| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brenda Toscano Márquez, Anna A Cook, Max Rice, Alexia Smileski, Kristen Vieira-Lomasney, François Charron, R Anne McKinney, Alanna J Wat. Molecular Identity and Location Influence Purkinje Cell Vulnerability in Autosomal-Recessive Spastic Ataxia of Charlevoix-Saguenay Mice. Frontiers in cellular neuroscience. vol 15. 2021-12-31. PMID:34970120. |
in patients with autosomal-recessive spastic ataxia of charlevoix-saguenay (arsacs) and mouse models of arsacs, it has been observed that purkinje cells in anterior cerebellar vermis are vulnerable to degeneration while those in posterior vermis are resilient. |
2021-12-31 |
2023-08-13 |
mouse |
| Deborah A Sival, Suus A M van Noort, Marina A J Tijssen, Tom J de Koning, Dineke S Verbee. Developmental neurobiology of cerebellar and Basal Ganglia connections. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 36. 2021-12-26. PMID:34954622. |
the high prevalence of mixed phenotypes of early onset ataxia (eoa) with comorbid dystonia has shifted the pathogenetic concept from the cerebellum towards the interconnected cerebellar motor network. |
2021-12-26 |
2023-08-13 |
Not clear |
| Lise Legrand, Jonathan W Weinsaft, Francoise Pousset, Claire Ewenczyk, Perrine Charles, Stéphane Hatem, Anna Heinzmann, Marie Biet, Alexandra Durr, Alban Redheui. Characterizing cardiac phenotype in Friedreich's ataxia: The CARFA study. Archives of cardiovascular diseases. 2021-12-18. PMID:34920960. |
friedreich's ataxia is an autosomal recessive mitochondrial disease caused by a triplet repeat expansion in the frataxin gene (fxn), exhibiting cerebellar sensory ataxia, diabetes and cardiomyopathy. |
2021-12-18 |
2023-08-13 |
Not clear |
| Carlos Del Pilar, Rafael Lebrón-Galán, Ester Pérez-Martín, Laura Pérez-Revuelta, Carmelo Antonio Ávila-Zarza, José Ramón Alonso, Diego Clemente, Eduardo Weruaga, David Día. The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations. Frontiers in cellular neuroscience. vol 15. 2021-12-17. PMID:34916910. |
consequently, a model of human cerebellar degeneration and ataxia -the purkinje cell degeneration (pcd) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., purkinje cells in the cerebellum and mitral cells in the olfactory bulb. |
2021-12-17 |
2023-08-13 |
mouse |
| Xiaoyang Liu, Linlin Wang, Jiajun Chen, Chunyang Kang, Jia L. Spinocerebellar ataxia type 28 in a Chinese pedigree: A case report and literature review. Medicine. vol 100. issue 50. 2021-12-17. PMID:34918652. |
spinocerebellar ataxia (sca) is a common neurogenetic disease that mainly manifests as ataxia of posture, gait, and limbs, cerebellar dysarthria, and cerebellar and supranuclear eye movement disorders. |
2021-12-17 |
2023-08-13 |
Not clear |
| Livia Asan, Stephan Klebe, Christoph Kleinschnitz, Mark Stettner, Martin Köhrman. Anti-GFAP-antibody positive postinfectious acute cerebellar ataxia and myoclonus after COVID-19: a case report. Therapeutic advances in neurological disorders. vol 14. 2021-12-13. PMID:34899988. |
this case suggests that anti-gfap-antibodies might be associated with some of the increasingly observed cases of postinfectious acute cerebellar ataxias in covid-19 patients and aid in the diagnosis of this autoimmune complication. |
2021-12-13 |
2023-08-13 |
Not clear |
| Angela J VanWagner, Benjamin Doerr, Stephanie Hernande. Posterior Inferior Cerebellar Infarct in a Younger Adult Male with Vertigo and Ataxia. Spartan medical research journal. vol 2. issue 2. 2021-12-11. PMID:33655124. |
posterior inferior cerebellar infarct in a younger adult male with vertigo and ataxia. |
2021-12-11 |
2023-08-13 |
Not clear |
