| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pierre-Olivier Frappart, Wei-Min Tong, Ilja Demuth, Ivan Radovanovic, Zdenko Herceg, Adriano Aguzzi, Martin Digweed, Zhao-Qi Wan. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nature medicine. vol 11. issue 5. 2005-07-12. PMID:15821748. |
here we show that inactivation of the nbn gene (also known as nbs1) in mouse neural tissues results in a combination of the neurological anomalies characteristic of nbs, ataxia telangiectasia and atld, including microcephaly, growth retardation, cerebellar defects and ataxia. |
2005-07-12 |
2023-08-12 |
mouse |
| D Timmann, M Gerwig, M Frings, M Maschke, F P Kol. Eyeblink conditioning in patients with hereditary ataxia: a one-year follow-up study. Experimental brain research. vol 162. issue 3. 2005-06-30. PMID:15586270. |
eyeblink conditioning may be a useful measure of cerebellar impairment in patients with hereditary ataxias that primarily affect the cerebellum (such as sca6). |
2005-06-30 |
2023-08-12 |
human |
| Yuetsu Ihara, Hiroshi Takata, Yasuyuki Tanabe, Keigo Nobukuni, Toshiyuki Hayabar. Influence of repetitive transcranial magnetic stimulation on disease severity and oxidative stress markers in the cerebrospinal fluid of patients with spinocerebellar degeneration. Neurological research. vol 27. issue 3. 2005-06-13. PMID:15845214. |
ataxia severity, cerebellar hemispheric blood flow (chbf), ascorbate free radical (afr), superoxide dismutase protein, superoxide scavenging activity, and 8-hydroxy-2'-deoxyguanosine (8-ohdg) in cerebrospinal fluid (csf) were compared before and after an 8-week course of repetitive transcranial magnetic stimulation (rtms) in 20 patients with spinocerebellar degenerations (scd). |
2005-06-13 |
2023-08-12 |
Not clear |
| Wensheng Lin, April Kemper, Ken D McCarthy, Peter Pytel, Jian-Ping Wang, Iain L Campbell, Manuel F Utset, Brian Popk. Interferon-gamma induced medulloblastoma in the developing cerebellum. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 45. 2005-06-10. PMID:15537876. |
more than 80% of these mice display severe ataxia and develop cerebellar tumors that express synaptophysin, the mouse atonal homolog math1, sonic hedgehog (shh), and gli1. |
2005-06-10 |
2023-08-12 |
mouse |
| Guy Cheron, Laurent Servais, Bernard Dan, David Gall, Céline Roussel, Serge N Schiffman. Fast oscillation in the cerebellar cortex of calcium binding protein-deficient mice: a new sensorimotor arrest rhythm. Progress in brain research. vol 148. 2005-05-24. PMID:15661189. |
the role played by this fast cerebellar oscillation in the emergence of ataxia is yet to be solved. |
2005-05-24 |
2023-08-12 |
mouse |
| Elena Porras-García, Jan Cendelin, Eduardo Domínguez-del-Toro, Frantisek Vozeh, José M Delgado-Garcí. Purkinje cell loss affects differentially the execution, acquisition and prepulse inhibition of skeletal and facial motor responses in Lurcher mice. The European journal of neuroscience. vol 21. issue 4. 2005-05-16. PMID:15787704. |
adult heterozygous lurcher mice show a degeneration of almost all purkinje cells and 90% of the granular cells of the cerebellum, resulting in ataxia or general deficits in motor coordination. |
2005-05-16 |
2023-08-12 |
mouse |
| F Ochsner, I Le Ber, G Said, M-C Moreira, P Michel, M Koenig, A Dürr, A Brice, T Kuntze. [Mutation of the aprataxin gene presenting with Charcot-Marie-Tooth-like neuropathy and cerebellar ataxia]. Revue neurologique. vol 161. issue 3. 2005-05-03. PMID:15800456. |
phenotype-genotype correlations, generally based on predominant associated signs, are being increasingly used to distinguish different types of autosomal recessive cerebellar ataxias (arca). |
2005-05-03 |
2023-08-12 |
Not clear |
| Ryuki Hirano, Hiroshi Takashima, Ryuichi Okubo, Keiko Tajima, Yuji Okamoto, Shimon Ishida, Kazuhito Tsuruta, Takayo Arisato, Hitoshi Arata, Masanori Nakagawa, Mitsuhiro Osame, Kimiyoshi Arimur. Fine mapping of 16q-linked autosomal dominant cerebellar ataxia type III in Japanese families. Neurogenetics. vol 5. issue 4. 2005-04-29. PMID:15455264. |
the autosomal dominant cerebellar ataxias (adcas) are a clinically and genetically heterogeneous group of disorders. |
2005-04-29 |
2023-08-12 |
Not clear |
| Elisa Fazzi, Sabrina G Signorini, Carla Uggetti, Paolo Emilio Bianchi, Josée Lanners, Giovanni Lanz. Towards improved clinical characterization of Leber congenital amaurosis: neurological and systemic findings. American journal of medical genetics. Part A. vol 132A. issue 1. 2005-04-18. PMID:15580639. |
the neurological examination was abnormal in 31 cases (hypotonia, ataxia with/without associated cerebellar signs). |
