| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| David J Horovitz, Laura A Askins, Grace M Regnier, Joseph A McQuai. Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions. Neurobiology of aging. vol 148. 2025-02-15. PMID:39954409. |
higher levels of the vesicular gaba transporter (vgat) were associated with better spatial learning in older rats, across several synaptic zones of the dorsal hippocampus, including the outer molecular layer of the dentate gyrus (dg), and the so, sr, slm, and pyramidal cell layers of both ca3 and ca1. |
2025-02-15 |
2025-02-18 |
rat |
| Mzia G Zhvania, Irina Sharikadze, Nadezhda Japaridze, Yousef Tizabi, Fuad Rzayev, Eldar Gasimov, Giorgi Lobzhanidz. Status epilepticus alters hippocampal ultrastructure in kainic acid rat model. Tissue & cell. vol 94. 2025-02-15. PMID:39954563. |
the findings suggest a time-dependent ultrastructural changes in ca1 region of the hippocampus in an animal model of focal epilepsy. |
2025-02-15 |
2025-02-18 |
rat |
| María C Gutiérrez, Ramiro G Comas Mutis, María C Perondi, Gastón D Calfa, Analía Valdomer. Perinatal Protein Restriction Induces Anhedonic-Like Behavior: Disturbed Hippocampal Neurotrophic Signaling and Neuronal Structural Plasticity in Adult Offspring. Hippocampus. vol 35. issue 2. 2025-02-14. PMID:39949067. |
this study explored how maternal protein restriction contributes to anhedonia, a key depression symptom, focusing on the hippocampal bdnf-trkb signaling and structural plasticity changes in the ca1 subregion of the dorsal hippocampus (dh). |
2025-02-14 |
2025-02-16 |
rat |
| Mariana A Cortes, Aundrea F Bartley, Qin Li, Taylor R Davis, Stephen E Cunningham, Mary Anne Garner, Patric J Perez, Adela C Harvey, Alecia K Gross, Lynn E Dobrun. Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice. Neuropeptides. vol 110. 2025-02-14. PMID:39951960. |
the ca1 region of hippocampus is important for anxiety regulation and highly expresses npy. |
2025-02-14 |
2025-02-18 |
mouse |
| Junjie Ma, Xinxin Zhong, Zhiyuan Li, Yongxia Jiang, Yongqu Jiang, Xiaoli Liu, Yue Hu, Zhou Yang, Guojie Zha. Di-Dang-Tang suppresses ferroptosis in the hippocampal CA1 region by targeting PGK1/NRF2/GPX4 signaling pathway to exert neuroprotection in vascular dementia. International immunopharmacology. vol 150. 2025-02-13. PMID:39946772. |
nissl staining, he staining and fjb staining were used to assess the effects of ddt on the degeneration and apoptosis of neurons in the ca1 region of the hippocampus. |
2025-02-13 |
2025-02-16 |
rat |
| Jing-Fan Zhang, Qing-Hua Long, Chu-Hua Zeng, Yi-Min Chen, Zhe-Yao Xie, Yuan-Qin Cai, Xi Wan. [Mechanism of Guben Jiannao Liquid on Alzheimer's disease by regulating autophagy based on LKB1/AMPK/mTOR pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929611. |
morris water maze was used to test the learning and memory ability of rats in each group; hematoxylin-eosin(he) and nissl staining were used to observe the morphological and quantitative changes of neurons and nissl bodies in the ca1 region of rat hippocampus; immunohistochemistry was utilized to detect aβ-positive cell expression in the ca1 region of rat hippocampus; transmission electron microscopy was employed to observe ultrastructural changes in rat hippocampal tissue, and western blot was used to examine the protein expression levels of lkb1, p-ampk/ampk, p-mtor/mtor, beclin1, p62, and lc3-Ⅱ in the hippocampal tissue of the rats. |
2025-02-10 |
2025-02-13 |
rat |
| Bo-Lun Chen, Jian-Zheng Lu, Xin-Mei Zhou, Xiao-Dong Wen, Yuan-Jing Jiang, Ning Lu. [Mechanism of Daotan Xixin Decoction in treating APP/PS1 mice based on high-throughput sequencing technology and bioinformatics analysis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 50. issue 2. 2025-02-10. PMID:39929612. |
