| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| N Tamura, Y Matsushita, T Iwama, S Harada, S Kishimoto, K Ito. Synthesis and biological activity of (S)-2-amino-3-(2,5-dihydro-5-oxo-4-isoxazolyl)propanoic acid (TAN-950 A) derivatives. Chemical & pharmaceutical bulletin. vol 39. issue 5. 1991-11-04. PMID:1655291. |
the 3-alkyl derivatives 15b, d--g, especially, showed a high affinity for the quisqualate subtype-receptor and had a strong activating effect on the hippocampal neurons (glutamate agonistic activity). |
1991-11-04 |
2023-08-11 |
Not clear |
| D M Terrian, T A Conner-Kerr, T H Privette, R L Ganno. Domoic acid enhances the K(+)-evoked release of endogenous glutamate from guinea pig hippocampal mossy fiber synaptosomes. Brain research. vol 551. issue 1-2. 1991-11-01. PMID:1680526. |
domoic acid enhances the k(+)-evoked release of endogenous glutamate from guinea pig hippocampal mossy fiber synaptosomes. |
1991-11-01 |
2023-08-11 |
Not clear |
| A Derouiche, M Frotsche. Astroglial processes around identified glutamatergic synapses contain glutamine synthetase: evidence for transmitter degradation. Brain research. vol 552. issue 2. 1991-10-31. PMID:1680531. |
here we report that immunoreactivity against glutamine synthetase (gs), one of the glutamate metabolizing enzymes, is localized in the fine astrocytic processes associated with identified glutamatergic synapses in the rat hippocampus. |
1991-10-31 |
2023-08-11 |
rat |
| T Behnisch, K Fjodorow, K G Reyman. L-2-amino-3-phosphonopropionate blocks late synaptic long-term potentiation. Neuroreport. vol 2. issue 7. 1991-10-30. PMID:1655108. |
the possible involvement of the metabotropic glutamate receptor in mechanisms of hippocampal long-term potentiation was investigated with the new antagonist 2-amino-3-phosphonopropionate (ap3). |
1991-10-30 |
2023-08-11 |
Not clear |
| J J Vornov, R C Tasker, J T Coyl. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1717307. |
direct observation of the agonist-specific regional vulnerability to glutamate, nmda, and kainate neurotoxicity in organotypic hippocampal cultures. |
1991-10-30 |
2023-08-11 |
Not clear |
| J J Vornov, R C Tasker, J T Coyl. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures. Experimental neurology. vol 114. issue 1. 1991-10-30. PMID:1717307. |
we have observed directly the time course and regional vulnerability of hippocampal neurons to glutamate receptor-mediated injury in organotypic hippocampal cultures, a preparation which combines accessibility and long-term survival with preservation of regional differentiation and neuroanatomic organization. |
1991-10-30 |
2023-08-11 |
Not clear |
| C E Virgin, T P Ha, D R Packan, G C Tombaugh, S H Yang, H C Horner, R M Sapolsk. Glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. Journal of neurochemistry. vol 57. issue 4. 1991-10-21. PMID:1680166. |
glucocorticoids inhibit glucose transport and glutamate uptake in hippocampal astrocytes: implications for glucocorticoid neurotoxicity. |
1991-10-21 |
2023-08-11 |
Not clear |
| A J Baker, M H Zornow, M S Scheller, T L Yaksh, S R Skilling, D H Smullin, A A Larson, R Kuczensk. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. Journal of neurochemistry. vol 57. issue 4. 1991-10-21. PMID:1895110. |
accordingly, this study was undertaken to examine the patterns of changes of extracellular glutamate, aspartate, glycine concentrations in the hippocampus, and dopamine, serotonin, and dopamine metabolites in the caudate nucleus with varying durations (5, 10, or 15 minutes) of transient global cerebral ischemia as evidence to support their pathogenetic roles. |
1991-10-21 |
2023-08-11 |
rabbit |
| A J Baker, M H Zornow, M S Scheller, T L Yaksh, S R Skilling, D H Smullin, A A Larson, R Kuczensk. Changes in extracellular concentrations of glutamate, aspartate, glycine, dopamine, serotonin, and dopamine metabolites after transient global ischemia in the rabbit brain. Journal of neurochemistry. vol 57. issue 4. 1991-10-21. PMID:1895110. |
that glutamate and aspartate concentrations in the hippocampus co-vary with the duration of global ischemia is taken as supportive evidence of their pathogenetic role in ischemic neuronal injury. |
1991-10-21 |
2023-08-11 |
rabbit |
| P Greengard, J Jen, A C Nairn, C F Steven. Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science (New York, N.Y.). vol 253. issue 5024. 1991-10-09. PMID:1716001. |
enhancement of the glutamate response by camp-dependent protein kinase in hippocampal neurons. |
1991-10-09 |
2023-08-11 |
human |
| S W Rogers, T E Hughes, M Hollmann, G P Gasic, E S Deneris, S Heineman. The characterization and localization of the glutamate receptor subunit GluR1 in the rat brain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 9. 1991-10-03. PMID:1652625. |
