| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Seonghan Kim, Yi Liu, Matthew Ziarnik, Yiwei Cao, X Frank Zhang, Wonpil I. Binding of Human ACE2 and RBD of Omicron Enhanced by Unique Interaction Patterns Among SARS-CoV-2 Variants of Concern. bioRxiv : the preprint server for biology. 2022-02-04. PMID:35118473. |
we report that the omicron brings an enhanced rbd-ace2 interface through n501y, q493k/r, and t478k mutations; the changes further lead to unique interaction patterns, reminiscing the features of previously dominated variants, alpha (n501y) and delta (l452r and t478k). |
2022-02-04 |
2023-08-13 |
human |
| Tetsuro Hikichi, Michiko Sakamoto, Makiko Harada, Maki Saito, Yuka Yamane, Kimihisa Tokumura, Yusuke Nakamur. Identification of cytotoxic T cells and their T cell receptor sequences targeting COVID-19 using MHC class I-binding peptides. Journal of human genetics. 2022-02-03. PMID:35110673. |
since severe acute respiratory syndrome coronavirus 2 (sars-cov-2, covid-19) was first reported in china in december 2019, various variants have been identified in different areas of the world such as united kingdom (alpha), south africa (beta and omicron), brazil (gamma), and india (delta). |
2022-02-03 |
2023-08-13 |
Not clear |
| b' R Navar\\xc4\\x8d\\xc3\\xadk, I Popov, J Vala\\xc5\\xa1kov\\xc3\\xa1, K Horkovi\\xc4\\x8dov\\xc3\\xa. SARS-COV-2 PANDEMIC FROM THE OPHTHALMOLOGIST`S PERSPECTIVE. A REVIEW. Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti. vol 2. issue Ahead of Print. 2022-02-02. PMID:35105149.' |
coronaviruses belong to enveloped ssrna viruses and are classified into four genera: alpha coronavirus, beta coronavirus, gamma coronavirus and delta coronavirus. |
2022-02-02 |
2023-08-13 |
human |
| Claudio Babiloni, Claudio Del Percio, Roberta Lizio, Susanna Lopez, Alfredo Pennica, Paolo Roma, Valentina Correr, Federica Cucciolla, Ginevra Toma, Andrea Soricelli, Francesco Di Campli, Antonio Aceti, Elisabetta Teti, Loredana Sarmati, Gloria Crocetti, Raffaele Ferri, Ivan Lorenzo, Massimo Galli, Cristina Negri, Gioacchino Angarano, Annalisa Saracino, Luciana Lepore, Massimo Di Pietro, Francesco Maria Fusco, Vincenzo Vullo, Gabriella D'Ettore, Pasquale Pagliano, Giusy Di Flumeri, Benedetto Maurizio Celesia, Elio Gentilini Cacciola, Giovanni Di Perri, Andrea Calcagno, Fabrizio Stocchi, Stefano Ferracuti, Paolo Onorati, Massimo Andreoni, Giuseppe Noc. PARIETAL INTRAHEMISPHERIC SOURCE CONNECTIVITY OF RESTING-STATE ELECTROENCEPHALOGRAPHIC ALPHA RHYTHMS IS ABNORMAL IN NAÏVE HIV PATIENTS. Brain research bulletin. 2022-02-01. PMID:35101575. |
previous evidence showed abnormal parietal sources of resting-state electroencephalographic (eeg) delta (< 4hz) and alpha (8-12hz) rhythms in treatment-naïve hiv (naïve hiv) subjects, as cortical neural synchronization markers in quiet wakefulness. |
2022-02-01 |
2023-08-13 |
human |
| Tara M Narowski, Kristin Raphel, Lily E Adams, Jenny Huang, Nadja A Vielot, Ramesh Jadi, Aravinda M de Silva, Ralph S Baric, John E Lafleur, Lakshmanane Premkuma. SARS-CoV-2 mRNA vaccine induces robust specific and cross-reactive IgG and unequal neutralizing antibodies in naive and previously infected people. Cell reports. 2022-01-29. PMID:35090596. |
in all individuals, neutralizing antibody responses against the alpha and delta variants were weaker than against the reference strain. |
2022-01-29 |
