C Matute, M Cuénod, P Strei. Glutamate-like immunoreactivity revealed in rat olfactory bulb, hippocampus and cerebellum by monoclonal antibody and sensitive staining method. Histochemistry. vol 90. issue 6. 1989-06-12. PMID:2469673. |
only this amongst several other immunohistochemical methods tried produced labeling patterns which showed terminal-like elements in brain regions such as olfactory bulb, hippocampus and cerebellum, and which were mostly consistent with already available information on systems using glutamate as neurotransmitter. |
1989-06-12 |
2023-08-11 |
rat |
| J W Swann, R J Brady, D L Marti. Postnatal development of GABA-mediated synaptic inhibition in rat hippocampus. Neuroscience. vol 28. issue 3. 1989-05-31. PMID:2710330. |
the activity of glutamate decarboxylase, the synthetic enzyme for gaba, was very low at 3 days in hippocampus, and increased until 30 days of age at which time adult values were obtained. |
1989-05-31 |
2023-08-11 |
rat |
| J W Swann, R J Brady, D L Marti. Postnatal development of GABA-mediated synaptic inhibition in rat hippocampus. Neuroscience. vol 28. issue 3. 1989-05-31. PMID:2710330. |
glutamate decarboxylase activities in microdissected ca3 and ca1 subfields were similar in immature hippocampus. |
1989-05-31 |
2023-08-11 |
rat |