compared with the app/ps1 group, daotan xixin decoction at different doses significantly improved the learning and memory abilities of app/ps1 mice, ameliorated the neuropathological damage in the ca1 region of the hippocampus, increased the number of neurons, and decreased the deposition of aβ_(1-42) in the brain. |
2025-02-10 |
2025-02-13 |
mouse |
| Sanggeon Park, Mijeong Park, Eun Joo Kim, Jeansok J Kim, Jeiwon Cho, Yeowool Hu. Distinct disruptions in CA1 and CA3 place cell function in Alzheimer's disease mice. iScience. vol 28. issue 2. 2025-02-06. PMID:39911347. |
these findings elucidate that distinct physiological perturbations in ca1 and ca3 place cells, coupled with disrupted hippocampal theta rhythmicity in ca1, potentially orchestrate the impairment of hippocampal-dependent spatial learning and memory in ad pathogenesis. |
2025-02-06 |
2025-02-08 |
mouse |
| Kamilla G Haugland, Sondre Valentin Jordbræk, Erik Knutsen, Kirsten B Kjelstrup, Vegard H Bru. Growth hormone alters remapping in the hippocampal area CA1 in a novel environment. eNeuro. 2025-02-03. PMID:39900507. |
to see how gh affects the hippocampal neural code, we recorded single neurons in the ca1 region of male long evans rats with locally altered gh levels. |
2025-02-03 |
2025-02-06 |
rat |
| Seyda Koc, Ekin Erdogmus, Ozlem Bozdemir, Deniz Ozkan-Vardar, Unzile Yaman, Pınar Erkekoglu, Naciye Dilara Zeybek, Belma Kocer-Gumuse. Prepubertal phthalate exposure can cause histopathological alterations, DNA methylation and histone acetylation changes in rat brain. Toxicology and industrial health. 2025-01-28. PMID:39873534. |
examining the hippocampus under the light microscope, pyramidal neuron loss was detected only in ca1 of the dehp-l group, while in dehp-h rats, pyramidal neuron losses were detected in the ca1, ca2, and ca3 regions. |
2025-01-28 |
2025-01-30 |
rat |
| Earl T Gilbert, Lianne M F Klaver, Kaiser C Arndt, Jongwoon Kim, Xiaoting Jia, Sam McKenzie, Daniel Fine Englis. Reciprocal interactions between CA1 pyramidal and axo-axonic cells control sharp wave-ripple events. bioRxiv : the preprint server for biology. 2025-01-27. PMID:39868302. |
for example, in hippocampus area ca1 the competition between inhibition and excitation organizes spike timing of pyramidal cells (pyr) in network events, including sharp wave-ripples (spw-r). |
2025-01-27 |
2025-01-29 |
mouse |
| Abdelaziz M Hussein, Ahmed F Abouelnaga, Walaa Obydah, Somaya Saad, Marwa Abass, Asmaa Yehia, Eman M Ibrahim, Ahmed T Ahmed, Osama A Abulseou. Lateral hypothalamic area high-frequency deep brain stimulation rescues memory decline in aged rat: behavioral, molecular, and electrophysiological study. Pflugers Archiv : European journal of physiology. 2025-01-21. PMID:39836224. |
old rats show significant decline in memories, antioxidant genes (nrf2 and ho-1), antioxidants (gsh and catalase), hsp70, bdnf, and synaptophysin with significant increase in mda in hippocampus (p < 0.05) and dbs for lha caused a significant improvement in memories in old rats, with significant rise in fast gamma and theta waves in ca1 region in old rats (p < 0.05). |
2025-01-21 |
2025-01-23 |
rat |
| Abdelaziz M Hussein, Ahmed F Abouelnaga, Walaa Obydah, Somaya Saad, Marwa Abass, Asmaa Yehia, Eman M Ibrahim, Ahmed T Ahmed, Osama A Abulseou. Lateral hypothalamic area high-frequency deep brain stimulation rescues memory decline in aged rat: behavioral, molecular, and electrophysiological study. Pflugers Archiv : European journal of physiology. 2025-01-21. PMID:39836224. |
this might be due to increase in fast gamma in ca1, attenuation of oxidative stress, upregulation of nrf2, ho-1, hsp70, bdnf, and synaptophysin in the hippocampus. |
2025-01-21 |
2025-01-23 |
rat |
| Charlie Lovatt, Thomas J O'Sullivan, Clara Ortega-de San Luis, Tomas J Ryan, Rene A W Fran. Memory engram synapse 3D molecular architecture visualized by cryoCLEM-guided cryoET. bioRxiv : the preprint server for biology. 2025-01-20. PMID:39829918. |
