| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M N Rasband, E W Park, T W Vanderah, J Lai, F Porreca, J S Trimme. Distinct potassium channels on pain-sensing neurons. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 23. 2001-12-07. PMID:11698689. |
importantly, kv1.4 is the sole kv1 alpha subunit expressed in smaller diameter neurons, suggesting that homomeric kv1.4 channels predominate in a delta and c fibers arising from these cells. |
2001-12-07 |
2023-08-12 |
Not clear |
| K Masur, K Lang, B Niggemann, K S Zanker, F Entschlade. High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells. Molecular biology of the cell. vol 12. issue 7. 2001-12-04. PMID:11451996. |
with the use of pkc alpha--specific inhibitors (safingol, go6976) as well as the pkc delta--specific inhibitor rottlerin, we showed that only pkc alpha plays a major role in the regulation of tumor cell migration. |
2001-12-04 |
2023-08-12 |
human |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
using mouse l(-tk) cells, we stably expressed the native gaba(a) receptor subunit combinations alpha(3)beta(3)gamma(2,) alpha(4)beta(3)gamma(2), and, for the first time, alpha(4)beta(3)delta and characterized their properties using a novel fluorescence resonance energy transfer assay of gaba-evoked depolarizations. |
2001-12-04 |
2023-08-12 |
mouse |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
when combined with alpha(4) and beta(3), delta subunits, compared with gamma(2), conferred greater sensitivity to the agonists gaba, 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol (thip), and muscimol and greater maximal efficacy to thip. |
2001-12-04 |
2023-08-12 |
mouse |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
alpha(4)beta(3)delta responses were markedly modulated by steroids and anesthetics. |
2001-12-04 |
2023-08-12 |
mouse |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
alphaxalone, pentobarbital, and pregnanolone were all 3-7-fold more efficacious at alpha(4)beta(3)delta compared with alpha(4)beta(3)gamma(2.) |
2001-12-04 |
2023-08-12 |
mouse |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
for gaba(a) receptors containing alpha(4) subunits, our experiments reveal that inclusion of delta instead of gamma(2) subunits can increase the affinity and in some cases the efficacy of agonists and can increase the efficacy of allosteric modulators. |
2001-12-04 |
2023-08-12 |
mouse |
| C E Adkins, G V Pillai, J Kerby, T P Bonnert, C Haldon, R M McKernan, J E Gonzalez, K Oades, P J Whiting, P B Simpso. alpha4beta3delta GABA(A) receptors characterized by fluorescence resonance energy transfer-derived measurements of membrane potential. The Journal of biological chemistry. vol 276. issue 42. 2001-12-04. PMID:11495904. |
pregnanolone was a particularly efficacious modulator of alpha(4)beta(3)delta receptors, consistent with a central role for this subunit combination in premenstrual syndrome. |
2001-12-04 |
2023-08-12 |
mouse |
| H E Moon, D S Bahia, A Cavalli, M Hoffmann, G Milliga. Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522323. |
control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of g(i1) by mutation of a receptor/g protein contact interface. |
2001-12-04 |
2023-08-12 |
Not clear |
| H E Moon, D S Bahia, A Cavalli, M Hoffmann, G Milliga. Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522323. |
fusion proteins were constructed between the delta opioid receptor and forms of the alpha subunit of g(i1) in which cysteine(351) was mutated to a range of amino acids. |
2001-12-04 |
2023-08-12 |
Not clear |
| H E Moon, D S Bahia, A Cavalli, M Hoffmann, G Milliga. Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522323. |
gdp reduced the binding of the agonist [(3)h]dadle but not the antagonist [(3)h]naltrindole to both the receptor alone and all the delta opioid receptor-cys(351)xaag(i1)alpha fusion proteins. |
2001-12-04 |
2023-08-12 |
Not clear |
| H E Moon, D S Bahia, A Cavalli, M Hoffmann, G Milliga. Control of the efficiency of agonist-induced information transfer and stability of the ternary complex containing the delta opioid receptor and the alpha subunit of G(i1) by mutation of a receptor/G protein contact interface. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522323. |
these results demonstrate that the stability of the ternary complex between delta opioid receptor, g(i1)alpha and an agonist (but not antagonist) ligand is dependent upon the nature of residue(351) of the g protein and that this determines the effectiveness of information flow from the receptor to the g protein. |
2001-12-04 |
2023-08-12 |
Not clear |
| S P Yusaf, J Goodman, R D Pinnock, A K Dixon, K Le. Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. Neuroscience letters. vol 311. issue 2. 2001-12-04. PMID:11567797. |
the calcium channel auxiliary subunits alpha(2)delta(1) and alpha(2)delta(2) showed a complementary pattern of distribution to that of alpha(2)delta(3) in drg neurons. |
2001-12-04 |
2023-08-12 |
rat |
| S P Yusaf, J Goodman, R D Pinnock, A K Dixon, K Le. Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. Neuroscience letters. vol 311. issue 2. 2001-12-04. PMID:11567797. |
alpha(2)delta(1) and alpha(2)delta(2) transcripts were expressed predominantly in small c-type sensory neurons and were present at lower levels in large abeta-type sensory neurons. |
2001-12-04 |
2023-08-12 |
rat |
| S P Yusaf, J Goodman, R D Pinnock, A K Dixon, K Le. Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. Neuroscience letters. vol 311. issue 2. 2001-12-04. PMID:11567797. |
in contrast, alpha(2)delta(3) mrna was present in high quantities in the large-diameter cells but was expressed at lower levels in small-diameter neurons of the drg. |
2001-12-04 |
2023-08-12 |
rat |
| S P Yusaf, J Goodman, R D Pinnock, A K Dixon, K Le. Expression of voltage-gated calcium channel subunits in rat dorsal root ganglion neurons. Neuroscience letters. vol 311. issue 2. 2001-12-04. PMID:11567797. |
the present study provides an insight into the molecular profile of calcium channel alpha(1) and alpha(2)delta subunits in the neurons responsible for transmitting sensory information. |
2001-12-04 |
2023-08-12 |
rat |
| R K Lees, I Ferrero, H R MacDonal. Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells. European journal of immunology. vol 31. issue 10. 2001-12-04. PMID:11592065. |
whereas the majority of nkt cells in the mouse express an alpha beta tcr (nktalpha beta cells), a small subset of nkt cells express a gamma delta tcr (nktgamma delta). |
2001-12-04 |
2023-08-12 |
mouse |
| R K Lees, I Ferrero, H R MacDonal. Tissue-specific segregation of TCRgamma delta+ NKT cells according to phenotype TCR repertoire and activation status: parallels with TCR alphabeta+NKT cells. European journal of immunology. vol 31. issue 10. 2001-12-04. PMID:11592065. |
we therefore propose that chronic tcr activation by tissue-specific endogenous ligands is a generic property of nkt cells of both the alpha beta and gamma delta lineages. |
2001-12-04 |
2023-08-12 |
mouse |
| T Mulroy, J Se. p38 MAP kinase activity modulates alpha beta T cell development. European journal of immunology. vol 31. issue 10. 2001-12-04. PMID:11592082. |
in the absence of p38 map kinase activity differentiation of alpha beta t cells, but not gamma delta t cells, was blocked. |
2001-12-04 |
2023-08-12 |
Not clear |
| C M Komar, O Braissant, W Wahli, T E Curr. Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period. Endocrinology. vol 142. issue 11. 2001-12-04. PMID:11606451. |
in contrast, mrnas for ppar alpha and delta were located primarily in theca and stroma, and their levels did not change during the intervals studied. |
2001-12-04 |
2023-08-12 |
human |