| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G E Fagg, H R Olpe, M F Pozza, J Baud, M Steinmann, M Schmutz, C Portet, P Baumann, K Thedinga, H Bittige. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. British journal of pharmacology. vol 99. issue 4. 1990-08-08. PMID:1972895. |
cgp 37849 and cgp 39551 were inactive as inhibitors of l-[3h]-glutamate uptake into rat brain synaptosomes and had no effect on the release of endogenous glutamate from rat hippocampal slices evoked by electrical field stimulation. |
1990-08-08 |
2023-08-11 |
mouse |
| G Erdemli, T Dalkara, R Onu. Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors. Brain research. vol 514. issue 2. 1990-08-01. PMID:1972639. |
glutamate and glycine induce a negative wave on hippocampal field response through nmda receptors. |
1990-08-01 |
2023-08-11 |
rat |
| G Erdemli, T Dalkara, R Onu. Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors. Brain research. vol 514. issue 2. 1990-08-01. PMID:1972639. |
in rats under urethane anesthesia, iontophoresis of large amounts (30-300 na) of glutamate in the hippocampus induced a negative wave on the field potential evoked by stimulation of fimbria/commissura or perforant pathway. |
1990-08-01 |
2023-08-11 |
rat |
| G Erdemli, T Dalkara, R Onu. Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors. Brain research. vol 514. issue 2. 1990-08-01. PMID:1972639. |
the negative waves were induced in all hippocampal layers except the dentate hilus by glutamate, nmdla and glycine. |
1990-08-01 |
2023-08-11 |
rat |
| G Erdemli, T Dalkara, R Onu. Glutamate and glycine induce a negative wave on hippocampal field response through NMDA receptors. Brain research. vol 514. issue 2. 1990-08-01. PMID:1972639. |
these data suggest that large amounts of glutamate activate nmda receptor/ion channels causing appearance of a long-lasting negative wave on the hippocampal field response. |
1990-08-01 |
2023-08-11 |
rat |
| A Najlerahim, P J Harrison, A J Barton, J Heffernan, R C Pearso. Distribution of messenger RNAs encoding the enzymes glutaminase, aspartate aminotransferase and glutamic acid decarboxylase in rat brain. Brain research. Molecular brain research. vol 7. issue 4. 1990-07-31. PMID:2163007. |
glut mrna does not appear to be present at high levels in all gad-containing neurons, but is seen prominently in many neuronal populations that may use glutamate as a neurotransmitter, such as neocortical and hippocampal pyramidal cells, the granule cells of the cerebellum and neurons of the dentate gyrus of the hippocampus. |
1990-07-31 |
2023-08-11 |
rat |
| M Ebadi, L C Murrin, R F Pfeiffe. Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions. Annals of the New York Academy of Sciences. vol 585. 1990-07-23. PMID:2192611. |
the proposed mechanism is that at physiological concentrations zinc stimulates the activity of the hippocampal pyridoxal kinase (50% stimulation at 1.7 x 10(-7) m), enhancing the formation of plp, whereas in pharmacological doses zinc inhibits the activity of glutamate decarboxylase (gad) directly (50% inhibition at 6.5 x 10(-4) m) by preventing the binding of plp to hologad. |
1990-07-23 |
2023-08-11 |
rat |
| M A Lynch, K L Vos. Arachidonic acid increases inositol phospholipid metabolism and glutamate release in synaptosomes prepared from hippocampal tissue. Journal of neurochemistry. vol 55. issue 1. 1990-07-20. PMID:1972388. |
arachidonic acid increases inositol phospholipid metabolism and glutamate release in synaptosomes prepared from hippocampal tissue. |
1990-07-20 |
2023-08-11 |
Not clear |
| G E Meredith, F G Wouterlood, A Pattiselann. Hippocampal fibers make synaptic contacts with glutamate decarboxylase-immunoreactive neurons in the rat nucleus accumbens. Brain research. vol 513. issue 2. 1990-07-16. PMID:2350704. |
hippocampal fibers make synaptic contacts with glutamate decarboxylase-immunoreactive neurons in the rat nucleus accumbens. |
1990-07-16 |
2023-08-11 |
rat |
| R A Lester, C E Jah. Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons. Neuron. vol 4. issue 5. 1990-07-05. PMID:1971515. |
the modulation of ca2+ currents by the excitatory neurotransmitter glutamate and its analogs was investigated in hippocampal neurons in culture. |
1990-07-05 |
2023-08-11 |
Not clear |
| J S Teitelbaum, R J Zatorre, S Carpenter, D Gendron, A C Evans, A Gjedde, N R Cashma. Neurologic sequelae of domoic acid intoxication due to the ingestion of contaminated mussels. The New England journal of medicine. vol 322. issue 25. 1990-07-05. PMID:1971710. |
