| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pierre Petitet, Gershon Spitz, Uzay E Emir, Heidi Johansen-Berg, Jacinta O'She. Age-related decline in cortical inhibitory tone strengthens motor memory. NeuroImage. vol 245. 2021-12-11. PMID:34728243. |
ageing disrupts the finely tuned excitation/inhibition balance (e:i) across cortex via a natural decline in inhibitory tone (γ-amino butyric acid, gaba), causing functional decrements. |
2021-12-11 |
2023-08-13 |
Not clear |
| Pierre Petitet, Gershon Spitz, Uzay E Emir, Heidi Johansen-Berg, Jacinta O'She. Age-related decline in cortical inhibitory tone strengthens motor memory. NeuroImage. vol 245. 2021-12-11. PMID:34728243. |
however, in young adults, experimentally lowering gaba in sensorimotor cortex enhances a specific domain of sensorimotor function: adaptation memory. |
2021-12-11 |
2023-08-13 |
Not clear |
| Bo-Wen Chen, Kai-Wen Zhang, Si-Jia Chen, Chun Yang, Peng-Gao L. Vitamin A Deficiency Exacerbates Gut Microbiota Dysbiosis and Cognitive Deficits in Amyloid Precursor Protein/Presenilin 1 Transgenic Mice. Frontiers in aging neuroscience. vol 13. 2021-11-19. PMID:34790112. |
our results show that vad aggravated the behavioral learning and memory deficits, reduced the retinol concentration in the liver and the serum, decreased the transcription of vitamin a (va)-related receptors and va-related enzymes in the cortex, increased amyloid-β peptides (aβ40 and aβ42) in the brain and gut, upregulate the translation of beta-site app-cleaving enzyme 1 (bace1) and phosphorylated tau in the cortex, and downregulate the expression of brain-derived neurotrophic factor (bdnf) and γ-aminobutyric acid (gaba) receptors in the cortex. |
2021-11-19 |
2023-08-13 |
mouse |
| Ana L Velasco, Pablo E Saucedo-Alvarado, Mariana Alejandre-Sánchez, Diana E Guzmán-Jiménez, Itzel González-Garcia, Francisco Velasc. New Horizons in Temporal Lobe Seizure Control. Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society. vol 38. issue 6. 2021-11-10. PMID:34261115. |
autoradiography analysis of surgical specimens from these patients demonstrated increased expression of benzodiazepine receptors and in gamma-aminobutyric acid content, particularly in the parahippocampal cortex. |
2021-11-10 |
2023-08-13 |
Not clear |
| Orhan Tansel Korkmaz, Sertan Arkan, Elif Mine Öncü-Kaya, Nurbay Ateş, Neşe Tunçe. Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP. Neuroscience letters. vol 765. 2021-11-08. PMID:34571088. |
in addition, the extracellular concentrations of gaba and glutamate and the gaba/glutamate ratio were measured by high-performance liquid chromatography in microdialysate samples collected from the somatosensorial cortex of wag/rij rats. |
2021-11-08 |
2023-08-13 |
rat |
| Orhan Tansel Korkmaz, Sertan Arkan, Elif Mine Öncü-Kaya, Nurbay Ateş, Neşe Tunçe. Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP. Neuroscience letters. vol 765. 2021-11-08. PMID:34571088. |
vip increased the extracellular concentration of gaba and the gaba/glutamate ratio in the somatosensory cortex. |
2021-11-08 |
2023-08-13 |
rat |
| Orhan Tansel Korkmaz, Sertan Arkan, Elif Mine Öncü-Kaya, Nurbay Ateş, Neşe Tunçe. Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP. Neuroscience letters. vol 765. 2021-11-08. PMID:34571088. |
in conclusion, vip has suppressive effects on absence seizures, possibly by increasing the gaba concentration and inducing the transformation of glutamate to gaba in the somatosensory cortex of wag/rij rats. |
2021-11-08 |
2023-08-13 |
rat |