2005-04-18 |
2023-08-12 |
human |
| Ingegerd Ahsgren, Ingela Baldwin, Christina Goetzinger-Falk, Anders Erikson, Olof Flodmark, Christopher Gillber. Ataxia, autism, and the cerebellum: a clinical study of 32 individuals with congenital ataxia. Developmental medicine and child neurology. vol 47. issue 3. 2005-03-16. PMID:15739725. |
ataxia, autism, and the cerebellum: a clinical study of 32 individuals with congenital ataxia. |
2005-03-16 |
2023-08-12 |
Not clear |
| Roberto Chiesa, Pedro Piccardo, Sara Dossena, Lisa Nowoslawski, Kevin A Roth, Bernardino Ghetti, David A Harri. Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 1. 2005-03-10. PMID:15618403. |
these mice develop a progressive neurological disorder characterized by ataxia and cerebellar atrophy, with massive apoptotic degeneration of granule neurons. |
2005-03-10 |
2023-08-12 |
mouse |
| C E Erasmus, T Beems, J J Rottevee. Frontal ataxia in childhood. Neuropediatrics. vol 35. issue 6. 2005-03-10. PMID:15627946. |
the frontal origin of ataxia should be considered in children presenting with a "cerebellar syndrome". |
2005-03-10 |
2023-08-12 |
Not clear |
| Hidehiro Mizusaw. [Autosomal dominant spinocerebellar degeneration--new forms and pathomechanisms]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651290. |
the outlines of some new members, namely autosomal dominant cortical cerebellar atrophy linked to chromosome 16 (16q-adcca), sca14, an ataxia caused by fgf14 mutation and a form of neuroferritinopathy were described. |
2005-03-04 |
2023-08-12 |
Not clear |
| Shoji Tsuj. [Clinical features and molecular genetics of autosomal recessive spinocerebellar degenerations]. Rinsho shinkeigaku = Clinical neurology. vol 44. issue 11. 2005-03-04. PMID:15651291. |
in this group of ar-scd, cerebellar atrophy is more marked compared to that observed in friedreich's ataxia. |
2005-03-04 |
2023-08-12 |
Not clear |
| Joseph H McCarty, Adam Lacy-Hulbert, Alain Charest, Roderick T Bronson, Denise Crowley, David Housman, John Savill, Jürgen Roes, Richard O Hyne. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (Cambridge, England). vol 132. issue 1. 2005-03-02. PMID:15576410. |
the remaining mutants survive for several months, but develop axonal deterioration in the spinal cord and cerebellum, leading to ataxia and loss of hindlimb coordination. |
2005-03-02 |
2023-08-12 |
mouse |
| G Cheron, L Servais, J Wagstaff, B Da. Fast cerebellar oscillation associated with ataxia in a mouse model of Angelman syndrome. Neuroscience. vol 130. issue 3. 2005-03-01. PMID:15590147. |
fast cerebellar oscillation associated with ataxia in a mouse model of angelman syndrome. |
2005-03-01 |
2023-08-12 |
mouse |
| Teresa Summavielle, Cecília J Alves, Pedro R R Monteiro, Maria Amélia Tavare. Abnormal immunoreactivity to serotonin in cerebellar Purkinje cells after neonatal cocaine exposure. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542772. |
changes in the cerebellar purkinje cells after drug exposure are well documented and result in impairment of movement and other cerebellar disorders such as ataxia. |
2005-02-18 |
2023-08-12 |
rat |
| Helen H Chun, Richard A Gatt. Ataxia-telangiectasia, an evolving phenotype. DNA repair. vol 3. issue 8-9. 2005-02-14. PMID:15279807. |
with the aid of molecular testing, a-t can now be distinguished from other autosomal recessive cerebellar ataxias (arcas) such as friedreich ataxia, mre11 deficiency (at-like disease), and the oculomotor apraxias 1 (aprataxin deficiency) and 2 (senataxin deficiency). |
2005-02-14 |
2023-08-12 |
Not clear |
| Susan L Perlma. Symptomatic and disease-modifying therapy for the progressive ataxias. The neurologist. vol 10. issue 5. 2005-02-02. PMID:15335445. |
the progressive ataxias are a diverse group of neurologic diseases that share features of degeneration of the cerebellum and its inflow/outflow pathways but differ in etiology, course, and associated noncerebellar system involvement. |
2005-02-02 |
2023-08-12 |
Not clear |
| Cynthia Gagnon, Johanne Desrosiers, Jean Mathie. Autosomal recessive spastic ataxia of Charlevoix-Saguenay: upper extremity aptitudes, functional independence and social participation. International journal of rehabilitation research. Internationale Zeitschrift fur Rehabilitationsforschung. Revue internationale de recherches de readaptation. vol 27. issue 3. 2005-02-01. PMID:15319698. |
autosomal recessive spastic ataxia of charlevoix-saguenay (arsacs) is an early-onset ataxia with pyramidal, cerebellar and distal neuropathic involvement. |
2005-02-01 |
2023-08-12 |
human |