| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Zafra, Sandra Ramírez, Pablo Castán, Renata Moreno, Felipe Cava, Cristina Vallés, Eddy Caro, José Berengue. A cytochrome c encoded by the nar operon is required for the synthesis of active respiratory nitrate reductase in Thermus thermophilus. FEBS letters. vol 523. issue 1-3. 2002-09-17. PMID:12123812. |
the alpha and delta subunits (narg, narj) of the nr were constitutively expressed in narc::kat mutants, but narg appeared in the soluble fraction instead of associated with the membranes. |
2002-09-17 |
2023-08-12 |
Not clear |
| Toshiya Tachibana, Koichi Noguchi, M A Rud. Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray. Neuroscience letters. vol 327. issue 2. 2002-09-13. PMID:12098653. |
seven genes, lecithin:cholesterol acyltransferase, dipeptidyl aminopeptidase related protein, phospholipase c delta 4, plasma membrane ca2+-atpase isoform 2, g-protein go alpha subunit, gaba transporter 3, and neuroendrocrine protein 7b2 were down-regulated greater than 50% in sci tissue. |
2002-09-13 |
2023-08-12 |
rat |
| Q-T Nguyen, R Miled. Inhibition of skeletal muscle nicotinic receptors by the atypical antipsychotic clozapine. Neuropharmacology. vol 42. issue 5. 2002-09-10. PMID:11985824. |
in this study we examined the effects of the atypical antipsychotic clozapine on nicotinic receptors of frog neuromuscular end-plates or in xenopus oocytes expressing the alpha(1)beta(1)gamma delta mouse skeletal muscle nicotinic receptor. |
2002-09-10 |
2023-08-12 |
mouse |
| Q-T Nguyen, R Miled. Inhibition of skeletal muscle nicotinic receptors by the atypical antipsychotic clozapine. Neuropharmacology. vol 42. issue 5. 2002-09-10. PMID:11985824. |
in oocytes, clozapine inhibited alpha(1)beta(1)gamma delta receptors with an ic(50) of 10 microm and a hill coefficient of 1. |
2002-09-10 |
2023-08-12 |
mouse |
| Q-T Nguyen, R Miled. Inhibition of skeletal muscle nicotinic receptors by the atypical antipsychotic clozapine. Neuropharmacology. vol 42. issue 5. 2002-09-10. PMID:11985824. |
blockage of alpha(1)beta(1)gamma delta receptors by clozapine bears several hallmarks of open-channel blockers, including faster response decays, strong voltage dependence of the block, large rebound currents upon wash, and reduction of peak responses even at saturating concentrations of acetylcholine. |
2002-09-10 |
2023-08-12 |
mouse |
| Deborah M Muoio, Paul S MacLean, David B Lang, Shi Li, Joseph A Houmard, James M Way, Deborah A Winegar, J Christopher Corton, G Lynis Dohm, William E Krau. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of biological chemistry. vol 277. issue 29. 2002-09-06. PMID:12118038. |
real time quantitative pcr analyses showed that unlike in liver and heart, in mouse skeletal muscle ppar delta is severalfold more abundant than either ppar alpha or ppar gamma. |
2002-09-06 |
2023-08-12 |
mouse |
| Deborah M Muoio, Paul S MacLean, David B Lang, Shi Li, Joseph A Houmard, James M Way, Deborah A Winegar, J Christopher Corton, G Lynis Dohm, William E Krau. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of biological chemistry. vol 277. issue 29. 2002-09-06. PMID:12118038. |
in both human and rodent myocytes, the highly selective ppar delta agonist gw742 increased fatty acid oxidation about 2-fold and induced expression of several lipid regulatory genes, including pyruvate-dehydrogenase kinase 4 and uncoupling protein 3, responses that were similar to those elicited by the ppar alpha agonist gw647. |
2002-09-06 |
2023-08-12 |
mouse |
| Deborah M Muoio, Paul S MacLean, David B Lang, Shi Li, Joseph A Houmard, James M Way, Deborah A Winegar, J Christopher Corton, G Lynis Dohm, William E Krau. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. The Journal of biological chemistry. vol 277. issue 29. 2002-09-06. PMID:12118038. |
these results show redundancy in the functions of ppars alpha and delta as transcriptional regulators of fatty acid homeostasis and suggest that in skeletal muscle high levels of the delta-subtype can compensate for deficiency of ppar alpha. |
2002-09-06 |
2023-08-12 |
mouse |
| Kazuki Mochizuki, Kazuhito Suruga, Naomi Sakaguchi, Sachiko Takase, Toshinao God. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Gene. vol 291. issue 1-2. 2002-09-05. PMID:12095700. |
in this study, we demonstrated that ppar alpha and ppar delta interacted with endogenous coactivators in intestinal cell line, caco-2 in a ligand specific manner. |
2002-09-05 |
2023-08-12 |
rat |
| Kazuki Mochizuki, Kazuhito Suruga, Naomi Sakaguchi, Sachiko Takase, Toshinao God. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Gene. vol 291. issue 1-2. 2002-09-05. PMID:12095700. |