2023-08-13 |
Not clear |
| Marcel Simis, Marta Imamura, Kevin Pacheco-Barrios, Anna Marduy, Paulo S de Melo, Augusto J Mendes, Paulo E P Teixeira, Linamara Battistella, Felipe Fregn. EEG theta and beta bands as brain oscillations for different knee osteoarthritis phenotypes according to disease severity. Scientific reports. vol 12. issue 1. 2022-01-28. PMID:35087082. |
from adjusted multivariate models, we found that: (1) increased frontocentral high-beta power and reduced central theta activity are positively correlated with pain intensity (β = 0.012, 95% ci 0.004-0.020; and β = - 0.008; 95% ci 0.014 to - 0.003; respectively); (2) delta and alpha oscillations have a direct relationship with higher cortical inhibition; (3) diffuse increased power at low frequencies (delta and theta) are associated with poor cognition, aging, and depressive symptoms; and (4) higher alpha and beta power over sensorimotor areas seem to be a maladaptive compensatory mechanism to poor motor function and severe joint degeneration. |
2022-01-28 |
2023-08-13 |
human |
| Dinh-Toi Chu, Suong-Mai Vu Ngoc, Hue Vu Thi, Yen-Vy Nguyen Thi, Thuy-Tien Ho, Van-Thuan Hoang, Vijai Singh, Jaffar A Al-Tawfi. COVID-19 in Southeast Asia: current status and perspectives. Bioengineered. vol 13. issue 2. 2022-01-27. PMID:35081861. |
nevertheless, with the occurrence of the common variants of concern (vocs), especially alpha (b.1.1.7), beta (b.1.351), delta (b.1.617.2), southeast asia is facing a significant increase in the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) infections. |
2022-01-27 |
2023-08-13 |
Not clear |
| Samah Hayek, Galit Shaham, Yatir Ben-Shlomo, Eldad Kepten, Noa Dagan, Daniel Nevo, Marc Lipsitch, Ben Y Reis, Ran D Balicer, Noam Bard. Indirect protection of children from SARS-CoV-2 infection through parental vaccination. Science (New York, N.Y.). 2022-01-27. PMID:35084938. |
we studied two periods separately- an early period (january 17, 2021 - march 28, 2021, alpha variant, two doses vs. no vaccination) and a late period (july 11, 2021 - september 30, 2021, delta variant, booster dose vs. two-vaccine doses). |
2022-01-27 |
2023-08-13 |
Not clear |
| Ting Y Wong, Alexander M Horspool, Brynnan P Russ, Chengjin Ye, Katherine S Lee, Michael T Winters, Justin R Bevere, Olivia A Miller, Nathaniel A Rader, Melissa Cooper, Theodore Kieffer, Julien Sourimant, Alexander Greninger, Richard K Plemper, James Denvir, Holly A Cyphert, Mariette Barbier, Jordi B Torrelles, Ivan Martinez, Luis Martinez-Sobrido, F Heath Damro. Evaluating antibody mediated protection against Alpha, Beta, and Delta SARS-CoV-2 variants of concern in K18-hACE2 transgenic mice. Journal of virology. 2022-01-26. PMID:35080423. |
while mice could be protected from wa-1 or alpha challenge with a single dose of hcp, six doses of hcp could not decrease mortality of delta challenged mice. |
2022-01-26 |
2023-08-13 |
mouse |
| J Vičar, E Patrasová, I Stiborová, V Balatka, F Chvojka, O Šácha, V Krá. Study of family clusters of COVID-19 in the Ústí nad Labem Region with a focus on children - clinical picture, secondary transmission, antibody response. Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne. vol 70. issue 4. 2022-01-25. PMID:35073700. |
data were collected from 3 march 2020 to 25 october 2020, that is at the time when the alpha or delta variants were not dominant. |
2022-01-25 |
