| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peng Fei Chang, Lars Arendt-Nielsen, Andrew C N Che. Dynamic changes and spatial correlation of EEG activities during cold pressor test in man. Brain research bulletin. vol 57. issue 5. 2002-05-23. PMID:11927371. |
(d) the decrease of alpha and increase of beta activities occurred immediately after the onset of cpt, but the increase of delta activity showed a relatively gradual process. |
2002-05-23 |
2023-08-12 |
Not clear |
| Goro Matsuzaki, Hisakata Yamada, Kenji Kishihara, Yasunobu Yoshikai, Kikuo Nomot. Mechanism of murine Vgamma1+ gamma delta T cell-mediated innate immune response against Listeria monocytogenes infection. European journal of immunology. vol 32. issue 4. 2002-05-20. PMID:11920558. |
furthermore, the il-12 receptor (il-12r) gene was expressed on the vgamma1+ gamma delta t cells of naive mice as well as those of l. monocytogenes-infected mice although naive alpha beta t cells lack il-12r expression. |
2002-05-20 |
2023-08-12 |
mouse |
| Anne-M Krogsdam, Curt A F Nielsen, Søren Neve, Dorte Holst, Torben Helledie, Bo Thomsen, Christian Bendixen, Susanne Mandrup, Karsten Kristianse. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. The Biochemical journal. vol 363. issue Pt 1. 2002-05-17. PMID:11903058. |
ncor interacted strongly with the ligand-binding domain of ppar delta, whereas interactions with the ligand-binding domains of ppar gamma and ppar alpha were significantly weaker. |
2002-05-17 |
2023-08-12 |
Not clear |
| Anne-M Krogsdam, Curt A F Nielsen, Søren Neve, Dorte Holst, Torben Helledie, Bo Thomsen, Christian Bendixen, Susanne Mandrup, Karsten Kristianse. Nuclear receptor corepressor-dependent repression of peroxisome-proliferator-activated receptor delta-mediated transactivation. The Biochemical journal. vol 363. issue Pt 1. 2002-05-17. PMID:11903058. |
interaction between ppar delta and ncor was unaffected by coexpression of retinoid x receptor (rxr) alpha. |
2002-05-17 |
2023-08-12 |
Not clear |
| U Hübscher, Y S Se. Replication of the lagging strand: a concert of at least 23 polypeptides. Molecules and cells. vol 12. issue 2. 2002-05-13. PMID:11710514. |
a replication fork has to be a very dynamic apparatus since frequent dna polymerase switches from the initiating dna polymerase alpha to the processive elongating dna polymerase delta occur at the leading strand (about 8 x 10(4) fold on both strands in one replication round) as well as at the lagging strand (about 2 x 10(7) fold on both strands in one replication round) in mammalian cells. |
2002-05-13 |
2023-08-12 |
Not clear |
| Chang-Shung Tung, Donal A Walsh, Jill Trewhell. A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11799117. |
we present here the results of a set of computations that lead to an atomic model of the camp-dependent protein kinase heterodimer, delta(1-91)r(iialpha)-c(alpha). |
2002-05-13 |
2023-08-12 |
rat |
| Chang-Shung Tung, Donal A Walsh, Jill Trewhell. A structural model of the catalytic subunit-regulatory subunit dimeric complex of the cAMP-dependent protein kinase. The Journal of biological chemistry. vol 277. issue 14. 2002-05-13. PMID:11799117. |
the first step in the modeling utilized the crystal structures for the porcine c(alpha) and bovine delta(1-90)r(ialpha) or rat delta(1-111)r(iibeta), to homology-model structures of the species and isoforms that had been used in the neutron scattering experiments (bovine c(alpha) subunit and murine delta(1-91)r(iialpha) subunit, respectively). |
2002-05-13 |