| Angela J VanWagner, Benjamin Doerr, Stephanie Hernande. Posterior Inferior Cerebellar Infarct in a Younger Adult Male with Vertigo and Ataxia. Spartan medical research journal. vol 2. issue 2. 2021-12-11. PMID:33655124. |
when differentiating benign forms of vertigo from cerebellar infarcts or other central causes, the clinician should take into account risk factors such as central symptoms including neurologic deficits and severe ataxia. |
2021-12-11 |
2023-08-13 |
Not clear |
| Sydney Martin, Michael S Salma. Assessing Children with Poor Coordination Can Be Tricky - A Review on Ataxia and Ataxia Mimickers and a Study of Three Children with Severe Epilepsy. Journal of multidisciplinary healthcare. vol 14. 2021-12-11. PMID:34876818. |
as ataxia may be vestibular, sensory, or cerebellar in origin, medical practitioners must evaluate the diverse symptoms and signs to effectively differentiate the various types of ataxia. |
2021-12-11 |
2023-08-13 |
Not clear |
| Marco Trombini, Federica Ferraro, Alice Nardelli, Lucilla Vestito, Giulia Schenone, Laura Mori, Carlo Trompetto, Silvana Dellepian. On the performance assessment during the practice of an exergame for cerebellar ataxia patients. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. vol 2021. 2021-12-11. PMID:34892425. |
cerebellar ataxias are a large family of movement disorders that generally follow a stroke. |
2021-12-11 |
2023-08-13 |
human |
| Zeynab Ghorbani, Mohammad Amin Abdollahifar, Kimia Vakili, Meysam Hassani Moghaddam, Mehdi Mehdizadeh, Hassan Marzban, Homa Rasoolijazi, Abbas Aliaghae. Melittin administration ameliorates motor function, prevents apoptotic cell death and protects Purkinje neurons in the rat model of cerebellar ataxia induced by 3-Acetylpyridine. Toxicon : official journal of the International Society on Toxinology. vol 205. 2021-12-10. PMID:34793821. |
the findings showed that the administration of mel in a 3-ap model of ataxia improved motor coordination (p < 0.001) and neuro-muscular activity (p < 0.05), prevented the cerebellar volume loss (p < 0.01), reduced the level of inflammatory cytokines (p < 0.05) and thwarted the degeneration of purkinje cells against 3-ap toxicity (p < 0.001). |
2021-12-10 |
2023-08-13 |
rat |
| Xu Zhang, Roeland Hancock, Sabato Santaniell. Transcranial direct current stimulation of cerebellum alters spiking precision in cerebellar cortex: A modeling study of cellular responses. PLoS computational biology. vol 17. issue 12. 2021-12-09. PMID:34882680. |
since the spatiotemporal precision of the pc spiking is critical to learning and coordination, our results suggest cerebellar tdcs as a viable therapeutic option for disorders involving cerebellar hyperactivity such as ataxia. |
2021-12-09 |
2023-08-13 |
Not clear |
| Alberto Benussi, Valentina Cantoni, Marta Manes, Ilenia Libri, Valentina Dell'Era, Abhishek Datta, Chris Thomas, Camilla Ferrari, Alessio Di Fonzo, Roberto Fancellu, Mario Grassi, Alfredo Brusco, Antonella Alberici, Barbara Borron. Motor and cognitive outcomes of cerebello-spinal stimulation in neurodegenerative ataxia. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33950222. |
cerebellar ataxias represent a heterogeneous group of disabling disorders characterized by motor and cognitive disturbances, for which no effective treatment is currently available. |
2021-12-08 |
2023-08-13 |
Not clear |
| Alberto Benussi, Valentina Cantoni, Marta Manes, Ilenia Libri, Valentina Dell'Era, Abhishek Datta, Chris Thomas, Camilla Ferrari, Alessio Di Fonzo, Roberto Fancellu, Mario Grassi, Alfredo Brusco, Antonella Alberici, Barbara Borron. Motor and cognitive outcomes of cerebello-spinal stimulation in neurodegenerative ataxia. Brain : a journal of neurology. vol 144. issue 8. 2021-12-08. PMID:33950222. |