mammalian two-hybrid assays in caco-2 cells revealed that p300 interacted with ppar alpha or ppar delta in the presence of their specific ligands more efficiently than cbp did. |
2002-09-05 |
2023-08-12 |
rat |
| Kazuki Mochizuki, Kazuhito Suruga, Naomi Sakaguchi, Sachiko Takase, Toshinao God. Major intestinal coactivator p300 strongly activates peroxisome proliferator-activated receptor in intestinal cell line, Caco-2. Gene. vol 291. issue 1-2. 2002-09-05. PMID:12095700. |
these results suggest that the major intestinal coactivator, p300 strongly interacts with ppar alpha and ppar delta. |
2002-09-05 |
2023-08-12 |
rat |
| Ning Qin, Susan Yagel, Mary-Lou Momplaisir, Ellen E Codd, Michael R D'Andre. Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Molecular pharmacology. vol 62. issue 3. 2002-09-05. PMID:12181424. |
the voltage-gated calcium channel is composed of a pore-forming alpha(1) subunit and several regulatory subunits: alpha(2)delta, beta, and gamma. |
2002-09-05 |
2023-08-12 |
human |
| Ning Qin, Susan Yagel, Mary-Lou Momplaisir, Ellen E Codd, Michael R D'Andre. Molecular cloning and characterization of the human voltage-gated calcium channel alpha(2)delta-4 subunit. Molecular pharmacology. vol 62. issue 3. 2002-09-05. PMID:12181424. |
we report here the identification of a novel alpha(2)delta subunit, alpha(2)delta-4, from the expressed sequence tag database followed by its cloning and characterization. |
2002-09-05 |
2023-08-12 |
human |
| Nicholas J Brandon, Jasmina N Jovanovic, Trevor G Smart, Stephen J Mos. Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 22. issue 15. 2002-09-03. PMID:12151513. |
these receptors are hetero-pentamers that can be assembled from a number of subunit classes: alpha(1-6), beta(1-3), gamma(1-3), delta(1), epsilon, theta;, and pi, but the majority of receptor subtypes is believed, however, to be composed of alpha, beta, and gamma2 subunits. |
2002-09-03 |
2023-08-12 |
Not clear |
| J Moraczewski, A Nowotniak, E Wróbel, M Castagna, J Gautron, I Martell. Differential changes in protein kinase C associated with regeneration of rat extensor digitorum longus and soleus muscles. The international journal of biochemistry & cell biology. vol 34. issue 8. 2002-08-30. PMID:12007632. |
pkc theta; being present the earliest, then delta, epsilon and alpha and finally zeta, beta and eta. |
2002-08-30 |
2023-08-12 |
rat |
| Tony T Huang, Shelby L Feinberg, Sainath Suryanarayanan, Shigeki Miyamot. The zinc finger domain of NEMO is selectively required for NF-kappa B activation by UV radiation and topoisomerase inhibitors. Molecular and cellular biology. vol 22. issue 16. 2002-08-30. PMID:12138192. |
the phospho-i kappa b alpha generated by uv is only detectable by expressing a delta f-box mutant of the ubiquitin ligase beta-trcp, which serves as a specific substrate trap for serine 32 and 36 phosphorylated i kappa b alpha. |
2002-08-30 |
2023-08-12 |
Not clear |
| Inger Sundstrom-Poromaa, Deborah H Smith, Qi Hua Gong, Thomas N Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams, Sheryl S Smit. Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nature neuroscience. vol 5. issue 8. 2002-08-29. PMID:12118257. |
hormonally regulated alpha(4)beta(2)delta gaba(a) receptors are a target for alcohol. |
2002-08-29 |
2023-08-12 |
rat |
| Inger Sundstrom-Poromaa, Deborah H Smith, Qi Hua Gong, Thomas N Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams, Sheryl S Smit. Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nature neuroscience. vol 5. issue 8. 2002-08-29. PMID:12118257. |
here we report that low concentrations of alcohol (1-3 mm) increased cl(-) currents gated by a recombinant gaba(a) receptor, alpha(4)beta(2)delta, by 40-50% in xenopus laevis oocytes. |
2002-08-29 |
2023-08-12 |
rat |
| Inger Sundstrom-Poromaa, Deborah H Smith, Qi Hua Gong, Thomas N Sabado, Xinshe Li, Adam Light, Martin Wiedmann, Keith Williams, Sheryl S Smit. Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nature neuroscience. vol 5. issue 8. 2002-08-29. PMID:12118257. |
we also found greater hippocampal expression of receptors containing alpha(4) and delta subunits, using a rat model of premenstrual syndrome (pms) in which 1-3 mm alcohol preferentially enhanced gaba-gated currents, and low doses of alcohol attenuated anxiety and behavioral reactivity. |
2002-08-29 |
2023-08-12 |
rat |
| Sandra M Hayes, Paul E Lov. Distinct structure and signaling potential of the gamma delta TCR complex. Immunity. vol 16. issue 6. 2002-08-29. PMID:12121664. |
alpha beta and gamma delta t cells are distinguished by the clonotypic subunits contained within their tcrs. |
2002-08-29 |
2023-08-12 |
Not clear |