although glutamate receptors are thought to be the most prevalent excitatory ligand-gated ion channel in the mammalian brain, immunohistochemistry reveals that the receptors recognized by these antisera are localized predominantly in neurons of the cerebellum and some structures of the limbic system, including the hippocampus, the central nucleus of the amygdala, and portions of the septum. |
1991-10-03 |
2023-08-11 |
rat |
| T Shigeno, T Mima, K Takakura, D I Graham, G Kato, Y Hashimoto, S Furukaw. Amelioration of delayed neuronal death in the hippocampus by nerve growth factor. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 9. 1991-10-03. PMID:1880556. |
although previous knowledge of ngf is limited to the survival of cholinergic neurons in the cns, it is assumed that other mechanisms must be operating in the hippocampus, for example, postsynaptic modification at dendrites or aberrant expression of ngf receptors possibly at the initial excitation period by glutamate. |
1991-10-03 |
2023-08-11 |
Not clear |
| P K Stanton, S Chattarji, T J Sejnowsk. 2-Amino-3-phosphonopropionic acid, an inhibitor of glutamate-stimulated phosphoinositide turnover, blocks induction of homosynaptic long-term depression, but not potentiation, in rat hippocampus. Neuroscience letters. vol 127. issue 1. 1991-09-30. PMID:1679224. |
we have also found that pairing of synaptic activity with postsynaptic hyperpolarization is sufficient to induce ltd. we report here that 2-amino-3-phosphonopropionate (ap3), a selective inhibitor of phosphoinositide (pi) turnover mediated by the metabotropic glutamate receptor, blocks the induction of associative ltd in hippocampal field ca1, but does not impair the induction of ltp. |
1991-09-30 |
2023-08-11 |
rat |
| H Bading, M E Greenber. Stimulation of protein tyrosine phosphorylation by NMDA receptor activation. Science (New York, N.Y.). vol 253. issue 5022. 1991-09-25. PMID:1715095. |
stimulation of cultured rat hippocampal cells with glutamate resulted in the rapid and transient tyrosine phosphorylation of a 39-kilodalton protein (p39). |
1991-09-25 |
2023-08-11 |
rat |
| R L Gannon, D M Terria. U-50,488H inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals. Brain research. vol 548. issue 1-2. 1991-09-19. PMID:1678297. |
u-50,488h inhibits dynorphin and glutamate release from guinea pig hippocampal mossy fiber terminals. |
1991-09-19 |
2023-08-11 |
Not clear |
| A Mihály, S L Erdö, U Kuhn. Time dependent loss of tissue GABA content and immunoreactivity in hippocampal slices. Brain research bulletin. vol 26. issue 4. 1991-09-17. PMID:1868355. |
in conclusion, while in hippocampal slices tissue glutamate and aspartate levels are only slightly affected by the in vitro maintenance, more than half of the tissue gaba content is lost during prolonged in vitro incubation. |
1991-09-17 |
2023-08-11 |
Not clear |
| W K Scholz, H C Palfre. Glutamate-stimulated protein phosphorylation in cultured hippocampal pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 8. 1991-09-13. PMID:1678425. |
these results suggest that glutamate stimulates the transient generation of second messengers that activate pkc in hippocampal neurons, resulting in a significant increase in the phosphorylation of three specific proteins. |
1991-09-13 |
2023-08-11 |
rat |
| J M Dubinsky, S M Rothma. Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 8. 1991-09-13. PMID:1678427. |
because hypoxic/ischemic neurodegeneration appears to be in part linked to glutamate neurotoxicity, we measured intracellular calcium (ca2+i) levels in cultured hippocampal neurons during exposure to toxic doses of glutamate (glu) and to an anoxic environment simulated by sodium cyanide (nacn). |
1991-09-13 |
2023-08-11 |
Not clear |
| R L Gannon, D M Terria. Presynaptic modulation of glutamate and dynorphin release by excitatory amino acids in the guinea-pig hippocampus. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1678499. |
presynaptic modulation of glutamate and dynorphin release by excitatory amino acids in the guinea-pig hippocampus. |
1991-09-13 |
2023-08-11 |
rat |
| R Torp, P Andiné, H Hagberg, T Karagülle, T W Blackstad, O P Otterse. Cellular and subcellular redistribution of glutamate-, glutamine- and taurine-like immunoreactivities during forebrain ischemia: a semiquantitative electron microscopic study in rat hippocampus. Neuroscience. vol 41. issue 2-3. 1991-09-13. PMID:1870699. |
the effect of 20 min of ischemia on the cellular and subcellular distribution of glutamate, glutamine and taurine in the rat hippocampus was studied by means of an immunocytochemical procedure based on antisera raised against protein glutaraldehyde conjugates of the respective amino acids. |
1991-09-13 |
2023-08-11 |
rat |