neuropathological studies in the four patients who died after mussel-induced intoxication demonstrated neuronal necrosis and loss, predominantly in the hippocampus and amygdala, in a pattern similar to that observed experimentally in animals after the administration of kainic acid, which is also structurally similar to glutamate and domoic acid. |
1990-07-05 |
2023-08-11 |
Not clear |
| C Miyazaki, K Matsuyama, M Ichikawa, S Goto, J Yamamot. Synthesis of valproyl-2-pyrrolidinone and its evaluation as a cognitive drug with the ability to modulate acidic amino acids in the brain. Journal of pharmacobio-dynamics. vol 13. issue 1. 1990-06-28. PMID:1971306. |
the quantitative experiment using hplc demonstrated a significant reduction of hippocampal aspartate (asp) and glutamate (glu) following the intraperitoneal administration of vp at a dose of 300 mg/kg. |
1990-06-28 |
2023-08-11 |
rat |
| J B Penney, W F Maragos, J T Greenamyre, D L Debowey, Z Hollingsworth, A B Youn. Excitatory amino acid binding sites in the hippocampal region of Alzheimer's disease and other dementias. Journal of neurology, neurosurgery, and psychiatry. vol 53. issue 4. 1990-06-25. PMID:2160518. |
quantitative receptor autoradiography was used to measure muscarinic cholinergic, benzodiazepine, kainate, phencyclidine (pcp), n-methyl-d-aspartate (nmda) (measured in tris acetate), quisqualate-sensitive, non-quisqualate-sensitive and total glutamate (measured in tris chloride buffer) binding sites in adjacent sections of the hippocampal region of 10 alzheimer's disease, nine control, and six demented, non-alzheimer's disease postmortem human brains. |
1990-06-25 |
2023-08-11 |
human |
| A C Duhaime, D T Ros. Degeneration of hippocampal CA1 neurons following transient ischemia due to raised intracranial pressure: evidence for a temperature-dependent excitotoxic process. Brain research. vol 512. issue 1. 1990-06-21. PMID:1970944. |
hypothermia appears to decrease hippocampal extracellular levels of glutamate during and after ischemia but provides only relative protection from ischemia as ca1 degeneration does occur with prolonged (30 min) periods of ischemia. |
1990-06-21 |
2023-08-11 |
Not clear |
| J R Clements, K R Magnusson, A J Beit. Ultrastructural description of glutamate-, aspartate-, taurine-, and glycine-like immunoreactive terminals from five rat brain regions. Journal of electron microscopy technique. vol 15. issue 1. 1990-06-19. PMID:1971014. |
in the hippocampus, mossy fiber terminals within the stratum lucidum of the ca3 region were immunoreactive for glutamate. |
1990-06-19 |
2023-08-11 |
rat |
| J R Clements, K R Magnusson, A J Beit. Ultrastructural description of glutamate-, aspartate-, taurine-, and glycine-like immunoreactive terminals from five rat brain regions. Journal of electron microscopy technique. vol 15. issue 1. 1990-06-19. PMID:1971014. |
localization of glutamate and aspartate to cerebellar parallel and mossy fibers, as well as the identification of glutamate in hippocampal mossy fibers, is consistent with the excitatory nature of these fibers as described in previous physiological studies. |
1990-06-19 |
2023-08-11 |
rat |
| P Kugle. Microphotometric determination of enzymes in brain sections. III. Glutamate dehydrogenase. Histochemistry. vol 93. issue 5. 1990-06-07. PMID:2332353. |
an incubation medium was established for the microphotometric demonstration of glutamate dehydrogenase (gldh) in cryostat sections of the rat hippocampus which served as an exemplary brain region. |
1990-06-07 |
2023-08-11 |
rat |
| P J Langlais, R G Mai. Protective effects of the glutamate antagonist MK-801 on pyrithiamine-induced lesions and amino acid changes in rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 5. 1990-06-06. PMID:1970604. |
significant reductions of aspartate and glutamate and increases of glycine were observed in 5 regions of thalamus, the hippocampus, hypothalamus, and mammillary bodies of both the early and late acute ptd groups. |
1990-06-06 |
2023-08-11 |
rat |
| D M Lovinger, G White, F F Weigh. NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 10. issue 4. 1990-05-25. PMID:2158533. |
the effect of ethanol (etoh) on synaptic transmission mediated by n-methyl-d-aspartate (nmda) and non-nmda glutamate receptors was investigated in slices from adult rat hippocampus. |
1990-05-25 |
2023-08-11 |
rat |
| T J Grudt, C E Jah. Quisqualate activates N-methyl-D-aspartate receptor channels in hippocampal neurons maintained in culture. Molecular pharmacology. vol 37. issue 4. 1990-05-24. PMID:1970115. |
whole-cell and single-channel patch-clamp recordings from hippocampal neurons in culture have been used to study the receptor channel selectivity of the glutamate analog quisqualate. |
1990-05-24 |
2023-08-11 |
Not clear |