| Jayarjun Ethiraj, Thulani Hansika Palpagama, Clinton Turner, Bert van der Werf, Henry John Waldvogel, Richard Lewis Maxwell Faull, Andrea Kwakowsk. The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex. Scientific reports. vol 11. issue 1. 2021-11-06. PMID:34728681. |
the effect of age and sex on the expression of gaba signaling components in the human hippocampus and entorhinal cortex. |
2021-11-06 |
2023-08-13 |
human |
| Matthew R Evrard, Michael Li, Hui Shen, Sheryl S Smit. Preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ GABA Scientific reports. vol 11. issue 1. 2021-10-30. PMID:34702942. |
preventing adolescent synaptic pruning in mouse prelimbic cortex via local knockdown of α4βδ gaba anxiety is increasingly reported, especially in adolescent females. |
2021-10-30 |
2023-08-13 |
mouse |
| Tianyun Zhao, Yanxin Chen, Zhixiang Sun, Ziwen Shi, Jingwen Qin, Junming Lu, Chuanxiang Li, Daqing Ma, Libing Zhou, Xingrong Son. Prenatal sevoflurane exposure causes neuronal excitatory/inhibitory imbalance in the prefrontal cortex and neurofunctional abnormality in rats. Neurobiology of disease. vol 146. 2021-10-25. PMID:33007389. |
the balance of excitatory and inhibitory neurons in the central nervous system is critical for maintaining brain function and sevoflurane, a general anesthetic and an gaba receptor modulator, may change the balance of excitatory and inhibitory neurons in the cortex during early brain development. |
2021-10-25 |
2023-08-13 |
rat |
| Laura Blanco-Hinojo, Jesus Pujol, Dídac Macià, Gerard Martínez-Vilavella, Rocío Martín-Santos, Víctor Pérez-Sola, Joan Deu. Mapping the Synchronization Effect of Gamma-Aminobutyric Acid Inhibition on the Cerebral Cortex Using Magnetic Resonance Imaging. Brain connectivity. vol 11. issue 5. 2021-10-25. PMID:33797949. |
mapping the synchronization effect of gamma-aminobutyric acid inhibition on the cerebral cortex using magnetic resonance imaging. |
2021-10-25 |
2023-08-13 |
Not clear |
| Meijuan Zhu, Yanhua Zhao, Yongjun Zheng, Diansan Su, Xiangrui Wan. Relative Higher Hematocrit Attenuates the Cerebral Excitatory Amino Acid Elevation Induced by Deep Hypothermic Circulatory Arrest in Rats. Therapeutic hypothermia and temperature management. vol 3. issue 3. 2021-10-21. PMID:24066268. |
high-performance liquid chromatography was used to determine the concentration of glutamate (glu), aspartate (asp), glycine (gly), gamma-aminobutyric acid (gaba), and taurine (tau) in the cerebral cortex, hippocampus, and thalamus. |
2021-10-21 |
2023-08-12 |
rat |
| Johanna Hiltunen, Xavier Ekolle Ndode-Ekane, Anssi Lipponen, Meinrad Drexel, Günther Sperk, Noora Puhakka, Asla Pitkäne. Regulation of Parvalbumin Interactome in the Perilesional Cortex after Experimental Traumatic Brain Injury. Neuroscience. vol 475. 2021-10-21. PMID:34455012. |
here, we assessed tbi-induced changes in perisomatic gamma aminobutyric acid (gaba)-ergic innervation in the perilesional cortex. |
2021-10-21 |
2023-08-13 |
rat |
| Celine Maes, Koen Cuypers, Kirstin-Friederike Heise, Richard A E Edden, Jolien Gooijers, Stephan P Swinne. GABA levels are differentially associated with bimanual motor performance in older as compared to young adults. NeuroImage. vol 231. 2021-10-15. PMID:33607278. |
furthermore, gaba levels were obtained within bilateral primary sensorimotor cortex (sm1), bilateral dorsal premotor cortex, the supplementary motor area and bilateral dorsolateral prefrontal cortex (dlpfc) using magnetic resonance spectroscopy. |
2021-10-15 |
2023-08-13 |
human |