2023-08-13 |
Not clear |
| Trudy M Wassenaar, Visanu Wanchai, Gregory Buzard, David W Usser. The first three waves of the Covid-19 pandemic hint at a limited genetic repertoire for SARS-CoV-2. FEMS microbiology reviews. 2022-01-25. PMID:35076068. |
we collectively call this janus, and it was eventually replaced by the alpha (b.1.1.7) variant of concern (voc), next replaced by delta (b.1.617.2), which itself might soon be replaced by a fourth pandemic wave consisting of omicron (b.1.1.529). |
2022-01-25 |
2023-08-13 |
Not clear |
| Branislav Kovacech, Lubica Fialova, Peter Filipcik, Rostislav Skrabana, Monika Zilkova, Natalia Paulenka-Ivanovova, Andrej Kovac, Denisa Palova, Gabriela Paulikova Rolkova, Katarina Tomkova, Natalia Turic Csokova, Karina Markova, Michaela Skrabanova, Kristina Sinska, Neha Basheer, Petra Majerova, Jozef Hanes, Vojtech Parrak, Michal Prcina, Ondrej Cehlar, Martin Cente, Juraj Piestansky, Michal Fresser, Michal Novak, Monika Slavikova, Kristina Borsova, Viktoria Cabanova, Bronislava Brejova, Tomas Vinař, Jozef Nosek, Boris Klempa, Ludek Eyer, Vaclav Hönig, Martin Palus, Daniel Ruzek, Tereza Vyhlidalova, Petra Strakova, Blanka Mrazkova, Dagmar Zudova, Gizela Koubkova, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Norbert Zilka, Eva Kontsekov. Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern. EBioMedicine. vol 76. 2022-01-25. PMID:35078012. |
the emergence of new sars-cov-2 variants of concern b.1.1.7 (alpha), b.1.351 (beta), p.1 (gamma) and b.1.617.2 (delta) that harbor mutations in the viral s protein raised concern about activity of current vaccines and therapeutic antibodies. |
2022-01-25 |
2023-08-13 |
Not clear |
| Gi Uk Jeong, Gun Young Yoon, Hyun Woo Moon, Wooseong Lee, Insu Hwang, Haesoo Kim, Kyun-Do Kim, Chonsaeng Kim, Dae-Gyun Ahn, Bum-Tae Kim, Seong-Jun Kim, Young-Chan Kwo. Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern. Viruses. vol 14. issue 1. 2022-01-22. PMID:35062259. |
some of these have been identified as variants of concern (vocs), including alpha (b.1.1.7, clade gry), beta (b.1.351, clade gh), gamma (p.1, clade gr), and delta (b.1.617.2, clade g). |
2022-01-22 |
2023-08-13 |
Not clear |
| Gi Uk Jeong, Gun Young Yoon, Hyun Woo Moon, Wooseong Lee, Insu Hwang, Haesoo Kim, Kyun-Do Kim, Chonsaeng Kim, Dae-Gyun Ahn, Bum-Tae Kim, Seong-Jun Kim, Young-Chan Kwo. Comparison of Plaque Size, Thermal Stability, and Replication Rate among SARS-CoV-2 Variants of Concern. Viruses. vol 14. issue 1. 2022-01-22. PMID:35062259. |
the mean plaque size of beta was the largest, followed by those of gamma, delta, and alpha. |
2022-01-22 |
2023-08-13 |
Not clear |
| Pushpendra Singh, Kuldeep Sharma, Priyanka Singh, Anudita Bhargava, Sanjay Singh Negi, Pratibha Sharma, Mayuri Bhise, Manish Kumar Tripathi, Atul Jindal, Nitin M Nagarka. Genomic characterization unravelling the causative role of SARS-CoV-2 Delta variant of lineage B.1.617.2 in 2nd wave of COVID-19 pandemic in Chhattisgarh, India. Microbial pathogenesis. 2022-01-22. PMID:35065253. |
the significant predominance of the sars-cov-2 variant of concern (voc), delta (lineage b.1.617.2) identified in sixty-four (77.1%) cases in contrast to b.1 and its sublineage in eleven (13.2%), variant under monitoring (vum), kappa (lineage b.1.617.1) in five (6.0%) and another voc alpha (lineage b.1.1.7) in three (3.6%) cases respectively (p < 0.05, χ |
