| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Zhang, I Spigelman, P L Carle. Whole-cell patch study of GABAergic inhibition in CA1 neurons of immature rat hippocampal slices. Brain research. Developmental brain research. vol 56. issue 1. 1991-03-11. PMID:2279324. |
inhibitory processes mediated by gamma-aminobutyric acid (gaba) were studied in immature rat hippocampal slices using the whole-cell patch clamp technique. |
1991-03-11 |
2023-08-11 |
rat |
| M Lazarova-Bakarova, V V Petkov, M Genkova-Papasov. Effect of diazepam and medazepam on pentylenetetrazol kindling in albino rats. Acta physiologica et pharmacologica Bulgarica. vol 16. issue 2. 1991-03-11. PMID:2281800. |
the evidence in the literature that the hippocampus plays the role of a pathologically determining structure in the realization of the ptz kindling and that neurotransmission in the inhibitory synapses in the hippocampus is achieved by gamma-aminobutyric acid (gaba), gives grounds to accept that the anticonvulsive effects of diazepam and medazepam, observed in ptz kindling, occur through gaba-ergic mechanisms, because the facilitating effect of benzodiazepines on the gaba-ergic neurotransmission is well known. |
1991-03-11 |
2023-08-11 |
rat |
| L S Premkumar, P W Gage, S H Chun. Coupled potassium channels induced by arachidonic acid in cultured neurons. Proceedings. Biological sciences. vol 242. issue 1303. 1991-03-08. PMID:1980738. |
exposure of the inside surface of patches of membrane excised from cultured rat hippocampal neurons to arachidonic acid (10-100 microm) caused the appearance of potassium currents of variable amplitude similar to those activated by gaba or baclofen in cell-attached patches. |
1991-03-08 |
2023-08-11 |
rat |
| b' U Ebert, K Krnjevi\\xc4\\x8. Systemic CI-966, a new gamma-aminobutyric acid uptake blocker, enhances gamma-aminobutyric acid action in CA1 pyramidal layer in situ. Canadian journal of physiology and pharmacology. vol 68. issue 9. 1991-03-04. PMID:2276082.' |
twenty to thirty minutes after injection there was a highly variable, but overall significant, enhancement of the inhibition of hippocampal population spikes by gaba applied by microiontophoresis in the ca1 region. |
1991-03-04 |
2023-08-11 |
rat |
| T Kihara, A Baba, Y Koyama, T Ishihara, H Iwat. Inhibition of [3H]glutamate release by Zn2+ in rat hippocampal slices. Journal of pharmacobio-dynamics. vol 13. issue 5. 1991-02-25. PMID:2273448. |
zn2+ at the concentration of 10 microm inhibited the depolarization-induced [3h]glutamate release from the preloaded rat hippocampal slices both in the presence and absence of ca2+ without affecting [3h]gaba and [3h]ach release. |
1991-02-25 |
2023-08-11 |
rat |
| K D Holland, K W Yoon, J A Ferrendelli, D F Covey, S M Rothma. Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist. Molecular pharmacology. vol 39. issue 1. 1991-02-19. PMID:1846222. |
here we have compared the effects of two gamma-butyrolactones, alpha-ethyl-alpha-methyl-gamma-butyrolactone (alpha emgbl) and alpha-isopropyl-alpha-methyl-gamma-butryolactone (alpha imgbl), on gaba currents and inhibitory postsynaptic currents (ipscs) in cultured, voltage-clamped, rat hippocampal neurons. |
1991-02-19 |
2023-08-11 |
rat |
| R A Morrisett, D D Mott, D V Lewis, H S Swartzwelder, W A Wilso. GABAB-receptor-mediated inhibition of the N-methyl-D-aspartate component of synaptic transmission in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 11. issue 1. 1991-02-14. PMID:1846009. |
gaba receptor regulation of nmda-receptor-mediated synaptic responses was studied in area ca1 of the rat hippocampus using extracellular and intracellular recording techniques. |
1991-02-14 |
2023-08-11 |
rat |
| V D Gerasimov, D P Artemenk. [The depressing effect of GABA on synaptic excitation in isolated rat hippocampal slices]. Neirofiziologiia = Neurophysiology. vol 22. issue 5. 1991-02-07. PMID:2175844. |
[the depressing effect of gaba on synaptic excitation in isolated rat hippocampal slices]. |
1991-02-07 |
2023-08-11 |
rat |
| V D Gerasimov, D P Artemenk. [The depressing effect of GABA on synaptic excitation in isolated rat hippocampal slices]. Neirofiziologiia = Neurophysiology. vol 22. issue 5. 1991-02-07. PMID:2175844. |
the action of various gamma-aminobutyric (gaba) concentrations on the amplitude of population epsps (pepsps) recorded from dendrites was examined in hippocampal slices. |
1991-02-07 |
2023-08-11 |
rat |
| V D Gerasimov, D P Artemenk. [The depressing effect of GABA on synaptic excitation in isolated rat hippocampal slices]. Neirofiziologiia = Neurophysiology. vol 22. issue 5. 1991-02-07. PMID:2175844. |
ca1 hippocampal pepsps were much more sensitive to gaba (threshold concentrations--3.10(-5)-2.10(-4)mol/l; ic50--5.10(-4)-1.10(-3) mol/l) the action of gaba on pepsps was not depressed by bicuculline, picrotoxin or penicillin. |