2023-08-12 |
rat |
| Beate Ritz-Laser, A Estreicher, B R Gauthier, A Mamin, H Edlund, J Philipp. The pancreatic beta-cell-specific transcription factor Pax-4 inhibits glucagon gene expression through Pax-6. Diabetologia. vol 45. issue 1. 2002-05-09. PMID:11845228. |
the paired-homeobox genes pax-4 and pax-6 are crucial for islet development; whereas the null mutation of pax-6 results in the nearly absence of glucagon-producing alpha cells, pax-4 homozygous mutant mice lack insulin and somatostatin-producing beta and delta cells but contain an increased number of alpha cells suggesting that alpha cells could develop by a default mechanism. |
2002-05-09 |
2023-08-12 |
mouse |
| L Martoft, L Lomholt, C Kolthoff, B E Rodriguez, E W Jensen, P F Jørgensen, H D Pedersen, A Forsli. Effects of CO2 anaesthesia on central nervous system activity in swine. Laboratory animals. vol 36. issue 2. 2002-05-09. PMID:11943075. |
in study 1, we monitored middle latency auditory evoked potentials (changes in latencies, amplitudes and a depth of anaesthesia index), electroencephalographic parameters (delta, theta, alpha and beta electroencephalographic power and 95% spectral edge frequency) and heart rate; and in study 2, we monitored body movements and arterial and venous partial pressure of co2 and o2. |
2002-05-09 |
2023-08-12 |
Not clear |
| V Plerou, P Gopikrishnan, L A Nunes Amaral, M Meyer, H E Stanle. Scaling of the distribution of price fluctuations of individual companies. Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics. vol 60. issue 6 Pt A. 2002-05-08. PMID:11970569. |
we study the probability distribution of returns over varying time scales delta t, where delta t varies by a factor of approximately 10(5), from 5 min up to approximately 4 yr. for time scales from 5 min up to approximately 16 days, we find that the tails of the distributions can be well described by a power-law decay, characterized by an exponent 2.5 < proportional to < 4, well outside the stable lévy regime 0 < alpha < 2. |
2002-05-08 |
2023-08-12 |
Not clear |
| Hisao Nagaya, Ikuo Wada, Yan-Jun Jia, Hideo Kano. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Molecular biology of the cell. vol 13. issue 1. 2002-05-06. PMID:11809841. |
we report here that the anterograde transport from the endoplasmic reticulum (er) to the golgi was markedly suppressed by diacylglycerol kinase delta (dgkdelta) that uniquely possesses a pleckstrin homology (ph) and a sterile alpha motif (sam) domain. |
2002-05-06 |
2023-08-12 |
Not clear |
| Chitra M Vaidya, Joel E Wright, Andre Rosowsk. Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931624. |
synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithine (pt523). |
2002-05-06 |
2023-08-12 |
human |
| Chitra M Vaidya, Joel E Wright, Andre Rosowsk. Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523). Journal of medicinal chemistry. vol 45. issue 8. 2002-05-06. PMID:11931624. |
details are disclosed for the synthesis of n(alpha)-[4-[2-(2,4-diaminoquinazolin-6-yl)ethyl]benzoyl]-n(delta)-hemiphthaloyl-l-ornithine (2) and n(alpha)-[4-[5-(2,4-diaminoteridin-6-yl)pent-1-yn-4-yl]benzoyl]-n(delta)-hemiphthaloyl-l-ornithine (6) as analogues of n(alpha)-(4-amino-4-deoxypteroyl)-n(delta)-hemiphthaloyl-l-ornithine (1, pt523), a nonpolyglutamatable antifolate currently in advanced preclinical development. |
2002-05-06 |
2023-08-12 |
human |
| X C Lu, A J Williams, F C Tortell. Quantitative electroencephalography spectral analysis and topographic mapping in a rat model of middle cerebral artery occlusion. Neuropathology and applied neurobiology. vol 27. issue 6. 2002-05-01. PMID:11903931. |