| Antoine Kavaye Kandeda, Germain Sotoing Taiwe, Rigobert Espoir Mbomo Ayissi, Clémentine Moutchid. An aqueous extract of Canarium schweinfurthii attenuates seizures and potentiates sleep in mice: Evidence for involvement of GABA Pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 142. 2021-09-22. PMID:34343898. |
in another set of experiments, mice were sacrificed for the estimation of gaba content and gaba-t activity in the cerebral cortex. |
2021-09-22 |
2023-08-13 |
mouse |
| Ilandarage Menu Neelaka Molagoda, Mirissa Hewage Dumindu Kavinda, Hyung Won Ryu, Yung Hyun Choi, Jin-Woo Jeong, Sanghyuck Kang, Gi-Young Ki. Gamma-Aminobutyric Acid (GABA) Inhibits α-Melanocyte-Stimulating Hormone-Induced Melanogenesis through GABA International journal of molecular sciences. vol 22. issue 15. 2021-09-06. PMID:34361022. |
gamma-aminobutyric acid (gaba) inhibits α-melanocyte-stimulating hormone-induced melanogenesis through gaba gamma-aminobutyric acid (gaba) is considered the primary inhibitory neurotransmitter in the human cortex. |
2021-09-06 |
2023-08-13 |
human |
| Hua-Wei Zou, Zi-Lin Li, Xiao-Yuan Jing, Yan Wang, Ying-Juan Liu, Lai-Fu L. The GABA(B1) receptor within the infralimbic cortex is implicated in stress resilience and vulnerability in mice. Behavioural brain research. vol 406. 2021-09-02. PMID:33727046. |
the gaba(b1) receptor within the infralimbic cortex is implicated in stress resilience and vulnerability in mice. |
2021-09-02 |
2023-08-13 |
mouse |
| Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Darisi Venkata Kishore, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasa. Acteoside Isolated from Colebrookea oppositifolia Smith Attenuates Epilepsy in Mice Via Modulation of Gamma-Aminobutyric Acid Pathways. Neurotoxicity research. vol 38. issue 4. 2021-08-20. PMID:32803629. |
therefore, further mechanism-based studies were performed on the ptz model, and the outcomes have revealed that there was a significant reduction in gaba (p < 0.01 for both regions) and elevation of glutamate (p < 0.01 for both regions) in the cortex and hippocampus regions of ptz-treated animals. |
2021-08-20 |
2023-08-13 |
mouse |
| Yue Zhang, Ji-Tao Li, Han Wang, Wei-Pan Niu, Chen-Chen Zhang, Yanan Zhang, Xiao-Dong Wang, Tian-Mei Si, Yun-Ai S. Role of trace amine‑associated receptor 1 in the medial prefrontal cortex in chronic social stress-induced cognitive deficits in mice. Pharmacological research. vol 167. 2021-08-19. PMID:33753244. |
biochemically, chronic stress reduced the ratio of vesicular transporters of glutamate-1 (vglut1) / vesicular gaba transporter (vgat) in the mpfc，most prominently in the prelimbic cortex, and ro5263397 restored the excitatory-inhibitory (e/i) imbalance. |
2021-08-19 |
2023-08-13 |
mouse |
| Junxia Liu, Guigui Zhao, Yan Niu, Ting Gan, Zhenyu Yan, Yasu Zhan. Effect of electro-acupuncture therapy on limb spasm and excitability of motor neurons in stroke rats. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 50. issue 3. 2021-08-18. PMID:34402251. |
the neural function was evaluated with bederson's scale and balance beam test; the muscle tension was measured with electrophysiography; the pathological changes of brain tissue was examined with he staining; the content of glutamic acid (glu) and γ-aminobutyric acid (gaba) in rat cerebral cortex was analyze with enzyme linked immunosorbent assay (elisa) method, the expression of metabotropic glutamate receptor 1a () and γ-aminobutyric acid type b receptor subunit 1 () mrna were detected with rt-qpcr. |
2021-08-18 |
2023-08-13 |
rat |