| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cliona M O'Mahony, Gerard Clarke, Sinead Gibney, Timothy G Dinan, John F Crya. Strain differences in the neurochemical response to chronic restraint stress in the rat: relevance to depression. Pharmacology, biochemistry, and behavior. vol 97. issue 4. 2011-04-25. PMID:21110995. |
wky animals showed similar stress-induced decreases in hippocampal gaba, noradrenaline and dopamine as their sd counterparts while exhibiting a divergent decrease in 5-ht, 5-hiaa and dopac. |
2011-04-25 |
2023-08-12 |
rat |
| Tope Lanre-Amos, Bernat Kocsi. Hippocampal oscillations in the rodent model of schizophrenia induced by amygdala GABA receptor blockade. Frontiers in psychiatry. vol 1. 2011-04-22. PMID:21308001. |
hippocampal oscillations in the rodent model of schizophrenia induced by amygdala gaba receptor blockade. |
2011-04-22 |
2023-08-12 |
rat |
| Timothy B Johnstone, Zhenglin Gu, Ryan F Yoshimura, Anne-Sophie Villegier, Derk J Hogenkamp, Edward R Whittemore, Jin-Cheng Huang, Minhtam B Tran, James D Belluzzi, Jerrel L Yakel, Kelvin W Ge. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159751. |
α5 subunit-containing gaba(a) receptors (gaba(a)rs) and α7 neuronal nicotinic-acetylcholine receptors (nachrs) are members of the cys-loop family of ligand-gated ion channels (lgics) that mediate cognitive and attentional processes in the hippocampus. |
2011-04-21 |
2023-08-12 |
rat |
| Timothy B Johnstone, Zhenglin Gu, Ryan F Yoshimura, Anne-Sophie Villegier, Derk J Hogenkamp, Edward R Whittemore, Jin-Cheng Huang, Minhtam B Tran, James D Belluzzi, Jerrel L Yakel, Kelvin W Ge. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159751. |
α5 gaba(a)rs alter network activity by tonic inhibition of ca1/ca3 pyramidal cells of the hippocampus. |
2011-04-21 |
2023-08-12 |
rat |
| Timothy B Johnstone, Zhenglin Gu, Ryan F Yoshimura, Anne-Sophie Villegier, Derk J Hogenkamp, Edward R Whittemore, Jin-Cheng Huang, Minhtam B Tran, James D Belluzzi, Jerrel L Yakel, Kelvin W Ge. Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. The Journal of pharmacology and experimental therapeutics. vol 336. issue 3. 2011-04-21. PMID:21159751. |
we show that combined transient application of two allosteric modulators that individually 1) inhibit α5 gaba(a)rs and 2) enhance α7 nachrs causes long-term potentiation (ltp) of mossy fiber stimulation-induced excitatory postsynaptic currents (epsc) from ca1 pyramidal neurons of rat hippocampal slices. |
2011-04-21 |
2023-08-12 |
rat |
| P Wyrembek, K Szczuraszek, M D Majewska, J W Mozrzyma. Intermingled modulatory and neurotoxic effects of thimerosal and mercuric ions on electrophysiological responses to GABA and NMDA in hippocampal neurons. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 6. 2011-04-21. PMID:21224507. |
intermingled modulatory and neurotoxic effects of thimerosal and mercuric ions on electrophysiological responses to gaba and nmda in hippocampal neurons. |
2011-04-21 |
2023-08-12 |
Not clear |
| P Wyrembek, K Szczuraszek, M D Majewska, J W Mozrzyma. Intermingled modulatory and neurotoxic effects of thimerosal and mercuric ions on electrophysiological responses to GABA and NMDA in hippocampal neurons. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 61. issue 6. 2011-04-21. PMID:21224507. |
we examined, using electrophysiological recordings, thimerosal effects on gaba and nmda-evoked currents in cultured hippocampal neurons. |
2011-04-21 |
2023-08-12 |
Not clear |
| Jobin Mathew, Gireesh Gangadharan, Korah P Kuruvilla, C S Paulos. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20821261. |
behavioral deficit and decreased gaba receptor functional regulation in the hippocampus of epileptic rats: effect of bacopa monnieri. |
2011-04-18 |
2023-08-12 |
rat |
| Jobin Mathew, Gireesh Gangadharan, Korah P Kuruvilla, C S Paulos. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20821261. |
in the present study, alterations of the general gaba and gaba(a) receptors in the hippocampus of pilocarpine-induced temporal lobe epileptic rats and the therapeutic application of bacopa monnieri and its active component bacoside-a were investigated. |
2011-04-18 |
2023-08-12 |
rat |
| Jobin Mathew, Gireesh Gangadharan, Korah P Kuruvilla, C S Paulos. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20821261. |
scatchard analysis of [³h]gaba and [³h]bicuculline in the hippocampus of the epileptic rat showed significant decrease in b(max) (p < 0.001) compared to control. |
2011-04-18 |
2023-08-12 |
rat |
| Jobin Mathew, Gireesh Gangadharan, Korah P Kuruvilla, C S Paulos. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20821261. |