we observed a significant improvement in all motor scores (scale for the assessment and rating of ataxia, international cooperative ataxia rating scale), in cognition (evaluated with the cerebellar cognitive affective syndrome scale), in quality-of-life scores, in motor cortex excitability and in cerebellar inhibition after real tdcs compared to sham stimulation and compared to baseline (t0), both at short and long-term. |
2021-12-08 |
2023-08-13 |
Not clear |
| Laxman K Senapati, Sudipta Patnaik, Priyadarsini Samanta, Sambit P Kar, Santosh Dash, Jayanti Mishr. Comparison of Cardiac Autonomic Function in Type 2 Spinocerebellar Ataxia With Normal Control Using Heart Rate Variability as a Tool: A Cross-Sectional Study in Eastern India. Cureus. vol 13. issue 11. 2021-12-08. PMID:34873557. |
spinocerebellar ataxia (sca) is a disease that refers to a category of inherited ataxias that are characterized by degenerative alterations in the cerebellum, pons, and spinocerebellar tracts. |
2021-12-08 |
2023-08-13 |
Not clear |
| Xianli Bian, Shang Wang, Suqin Jin, Shunliang Xu, Hong Zhang, Dewei Wang, Wei Shang, Ping Wan. Two novel missense variants in SPTBN2 likely associated with spinocerebellar ataxia type 5. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 42. issue 12. 2021-12-06. PMID:33797620. |
spinocerebellar ataxia type 5 (sca5) is a rare autosomal-dominant ataxia with pure cerebellum involvement. |
2021-12-06 |
2023-08-13 |
Not clear |
| David Moreno-Ajona, Laura Álvarez-Gómez, Raquel Manrique-Huarte, Estefanía Rivas, Eduardo Martínez-Vila, Nicolás Pérez-Fernánde. VEMPs and Dysautonomia Assessment in Definite Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS): a Case Series Study. Cerebellum (London, England). vol 20. issue 5. 2021-11-30. PMID:31414248. |
all patients had clinically definite canvas as brain mri showed vermal cerebellar atrophy, neurophysiological studies showed a sensory neuronopathy pattern (absent sensory action potentials), vvor was abnormal bilaterally, and genetic tests ruled out other causes of ataxia including sca 3 and friedreich ataxia. |
2021-11-30 |
2023-08-13 |
Not clear |
| Juan Fernando Ortiz, Ahmed Eissa-Garces, Samir Ruxmohan, Victor Cuenca, Mandeep Kaur, Stephanie P Fabara, Mahika Khurana, Jashank Parwani, Maria Paez, Fatima Anwar, Hyder Tamton, Wilson Cuev. Understanding Parinaud's Syndrome. Brain sciences. vol 11. issue 11. 2021-11-30. PMID:34827468. |
finally, ataxia is caused by compression of the superior cerebellar peduncle. |
2021-11-30 |
2023-08-13 |
Not clear |
| Francesca Potenza, Maria Concetta Cufaro, Linda Di Biase, Valeria Panella, Antonella Di Campli, Anna Giulia Ruggieri, Beatrice Dufrusine, Elena Restelli, Laura Pietrangelo, Feliciano Protasi, Damiana Pieragostino, Vincenzo De Laurenzi, Luca Federici, Roberto Chiesa, Michele Salles. Proteomic Analysis of Marinesco-Sjogren Syndrome Fibroblasts Indicates Pro-Survival Metabolic Adaptation to SIL1 Loss. International journal of molecular sciences. vol 22. issue 22. 2021-11-30. PMID:34830330. |
maladaptive upr may explain the cerebellar and skeletal muscle degeneration responsible for the ataxia and muscle weakness typical of mss. |
2021-11-30 |
2023-08-13 |
Not clear |
| Asem Almansour, Hiroyuki Ishiura, Jun Mitsui, Takashi Matsukawa, Miho Kawabe Matsukawa, Hideaki Shimizu, Atsuhiko Sugiyama, Tatsushi Toda, Shoji Tsuj. Frequency of FMR1 Premutation Alleles in Patients with Undiagnosed Cerebellar Ataxia and Multiple System Atrophy in the Japanese Population. Cerebellum (London, England). 2021-11-30. PMID:34845661. |
fxtas can be misdiagnosed with many neurodegenerative disorders manifesting with cerebellar ataxias owing to their overlapping clinical and radiological features. |
2021-11-30 |
2023-08-13 |
Not clear |