here, we demonstrate the use of engram labelling technology and cryogenic correlated light and electron microscopy (cryoclem)-guided cryogenic electron tomography (cryoet) to visualize the in-tissue 3d molecular architecture of engram synapses of a contextual fear memory within the ca1 region of the mouse hippocampus. |
2025-01-20 |
2025-01-23 |
mouse |
| Ivette Espinoza, Ma de Jesús Gómez-Villalobos, Leonardo Aguilar-Hernández, Gonzalo Flores, Julio César Morales-Medin. Cerebrolysin treatment improved short-term memory deficits while simultaneously increasing hippocampal spine density in hypertensive female rats. Behavioural brain research. vol 481. 2025-01-19. PMID:39826813. |
this research aims to investigate the behavioral outcomes in locomotion and recognition memory in the novel object recognition test (nort) and assess the neuroreparative effect of cbl on the cytoarchitecture of neurons and the spine density in pyramidal neurons of the prefrontal cortex (pfc), the entorhinal cortex (ec) and the ca1 region of the dorsal hippocampus, as well as spheroidal neurons of the dentate gyrus (dg). |
2025-01-19 |
2025-01-23 |
rat |
| Ivette Espinoza, Ma de Jesús Gómez-Villalobos, Leonardo Aguilar-Hernández, Gonzalo Flores, Julio César Morales-Medin. Cerebrolysin treatment improved short-term memory deficits while simultaneously increasing hippocampal spine density in hypertensive female rats. Behavioural brain research. vol 481. 2025-01-19. PMID:39826813. |
moreover, cbl treatment increased arborization in both normotensive and hypertensive rats in the ca1, and dg regions of hippocampus and ec and selectively increased spine density in the hippocampus of hypertensive rats. |
2025-01-19 |
2025-01-23 |
rat |
| Made Astawan, Aprilia F Damayanti, Tutik Wresdiyati, Diana N Afifah, Irma S Rahmawat. Potential of soybean-velvet bean combination tempe in improving cognitive function. Narra J. vol 4. issue 3. 2025-01-16. PMID:39816105. |
this study examined cognitive performance by measuring maze completion time, while brain mass and volume, hippocampus histology for neuron cell counts in the dentate gyrus section, cornu ammonis 1 (ca1), and cornu ammonis 3 (ca3), brain dopamine and β- amyloid serum levels were measured after eight weeks of intervention. |
2025-01-16 |
2025-01-19 |
rat |
| Anqing Liu, Qingqiang Tu, Ming Huan. Feasibility study of PET/CT for the detection and localization of nervous system damage caused by trimethyltin chloride. Scientific reports. vol 15. issue 1. 2025-01-09. PMID:39779731. |
moreover, tmt induced neuronal damage within the cerebral cortex, hippocampal ca1, ca3 and dg regions as well as the cerebellum while also promoting gliosis surrounding the hippocampus. |
2025-01-09 |
2025-01-13 |
rat |
| Ingrid Dudink, Amy E Sutherland, Margie Castillo-Melendez, Elham Ahmadzadeh, Tegan A White, Atul Malhotra, Harold A Coleman, Helena C Parkington, Justin M Dean, Yen Pham, Tamara Yawno, Tara Sepehrizadeh, Graham Jenkin, Emily J Camm, Beth J Allison, Suzanne L Mille. Fetal growth restriction adversely impacts trajectory of hippocampal neurodevelopment and function. Brain pathology (Zurich, Switzerland). 2025-01-09. PMID:39780443. |
ex vivo electrophysiology analysis shows that paired-pulse facilitation was reduced in fgr compared to controls for cornu ammonis 1 hippocampal outputs, reflecting synaptic dysfunction. |
2025-01-09 |
2025-01-13 |
Not clear |
| Melis Onay, Patrick N Harter, Katherina Weber, Albrecht Piiper, Marcus Czabanka, Karl H Plate, Thomas M Freiman, Florian Gessler, Barbara Puhahn-Schmeise. Mossy Fiber Sprouting in Temporal Lobe Epilepsy: The Impact of Netrin-1, DCC, and Gene Expression Changes. Biomedicines. vol 12. issue 12. 2025-01-08. PMID:39767775. |
temporal lobe epilepsy (tle) is the most common form of drug-resistant epilepsy, often associated with hippocampal sclerosis (hs), which involves selective neuronal loss in the cornu ammonis subregion 1 ca1 and ca4 regions of the hippocampus. |
2025-01-08 |
2025-01-13 |
Not clear |