reperfusion appeared to promote delta and alpha recovery more efficiently. |
2002-05-01 |
2023-08-12 |
rat |
| L Saraiva, P Fresco, E Pinto, H Portugal, J Gonçalve. Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta. Planta medica. vol 67. issue 9. 2002-04-29. PMID:11745011. |
in the present study daphnetoxin and mezerein were compared as pkc activators on classical (alpha and beta i), novel (delta) and atypical (zeta) isoforms, using an alternative in vivo yeast phenotypic assay. |
2002-04-29 |
2023-08-12 |
Not clear |
| L Saraiva, P Fresco, E Pinto, H Portugal, J Gonçalve. Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta. Planta medica. vol 67. issue 9. 2002-04-29. PMID:11745011. |
mezerein inhibited the growth of yeast expressing pkc alpha (ic(50) = 1190 +/- 237 nm; n = 20), pkc beta i (ic(50) = 908 +/- 46 nm; n = 20), and pkc delta (ic(50) = 141 +/- 25 nm; n = 20) but not of yeast expressing pkc zeta. |
2002-04-29 |
2023-08-12 |
Not clear |
| L Saraiva, P Fresco, E Pinto, H Portugal, J Gonçalve. Differential activation by daphnetoxin and mezerein of PKC-isotypes alpha, beta I, delta and zeta. Planta medica. vol 67. issue 9. 2002-04-29. PMID:11745011. |
daphnetoxin also inhibited the growth of yeast expressing isoforms alpha, beta i and delta, being more potent than mezerein on pkc alpha (ic(50) = 536 +/- 183 nm; n = 20; p < 0.05), as potent as mezerein on pkc beta i (ic(50) = 902 +/- 129 nm; n = 20) and less potent than mezerein upon pkc delta (ic(50) = 3370 +/- 492 nm; n = 20; p < 0.05). |
2002-04-29 |
2023-08-12 |
Not clear |
| Klaus Fink, David J Dooley, Wolfgang P Meder, Nirmala Suman-Chauhan, Sandra Duffy, Hans Clusmann, Manfred Göther. Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex. Neuropharmacology. vol 42. issue 2. 2002-04-29. PMID:11804619. |
gabapentin and pregabalin may bind to the ca(2+) channel alpha 2 delta subunit to selectively attenuate depolarization-induced ca(2+) influx of presynaptic p/q-type ca(2+) channels; this results in decreased glutamate/aspartate release from excitatory amino acid nerve terminals leading to a reduced activation of ampa heteroreceptors on noradrenergic nerve terminals. |
2002-04-29 |
2023-08-12 |
human |
| Brice Junoy, Helene Maccario, Jean-Louis Mas, Alain Enjalbert, Sophia V Drouv. Proteasome implication in phorbol ester- and GnRH-induced selective down-regulation of PKC (alpha, epsilon, zeta) in alpha T(3)-1 and L beta T(2) gonadotrope cell lines. Endocrinology. vol 143. issue 4. 2002-04-29. PMID:11897696. |
we demonstrated that, as in alpha t(3)-1 cells, in a more differentiated gonadotrope cell line l beta t(2) the gnrh-receptor coupling (plc, pla2, pld) generated second messengers essential for pkcs activation; the characterized isoforms (alpha, beta ii, delta, epsilon, zeta) were selectively and differentially down-regulated by tpa (alpha, beta ii, delta, epsilon) or gnrh (delta, epsilon). |
2002-04-29 |
2023-08-12 |
rat |
| K G Sutton, D J Martin, R D Pinnock, K Lee, R H Scot. Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones. British journal of pharmacology. vol 135. issue 1. 2002-04-26. PMID:11786502. |
inhibition was significantly decreased in the presence of the neutral amino acid l-isoleucine (25 microm) but unaffected by application of the gaba(b) antagonist, saclofen (200 microm), suggesting a direct action on the alpha(2)delta subunit of the ca(2+) channel. |
2002-04-26 |
2023-08-12 |
rat |