1991-02-07 |
2023-08-11 |
rat |
| V D Gerasimov, D P Artemenk. [The depressing effect of GABA on synaptic excitation in isolated rat hippocampal slices]. Neirofiziologiia = Neurophysiology. vol 22. issue 5. 1991-02-07. PMID:2175844. |
it is concluded that gaba inhibitory effects on ca1 hippocampal pepsps are caused in the main by its presynaptic action mediated by gaba(b)-receptors located probably on axon terminals of the schaffer collaterals. |
1991-02-07 |
2023-08-11 |
rat |
| P Martin, P Pichat, J Massol, P Soubrié, K G Lloyd, A J Puec. Decreased GABA B receptors in helpless rats: reversal by tricyclic antidepressants. Neuropsychobiology. vol 22. issue 4. 1991-01-31. PMID:2562083. |
in the olfactory bulbectomized rat, gaba b receptors are down regulated in the frontal cortex and in the learned helplessness paradigm, gaba release is diminished in the hippocampus. |
1991-01-31 |
2023-08-11 |
rat |
| P A Nerus. [The effect of dexamethasone on the orientation and exploratory activity and the amino acid composition in different CNS structures of rats in experimental neurosis]. Farmakologiia i toksikologiia. vol 53. issue 5. 1991-01-24. PMID:2253742. |
this manifested itself in an increase of gaba amounts in the frontal cortex, hippocampus and striatum by 56, 29 and 27%, respectively (p less than 0.001, 0.05 and 0.001). |
1991-01-24 |
2023-08-11 |
rat |
| E Cherubini, C Rovira, J L Gaiarsa, R Corradetti, Y Ben Ar. GABA mediated excitation in immature rat CA3 hippocampal neurons. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 8. issue 4. 1991-01-14. PMID:2174638. |
gaba mediated excitation in immature rat ca3 hippocampal neurons. |
1991-01-14 |
2023-08-11 |
rat |
| P T Francis, S L Lowe, D M Bowen, J G Jeffery. Lack of change in neurochemical markers during the postepileptic phase of intrahippocampal tetanus toxin syndrome in rats. Epilepsia. vol 31. issue 6. 1991-01-09. PMID:1700950. |
therefore, the long-term reduction in hippocampal excitability cannot be attributed to any major loss of afferents or hippocampal neurons using aspartate, acetylcholine, gamma-aminobutyric acid (gaba), glutamate, norepinephrine (ne), or serotonin as their transmitters. |
1991-01-09 |
2023-08-11 |
rat |
| D Haţegan, C Bălăiţă, E Manole, V Voiculescu, A Ulmean. Brain amino acid levels in audiogenic seizure-susceptible rats following habituation to the auditory stimulus. Romanian journal of neurology and psychiatry = Revue roumaine de neurologie et psychiatrie. vol 28. issue 1. 1991-01-03. PMID:2242332. |
it was found that the habituation process is associated with: a) increased levels of aspartate in hippocampus and pons; b) significantly decreased levels of glycine in the hippocampus and pons; c) decreased concentration of glutamate in the pons; d) no significant changes in the gaba concentrations in hippocampus and brain stem. |
1991-01-03 |
2023-08-11 |
rat |
| H Czyzewska-Szafran, M Wutkiewicz, M Remiszewska, Z Jastrzebski, A Czarnecki, A Danys. Down-regulation of the GABA-ergic system in selected brain areas of spontaneously hypertensive rats (SHR). Polish journal of pharmacology and pharmacy. vol 41. issue 6. 1990-12-13. PMID:2562065. |
out of 9 brain areas studied the gaba content was significantly lower in the substantia nigra, hypothalamus, hypothalamus posterior and hippocampus of shr rats. |
1990-12-13 |
2023-08-11 |
rat |
| T F Freund, A I Gulyás, L Acsády, T Görcs, K Tót. Serotonergic control of the hippocampus via local inhibitory interneurons. Proceedings of the National Academy of Sciences of the United States of America. vol 87. issue 21. 1990-12-07. PMID:1700433. |
information flow and processing in hippocampal neuronal networks is determined by a wide range of inhibitory mechanisms [e.g., feedforward or feedback, gamma-aminobutyrate (gaba) a or b receptor-mediated, perisomatic shunting, or distal dendritic inhibition], each subserving specialized functions. |
1990-12-07 |
2023-08-11 |
Not clear |
| N L Harrison, N A Lamber. Modification of GABAA receptor function by an analog of cyclic AMP. Neuroscience letters. vol 105. issue 1-2. 1990-12-06. PMID:2484725. |
chloride-dependent current responses to gamma-aminobutyric acid (gaba) were recorded from cultured rat hippocampal neurons under voltage clamp. |
1990-12-06 |
2023-08-11 |
rat |
| L S Premkumar, S H Chung, P W Gag. GABA-induced potassium channels in cultured neurons. Proceedings. Biological sciences. vol 241. issue 1301. 1990-12-04. PMID:1978342. |
when gamma-aminobutyric acid (gaba) or baclofen were applied to cultured rat hippocampal neurons, single-channel potassium currents appeared after a delay of 30 s or more in patches of membrane on the cell surface isolated from the agonists by the recording pipette. |
1990-12-04 |
2023-08-11 |
rat |