2022-01-22 |
2023-08-13 |
Not clear |
| Hannah W Despres, Margaret G Mills, David J Shirley, Madaline M Schmidt, Meei-Li Huang, Pavitra Roychoudhury, Keith R Jerome, Alexander L Greninger, Emily A Bruc. Measuring infectious SARS-CoV-2 in clinical samples reveals a higher viral titer:RNA ratio for Delta and Epsilon vs. Alpha variants. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 5. 2022-01-21. PMID:35058348. |
measuring infectious sars-cov-2 in clinical samples reveals a higher viral titer:rna ratio for delta and epsilon vs. alpha variants. |
2022-01-21 |
2023-08-13 |
Not clear |
| Lianghui Zhang, Soumajit Dutta, Shiqin Xiong, Matthew Chan, Kui K Chan, Timothy M Fan, Keith L Bailey, Matthew Lindeblad, Laura M Cooper, Lijun Rong, Anthony F Gugliuzza, Diwakar Shukla, Erik Procko, Jalees Rehman, Asrar B Mali. Engineered ACE2 decoy mitigates lung injury and death induced by SARS-CoV-2 variants. Nature chemical biology. 2022-01-20. PMID:35046611. |
using molecular dynamics simulations and functional assays, we show that three amino acid substitutions in an engineered soluble ace2 protein markedly augmented the affinity for the s protein of the sars-cov-2 wa-1/2020 isolate and multiple vocs: b.1.1.7 (alpha), b.1.351 (beta), p.1 (gamma) and b.1.617.2 (delta). |
2022-01-20 |
2023-08-13 |
mouse |
| Warish Ahmed, Aaron Bivins, Wendy J M Smith, Suzanne Metcalfe, Mikayla Stephens, Amy V Jennison, Frederick A J Moore, Jayden Bourke, Sanmarie Schlebusch, Jamie McMahon, Glen Hewitson, Son Nguyen, Jean Barcelon, Greg Jackson, Jochen F Mueller, John Ehret, Ian Hosegood, Wei Tian, Haofei Wang, Lin Yang, Paul Bertsch, Josh Tynan, Kevin V Thomas, Kyle Bibby, Tyson E Graber, Ryan Ziels, Stuart L Simpso. Detection of the Omicron (B.1.1.529) variant of SARS-CoV-2 in aircraft wastewater. The Science of the total environment. 2022-01-20. PMID:35051459. |
the genome of the omicron voc contains more than 50 mutations, many of which have been associated with increased transmissibility, differing disease severity, and potential to evade immune responses developed for previous vocs such as alpha and delta. |
2022-01-20 |
2023-08-13 |
Not clear |
| Karl R Franke, Robert Isett, Alan Robbins, Carrie Paquette-Straub, Craig A Shapiro, Mary M Lee, Erin L Crowge. Genomic surveillance of SARS-CoV-2 in the state of Delaware reveals tremendous genomic diversity. PloS one. vol 17. issue 1. 2022-01-19. PMID:35045124. |
a total of 411 samples belonging to the alpha 20i/501y.v1 (b.1.1.7) strain of concern were identified, as well as one sample belonging to beta 20h/501.v2 (b.1.351), thirteen belonging to epsilon 20c/s:452r (b.1.427/b.1.429), two belonging to delta 20a/s:478k (b.1.617.2), and 15 belonging to gamma 20j/501y.v3 (p.1). |
2022-01-19 |
2023-08-13 |
Not clear |
| Duygu Beduk, José Ilton de Oliveira Filho, Tutku Beduk, Duygu Harmanci, Figen Zihnioglu, Candan Cicek, Ruchan Sertoz, Bilgin Arda, Tuncay Goksel, Kutsal Turhan, Khaled Nabil Salama, Suna Timu. 'All In One' SARS-CoV-2 variant recognition platform: Machine learning-enabled point of care diagnostics. Biosensors & bioelectronics: X. vol 10. 2022-01-17. PMID:35036904. |
clinical study has been conducted with nasopharyngeal swabs from 63 patients having alpha (b.1.1.7), beta (b.1.351), delta (b.1.617.2) variants, patients without mutation and negative patients. |
2022-01-17 |
2023-08-13 |
Not clear |