real time pcr amplification of gaba(a) receptor sub-units such as gaba(aά₁), gaba(aά₅) gaba(aδ), and gad were down regulated (p < 0.001) in the hippocampus of the epileptic rats compared to control. |
2011-04-18 |
2023-08-12 |
rat |
| Jobin Mathew, Gireesh Gangadharan, Korah P Kuruvilla, C S Paulos. Behavioral deficit and decreased GABA receptor functional regulation in the hippocampus of epileptic rats: effect of Bacopa monnieri. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20821261. |
our results suggest that decreased gaba receptors in the hippocampus have an important role in epilepsy associated behavioral deficit, bacopa monnieri and bacoside-a have clinical significance in the management of epilepsy. |
2011-04-18 |
2023-08-12 |
rat |
| Yi Shen, A Kerstin Lindemeyer, Igor Spigelman, Werner Sieghart, Richard W Olsen, Jing Lian. Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons. Molecular pharmacology. vol 79. issue 3. 2011-04-18. PMID:21163967. |
here, we were able to reproduce in primary cultured hippocampal neurons many of the effects of in vivo etoh exposure on gaba(a) receptors (gaba(a)rs). |
2011-04-18 |
2023-08-12 |
rat |
| N Pozdnyakova, L Yatsenko, N Parkhomenko, N Himmelreic. Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:20970472. |
perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. |
2011-03-31 |
2023-08-12 |
rat |
| N Pozdnyakova, L Yatsenko, N Parkhomenko, N Himmelreic. Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:20970472. |
a level of the extracellular gaba and the initial velocity of gaba uptake were measured in the brain cortex, hippocampus and thalamus using isolated nerve terminals (synaptosomes). |
2011-03-31 |
2023-08-12 |
rat |
| N Pozdnyakova, L Yatsenko, N Parkhomenko, N Himmelreic. Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:20970472. |
it has been revealed that the extracellular [(3)h]gaba level maintained by cortical and hippocampal synaptosomes in standard conditions (with glucose as an energy substrate) was significantly higher in adult rats exposed to hypoxia/seizures at p10-12 than in the control ones, and, moreover, became unstable with tendency to increase. |
2011-03-31 |
2023-08-12 |
rat |
| N Pozdnyakova, L Yatsenko, N Parkhomenko, N Himmelreic. Perinatal hypoxia induces a long-lasting increase in unstimulated gaba release in rat brain cortex and hippocampus. The protective effect of pyruvate. Neurochemistry international. vol 58. issue 1. 2011-03-31. PMID:20970472. |
thalamus was insensible to the action of perinatal hypoxia/seizures, and thalamic gats, in contrast to cortical and hippocampal ones, had a lower affinity to gaba (the apparent km is 39.2±3.1 μm gaba vs 8.9±1.8 μm gaba in the hippocampus). |
2011-03-31 |
2023-08-12 |
rat |
| Kyung-Ok Cho, Seong Yun Ki. Effects of brain insults and pharmacological manipulations on the adult hippocampal neurogenesis. Archives of pharmacal research. vol 33. issue 10. 2011-03-07. PMID:21052928. |
further, we discuss the stimulatory and inhibitory actions on adult hippocampal neurogenesis by biochemicals and pharmacological agents, including antidepressants, antipsychotics, agonists and antagonists of glutamate and gaba, adrenal corticoids, gonadal hormones, growth factors such as insulin-like growth factor i, erythropoietin, and drugs of abuse, including nicotine, alcohol, opiates, cocaine, methamphetamine, and 3,4-methylenedioxymethamphetamine ("ecstasy"). |
2011-03-07 |
2023-08-12 |
human |
| Shukuko Yoshida, Satoshi Yamamura, Keiko Ohoyama, Masanori Nakagawa, Eishi Motomura, Sunao Kaneko, Motohiro Okad. Effects of valproate on neurotransmission associated with ryanodine receptors. Neuroscience research. vol 68. issue 4. 2011-03-02. PMID:20832432. |
to clarify the antiepileptic mechanisms of valproate (vpa), we determined the effects of acute and sub-acute administrations of vpa on ryanodine receptor (ryr)-associated hippocampal releases of gaba and glutamate using microdialysis, as well expression of mrna and protein of ryr subtypes in the rat hippocampus. |
2011-03-02 |
2023-08-12 |
rat |
| Shukuko Yoshida, Satoshi Yamamura, Keiko Ohoyama, Masanori Nakagawa, Eishi Motomura, Sunao Kaneko, Motohiro Okad. Effects of valproate on neurotransmission associated with ryanodine receptors. Neuroscience research. vol 68. issue 4. 2011-03-02. PMID:20832432. |
acute administration of therapeutic-relevant vpa did not affect the hippocampal extracellular levels of gaba or glutamate, whereas sub-acute administration increased gaba level without affecting that of glutamate. |
2011-03-02 |
2023-08-12 |
rat |